| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gang Chen, Zunji Ke, Mei Xu, Mingjun Liao, Xin Wang, Yuanlin Qi, Tao Zhang, Jacqueline A Frank, Kimberly A Bower, Xianglin Shi, Jia Lu. Autophagy is a protective response to ethanol neurotoxicity. Autophagy. vol 8. issue 11. 2013-07-10. PMID:22874567. |
ethanol modulation of autophagic activity may be mediated by the mtor pathway. |
2013-07-10 |
2023-08-12 |
Not clear |
| Wei Ge, Rui Guo, Jun Re. AMP-dependent kinase and autophagic flux are involved in aldehyde dehydrogenase-2-induced protection against cardiac toxicity of ethanol. Free radical biology & medicine. vol 51. issue 9. 2012-03-27. PMID:21871561. |
ethanol challenge facilitated myocardial autophagy as evidenced by enhanced expression of beclin, atg7, and lc3b ii, as well as mtor dephosphorylation, which was alleviated by aldh2. |
2012-03-27 |
2023-08-12 |
mouse |
| Wen-Xing Ding, Min Li, Xiao-Ming Yi. Selective taste of ethanol-induced autophagy for mitochondria and lipid droplets. Autophagy. vol 7. issue 2. 2011-04-25. PMID:21150309. |
we have found that ethanol treatment results in autophagy activation, which is at least in part due to the inhibition of mtor signaling by reactive oxygen species. |
2011-04-25 |
2023-08-12 |
Not clear |
| David A Foste. Reduced mortality and moderate alcohol consumption: the phospholipase D-mTOR connection. Cell cycle (Georgetown, Tex.). vol 9. issue 7. 2011-03-31. PMID:20372065. |
in the presence of ethanol, phosphatidyl-ethanol is generated at the expense of pa leading to the suppression of mtor. |
2011-03-31 |
2023-08-12 |
Not clear |
| Patrick R Hagner, Krystyna Mazan-Mamczarz, Bojie Dai, Sharon Corl, X Frank Zhao, Ronald B Gartenhau. Alcohol consumption and decreased risk of non-Hodgkin lymphoma: role of mTOR dysfunction. Blood. vol 113. issue 22. 2009-06-16. PMID:19293424. |
we demonstrate that low-dose chronic exposure to ethanol inhibits mammalian target of rapamycin (mtor) c1 complex formation, resulting in decreased phosphorylation events involved in mtor pathway signaling in a lymphoid-tissue specific manner. |
2009-06-16 |
2023-08-12 |
human |
| Patrick R Hagner, Krystyna Mazan-Mamczarz, Bojie Dai, Sharon Corl, X Frank Zhao, Ronald B Gartenhau. Alcohol consumption and decreased risk of non-Hodgkin lymphoma: role of mTOR dysfunction. Blood. vol 113. issue 22. 2009-06-16. PMID:19293424. |
our data support a paradigm in which chronic ethanol exposure inhibits mtor signaling in lymphocytes with a significant repression of cap-dependent translation, reducing the tumorigenic capacity of non-hodgkin lymphoma in a human xenograft model. |
2009-06-16 |
2023-08-12 |
human |
| Irina Vetter, Bruce D Wyse, Sarah J Roberts-Thomson, Gregory R Monteith, Peter J Cabo. Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol. European journal of pain (London, England). vol 12. issue 4. 2008-04-07. PMID:17826200. |
among other plausible mechanisms, such as non-specific inhibition of kinases including mtor, dna-pk, mlck, mapk and polo-like kinases, this suggests that ethanol may affect the pip2-trpv1 interaction. |
2008-04-07 |
2023-08-12 |
Not clear |
| Charles H Lang, Robert A Frost, Nobuko Deshpande, Vinayshree Kumar, Thomas C Vary, Leonard S Jefferson, Scot R Kimbal. Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle. American journal of physiology. Endocrinology and metabolism. vol 285. issue 6. 2004-01-08. PMID:12944322. |
hence, ethanol produces a leucine resistance in skeletal muscle, as evidenced by the impaired phosphorylation of 4e-bp1, eif4g, s6k1, and mtor, that is independent of elevations in endogenous glucocorticoids. |
2004-01-08 |
2023-08-12 |
rat |