| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Correia-Branco, Elisa Keating, Fátima Marte. Involvement of mTOR, JNK and PI3K in the negative effect of ethanol and metformin on the human first-trimester extravillous trophoblast HTR-8/SVneo cell line. European journal of pharmacology. vol 833. 2018-10-29. PMID:29807029. |
involvement of mtor, jnk and pi3k in the negative effect of ethanol and metformin on the human first-trimester extravillous trophoblast htr-8/svneo cell line. |
2018-10-29 |
2023-08-13 |
human |
| Zeyan Li, Yueqing Tang, Shiqin Zhu, Dawei Li, Xiao Han, Gangli Gu, Naidong Xing, Juchao Ren, Zhaoxin Guo, Wei Jiao, Lei Yan, Zhonghua Xu, Wenhua Zhan. Ethanol extract of Patrinia scabiosaefolia induces the death of human renal cell carcinoma 786-O cells via SIRT-1 and mTOR signaling-mediated metabolic disruptions. Oncology reports. vol 39. issue 2. 2018-08-23. PMID:29251317. |
ethanol extract of patrinia scabiosaefolia induces the death of human renal cell carcinoma 786-o cells via sirt-1 and mtor signaling-mediated metabolic disruptions. |
2018-08-23 |
2023-08-13 |
human |
| Weilong Chang, Jie Bai, Shaobo Tian, Muyuan Ma, Wei Li, Yuping Yin, Rui Deng, Jinyuan Cui, Jinjin Li, Guobin Wang, Peng Zhang, Kaixiong Ta. Autophagy protects gastric mucosal epithelial cells from ethanol-induced oxidative damage via mTOR signaling pathway. Experimental biology and medicine (Maywood, N.J.). vol 242. issue 10. 2017-07-03. PMID:28056554. |
our results demonstrated that ethanol exposure induced gastric mucosal epithelial cell damage, which was accompanied by the downregulation of mtor signaling pathway and activation of autophagy. |
2017-07-03 |
2023-08-13 |
rat |
| Weilong Chang, Jie Bai, Shaobo Tian, Muyuan Ma, Wei Li, Yuping Yin, Rui Deng, Jinyuan Cui, Jinjin Li, Guobin Wang, Peng Zhang, Kaixiong Ta. Autophagy protects gastric mucosal epithelial cells from ethanol-induced oxidative damage via mTOR signaling pathway. Experimental biology and medicine (Maywood, N.J.). vol 242. issue 10. 2017-07-03. PMID:28056554. |
in conclusion, these findings provide evidence that ethanol can activate autophagy via downregulation of the mtor signaling pathway, serving as an adaptive mechanism to ameliorate oxidative damage induced by ethanol in gastric mucosal epithelial cells. |
2017-07-03 |
2023-08-13 |
rat |
| Weilong Chang, Jie Bai, Shaobo Tian, Muyuan Ma, Wei Li, Yuping Yin, Rui Deng, Jinyuan Cui, Jinjin Li, Guobin Wang, Peng Zhang, Kaixiong Ta. Autophagy protects gastric mucosal epithelial cells from ethanol-induced oxidative damage via mTOR signaling pathway. Experimental biology and medicine (Maywood, N.J.). vol 242. issue 10. 2017-07-03. PMID:28056554. |
we have shown that ethanol can activate autophagy via downregulation of the mtor signaling pathway, serving as an adaptive mechanism to ameliorate ethanol-induced oxidative damage in gastric mucosal epithelial cells. |
2017-07-03 |
2023-08-13 |
rat |
| Xiaoling Fu, Zhe Guo, Chang Gao, Qinying Chu, Jianhua Li, Hongying Ma, Gangming Sh. Long-Term Alcohol-Induced Activation of Mammalian Target of Rapamycin is a Key Risk Factor of Epilepsy. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-05-08. PMID:27779177. |
in addition, mouse neuroblastoma ng108-15 cells were treated ethanol for 3 days and subsequently treated with akt inhibitor ly294002 for 2-12 h. the in vitro kinase assay was performed for determining mtor activity. |
2017-05-08 |
2023-08-13 |
mouse |
| Xiaoling Fu, Zhe Guo, Chang Gao, Qinying Chu, Jianhua Li, Hongying Ma, Gangming Sh. Long-Term Alcohol-Induced Activation of Mammalian Target of Rapamycin is a Key Risk Factor of Epilepsy. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-05-08. PMID:27779177. |
in addition, the in vitro kinase assay showed mtor activity was activated by ethanol. |
2017-05-08 |
2023-08-13 |
mouse |
| Jongwan Kim, Eun-Young Yun, Seong-Won Park, Tae-Won Goo, Minchul Se. Allomyrina Dichotoma Larvae Regulate Food Intake and Body Weight in High Fat Diet-Induced Obese Mice Through mTOR and Mapk Signaling Pathways. Nutrients. vol 8. issue 2. 2016-10-24. PMID:26901224. |
intracerebroventricular (icv) administration of ethanol extract of adl (ade) suggested that an antagonizing effect on ghrelin-induced feeding behavior through the mtor and mapk signaling pathways. |
2016-10-24 |
2023-08-13 |
mouse |
| Antoni Pla, María Pascual, Consuelo Guerr. Autophagy Constitutes a Protective Mechanism against Ethanol Toxicity in Mouse Astrocytes and Neurons. PloS one. vol 11. issue 4. 2016-08-29. PMID:27070930. |
our results show that ethanol induces overexpression of several autophagy markers (atg12, lc3-ii, ctsb), and increases the number of lysosomes in wt astrocytes, effects accompanied by a basification of lysosomal ph and by lowered phosphorylation levels of autophagy inhibitor mtor, along with activation of complexes beclin-1 and ulk1. |
2016-08-29 |
2023-08-13 |
mouse |
| Shuai Li, Guang Wang, Lin-Rui Gao, Wen-Hui Lu, Xiao-Yu Wang, Manli Chuai, Kenneth Ka Ho Lee, Liu Cao, Xuesong Yan. Autophagy is involved in ethanol-induced cardia bifida during chick cardiogenesis. Cell cycle (Georgetown, Tex.). vol 14. issue 20. 2016-08-18. PMID:26317250. |
mtor was found to be inhibited by ethanol exposure. |
2016-08-18 |
2023-08-13 |
chicken |
| Jennifer L Steiner, Charles H Lan. Alcohol intoxication following muscle contraction in mice decreases muscle protein synthesis but not mTOR signal transduction. Alcoholism, clinical and experimental research. vol 39. issue 1. 2016-05-19. PMID:25623400. |
alcohol (ethanol [etoh]) intoxication antagonizes stimulation of muscle protein synthesis and mammalian target of rapamycin (mtor) signaling. |
2016-05-19 |
2023-08-13 |
mouse |
| Jia Lu. Autophagy and ethanol neurotoxicity. Autophagy. vol 10. issue 12. 2015-12-08. PMID:25484085. |
ethanol may stimulate autophagy through multiple mechanisms; these include induction of oxidative stress and endoplasmic reticulum stress, modulation of mtor and ampk signaling, alterations in bcl2 family proteins, and disruption of intracellular calcium (ca2+) homeostasis. |
2015-12-08 |
2023-08-13 |
Not clear |
| Krystyna Mazan-Mamczarz, Raymond J Peroutka, James J Steinhardt, Moriah Gidoni, Yongqing Zhang, Elin Lehrmann, Ari L Landon, Bojie Dai, Simone Houng, Parameswary A Muniandy, Sol Efroni, Kevin G Becker, Ronald B Gartenhau. Distinct inhibitory effects on mTOR signaling by ethanol and INK128 in diffuse large B-cell lymphoma. Cell communication and signaling : CCS. vol 13. 2015-09-21. PMID:25849580. |
distinct inhibitory effects on mtor signaling by ethanol and ink128 in diffuse large b-cell lymphoma. |
2015-09-21 |
2023-08-13 |
Not clear |
| Krystyna Mazan-Mamczarz, Raymond J Peroutka, James J Steinhardt, Moriah Gidoni, Yongqing Zhang, Elin Lehrmann, Ari L Landon, Bojie Dai, Simone Houng, Parameswary A Muniandy, Sol Efroni, Kevin G Becker, Ronald B Gartenhau. Distinct inhibitory effects on mTOR signaling by ethanol and INK128 in diffuse large B-cell lymphoma. Cell communication and signaling : CCS. vol 13. 2015-09-21. PMID:25849580. |
ethanol (etoh), similar to pharmacologic mtor inhibitors, has been shown to suppress the mtor signaling pathway, though in a non-catalytic manner. |
2015-09-21 |
2023-08-13 |
Not clear |
| A Pla, M Pascual, J Renau-Piqueras, C Guerr. TLR4 mediates the impairment of ubiquitin-proteasome and autophagy-lysosome pathways induced by ethanol treatment in brain. Cell death & disease. vol 5. 2014-10-21. PMID:24556681. |
ethanol also upregulates mtor phosphorylation, leading to a downregulation of the autophagy-lysosome pathway (atg12, atg5, cathepsin b, p62, lc3) and alters the volume of autophagic vacuoles. |
2014-10-21 |
2023-08-12 |
mouse |
| Anna Onishi, Masami Miyamae, Hiroshi Inoue, Kazuhiro Kaneda, Chika Okusa, Yoshitaka Inamura, Mayumi Shiomi, Shizuka Koshinuma, Yoshihiro Momota, Vincent M Figuered. Sevoflurane confers additive cardioprotection to ethanol preconditioning associated with enhanced phosphorylation of glycogen synthase kinase-3β and inhibition of mitochondrial permeability transition pore opening. Journal of cardiothoracic and vascular anesthesia. vol 27. issue 5. 2014-05-19. PMID:23266287. |
the purposes of this study were to investigate whether sevoflurane (sevo) enhances moderate-dose ethanol (etoh) preconditioning and whether this additional cardioprotection is associated with glycogen synthase kinase-3β (gsk-3β), protein kinase b (akt), mammalian target of rapamycin (mtor), 70-kda ribosomal s6 kinase-1 (p70s6k), and/or mitochondrial permeability transition pore (mptp) opening. |
2014-05-19 |
2023-08-12 |
Not clear |
| Machender R Kandadi, Nan Hu, Jun Re. ULK1 plays a critical role in AMPK-mediated myocardial autophagy and contractile dysfunction following acute alcohol challenge. Current pharmaceutical design. vol 19. issue 27. 2014-02-11. PMID:23448468. |
ethanol exposure facilitated myocardial autophagy as evidenced by enhanced lc3-ii level, as well as phosphorylation of ampk, raptor, and dephosphorylation of mtor and ulki in wt hearts, which were alleviated by ampk knockout. |
2014-02-11 |
2023-08-12 |
mouse |
| Jian-Li Hu, Lan Xiao, Zhen-Yun Li, Qiong Wang, Yu Chang, Yi Ji. Upregulation of HO-1 is accompanied by activation of p38MAPK and mTOR in human oesophageal squamous carcinoma cells. Cell biology international. vol 37. issue 6. 2014-02-05. PMID:23412940. |
ho-1 expression was upregulated in the presence of ethanol, and was accompanied by activation of p38mapk and mtor. |
2014-02-05 |
2023-08-12 |
human |
| Valentina Sabino, Aditi R Narayan, Tamara Zeric, Luca Steardo, Pietro Cotton. mTOR activation is required for the anti-alcohol effect of ketamine, but not memantine, in alcohol-preferring rats. Behavioural brain research. vol 247. 2013-10-21. PMID:23466691. |
finally, ethanol self-administration was assessed in rats administered with either memantine or ketamine but pretreated with the mtor inhibitor rapamycin (2.5mg/kg). |
2013-10-21 |
2023-08-12 |
rat |
| Gang Chen, Zunji Ke, Mei Xu, Mingjun Liao, Xin Wang, Yuanlin Qi, Tao Zhang, Jacqueline A Frank, Kimberly A Bower, Xianglin Shi, Jia Lu. Autophagy is a protective response to ethanol neurotoxicity. Autophagy. vol 8. issue 11. 2013-07-10. PMID:22874567. |
furthermore, ethanol inhibited the mtor pathway and downregulation of mtor offered neuroprotection. |
2013-07-10 |
2023-08-12 |
Not clear |