| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emine B Yalcin, Ming Tong, Busra Delikkaya, William Pelit, Yiwen Yang, Suzanne M de la Mont. Differential effects of moderate chronic ethanol consumption on neurobehavior, white matter glial protein expression, and mTOR pathway signaling with adolescent brain maturation. The American journal of drug and alcohol abuse. 2024-06-07. PMID:38847790. |
differential effects of moderate chronic ethanol consumption on neurobehavior, white matter glial protein expression, and mtor pathway signaling with adolescent brain maturation. |
2024-06-07 |
2024-06-10 |
Not clear |
| Xia-Xia Zhang, Yan-Fei Lang, Xin Li, Zheng Li, You-Qing Xu, Hong-Qian Ch. The protective effect of puerarin-loaded mesoporous silicon nanoparticles on alcoholic hepatitis through mTOR-mediated autophagy pathway. Biomedical microdevices. vol 24. issue 4. 2022-10-29. PMID:36308627. |
furthermore, acute-on-chronic ethanol feeding also resulted in the activiation of erk activation and mtor expression, which were reversed with msns@pue administration and better than the usage of puerarin alone. |
2022-10-29 |
2023-08-14 |
mouse |
| Malgorzata Lopatynska-Mazurek, Anna Antolak, Pawel Grochecki, Ewa Gibula-Tarlowska, Anna Bodzon-Kulakowska, Joanna Listos, Ewa Kedzierska, Piotr Suder, Jerzy Silberring, Jolanta H Kotlinsk. Rapamycin Improves Spatial Learning Deficits, Vulnerability to Alcohol Addiction and Altered Expression of the GluN2B Subunit of the NMDA Receptor in Adult Rats Exposed to Ethanol during the Neonatal Period. Biomolecules. vol 11. issue 5. 2021-09-22. PMID:33924998. |
ethanol exposure during pregnancy alters the mammalian target of rapamycin (mtor) signaling pathway in the fetal brain. |
2021-09-22 |
2023-08-13 |
human |
| Malgorzata Lopatynska-Mazurek, Anna Antolak, Pawel Grochecki, Ewa Gibula-Tarlowska, Anna Bodzon-Kulakowska, Joanna Listos, Ewa Kedzierska, Piotr Suder, Jerzy Silberring, Jolanta H Kotlinsk. Rapamycin Improves Spatial Learning Deficits, Vulnerability to Alcohol Addiction and Altered Expression of the GluN2B Subunit of the NMDA Receptor in Adult Rats Exposed to Ethanol during the Neonatal Period. Biomolecules. vol 11. issue 5. 2021-09-22. PMID:33924998. |
hence, in adult rats exposed to ethanol during the neonatal period, we investigated the influence of rapamycin, an mtor complex 1 (mtorc1) inhibitor, on deficits in spatial memory and reversal learning in the barnes maze task, as well as the ethanol-induced rewarding effects (1.0 or 1.5 g/kg) using the conditioning place preference (cpp) paradigm. |
2021-09-22 |
2023-08-13 |
human |
| Malgorzata Lopatynska-Mazurek, Anna Pankowska, Ewa Gibula-Tarlowska, Radoslaw Pietura, Jolanta H Kotlinsk. Rapamycin Improves Recognition Memory and Normalizes Amino-Acids and Amines Levels in the Hippocampal Dentate Gyrus in Adult Rats Exposed to Ethanol during the Neonatal Period. Biomolecules. vol 11. issue 3. 2021-09-15. PMID:33673489. |
research suggests that ethanol exposure during pregnancy alters the mtor signaling pathway in the fetal hippocampus. |
2021-09-15 |
2023-08-13 |
human |
| María Pascual, Rosa López-Hidalgo, Sandra Montagud-Romero, Juan R Ureña-Peralta, Marta Rodríguez-Arias, Consuelo Guerr. Role of mTOR-regulated autophagy in spine pruning defects and memory impairments induced by binge-like ethanol treatment in adolescent mice. Brain pathology (Zurich, Switzerland). vol 31. issue 1. 2021-09-04. PMID:32876364. |
changes in synaptic plasticity and its regulation by mtor have also been suggested to play a role in the behavioral dysfunction of binge ethanol drinking in adolescence. |
2021-09-04 |
2023-08-13 |
mouse |
| María Pascual, Rosa López-Hidalgo, Sandra Montagud-Romero, Juan R Ureña-Peralta, Marta Rodríguez-Arias, Consuelo Guerr. Role of mTOR-regulated autophagy in spine pruning defects and memory impairments induced by binge-like ethanol treatment in adolescent mice. Brain pathology (Zurich, Switzerland). vol 31. issue 1. 2021-09-04. PMID:32876364. |
therefore, by considering the critical role of mtor in both autophagy and synaptic plasticity in the developing brain, the present study aims to evaluate whether binge ethanol treatment in adolescence would induce dysfunctions in synaptic plasticity and cognitive functions and if mtor inhibition with rapamycin is capable of restoring both effects. |
2021-09-04 |
2023-08-13 |
mouse |
| Zhaoping Li, Deqiang Shen, Yan Meng, Hongzhao Xu, Huacai Yuan, Liyong Che. miR-155-5p alleviates ethanol-induced myocardial insulin resistance in H9C2 cells via regulating the mTOR signalling pathway. Molecular biology reports. vol 47. issue 12. 2021-05-27. PMID:33159675. |
the mir-155-5p level increased under ethanol exposure, accompanied by a decrease in glucose uptake, an increase in p-irs1(ser 307) and activation of the mtor signaling pathway in h9c2 cells. |
2021-05-27 |
2023-08-13 |
Not clear |
| Ayuni Yussof, Paul Yoon, Cayley Krkljes, Sarah Schweinberg, Jessica Cottrell, Tinchun Chu, Sulie L Chan. A meta-analysis of the effect of binge drinking on the oral microbiome and its relation to Alzheimer's disease. Scientific reports. vol 10. issue 1. 2021-03-17. PMID:33199776. |
the qiagen ingenuity pathway analysis (ipa) shows that high levels of ethanol in binge drinkers cause a shift in the microbiome that leads to the development of ad through the activation of eif2, regulation of eif4 and p70s6k signaling, and mtor signaling pathways. |
2021-03-17 |
2023-08-13 |
Not clear |
| Pongsak Sangaunchom, Permphan Dharmasaroj. Caffeine Potentiates Ethanol-Induced Neurotoxicity Through mTOR/p70S6K/4E-BP1 Inhibition in SH-SY5Y Cells. International journal of toxicology. vol 39. issue 2. 2021-02-10. PMID:31955628. |
the phosphorylation of mtor, p70s6k, and 4e-bp1 markedly decreased in cells exposed to caffeine after ethanol pretreatment, associated with a decrease of the mitochondrial membrane potential (ΔΨm). |
2021-02-10 |
2023-08-13 |
human |
| Jin-Ho Koh, Ki-Hoon Kim, Sol-Yi Park, Yong-Woon Kim, Jong-Yeon Ki. PPARδ Attenuates Alcohol-Mediated Insulin Resistance by Enhancing Fatty Acid-Induced Mitochondrial Uncoupling and Antioxidant Defense in Skeletal Muscle. Frontiers in physiology. vol 11. 2020-09-28. PMID:32760285. |
we show that consumption of ethanol (etoh) reduces the activation of 5'amp-activated protein kinase (ampk) and mammalian target of rapamycin (mtor) as well as the protein of carnitine palmitoyltransferase 1 (cpt1) and glucose transporter type 4 (glut4) in c |
2020-09-28 |
2023-08-13 |
Not clear |
| Qianhao Yang, Wenjing Yin, Yixuan Chen, Daoyu Zhu, Junhui Yin, Changqing Zhang, Youshui Ga. Betaine alleviates alcohol-induced osteonecrosis of the femoral head via mTOR signaling pathway regulation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 120. 2020-04-07. PMID:31586901. |
in vitro, we found that ethanol significantly downregulated the expression of osteocalcin (ocn), collagen 1 (col1) and runx2 via activating the mammalian target of rapamycin (mtor) signaling cascade. |
2020-04-07 |
2023-08-13 |
human |
| Yongchao Wang, Xin Wang, Hui Li, Mei Xu, Jacqueline Frank, Jia Lu. Binge ethanol exposure induces endoplasmic reticulum stress in the brain of adult mice. Toxicology and applied pharmacology. vol 356. 2019-03-21. PMID:30114398. |
the current study sought to determine whether binge ethanol exposure induces er stress in adult mouse brain and the role mtor signaling during this process. |
2019-03-21 |
2023-08-13 |
mouse |
| Yongchao Wang, Xin Wang, Hui Li, Mei Xu, Jacqueline Frank, Jia Lu. Binge ethanol exposure induces endoplasmic reticulum stress in the brain of adult mice. Toxicology and applied pharmacology. vol 356. 2019-03-21. PMID:30114398. |
binge ethanol exposure caused neurodegeneration and neuroinflammation after 5 days of exposure, and a concomitant increase of er stress and inhibition of mtor. |
2019-03-21 |
2023-08-13 |
mouse |
| Jorge Montesinos, María Pascual, David Millán-Esteban, Consuelo Guerr. Binge-like ethanol treatment in adolescence impairs autophagy and hinders synaptic maturation: Role of TLR4. Neuroscience letters. vol 682. 2019-03-11. PMID:29864452. |
with wild-type (wt) and tlr4-deficient (tlr4-ko) adolescent mice treated intermittently with ethanol (3.0 g/kg) for 2 weeks, we show that binge-like ethanol exposure in adolescence impairs autophagy machinery by increasing autophagy inhibitor mtor by lowering lc3-ii levels and accumulating p62. |
2019-03-11 |
2023-08-13 |
mouse |
| Hanqing Chen, Feng Shen, Alex Sherban, Allison Nocon, Yu Li, Hua Wang, Ming-Jiang Xu, Xianliang Rui, Jinyan Han, Bingbing Jiang, Donghwan Lee, Na Li, Farnaz Keyhani-Nejad, Jian-Gao Fan, Feng Liu, Amrita Kamat, Nicolas Musi, Leonard Guarente, Pal Pacher, Bin Gao, Mengwei Zan. DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease. Hepatology (Baltimore, Md.). vol 68. issue 2. 2019-01-31. PMID:29457836. |
chronic-plus-binge ethanol feeding led to hyperactivation of mtorc1, as evidenced by increased phosphorylation of mtor and its downstream kinase s6 kinase 1 (s6k1) in hepatocytes. |
2019-01-31 |
2023-08-13 |
mouse |
| Ana Correia-Branco, Elisa Keating, Fátima Marte. Involvement of mTOR, JNK and PI3K in the negative effect of ethanol and metformin on the human first-trimester extravillous trophoblast HTR-8/SVneo cell line. European journal of pharmacology. vol 833. 2018-10-29. PMID:29807029. |
involvement of mtor, jnk and pi3k in the negative effect of ethanol and metformin on the human first-trimester extravillous trophoblast htr-8/svneo cell line. |
2018-10-29 |
2023-08-13 |
human |
| Zeyan Li, Yueqing Tang, Shiqin Zhu, Dawei Li, Xiao Han, Gangli Gu, Naidong Xing, Juchao Ren, Zhaoxin Guo, Wei Jiao, Lei Yan, Zhonghua Xu, Wenhua Zhan. Ethanol extract of Patrinia scabiosaefolia induces the death of human renal cell carcinoma 786-O cells via SIRT-1 and mTOR signaling-mediated metabolic disruptions. Oncology reports. vol 39. issue 2. 2018-08-23. PMID:29251317. |
ethanol extract of patrinia scabiosaefolia induces the death of human renal cell carcinoma 786-o cells via sirt-1 and mtor signaling-mediated metabolic disruptions. |
2018-08-23 |
2023-08-13 |
human |
| Weilong Chang, Jie Bai, Shaobo Tian, Muyuan Ma, Wei Li, Yuping Yin, Rui Deng, Jinyuan Cui, Jinjin Li, Guobin Wang, Peng Zhang, Kaixiong Ta. Autophagy protects gastric mucosal epithelial cells from ethanol-induced oxidative damage via mTOR signaling pathway. Experimental biology and medicine (Maywood, N.J.). vol 242. issue 10. 2017-07-03. PMID:28056554. |
our results demonstrated that ethanol exposure induced gastric mucosal epithelial cell damage, which was accompanied by the downregulation of mtor signaling pathway and activation of autophagy. |
2017-07-03 |
2023-08-13 |
rat |
| Weilong Chang, Jie Bai, Shaobo Tian, Muyuan Ma, Wei Li, Yuping Yin, Rui Deng, Jinyuan Cui, Jinjin Li, Guobin Wang, Peng Zhang, Kaixiong Ta. Autophagy protects gastric mucosal epithelial cells from ethanol-induced oxidative damage via mTOR signaling pathway. Experimental biology and medicine (Maywood, N.J.). vol 242. issue 10. 2017-07-03. PMID:28056554. |
in conclusion, these findings provide evidence that ethanol can activate autophagy via downregulation of the mtor signaling pathway, serving as an adaptive mechanism to ameliorate oxidative damage induced by ethanol in gastric mucosal epithelial cells. |
2017-07-03 |
2023-08-13 |
rat |