| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Mendel, N Kerlero de Rosbo, A Ben-Nu. A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells. European journal of immunology. vol 25. issue 7. 1995-08-29. PMID:7621871. |
a predominant response to myelin oligodendrocyte glycoprotein (mog) was recently observed in patients with multiple sclerosis (ms). |
1995-08-29 |
2023-08-12 |
mouse |
| N Schaeren-Wiemers, C Schaefer, D M Valenzuela, G D Yancopoulos, M E Schwa. Identification of new oligodendrocyte- and myelin-specific genes by a differential screening approach. Journal of neurochemistry. vol 65. issue 1. 1995-07-26. PMID:7790852. |
four of these genes are exclusively expressed by oligodendrocytes: three of these are not related to known genes, whereas one encodes the myelin oligodendrocyte glycoprotein (mog). |
1995-07-26 |
2023-08-12 |
rat |
| A A Hilton, A J Slavin, D J Hilton, C C Bernar. Characterization of cDNA and genomic clones encoding human myelin oligodendrocyte glycoprotein. Journal of neurochemistry. vol 65. issue 1. 1995-07-26. PMID:7790876. |
myelin oligodendrocyte glycoprotein (mog) is a transmembrane protein expressed only in the cns and is a possible target autoantigen in multiple sclerosis (ms). |
1995-07-26 |
2023-08-12 |
human |
| I Huitinga, S R Ruuls, S Jung, N Van Rooijen, H P Hartung, C D Dijkstr. Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats. Clinical and experimental immunology. vol 100. issue 2. 1995-06-15. PMID:7743675. |
t cell-eae with pronounced demyelination as induced by an additionally injected moab directed against myelin oligodendrocyte glycoprotein (mog) was also significantly ameliorated after macrophage depletion. |
1995-06-15 |
2023-08-12 |
rat |
| C Fressinaud, J M Vallat, G Labourdett. Basic fibroblast growth factor down-regulates myelin basic protein gene expression and alters myelin compaction of mature oligodendrocytes in vitro. Journal of neuroscience research. vol 40. issue 3. 1995-06-14. PMID:7745622. |
moreover, the percentage of oligodendrocytes labelled with anti-mbp antibodies decreased by 50%, as well as that of oligodendrocytes expressing myelin oligodendrocyte glycoprotein (mog), whereas proteolipid protein (plp) immunolabelled cells were less affected. |
1995-06-14 |
2023-08-12 |
rat |
| N Kerlero de Rosbo, I Mendel, A Ben-Nu. Chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in PL/J mice by myelin oligodendrocyte glycoprotein (MOG)-derived peptide: preliminary analysis of MOG T cell epitopes. European journal of immunology. vol 25. issue 4. 1995-06-07. PMID:7737302. |
chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in pl/j mice by myelin oligodendrocyte glycoprotein (mog)-derived peptide: preliminary analysis of mog t cell epitopes. |
1995-06-07 |
2023-08-12 |
mouse |
| N Kerlero de Rosbo, I Mendel, A Ben-Nu. Chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in PL/J mice by myelin oligodendrocyte glycoprotein (MOG)-derived peptide: preliminary analysis of MOG T cell epitopes. European journal of immunology. vol 25. issue 4. 1995-06-07. PMID:7737302. |
however, there is increasing evidence to suggest that autoimmune reactivity against the quantitatively minor myelin component, myelin oligodendrocyte glycoprotein (mog), can also play a role in the pathogenicity of ms. we recently demonstrated a predominant response to mog by peripheral blood lymphocytes from patients with ms tested for their reactivity against various myelin antigens, including mbp and plp. |
1995-06-07 |
2023-08-12 |
mouse |
| S Amor, N Groome, C Linington, M M Morris, K Dornmair, M V Gardinier, J M Matthieu, D Bake. Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice. Journal of immunology (Baltimore, Md. : 1950). vol 153. issue 10. 1994-12-07. PMID:7525700. |
a recombinant protein corresponding to the ig-like domain of myelin oligodendrocyte glycoprotein (mog) and synthetic 15-mer peptides of the whole mog molecule with eight amino acid overlaps were screened for their ability to induce experimental allergic encephalomyelitis (eae) in biozzi ab/h (h-2dq1) and sjl (h-2s) mice. |
1994-12-07 |
2023-08-12 |
mouse |
| C Z Lu, S Fredrikson, B G Xiao, H Lin. Interleukin-2 secreting cells in multiple sclerosis and controls. Journal of the neurological sciences. vol 120. issue 1. 1994-02-22. PMID:8289087. |
numbers of il-2 secreting cells were higher in ms patients compared to patients with am + th after stimulation with myelin proteolipid protein (plp), myelin associated glycoprotein (mag) and myelin oligodendrocyte glycoprotein (mog), but not after stimulation with myelin basic protein (mbp). |
1994-02-22 |
2023-08-12 |
Not clear |
| N Kerlero de Rosbo, R Milo, M B Lees, D Burger, C C Bernard, A Ben-Nu. Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. The Journal of clinical investigation. vol 92. issue 6. 1994-01-12. PMID:7504688. |
although t cell responses to the quantitatively major myelin proteins, myelin basic protein (mbp) and proteolipid protein (plp), are likely to be of importance in the course of multiple sclerosis (ms), cell-mediated autoimmune responses to other myelin antigens, in particular quantitatively minor myelin antigens, such as myelin-associated glycoprotein (mag) and the central nervous system-specific myelin oligodendrocyte glycoprotein (mog), could also play a prevalent role in disease initiation or progression. |
1994-01-12 |
2023-08-12 |
Not clear |
| S Abo, C C Bernard, M Webb, T G Johns, A Alafaci, L D Ward, R J Simpson, N Kerlero de Rosb. Preparation of highly purified human myelin oligodendrocyte glycoprotein in quantities sufficient for encephalitogenicity and immunogenicity studies. Biochemistry and molecular biology international. vol 30. issue 5. 1993-11-26. PMID:8220243. |
myelin oligodendrocyte glycoprotein, (mog), a quantitatively minor central nervous system (cns) myelin component, is a candidate target antigen for autoimmune-mediated demyelination. |
1993-11-26 |
2023-08-12 |
human |
| M V Gardinier, J M Matthie. Cloning and cDNA sequence analysis of myelin/oligodendrocyte glycoprotein: a novel member of the immunoglobulin gene superfamily. Schweizer Archiv fur Neurologie und Psychiatrie (Zurich, Switzerland : 1985). vol 144. issue 3. 1993-08-17. PMID:7687365. |
myelin/oligodendrocyte glycoprotein (mog) is a cns-specific protein that has been identified on the external myelin sheath and oligodendrocyte processes. |
1993-08-17 |
2023-08-12 |
rat |
| C A Dye. Novel oligodendrocyte transmembrane signaling systems. Investigations utilizing antibodies as ligands. Molecular neurobiology. vol 7. issue 1. 1993-08-05. PMID:8391270. |
binding of specific antibodies to the oligodendrocyte membrane surface markers myelin/oligodendrocyte glycoprotein (mog), myelin/oligodendrocyte specific protein (mosp), galactocerebroside (galc), and sulfatide on cultured murine oligodendrocytes results in different effects with regard to phospholipid turnover, ca2+ influxes, and antibody:marker distribution. |
1993-08-05 |
2023-08-12 |
Not clear |
| C Linington, T Berger, L Perry, S Weerth, D Hinze-Selch, Y Zhang, H C Lu, H Lassmann, H Wekerl. T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system. European journal of immunology. vol 23. issue 6. 1993-07-01. PMID:7684687. |
myelin oligodendrocyte glycoprotein (mog)-specific t cells mediate an autoimmune inflammatory response in the central nervous system (cns) that differs radically from conventional models of t cell-mediated experimental allergic encephalomyelitis (eae). |
1993-07-01 |
2023-08-12 |
rat |
| J B Su. Autoreactive T and B cells in nervous system diseases. Acta neurologica Scandinavica. Supplementum. vol 142. 1993-03-30. PMID:8382894. |
abnormal autoimmunity could play a role in the pathogenesis of multiple sclerosis (ms), in analogy with its model experimental allergic encephalomyelitis (eae) which can be transferred by t cell lines directed to myelin basic protein (mbp) and myelin proteolipid protein (plp), and worsened with antibody to myelin oligodendrocyte glycoprotein (mog). |
1993-03-30 |
2023-08-12 |
Not clear |
| C Linington, B Engelhardt, G Kapocs, H Lassma. Induction of persistently demyelinated lesions in the rat following the repeated adoptive transfer of encephalitogenic T cells and demyelinating antibody. Journal of neuroimmunology. vol 40. issue 2-3. 1992-12-01. PMID:1385471. |
a chronic relapsing model of demyelinating experimental allergic encephalomyelitis (eae) was induced in lewis rats by the repeated co-transfer of encephalitogenic, myelin basic protein (mbp)-specific t cells in combination with a demyelinating monoclonal antibody (mab) specific for the myelin oligodendrocyte glycoprotein (mog). |
1992-12-01 |
2023-08-11 |
rat |
| P Amiguet, M V Gardinier, J P Zanetta, J M Matthie. Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein. Journal of neurochemistry. vol 58. issue 5. 1992-05-11. PMID:1373175. |
the myelin/oligodendrocyte glycoprotein (mog) is found exclusively in the cns, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes. |
1992-05-11 |
2023-08-11 |
mouse |
| S Fredrikson, J Sun, B G Xiao, H Lin. Cord blood contains cells secreting antibodies to nervous system components. Clinical and experimental immunology. vol 84. issue 2. 1991-06-11. PMID:1709072. |
umbilical cord blood of newborns and peripheral blood of healthy adults were investigated by an immunospot assay for cells secreting igg, iga and igm antibodies against myelin basic protein (mbp), proteolipid protein (plp), myelin-associated glycoprotein (mag) and myelin oligodendrocyte glycoprotein (mog) which represent putative antigens for an autoimmune attack in multiple sclerosis (ms) and against acetylcholine receptor (achr) which is considered an important autoantigen in myasthenia gravis. |
1991-06-11 |
2023-08-11 |
Not clear |
| J M Matthieu, P Amigue. Myelin/oligodendrocyte glycoprotein expression during development in normal and myelin-deficient mice. Developmental neuroscience. vol 12. issue 4-5. 1991-04-03. PMID:2289413. |
mog is localized on the surface of myelin and oligodendrocyte processes. |
1991-04-03 |
2023-08-11 |
mouse |
| S K Ludwi. Phagocytosis in the rat optic nerve following Wallerian degeneration. Acta neuropathologica. vol 80. issue 3. 1990-10-16. PMID:2399808. |
oligodendrocytes were demonstrated ultrastructurally using immunohistochemistry with monoclonal antibodies against myelin oligodendrocyte glycoprotein (mog). |
1990-10-16 |
2023-08-11 |
rat |