| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroyuki Ichijo, Nguyen Thi Van Trang, Tomoya Nakamur. Topographic Organization of Glutamatergic and GABAergic Parvalbumin Positive Neurons in the Lateral Habenula. eNeuro. 2024-07-03. PMID:38960707. |
to achieve this, we investigated the proportions of the transmitter machinery in lhb pv neurons, including gabaergic, glutamatergic, serotonergic, cholinergic, and dopaminergic neurotransmitter markers, using transcriptome analysis, mrna in situ hybridization chain reaction, and immunohistochemistry. |
2024-07-03 |
2024-07-10 |
mouse |
| Guoyi Tang, Yuan Guo, Ruotong Li, Yixuan Wang, Jie Yang, Shasha Gao, Jian Li. Lateral habenula 5-HT Neurochemistry international. 2024-05-16. PMID:38750961. |
lateral habenula 5-ht although the output of the lateral habenula (lhb) controls the activity of midbrain dopaminergic and serotonergic systems, which are implicated in the pathophysiology of anxiety, it is not clear the role of lhb 5-ht |
2024-05-16 |
2024-05-27 |
Not clear |
| Huihui Tan, Chengxue Du, Li Zhang, Yuan Guo, Yaxin Yang, Qingfeng Sun, Qiaojun Zhang, Libo L. Lesions of the lateral habenula excite dopamine neurons in the ventral tegmental area and serotonin neurons in the dorsal raphe nuclei in hemiparkinsonian rats. Brain research. 2024-04-08. PMID:38588847. |
these finding suggest that lesions of the lhb enhance the activity of mesocorticolimbic dopaminergic and serotonergic systems in pd. |
2024-04-08 |
2024-04-11 |
rat |
| Arman Hajikarim-Hamedani, Amirhossein Heidari, Mitra-Sadat Sadat-Shirazi, Sarah Mahboubi, Samira Raminfard, Solmaz Khalifeh, Mohammad-Reza Zarrindas. The role of lateral habenula NMDA receptors in tramadol-induced conditioning. Behavioural pharmacology. 2023-07-04. PMID:37401401. |
the role of the lateral habenula (lhb) as a hub for receiving and relaying signals from the limbic system to serotonergic, dopaminergic, and norepinephrinergic regions in the brainstem makes this area a critical region in the control of reward and addiction. |
2023-07-04 |
2023-08-14 |
rat |
| Dan Dong, Xiaofeng Liu, Lijiang Ma, Yu Lei Hao, Li Zhang, Meiying Song, Zhonggao Xu, Hua Zha. Dapagliflozin inhibits the activity of lateral habenula to alleviate diabetes mellitus-induced depressive-like behavior. Experimental neurology. 2023-05-21. PMID:37211324. |
these results suggest that dapagliflozin directly acts on the lhb to alleviate dm-induced depressive-like behavior and that the underlying mechanism involves activating the ampk signaling pathway, leading to the inhibition of lhb neuronal activity, which in turn increases serotonergic activity in the drn. |
2023-05-21 |
2023-08-14 |
rat |
| M E Flanigan, O J Hon, S D'Ambrosio, K M Boyt, L Hassanein, M Castle, H L Haun, M M Pina, T L Kas. Subcortical serotonin 5HT Nature communications. vol 14. issue 1. 2023-03-31. PMID:37002196. |
these negative behavioral outcomes were associated with sex-specific adaptations in serotonergic signaling systems within the lateral habenula (lhb) and the bed nucleus of the stria terminalis (bnst), particularly those related to the receptor 5ht |
2023-03-31 |
2023-08-14 |
mouse |
| Yaxin Yang, Jian Liu, Yixuan Wang, Xiang Wu, Libo Li, Guanyun Bian, Wenjuan Li, Haifeng Yuan, Qiaojun Zhan. Blockade of pre-synaptic and post-synaptic GABA Neuropharmacology. vol 196. 2021-10-01. PMID:34246684. |
blockade of pre-synaptic and post-synaptic gaba although the output of the lateral habenula (lhb) controls the activity of midbrain dopaminergic and serotonergic systems, which are implicated in the pathophysiology of anxiety, it is not known how blockade of gaba |
2021-10-01 |
2023-08-13 |
Not clear |
| Anna Tchenio, Kristina Valentinova, Manuel Mamel. Can the Lateral Habenula Crack the Serotonin Code? Frontiers in synaptic neuroscience. vol 8. 2020-10-01. PMID:27822183. |
we then describe the type, properties and pharmacology of serotonergic receptors expressed throughout the lhb. |
2020-10-01 |
2023-08-13 |
Not clear |
| Anna Tchenio, Kristina Valentinova, Manuel Mamel. Can the Lateral Habenula Crack the Serotonin Code? Frontiers in synaptic neuroscience. vol 8. 2020-10-01. PMID:27822183. |
altogether, we combine a mechanistic- and circuit-level knowledge to provide an overview on how the lhb integrates serotonergic signals, a process potentially contributing to lhb-dependent encoding of valenced external stimuli. |
2020-10-01 |
2023-08-13 |
Not clear |
| Anna Tchenio, Kristina Valentinova, Manuel Mamel. Can the Lateral Habenula Crack the Serotonin Code? Frontiers in synaptic neuroscience. vol 8. 2020-10-01. PMID:27822183. |
the lateral habenula (lhb) and the serotonergic system both contribute to motivational states by encoding rewarding and aversive signals. |
2020-10-01 |
2023-08-13 |
Not clear |
| Anna Tchenio, Kristina Valentinova, Manuel Mamel. Can the Lateral Habenula Crack the Serotonin Code? Frontiers in synaptic neuroscience. vol 8. 2020-10-01. PMID:27822183. |
finally, we discuss physiological data reporting how serotonergic signaling modifies synaptic transmission and neuronal activity within the lhb. |
2020-10-01 |
2023-08-13 |
Not clear |
| Anna Tchenio, Kristina Valentinova, Manuel Mamel. Can the Lateral Habenula Crack the Serotonin Code? Frontiers in synaptic neuroscience. vol 8. 2020-10-01. PMID:27822183. |
anatomical and functional studies indicate that the serotonergic system and the lhb are interconnected in a forward-feedback loop. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jin Zhang, Yong Wang, Yi Na Sun, Li Bo Li, Li Zhang, Yuan Guo, Tao Wang, Lu Yao, Li Chen, Jian Li. Blockade of calcium-permeable AMPA receptors in the lateral habenula produces increased antidepressant-like effects in unilateral 6-hydroxydopamine-lesioned rats compared to sham-lesioned rats. Neuropharmacology. vol 157. 2020-07-21. PMID:31251995. |
our findings indicate that blockade of lhb cp-ampars produces antidepressant-like effects, which attribute to decreased firing activity of lhb neurons and increased levels of dopamine and serotonin in the mpfc, and provide further evidence that lhb cp-ampars regulate the firing activity of pvta dopaminergic neurons and mrn serotonergic neurons indirectly via the rmtg. |
2020-07-21 |
2023-08-13 |
rat |
| Hailan Hu, Yihui Cui, Yan Yan. Circuits and functions of the lateral habenula in health and in disease. Nature reviews. Neuroscience. vol 21. issue 5. 2020-05-11. PMID:32269316. |
the lhb, sometimes referred to as the brain's 'antireward centre', receives inputs from diverse limbic forebrain and basal ganglia structures, and targets essentially all midbrain neuromodulatory systems, including the noradrenergic, serotonergic and dopaminergic systems. |
2020-05-11 |
2023-08-13 |
Not clear |
| Jin Zhang, Shuxuan Lv, Guoyi Tang, Guanyun Bian, Yaxin Yang, Ruotong Li, Jie Yang, Jian Li. Activation of calcium-impermeable GluR2-containing AMPA receptors in the lateral habenula produces antidepressant-like effects in a rodent model of Parkinson's disease. Experimental neurology. vol 322. 2020-02-24. PMID:31499061. |
collectively, antidepressant-like effects produced by (s)-ampa attribute to activation of lhb neurons expressing ci-ampar, which excites avta dopaminergic neurons and drn serotonergic neurons via the direct projection, thereby increasing release of mpfc da and 5-ht. |
2020-02-24 |
2023-08-13 |
rat |
| Francis Delicata, Cristiano Bombardi, Massimo Pierucci, Roberto Di Maio, Philippe De Deurwaerdère, Giuseppe Di Giovann. Preferential modulation of the lateral habenula activity by serotonin-2A rather than -2C receptors: Electrophysiological and neuroanatomical evidence. CNS neuroscience & therapeutics. vol 24. issue 8. 2019-05-29. PMID:29479825. |
serotonergic (5-ht) modulation of the lateral habenula (lhb) activity is central in normal and pathologic conditions such as mood disorders. |
2019-05-29 |
2023-08-13 |
Not clear |
| Cheng Xue Du, Jian Liu, Yuan Guo, Li Zhang, Qiao Jun Zhan. Lesions of the lateral habenula improve working memory performance in hemiparkinsonian rats. Neuroscience letters. vol 662. 2018-06-29. PMID:29054431. |
the lateral habenula (lhb) is an important structure involved in various brain functions, because it controls the activity of dopaminergic and serotonergic systems in the midbrain. |
2018-06-29 |
2023-08-13 |
rat |
| Phillip M Baker, Thomas Jhou, Bo Li, Masayuki Matsumoto, Sheri J Y Mizumori, Marcus Stephenson-Jones, Aleksandra Vicenti. The Lateral Habenula Circuitry: Reward Processing and Cognitive Control. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 45. 2017-07-17. PMID:27911751. |
the lhb gets major inputs from the habenula-projecting globus pallidus and the mpfc, sending its efferents to the dopaminergic vta and snc, serotonergic dorsal raphe nuclei, and the gabaergic rostromedial tegmental nucleus. |
2017-07-17 |
2023-08-13 |
Not clear |
| Xiao Feng Luo, Bei Lin Zhang, Ji Cheng Li, Ying Ying Yang, Yan Fei Sun, Hua Zha. Lateral habenula as a link between dopaminergic and serotonergic systems contributes to depressive symptoms in Parkinson's disease. Brain research bulletin. vol 110. 2015-09-09. PMID:25499570. |
thus, lhb contributes to the depressive-like behavior in pd rats via mediating the effects of dopaminergic neurons in the substantia nigra on serotonergic neurons in the raphe nuclei. |
2015-09-09 |
2023-08-13 |
rat |
| Hua Zhao, Bei-Lin Zhang, Shao-Jun Yang, Benjamin Rusa. The role of lateral habenula-dorsal raphe nucleus circuits in higher brain functions and psychiatric illness. Behavioural brain research. vol 277. 2015-09-08. PMID:25234226. |
the lhb is a key regulator of the activity of drn serotonergic neurons, and it also receives reciprocal input from the drn. |
2015-09-08 |
2023-08-13 |
Not clear |