| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| René Bernard, Rüdiger W Ve. Individual neurons in the rat lateral habenular complex project mostly to the dopaminergic ventral tegmental area or to the serotonergic raphe nuclei. The Journal of comparative neurology. vol 520. issue 11. 2012-09-28. PMID:22492391. |
our results show that 1) the distribution of neurons in the lhb projecting to the three monoamine nuclei is similar and exhibits a great overlap, 2) the vast majority of lhb projection neurons target one monoaminergic nucleus only, and 3) very few, heterogeneously distributed lhb neurons project to both dopaminergic and serotonergic nuclei. |
2012-09-28 |
2023-08-12 |
rat |
| Xuefeng Shen, Xiaoguo Ruan, Hua Zha. Stimulation of midbrain dopaminergic structures modifies firing rates of rat lateral habenula neurons. PloS one. vol 7. issue 4. 2012-07-27. PMID:22485164. |
the vta and snpc give rise to dopaminergic projections that innervate the lhb, which is also known to be involved in processing painful stimuli. |
2012-07-27 |
2023-08-12 |
rat |
| Xuefeng Shen, Xiaoguo Ruan, Hua Zha. Stimulation of midbrain dopaminergic structures modifies firing rates of rat lateral habenula neurons. PloS one. vol 7. issue 4. 2012-07-27. PMID:22485164. |
we conclude that lhb pain-activated neurons can receive diverse reward-related signals originating from midbrain dopaminergic structures, and thus participate in the regulation of the brain reward system via both positive and negative feedback mechanisms. |
2012-07-27 |
2023-08-12 |
rat |
| Steven J Shabel, Christophe D Proulx, Anthony Trias, Ryan T Murphy, Roberto Malino. Input to the lateral habenula from the basal ganglia is excitatory, aversive, and suppressed by serotonin. Neuron. vol 74. issue 3. 2012-07-12. PMID:22578499. |
the lateral habenula (lhb) has recently been identified as a key regulator of the reward system by driving inhibition onto dopaminergic neurons. |
2012-07-12 |
2023-08-12 |
Not clear |
| W C Poller, R Bernard, C Derst, T Weiss, V I Madai, R W Ve. Lateral habenular neurons projecting to reward-processing monoaminergic nuclei express hyperpolarization-activated cyclic nucleotid-gated cation channels. Neuroscience. vol 193. 2012-01-18. PMID:21798320. |
major projections of lhb neurons target the dopaminergic ventral tegmental area (vta) and the serotonergic dorsal (dr) and median raphe nuclei (mnr). |
2012-01-18 |
2023-08-12 |
rat |
| K Brinschwitz, A Dittgen, V I Madai, R Lommel, S Geisler, R W Ve. Glutamatergic axons from the lateral habenula mainly terminate on GABAergic neurons of the ventral midbrain. Neuroscience. vol 168. issue 2. 2010-08-19. PMID:20353812. |
in addition, however, a small number of lhb terminals in the vta actually contacts dopaminergic neurons. |
2010-08-19 |
2023-08-12 |
Not clear |
| Jason Shumake, Anton Ilango, Henning Scheich, Wolfram Wetzel, Frank W Oh. Differential neuromodulation of acquisition and retrieval of avoidance learning by the lateral habenula and ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 17. 2010-05-24. PMID:20427648. |
previous work has linked lhb activation to the inhibition of dopaminergic neurons during loss of reward, as well as to deficits in escape and avoidance learning. |
2010-05-24 |
2023-08-12 |
Not clear |
| A B Kowski, R W Veh, T Weis. Dopaminergic activation excites rat lateral habenular neurons in vivo. Neuroscience. vol 161. issue 4. 2009-08-25. PMID:19374940. |
the lhb has been implicated in the regulation of ascending monoaminergic transmission, particularly midbrain dopaminergic neuronal activity. |
2009-08-25 |
2023-08-12 |
human |
| A B Kowski, R W Veh, T Weis. Dopaminergic activation excites rat lateral habenular neurons in vivo. Neuroscience. vol 161. issue 4. 2009-08-25. PMID:19374940. |
here, we have investigated whether the lhb in turn is subject to dopaminergic modulation. |
2009-08-25 |
2023-08-12 |
human |
| A B Kowski, R W Veh, T Weis. Dopaminergic activation excites rat lateral habenular neurons in vivo. Neuroscience. vol 161. issue 4. 2009-08-25. PMID:19374940. |
alterations in spontaneous neuronal activity within the lhb following systemic application of dopaminergic drugs have been examined in anesthetized rats using extracellular single unit recordings. |
2009-08-25 |
2023-08-12 |
human |
| A B Kowski, R W Veh, T Weis. Dopaminergic activation excites rat lateral habenular neurons in vivo. Neuroscience. vol 161. issue 4. 2009-08-25. PMID:19374940. |
likewise, within the medial division of the lhb, a region that preferentially receives projections from dopaminergic midbrain nuclei, the majority of neurons failed to show apomorphine-mediated alterations in action potential firing. |
2009-08-25 |
2023-08-12 |
human |
| A B Kowski, R W Veh, T Weis. Dopaminergic activation excites rat lateral habenular neurons in vivo. Neuroscience. vol 161. issue 4. 2009-08-25. PMID:19374940. |
the present study demonstrates that spontaneous activity of distinct subsets of neurons within the lhb is strongly enhanced by systemic activation of dopaminergic receptors. |
2009-08-25 |
2023-08-12 |
human |
| Simon Hong, Okihide Hikosak. The globus pallidus sends reward-related signals to the lateral habenula. Neuron. vol 60. issue 4. 2009-01-16. PMID:19038227. |
these results suggest that gpi may initiate reward-related signals through its effects on the lhb, which then influences the dopaminergic and serotonergic systems. |
2009-01-16 |
2023-08-12 |
monkey |
| Clemens Gruber, Anja Kahl, Lydia Lebenheim, Alexander Kowski, Anja Dittgen, Rüdiger W Ve. Dopaminergic projections from the VTA substantially contribute to the mesohabenular pathway in the rat. Neuroscience letters. vol 427. issue 3. 2008-02-25. PMID:17949902. |
recent evidence suggests that the lateral habenular complex (lhb) is a source of negative reward signals in midbrain dopaminergic neurons. |
2008-02-25 |
2023-08-12 |
rat |
| Clemens Gruber, Anja Kahl, Lydia Lebenheim, Alexander Kowski, Anja Dittgen, Rüdiger W Ve. Dopaminergic projections from the VTA substantially contribute to the mesohabenular pathway in the rat. Neuroscience letters. vol 427. issue 3. 2008-02-25. PMID:17949902. |
consequently, the present study used contemporary techniques to reexamine the origin of dopaminergic fibers to the lhb. |
2008-02-25 |
2023-08-12 |
rat |
| Clemens Gruber, Anja Kahl, Lydia Lebenheim, Alexander Kowski, Anja Dittgen, Rüdiger W Ve. Dopaminergic projections from the VTA substantially contribute to the mesohabenular pathway in the rat. Neuroscience letters. vol 427. issue 3. 2008-02-25. PMID:17949902. |
in addition, our data suggest that also incerto-hypothalamic and periventricular neurons contribute dopaminergic terminals to the lhb. |
2008-02-25 |
2023-08-12 |
rat |
| G R Christoph, R J Leonzio, K S Wilco. Stimulation of the lateral habenula inhibits dopamine-containing neurons in the substantia nigra and ventral tegmental area of the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 3. 1986-05-08. PMID:3958786. |
in order to study the influence of the habenula on dopaminergic activity, single-cell electrophysiological techniques were used to record unit discharge of dopamine-containing neurons in the snc and vta during electrical stimulation of the lhb or adjacent structures. |
1986-05-08 |
2023-08-11 |
rat |
| P Ramm, R J Beninger, B J Fros. Functional activity in the lateral habenular and dorsal raphe nuclei following administration of several dopamine receptor antagonists. Canadian journal of physiology and pharmacology. vol 62. issue 12. 1985-05-08. PMID:6529709. |
these results converge with previous reports suggesting that the functional status of the lhb is regulated by dopaminergic systems, and that lhb efferents may exert a major influence upon dr neurons. |
1985-05-08 |
2023-08-12 |
rat |