| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin Zhang, Shuxuan Lv, Guoyi Tang, Guanyun Bian, Yaxin Yang, Ruotong Li, Jie Yang, Jian Li. Activation of calcium-impermeable GluR2-containing AMPA receptors in the lateral habenula produces antidepressant-like effects in a rodent model of Parkinson's disease. Experimental neurology. vol 322. 2020-02-24. PMID:31499061. |
collectively, antidepressant-like effects produced by (s)-ampa attribute to activation of lhb neurons expressing ci-ampar, which excites avta dopaminergic neurons and drn serotonergic neurons via the direct projection, thereby increasing release of mpfc da and 5-ht. |
2020-02-24 |
2023-08-13 |
rat |
| Christophe D Proulx, Sage Aronson, Djordje Milivojevic, Cris Molina, Alan Loi, Bradley Monk, Steven J Shabel, Roberto Malino. A neural pathway controlling motivation to exert effort. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 22. 2018-09-04. PMID:29752382. |
here, we examine in rodents if reduced motivation to exert effort is controlled by transmission from the lateral habenula (lhb), a nucleus overactive in depressed-like states, to the rostromedial tegmental nucleus (rmtg), a nucleus that inhibits dopaminergic neurons. |
2018-09-04 |
2023-08-13 |
Not clear |
| Cheng Xue Du, Jian Liu, Yuan Guo, Li Zhang, Qiao Jun Zhan. Lesions of the lateral habenula improve working memory performance in hemiparkinsonian rats. Neuroscience letters. vol 662. 2018-06-29. PMID:29054431. |
the lateral habenula (lhb) is an important structure involved in various brain functions, because it controls the activity of dopaminergic and serotonergic systems in the midbrain. |
2018-06-29 |
2023-08-13 |
rat |
| Franziska Wagner, Torsten Weiss, Rüdiger W Ve. Electrophysiological properties of neurons and synapses in the lateral habenular complex (LHb). Pharmacology, biochemistry, and behavior. vol 162. 2018-06-18. PMID:28746826. |
in contrast, when the situation takes a turn for the worse, lhb neurons are stimulated, completely shutting down the activity of dopaminergic cells in the vta. |
2018-06-18 |
2023-08-13 |
human |
| Phillip M Baker, Sheri J Y Mizumor. Control of behavioral flexibility by the lateral habenula. Pharmacology, biochemistry, and behavior. vol 162. 2018-06-18. PMID:28778738. |
this proposed role extends the known contributions of the lhb to motivated behaviors and suggests that the fundamental role of the lhb in these behaviors goes beyond signaling rewards and punishments to dopaminergic systems. |
2018-06-18 |
2023-08-13 |
Not clear |
| Jiangping Chan, Yiling Ni, Pengyue Zhang, Jichuan Zhang, Yanmei Che. D1-like dopamine receptor dysfunction in the lateral habenula nucleus increased anxiety-like behavior in rat. Neuroscience. vol 340. 2017-11-07. PMID:27865867. |
lhb is reciprocally connected with ventral tegmental area, acting as a regulatory center for the dopaminergic system. |
2017-11-07 |
2023-08-13 |
rat |
| Phillip M Baker, Thomas Jhou, Bo Li, Masayuki Matsumoto, Sheri J Y Mizumori, Marcus Stephenson-Jones, Aleksandra Vicenti. The Lateral Habenula Circuitry: Reward Processing and Cognitive Control. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 45. 2017-07-17. PMID:27911751. |
the lhb gets major inputs from the habenula-projecting globus pallidus and the mpfc, sending its efferents to the dopaminergic vta and snc, serotonergic dorsal raphe nuclei, and the gabaergic rostromedial tegmental nucleus. |
2017-07-17 |
2023-08-13 |
Not clear |
| Leora Yetnikoff, Anita Y Cheng, Heather N Lavezzi, Kenneth P Parsley, Daniel S Zah. Sources of input to the rostromedial tegmental nucleus, ventral tegmental area, and lateral habenula compared: A study in rat. The Journal of comparative neurology. vol 523. issue 16. 2016-06-21. PMID:25940654. |
profound inhibitory control exerted on midbrain dopaminergic neurons by the lateral habenula (lhb), which has mainly excitatory outputs, is mediated by the gabaergic rostromedial tegmental nucleus (rmtg), which strongly innervates dopaminergic neurons in the ventral midbrain. |
2016-06-21 |
2023-08-13 |
rat |
| Nora L Salaberry, Jorge Mendoz. Insights into the Role of the Habenular Circadian Clock in Addiction. Frontiers in psychiatry. vol 6. 2016-01-18. PMID:26779042. |
here, we describe the current insights on the role of the lhb as a circadian oscillator and its possible implications on the rhythmic regulation of the dopaminergic activity and drug intake. |
2016-01-18 |
2023-08-13 |
Not clear |
| Xiao Feng Luo, Bei Lin Zhang, Ji Cheng Li, Ying Ying Yang, Yan Fei Sun, Hua Zha. Lateral habenula as a link between dopaminergic and serotonergic systems contributes to depressive symptoms in Parkinson's disease. Brain research bulletin. vol 110. 2015-09-09. PMID:25499570. |
thus, lhb contributes to the depressive-like behavior in pd rats via mediating the effects of dopaminergic neurons in the substantia nigra on serotonergic neurons in the raphe nuclei. |
2015-09-09 |
2023-08-13 |
rat |
| Lely A Quina, Lynne Tempest, Lydia Ng, Julie A Harris, Susan Ferguson, Thomas C Jhou, Eric E Turne. Efferent pathways of the mouse lateral habenula. The Journal of comparative neurology. vol 523. issue 1. 2015-07-21. PMID:25099741. |
recent studies of the lhb have focused on its projections to the ventral tegmental area (vta) and rostromedial tegmental nucleus (rmtg), which contain γ-aminobutyric acid (gaba)ergic neurons that mediate reward prediction error via inhibition of dopaminergic activity. |
2015-07-21 |
2023-08-13 |
mouse |
| Ewoud Roberto Eduard Schmidt, Sara Brignani, Youri Adolfs, Suzanne Lemstra, Jeroen Demmers, Marina Vidaki, Amber-Lee Skye Donahoo, Kersti Lilleväli, Eero Vasar, Linda Jane Richards, Domna Karagogeos, Sharon Margriet Kolk, Ronald Jeroen Pasterkam. Subdomain-mediated axon-axon signaling and chemoattraction cooperate to regulate afferent innervation of the lateral habenula. Neuron. vol 83. issue 2. 2014-09-12. PMID:25033181. |
here, we demonstrate that the lateral subnucleus of the habenula (lhb) determines its own afferent innervation by sending out efferent projections that express the cell adhesion molecule lamp to reciprocally collect and guide dopaminergic afferents to the lhb-a phenomenon we term subdomain-mediated axon-axon signaling. |
2014-09-12 |
2023-08-13 |
Not clear |
| Chun-Xiao Zhang, Hong Zhang, Hai-Yan Xu, Ming-Xian Li, Shao Wan. The lateral habenula is a common target of cocaine and dexamethasone. Neuroscience letters. vol 555. 2014-01-31. PMID:24055298. |
the lateral habenular nucleus (lhb) receives projections from areas rich in dopaminergic neurons and sends efferent fibers to these areas, suggesting that the lhb has a role in dopaminergic reward-related activity. |
2014-01-31 |
2023-08-12 |
Not clear |
| Anton Ilango, Jason Shumake, Wolfram Wetzel, Henning Scheich, Frank W Oh. Electrical stimulation of lateral habenula during learning: frequency-dependent effects on acquisition but not retrieval of a two-way active avoidance response. PloS one. vol 8. issue 6. 2014-01-21. PMID:23840355. |
the lateral habenula (lhb) is an epithalamic structure involved in signaling reward omission and aversive stimuli, and it inhibits dopaminergic neurons during motivated behavior. |
2014-01-21 |
2023-08-12 |
Not clear |
| Alice M Stamatakis, Joshua H Jennings, Randall L Ung, Grace A Blair, Richard J Weinberg, Rachael L Neve, Frederick Boyce, Joanna Mattis, Charu Ramakrishnan, Karl Deisseroth, Garret D Stube. A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward. Neuron. vol 80. issue 4. 2014-01-15. PMID:24267654. |
lateral habenula (lhb) neurons convey aversive and negative reward conditions through potent indirect inhibition of ventral tegmental area (vta) dopaminergic neurons. |
2014-01-15 |
2023-08-12 |
Not clear |
| Alice M Stamatakis, Joshua H Jennings, Randall L Ung, Grace A Blair, Richard J Weinberg, Rachael L Neve, Frederick Boyce, Joanna Mattis, Charu Ramakrishnan, Karl Deisseroth, Garret D Stube. A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward. Neuron. vol 80. issue 4. 2014-01-15. PMID:24267654. |
although vta dopaminergic neurons reciprocally project to the lhb, the electrophysiological properties and the behavioral consequences associated with selective manipulations of this circuit are unknown. |
2014-01-15 |
2023-08-12 |
Not clear |
| Alice M Stamatakis, Joshua H Jennings, Randall L Ung, Grace A Blair, Richard J Weinberg, Rachael L Neve, Frederick Boyce, Joanna Mattis, Charu Ramakrishnan, Karl Deisseroth, Garret D Stube. A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward. Neuron. vol 80. issue 4. 2014-01-15. PMID:24267654. |
here, we identify an inhibitory input to the lhb arising from a unique population of vta neurons expressing dopaminergic markers. |
2014-01-15 |
2023-08-12 |
Not clear |
| Alice M Stamatakis, Joshua H Jennings, Randall L Ung, Grace A Blair, Richard J Weinberg, Rachael L Neve, Frederick Boyce, Joanna Mattis, Charu Ramakrishnan, Karl Deisseroth, Garret D Stube. A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward. Neuron. vol 80. issue 4. 2014-01-15. PMID:24267654. |
instead, stimulation produced gaba-mediated inhibitory synaptic transmission, which suppressed the firing of postsynaptic lhb neurons in brain slices and increased the spontaneous firing rate of vta dopaminergic neurons in vivo. |
2014-01-15 |
2023-08-12 |
Not clear |
| Hidenori Aizawa, Shin Yanagihara, Megumi Kobayashi, Kazue Niisato, Takashi Takekawa, Rie Harukuni, Thomas J McHugh, Tomoki Fukai, Yoshikazu Isomura, Hitoshi Okamot. The synchronous activity of lateral habenular neurons is essential for regulating hippocampal theta oscillation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 20. 2013-08-02. PMID:23678132. |
lateral habenula (lhb) has attracted growing interest as a regulator of serotonergic and dopaminergic neurons in the cns. |
2013-08-02 |
2023-08-12 |
rat |
| René Bernard, Rüdiger W Ve. Individual neurons in the rat lateral habenular complex project mostly to the dopaminergic ventral tegmental area or to the serotonergic raphe nuclei. The Journal of comparative neurology. vol 520. issue 11. 2012-09-28. PMID:22492391. |
the modulatory role of the lhb is partially assumed by putative spontaneously active lhb neurons projecting to the dopaminergic ventral tegmental area (vta) and to the serotonergic median (mnr) and dorsal raphe nuclei (dr). |
2012-09-28 |
2023-08-12 |
rat |