| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroyuki Ichijo, Nguyen Thi Van Trang, Tomoya Nakamur. Topographic Organization of Glutamatergic and GABAergic Parvalbumin Positive Neurons in the Lateral Habenula. eNeuro. 2024-07-03. PMID:38960707. |
to achieve this, we investigated the proportions of the transmitter machinery in lhb pv neurons, including gabaergic, glutamatergic, serotonergic, cholinergic, and dopaminergic neurotransmitter markers, using transcriptome analysis, mrna in situ hybridization chain reaction, and immunohistochemistry. |
2024-07-03 |
2024-07-10 |
mouse |
| Guoyi Tang, Yuan Guo, Ruotong Li, Yixuan Wang, Jie Yang, Shasha Gao, Jian Li. Lateral habenula 5-HT Neurochemistry international. 2024-05-16. PMID:38750961. |
lateral habenula 5-ht although the output of the lateral habenula (lhb) controls the activity of midbrain dopaminergic and serotonergic systems, which are implicated in the pathophysiology of anxiety, it is not clear the role of lhb 5-ht |
2024-05-16 |
2024-05-27 |
Not clear |
| In-Beom Jin, Nam-Heon Kim, Jung-Soo Ha. Emerging role of the lateral habenula in conditioned inhibition and depression. Behavioral neuroscience. 2024-04-18. PMID:38635178. |
recent research has shed light on the lateral habenula (lhb) engagement in conditioned inhibition, along with the midbrain dopaminergic neurons. |
2024-04-18 |
2024-04-20 |
Not clear |
| Huihui Tan, Chengxue Du, Li Zhang, Yuan Guo, Yaxin Yang, Qingfeng Sun, Qiaojun Zhang, Libo L. Lesions of the lateral habenula excite dopamine neurons in the ventral tegmental area and serotonin neurons in the dorsal raphe nuclei in hemiparkinsonian rats. Brain research. 2024-04-08. PMID:38588847. |
these finding suggest that lesions of the lhb enhance the activity of mesocorticolimbic dopaminergic and serotonergic systems in pd. |
2024-04-08 |
2024-04-11 |
rat |
| Jamie C Moffa, India N Bland, Jessica R Tooley, Vani Kalyanaraman, Monique Heitmeier, Meaghan C Creed, Bryan A Copit. Cell specific single viral vector CRISPR/Cas9 editing and genetically encoded tool delivery in the central and peripheral nervous systems. bioRxiv : the preprint server for biology. 2023-10-24. PMID:37873336. |
we tested these tools in multiple brain regions and cell types, including gabaergic neurons in the nucleus accumbens (nac), glutamatergic neurons projecting from the ventral pallidum (vp) to the lateral habenula (lhb), dopaminergic neurons in the ventral tegmental area (vta), and parvalbumin (pv)-positive proprioceptive neurons in the periphery. |
2023-10-24 |
2023-11-08 |
mouse |
| Chun-Kui Zhang, Pan Wang, Yuan-Yuan Ji, Jian-Shuai Zhao, Jun-Xiang Gu, Xian-Xia Yan, Hong-Wei Fan, Ming-Ming Zhang, Yu Qiao, Xiao-Die Liu, Bao-Juan Li, Ming-Hui Wang, Hai-Long Dong, Hao-Hong Li, Peng-Cheng Huang, Yun-Qing Li, Wu-Gang Hou, Jin-Lian Li, Tao Che. Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain. Science China. Life sciences. 2023-10-20. PMID:37864083. |
we determined that the spike discharges of the ventral tegmental area (vta)-projecting lateral habenula (lhb) glutamatergic (glu) neurons were sequentially increased in sham, resilient and susceptible mice, which consequently inhibited vta dopaminergic (da) neurons through a lhb |
2023-10-20 |
2023-11-08 |
mouse |
| Arman Hajikarim-Hamedani, Amirhossein Heidari, Mitra-Sadat Sadat-Shirazi, Sarah Mahboubi, Samira Raminfard, Solmaz Khalifeh, Mohammad-Reza Zarrindas. The role of lateral habenula NMDA receptors in tramadol-induced conditioning. Behavioural pharmacology. 2023-07-04. PMID:37401401. |
the role of the lateral habenula (lhb) as a hub for receiving and relaying signals from the limbic system to serotonergic, dopaminergic, and norepinephrinergic regions in the brainstem makes this area a critical region in the control of reward and addiction. |
2023-07-04 |
2023-08-14 |
rat |
| Soo Hyun Yang, Esther Yang, Jaekwang Lee, Jin Yong Kim, Hyeijung Yoo, Hyung Sun Park, Jin Taek Jung, Dongmin Lee, Sungkun Chun, Yong Sang Jo, Gyeong Hee Pyeon, Jae-Yong Park, Hyun Woo Lee, Hyun Ki. Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice. Nature communications. vol 14. issue 1. 2023-04-27. PMID:37105975. |
chronic stress drives depression by excitation of the lateral habenula (lhb), which silences dopaminergic neurons in the ventral tegmental area (vta) via gabaergic neuronal projection from the rostromedial tegmental nucleus (rmtg). |
2023-04-27 |
2023-08-14 |
mouse |
| Soo Hyun Yang, Esther Yang, Jaekwang Lee, Jin Yong Kim, Hyeijung Yoo, Hyung Sun Park, Jin Taek Jung, Dongmin Lee, Sungkun Chun, Yong Sang Jo, Gyeong Hee Pyeon, Jae-Yong Park, Hyun Woo Lee, Hyun Ki. Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice. Nature communications. vol 14. issue 1. 2023-04-27. PMID:37105975. |
here, we used fluorescent in situ hybridisation and in vivo electrophysiology in mice to show that lhb aromatic l-amino acid decarboxylase-expressing neurons (d-neurons) are activated by acute stressors and suppress rmtg gabaergic neurons via trace aminergic signalling, thus activating vta dopaminergic neurons. |
2023-04-27 |
2023-08-14 |
mouse |
| Xiaofeng Liu, Meiying Song, Xiaowei Chen, Yanfei Sun, Renfei Fan, Liping Wang, Weihong Lin, Zheng Hu, Hua Zha. Activation of Estrogen Receptor β in the Lateral Habenula Improves Ovariectomy-Induced Anxiety-Like Behavior in Rats. Frontiers in behavioral neuroscience. vol 16. 2022-05-26. PMID:35615566. |
estrogen receptor beta (erβ) is highly expressed in the lateral habenula (lhb), a key site for controlling the activities of dopaminergic neurons in the ventral tegmental area (vta) and serotoninergic neurons in the dorsal raphe nucleus (drn) that are known to be involved in anxiety. |
2022-05-26 |
2023-08-13 |
rat |
| Iwona Olejniczak, Jürgen A Ripperger, Federica Sandrelli, Anna Schnell, Laureen Mansencal-Strittmatter, Katrin Wendrich, Ka Yi Hui, Andrea Brenna, Naila Ben Fredj, Urs Albrech. Light affects behavioral despair involving the clock gene Period 1. PLoS genetics. vol 17. issue 7. 2021-10-29. PMID:34237069. |
taken together we show that light affects mood-related behavior in mice at least in part via induction of per1 in the lhb with consequences on mood-related behavior and signaling mechanisms in the mesolimbic dopaminergic system. |
2021-10-29 |
2023-08-13 |
mouse |
| Sunila G Nair, Denis S Smirnov, Melissa M Estabrook, Ashlee D Chisholm, Phillip R Silva, John F Neumaie. Effect of chemogenetic inhibition of lateral habenula neuronal activity on cocaine- and food-seeking behaviors in the rat. Addiction biology. vol 26. issue 1. 2021-10-05. PMID:31994279. |
the lateral habenula (lhb), an epithalamic nucleus, regulates midbrain dopaminergic systems that are known to be involved in cocaine taking and seeking behaviors. |
2021-10-05 |
2023-08-13 |
rat |
| Yaxin Yang, Jian Liu, Yixuan Wang, Xiang Wu, Libo Li, Guanyun Bian, Wenjuan Li, Haifeng Yuan, Qiaojun Zhan. Blockade of pre-synaptic and post-synaptic GABA Neuropharmacology. vol 196. 2021-10-01. PMID:34246684. |
blockade of pre-synaptic and post-synaptic gaba although the output of the lateral habenula (lhb) controls the activity of midbrain dopaminergic and serotonergic systems, which are implicated in the pathophysiology of anxiety, it is not known how blockade of gaba |
2021-10-01 |
2023-08-13 |
Not clear |
| Rodrigo Sosa, Jesús Mata-Luévanos, Mario Buenrostro-Jáuregu. The Role of the Lateral Habenula in Inhibitory Learning from Reward Omission. eNeuro. vol 8. issue 3. 2021-07-02. PMID:33962969. |
the most widely described physiological effect of lhb activation is acutely suppressing midbrain dopaminergic signaling. |
2021-07-02 |
2023-08-13 |
Not clear |
| Bo-Ryoung Choi, Dong-Hee Kim, Michela Gallagher, Jung-Soo Ha. Engagement of the Lateral Habenula in the Association of a Conditioned Stimulus with the Absence of an Unconditioned Stimulus. Neuroscience. vol 444. 2021-05-14. PMID:32717296. |
neurons in the lateral habenula (lhb) are activated by reward omission and inhibited by reward delivery-reward processing functions opposite those of midbrain dopaminergic neurons. |
2021-05-14 |
2023-08-13 |
rat |
| Bo-Ryoung Choi, Dong-Hee Kim, Michela Gallagher, Jung-Soo Ha. Engagement of the Lateral Habenula in the Association of a Conditioned Stimulus with the Absence of an Unconditioned Stimulus. Neuroscience. vol 444. 2021-05-14. PMID:32717296. |
the number of c-fos-positive signals in lhb neurons projecting to dopaminergic midbrain neurons was higher in the unpaired group than in the paired group. |
2021-05-14 |
2023-08-13 |
rat |
| Michael L Wallace, Kee Wui Huang, Daniel Hochbaum, Minsuk Hyun, Gianna Radeljic, Bernardo L Sabatin. Anatomical and single-cell transcriptional profiling of the murine habenular complex. eLife. vol 9. 2021-04-02. PMID:32043968. |
in the lhb, we describe four neuronal subtypes and show that they differentially target dopaminergic and gabaergic cells in the ventral tegmental area (vta). |
2021-04-02 |
2023-08-13 |
mouse |
| Zijing Xie, Guohui Li, Jiang-Hong Y. Acute effects of ethanol on GABA Open journal of neuroscience. vol 3. 2020-10-01. PMID:28066680. |
recently, the lateral habenula (lhb) has attracted a great deal of attention as another target for abused drugs in the brain because its role in regulating dopaminergic system, among others. |
2020-10-01 |
2023-08-13 |
rat |
| Jin Zhang, Yong Wang, Yi Na Sun, Li Bo Li, Li Zhang, Yuan Guo, Tao Wang, Lu Yao, Li Chen, Jian Li. Blockade of calcium-permeable AMPA receptors in the lateral habenula produces increased antidepressant-like effects in unilateral 6-hydroxydopamine-lesioned rats compared to sham-lesioned rats. Neuropharmacology. vol 157. 2020-07-21. PMID:31251995. |
our findings indicate that blockade of lhb cp-ampars produces antidepressant-like effects, which attribute to decreased firing activity of lhb neurons and increased levels of dopamine and serotonin in the mpfc, and provide further evidence that lhb cp-ampars regulate the firing activity of pvta dopaminergic neurons and mrn serotonergic neurons indirectly via the rmtg. |
2020-07-21 |
2023-08-13 |
rat |
| Hailan Hu, Yihui Cui, Yan Yan. Circuits and functions of the lateral habenula in health and in disease. Nature reviews. Neuroscience. vol 21. issue 5. 2020-05-11. PMID:32269316. |
the lhb, sometimes referred to as the brain's 'antireward centre', receives inputs from diverse limbic forebrain and basal ganglia structures, and targets essentially all midbrain neuromodulatory systems, including the noradrenergic, serotonergic and dopaminergic systems. |
2020-05-11 |
2023-08-13 |
Not clear |