| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carsten Minten, Rachael Terry, Celine Deffrasnes, Nicholas J C King, Iain L Campbel. IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS. PloS one. vol 7. issue 11. 2013-06-20. PMID:23166780. |
in support of this, in mice with a targeted disruption of the irf8 gene, microglia were increased in number and showed gross alterations in morphology and surface area. |
2013-06-20 |
2023-08-12 |
mouse |
| Carsten Minten, Rachael Terry, Celine Deffrasnes, Nicholas J C King, Iain L Campbel. IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS. PloS one. vol 7. issue 11. 2013-06-20. PMID:23166780. |
we conclude irf8 is a constitutively produced nuclear factor in resident microglia of the cns being a crucial transcriptional determinant of the phenotype of these cells in the healthy brain. |
2013-06-20 |
2023-08-12 |
mouse |
| Takahiro Masuda, Makoto Tsuda, Ryohei Yoshinaga, Hidetoshi Tozaki-Saitoh, Keiko Ozato, Tomohiko Tamura, Kazuhide Inou. IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype. Cell reports. vol 1. issue 4. 2013-03-17. PMID:22832225. |
irf8 is a critical transcription factor for transforming microglia into a reactive phenotype. |
2013-03-17 |
2023-08-12 |
mouse |
| Takahiro Masuda, Makoto Tsuda, Ryohei Yoshinaga, Hidetoshi Tozaki-Saitoh, Keiko Ozato, Tomohiko Tamura, Kazuhide Inou. IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype. Cell reports. vol 1. issue 4. 2013-03-17. PMID:22832225. |
here, we identify the transcription factor interferon regulatory factor 8 (irf8) as a critical regulator of reactive microglia. |
2013-03-17 |
2023-08-12 |
mouse |
| Takahiro Masuda, Makoto Tsuda, Ryohei Yoshinaga, Hidetoshi Tozaki-Saitoh, Keiko Ozato, Tomohiko Tamura, Kazuhide Inou. IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype. Cell reports. vol 1. issue 4. 2013-03-17. PMID:22832225. |
within the spinal cord, irf8 expression was normally low; however, the expression was markedly upregulated in microglia, but not in neurons or astrocytes, after peripheral nerve injury (pni). |
2013-03-17 |
2023-08-12 |
mouse |
| Takahiro Masuda, Makoto Tsuda, Ryohei Yoshinaga, Hidetoshi Tozaki-Saitoh, Keiko Ozato, Tomohiko Tamura, Kazuhide Inou. IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype. Cell reports. vol 1. issue 4. 2013-03-17. PMID:22832225. |
irf8 overexpression in cultured microglia promoted the transcription of genes associated with reactive states; conversely, irf8 deficiency prevented these gene expressions in the spinal cord following pni. |
2013-03-17 |
2023-08-12 |
mouse |
| Takahiro Masuda, Makoto Tsuda, Ryohei Yoshinaga, Hidetoshi Tozaki-Saitoh, Keiko Ozato, Tomohiko Tamura, Kazuhide Inou. IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype. Cell reports. vol 1. issue 4. 2013-03-17. PMID:22832225. |
therefore, irf8 may activate a program of gene expression that transforms microglia into a reactive phenotype. |
2013-03-17 |
2023-08-12 |
mouse |