| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takahiro Masuda, Shosuke Iwamoto, Satsuki Mikuriya, Hidetoshi Tozaki-Saitoh, Tomohiko Tamura, Makoto Tsuda, Kazuhide Inou. Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia. Journal of pharmacological sciences. vol 128. issue 4. 2016-05-31. PMID:26318672. |
irf8 transduction in cultured microglia induced de novo gene expression of irf1. |
2016-05-31 |
2023-08-13 |
Not clear |
| Claudia C Wehrspaun, Wilfried Haerty, Chris P Pontin. Microglia recapitulate a hematopoietic master regulator network in the aging human frontal cortex. Neurobiology of aging. vol 36. issue 8. 2016-03-17. PMID:26002684. |
we identified a subnetwork of transcription factors, including runx1, irf8, pu.1, and tal1, which are master regulators (mrs) for the age-dependent microglia module. |
2016-03-17 |
2023-08-13 |
human |
| Celia E Shiau, Zoe Kaufman, Ana M Meireles, William S Talbo. Differential requirement for irf8 in formation of embryonic and adult macrophages in zebrafish. PloS one. vol 10. issue 1. 2016-01-04. PMID:25615614. |
as development progresses, tissue macrophages become apparent in zebrafish irf8 mutants, with the possible exception of microglia. |
2016-01-04 |
2023-08-13 |
zebrafish |
| Sung-Hye Kim, Jenna Burton, Cheng-Rong Yu, Lin Sun, Chang He, Hongsheng Wang, Herbert C Morse, Charles E Egwuag. Dual Function of the IRF8 Transcription Factor in Autoimmune Uveitis: Loss of IRF8 in T Cells Exacerbates Uveitis, Whereas Irf8 Deletion in the Retina Confers Protection. Journal of immunology (Baltimore, Md. : 1950). vol 195. issue 4. 2015-11-24. PMID:26163590. |
ifn regulatory factor 8 (irf8) is constitutively expressed in monocytes and b cells and plays a critical role in the functional maturation of microglia cells. |
2015-11-24 |
2023-08-13 |
mouse |
| Takahiro Masuda, Shosuke Iwamoto, Ryohei Yoshinaga, Hidetoshi Tozaki-Saitoh, Akira Nishiyama, Tak W Mak, Tomohiko Tamura, Makoto Tsuda, Kazuhide Inou. Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain. Nature communications. vol 5. 2015-09-30. PMID:24818655. |
furthermore, we found that expression of irf5 in microglia is regulated by irf8. |
2015-09-30 |
2023-08-13 |
mouse |
| S Nardone, D Sharan Sams, E Reuveni, D Getselter, O Oron, M Karpuj, E Elliot. DNA methylation analysis of the autistic brain reveals multiple dysregulated biological pathways. Translational psychiatry. vol 4. 2015-08-19. PMID:25180572. |
among these genes there were c1q, c3, itgb2 (c3r), tnf-α, irf8 and spi1, which have recently been implicated in synaptic pruning and microglial cell specification. |
2015-08-19 |
2023-08-13 |
Not clear |
| Takahiro Masuda, Nao Nishimoto, Daisuke Tomiyama, Tsuyoshi Matsuda, Hidetoshi Tozaki-Saitoh, Tomohiko Tamura, Shinichi Kohsaka, Makoto Tsuda, Kazuhide Inou. IRF8 is a transcriptional determinant for microglial motility. Purinergic signalling. vol 10. issue 3. 2015-06-15. PMID:24798612. |
we found that atp and complement component, c5a, induced chemotaxis of irf8 wild-type microglia. |
2015-06-15 |
2023-08-13 |
Not clear |
| Takahiro Masuda, Nao Nishimoto, Daisuke Tomiyama, Tsuyoshi Matsuda, Hidetoshi Tozaki-Saitoh, Tomohiko Tamura, Shinichi Kohsaka, Makoto Tsuda, Kazuhide Inou. IRF8 is a transcriptional determinant for microglial motility. Purinergic signalling. vol 10. issue 3. 2015-06-15. PMID:24798612. |
however, these responses were markedly suppressed in microglia lacking irf8 (irf8 (-/-)). |
2015-06-15 |
2023-08-13 |
Not clear |
| Takahiro Masuda, Nao Nishimoto, Daisuke Tomiyama, Tsuyoshi Matsuda, Hidetoshi Tozaki-Saitoh, Tomohiko Tamura, Shinichi Kohsaka, Makoto Tsuda, Kazuhide Inou. IRF8 is a transcriptional determinant for microglial motility. Purinergic signalling. vol 10. issue 3. 2015-06-15. PMID:24798612. |
in a consistent manner, phosphorylation of akt (which plays a crucial role in atp-induced chemotaxis) was abolished in irf8 (-/-)microglia. |
2015-06-15 |
2023-08-13 |
Not clear |
| Takahiro Masuda, Nao Nishimoto, Daisuke Tomiyama, Tsuyoshi Matsuda, Hidetoshi Tozaki-Saitoh, Tomohiko Tamura, Shinichi Kohsaka, Makoto Tsuda, Kazuhide Inou. IRF8 is a transcriptional determinant for microglial motility. Purinergic signalling. vol 10. issue 3. 2015-06-15. PMID:24798612. |
real-time polymerase chain reaction analysis revealed that motility-related microglial genes such as p2y12 receptor were significantly suppressed in irf8 (-/-)microglia. |
2015-06-15 |
2023-08-13 |
Not clear |
| Takahiro Masuda, Nao Nishimoto, Daisuke Tomiyama, Tsuyoshi Matsuda, Hidetoshi Tozaki-Saitoh, Tomohiko Tamura, Shinichi Kohsaka, Makoto Tsuda, Kazuhide Inou. IRF8 is a transcriptional determinant for microglial motility. Purinergic signalling. vol 10. issue 3. 2015-06-15. PMID:24798612. |
furthermore, irf8 (-/-)microglia exhibited a differential expression pattern of nucleotide-degrading enzymes compared with their wild-type counterparts. |
2015-06-15 |
2023-08-13 |
Not clear |
| Takanori Akagi, Yuta Matsumura, Masaya Yasui, Emiko Minami, Hidemasa Inoue, Takahiro Masuda, Hidetoshi Tozaki-Saitoh, Tomohiko Tamura, Kazue Mizumura, Makoto Tsuda, Hiroshi Kiyama, Kazuhide Inou. Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents. Journal of pharmacological sciences. vol 126. issue 2. 2015-05-12. PMID:25273233. |
expression of irf8 was significantly increased in the spinal cord of rcs-exposed mice and was localized in microglia. |
2015-05-12 |
2023-08-13 |
mouse |
| Takanori Akagi, Yuta Matsumura, Masaya Yasui, Emiko Minami, Hidemasa Inoue, Takahiro Masuda, Hidetoshi Tozaki-Saitoh, Tomohiko Tamura, Kazue Mizumura, Makoto Tsuda, Hiroshi Kiyama, Kazuhide Inou. Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents. Journal of pharmacological sciences. vol 126. issue 2. 2015-05-12. PMID:25273233. |
thus, rcs exposure activates spinal microglia and upregulation of irf8 in these cells is involved in the development of tactile allodynia after rcs exposure. |
2015-05-12 |
2023-08-13 |
mouse |
| Makoto Tsud. [Mechanisms underlying the pathogenesis of neuropathic pain revealing by the role of glial cells]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 35. issue 1. 2015-04-30. PMID:25816633. |
furthermore, interferon regulatory factor-8 (irf8) and irf5 are identified as microglial transcription factors whose expression is upregulated in spinal microglia after pni, and the irf8-irf5 transcriptional cascade is the core process for shifting spinal microglia toward a state with high expression of p2x4 receptors. |
2015-04-30 |
2023-08-13 |
Not clear |
| Yuko Yoshida, Ryusuke Yoshimi, Hiroaki Yoshii, Daniel Kim, Anup Dey, Huabao Xiong, Jeeva Munasinghe, Itaru Yazawa, Michael J O'Donovan, Olga A Maximova, Suveena Sharma, Jinfang Zhu, Hongsheng Wang, Herbert C Morse, Keiko Ozat. The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation. Immunity. vol 40. issue 2. 2014-04-28. PMID:24485804. |
furthermore, expression of irf8 in antigen-presenting cells (apcs, such as macrophages, dendritic cells, and microglia), but not in t cells, facilitated disease onset and progression through multiple pathways. |
2014-04-28 |
2023-08-12 |
mouse |
| Yuko Yoshida, Ryusuke Yoshimi, Hiroaki Yoshii, Daniel Kim, Anup Dey, Huabao Xiong, Jeeva Munasinghe, Itaru Yazawa, Michael J O'Donovan, Olga A Maximova, Suveena Sharma, Jinfang Zhu, Hongsheng Wang, Herbert C Morse, Keiko Ozat. The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation. Immunity. vol 40. issue 2. 2014-04-28. PMID:24485804. |
finally, irf8 activated microglia and exacerbated neuroinflammation. |
2014-04-28 |
2023-08-12 |
mouse |
| Makoto Tsuda, Takahiro Masuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inou. P2X4 receptors and neuropathic pain. Frontiers in cellular neuroscience. vol 7. 2014-03-25. PMID:24191146. |
those include the cc chemokine ccl21 derived from damaged neurons, the extracellular matrix protein fibronectin in the spinal cord, and the transcription factor interferon regulatory factor 8 (irf8) expressed in microglia. |
2014-03-25 |
2023-08-12 |
Not clear |
| Makoto Tsuda, Takahiro Masuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inou. Microglial regulation of neuropathic pain. Journal of pharmacological sciences. vol 121. issue 2. 2014-02-04. PMID:23337437. |
a recent study also reveals that the transcription factor irf8 (interferon regulatory factor 8) is a critical regulator of the nerve injury-induced gene expression in microglia. |
2014-02-04 |
2023-08-12 |
Not clear |
| Carsten Minten, Rachael Terry, Celine Deffrasnes, Nicholas J C King, Iain L Campbel. IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS. PloS one. vol 7. issue 11. 2013-06-20. PMID:23166780. |
whether irf8 plays a role in the development and function of microglia, the tissue-resident myeloid cells of the brain, is unknown. |
2013-06-20 |
2023-08-12 |
mouse |
| Carsten Minten, Rachael Terry, Celine Deffrasnes, Nicholas J C King, Iain L Campbel. IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS. PloS one. vol 7. issue 11. 2013-06-20. PMID:23166780. |
here, we show irf8 is a constitutively produced nuclear factor in microglia, which suggested that irf8 might also be a key homeostatic transcriptional determinant of the microglial cell phenotype. |
2013-06-20 |
2023-08-12 |
mouse |