| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ping Song, Dhwani Parsana, Rupesh Singh, Lana M Pollock, Bela Anand-Apte, Brian D Perkin. Photoreceptor regeneration occurs normally in microglia-deficient irf8 mutant zebrafish following acute retinal damage. Scientific reports. vol 14. issue 1. 2024-08-29. PMID:39209978. |
we evaluated the retinal architecture and retinal regeneration in adult zebrafish irf8 mutants, which have significantly depleted numbers of microglia. |
2024-08-29 |
2024-09-04 |
zebrafish |
| Ayato Yamasaki, Iroha Imanishi, Kaori Tanaka, Yasuyuki Ohkawa, Makoto Tsuda, Takahiro Masud. IRF8 and MAFB drive distinct transcriptional machineries in different resident macrophages of the central nervous system. Communications biology. vol 7. issue 1. 2024-07-23. PMID:39043941. |
here we show, by myeloid cell-specific deletion of transcription factors, irf8 and mafb, that both adult microglia and cams utilize irf8 to maintain their core gene signatures, although the genes altered by irf8 deletion are different in the two macrophage populations. |
2024-07-23 |
2024-07-26 |
Not clear |
| Lili Ma, Na Mi, Zhi Wang, Rui Bao, Jing Fang, Yajing Ren, Xiuzhi Xu, Hongjia Zhang, Ying Tan. Knockdown of IRF8 alleviates neuroinflammation through regulating microglial activation in Parkinson's disease. Journal of chemical neuroanatomy. 2024-04-26. PMID:38670441. |
the upregulation of interferon regulatory factor 8 (irf8) in microglia following peripheral nerve injury has been observed to induce microglial activation. |
2024-04-26 |
2024-04-29 |
mouse |
| Lili Ma, Na Mi, Zhi Wang, Rui Bao, Jing Fang, Yajing Ren, Xiuzhi Xu, Hongjia Zhang, Ying Tan. Knockdown of IRF8 alleviates neuroinflammation through regulating microglial activation in Parkinson's disease. Journal of chemical neuroanatomy. 2024-04-26. PMID:38670441. |
upon irf8 silencing in the pd mouse and cell models, the knockdown of irf8 ameliorated mptp-induced behavioral deficits, increased the counts of th and nissl-positive neurons and da content, reduced the number of iba-1-positive microglia, and reduced the content of inflammatory factors, possibly by inhibiting the ampk/mtor signaling pathway. |
2024-04-26 |
2024-04-29 |
mouse |
| Keita Saeki, Richard Pan, Eunju Lee, Daisuke Kurotaki, Keiko Ozat. IRF8 configures enhancer landscape in postnatal microglia and directs microglia specific transcriptional programs. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645844. |
irf8 configures enhancer landscape in postnatal microglia and directs microglia specific transcriptional programs. |
2023-08-30 |
2023-09-07 |
mouse |
| Keita Saeki, Richard Pan, Eunju Lee, Daisuke Kurotaki, Keiko Ozat. IRF8 configures enhancer landscape in postnatal microglia and directs microglia specific transcriptional programs. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645844. |
transcription factor irf8 is highly expressed in microglia. |
2023-08-30 |
2023-09-07 |
mouse |
| Keita Saeki, Richard Pan, Eunju Lee, Daisuke Kurotaki, Keiko Ozat. IRF8 configures enhancer landscape in postnatal microglia and directs microglia specific transcriptional programs. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645844. |
we demonstrate here that irf8 binds to enhancer regions of postnatal microglia in a stepwise fashion reaching a maximum after day 14, which coincided with the initiation of microglia function. |
2023-08-30 |
2023-09-07 |
mouse |
| Keita Saeki, Richard Pan, Eunju Lee, Daisuke Kurotaki, Keiko Ozat. IRF8 configures enhancer landscape in postnatal microglia and directs microglia specific transcriptional programs. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645844. |
constitutive irf8 deletion led to the loss of microglia identity gene expression and aberrant induction of alzheimer's disease and neurodegeneration associated genes. |
2023-08-30 |
2023-09-07 |
mouse |
| Keita Saeki, Richard Pan, Eunju Lee, Daisuke Kurotaki, Keiko Ozat. IRF8 configures enhancer landscape in postnatal microglia and directs microglia specific transcriptional programs. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645844. |
conditional irf8 deletion in adult microglia showed similar transcriptome profiles, revealing the requirement of continuous irf8 expression. |
2023-08-30 |
2023-09-07 |
mouse |
| Keita Saeki, Richard Pan, Eunju Lee, Daisuke Kurotaki, Keiko Ozat. IRF8 configures enhancer landscape in postnatal microglia and directs microglia specific transcriptional programs. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645844. |
together, irf8 sets the microglia epigenome landscape, required for eliciting microglia identity and function. |
2023-08-30 |
2023-09-07 |
mouse |
| Sijia He, Xin Li, Namrata Mittra, Anindita Bhattacharjee, Hu Wang, Shangang Zhao, Feng Liu, Xianlin Ha. Microglial cGAS deletion protects against amyloid-β induced Alzheimer's disease pathogenesis. bioRxiv : the preprint server for biology. 2023-08-23. PMID:37609338. |
mechanistically, we found cgas was necessary for plaque-associated microglial enrichment potentially driven by irf8, and was indispensable for the development of disease-associated microglia (dam) phenotype. |
2023-08-23 |
2023-09-07 |
mouse |
| Thomas Jacobus Geus, Glenn Franken, Bert Bert Jooste. Conventional, High Frequency and Differential Targeted Multiplexed Spinal Cord Stimulation in experimental Painful Diabetic Peripheral Neuropathy: pain behavior and role of the central inflammatory balance. Molecular pain. 2023-07-25. PMID:37488684. |
the inflammatory balance and glial response were analyzed in the dorsal spinal cord based on rna expression of pro- and anti-inflammatory cytokines (tnf-α, il-1ß, il-4, il-10), a microglia marker (itgam), an astrocyte marker (gfap), a t-cell marker (cd3d), microglia proliferation markers (irf8, adgre1) and p2x4, p13-mapk, bdnf signaling markers (p2x4, mapk14, bdnf). |
2023-07-25 |
2023-08-14 |
Not clear |
| Chang-Shun Xu, Chun Lin, Zhen-Yu Ca. [Effects of intrathecal injection of IRF8 SiRNA on pain threshold and activation of spinal cord microglia in rats with postoperative persistent pain]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 38. issue 2. 2022-08-28. PMID:36031567. |
[effects of intrathecal injection of irf8 sirna on pain threshold and activation of spinal cord microglia in rats with postoperative persistent pain]. |
2022-08-28 |
2023-08-14 |
rat |
| Philip A Feinberg, Shannon C Becker, Leeyup Chung, Loris Ferrari, David Stellwagen, Christelle Anaclet, Violeta Durán-Laforet, Travis E Faust, Rachita K Sumbria, Dorothy P Schafe. Elevated TNF-α leads to neural circuit instability in the absence of Interferon Regulatory Factor 8. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-07-05. PMID:35790400. |
interferon regulatory factor 8 (irf8) is a transcription factor necessary for the maturation of microglia, as well as other peripheral immune cells. |
2022-07-05 |
2023-08-14 |
Not clear |
| Jiang Wu, Mark Hocevar, Bihua Bie, Joseph F Foss, Mohamed Nagui. Cannabinoid Type 2 Receptor System Modulates Paclitaxel-Induced Microglial Dysregulation and Central Sensitization in Rats. The journal of pain. vol 20. issue 5. 2020-08-19. PMID:30414958. |
paclitaxel induced epigenetic upregulation of irf8 and p2x purinoceptor 4 (p2x4) in microglia and subsequently increased the expression of alpha isoform of calcium/calmodulin-dependent protein kinase ii (camkiiα), transcriptional factors p-creb and Δfosb, leading to the overproduction of bdnf in microglia. |
2020-08-19 |
2023-08-13 |
rat |
| Nan Zhou, Kaili Liu, Yue Sun, Ying Cao, Jing Yan. Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition. Protein & cell. vol 10. issue 2. 2020-01-29. PMID:30484118. |
we show that transcription factors irf8 and pu.1 are both indispensible for microglial activation, as their specific post-developmental deletion in microglia abolishes the process. |
2020-01-29 |
2023-08-13 |
Not clear |
| Rongguo Liu, Xueru Xu, Yunlu Xu, Xiangyu Fang, Xingwu Li. Pulsed Radiofrequency on Dorsal Root Ganglion Relieved Neuropathic Pain Associated with Downregulation of the Spinal Interferon Regulatory Factor 8, Microglia, p38MAPK Expression in a CCI Rat Model. Pain physician. vol 21. issue 4. 2019-02-27. PMID:30045596. |
interferon regulatory factor 8 (irf8), which is induced by peripheral nerve injury (pni), plays a key role in activating spinal microglia to release inflammatory cytokines in a p38-dependent way, thereafter results in formation of central sensitization. |
2019-02-27 |
2023-08-13 |
rat |
| Antony Cougnoux, Rebecca A Drummond, Amanda L Collar, James R Iben, Alexander Salman, Harrison Westgarth, Christopher A Wassif, Niamh X Cawley, Nicole Y Farhat, Keiko Ozato, Michail S Lionakis, Forbes D Porte. Microglia activation in Niemann-Pick disease, type C1 is amendable to therapeutic intervention. Human molecular genetics. vol 27. issue 12. 2019-02-25. PMID:29617956. |
in addition, impairing microglia mediated neuroinflammation by genetic deletion of irf8 led to decreased symptoms and increased lifespan. |
2019-02-25 |
2023-08-13 |
mouse |
| Kazuhide Inou. Purinergic signaling in microglia in the pathogenesis of neuropathic pain. Proceedings of the Japan Academy. Series B, Physical and biological sciences. vol 93. issue 4. 2017-04-24. PMID:28413195. |
the p2x4 receptor (p2x4r), a subtype of ionotropic atp receptors, is upregulated in spinal microglia after nerve injury by several factors, including cc chemokine receptor ccr2, the extracellular matrix protein fibronectin in the spinal cord, interferon regulatory factor 8 (irf8) and irf5. |
2017-04-24 |
2023-08-13 |
Not clear |
| Takahiro Masuda, Shosuke Iwamoto, Satsuki Mikuriya, Hidetoshi Tozaki-Saitoh, Tomohiko Tamura, Makoto Tsuda, Kazuhide Inou. Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia. Journal of pharmacological sciences. vol 128. issue 4. 2016-05-31. PMID:26318672. |
interferon regulatory factor-8 (irf8) plays a crucial role in the transformation of microglia to a reactive state by regulating the expression of various genes. |
2016-05-31 |
2023-08-13 |
Not clear |