| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Kim, G Lee, Y H Huh, S Y Lee, K H Park, S Kim, J Kim, J Koh, J Ry. NAMPT Is an Essential Regulator of RA-Mediated Periodontal Inflammation. Journal of dental research. vol 96. issue 6. 2017-08-08. PMID:28165872. |
when nampt was overexpressed with the nampt-synthesizing adenovirus vector (ad- nampt), the pdl cells exhibited an increased expression of cytokines (il6), chemokines (il8 and chemokine [c-c motif] ligand 5 [ccl5]), inflammatory mediators (cyclooxygenase 2 [cox-2]), and matrix-degrading enzymes (matrix metalloproteinase [mmp] 1 and mmp3). |
2017-08-08 |
2023-08-13 |
mouse |
| Biao Feng, Shali Chen, Andrew Devon Gordon, Subrata Chakrabart. miR-146a mediates inflammatory changes and fibrosis in the heart in diabetes. Journal of molecular and cellular cardiology. vol 105. 2017-05-31. PMID:28279663. |
in hearts of wild type mice with diabetes, increased expression of inflammatory markers and extracellular matrix proteins (il6, tnfα, il-1β, mcp-1, nf-κb, col1α1, col4α1) were seen compared to wild type controls. |
2017-05-31 |
2023-08-13 |
mouse |
| Hamid Galehdari, Samira Negahdari, Mahnaz Kesmati, Anahita Rezaie, Gholamreza Shariat. Effect of the herbal mixture composed of Aloe Vera, Henna, Adiantum capillus-veneris, and Myrrha on wound healing in streptozotocin-induced diabetic rats. BMC complementary and alternative medicine. vol 16. issue 1. 2017-01-31. PMID:27716154. |
matrix metalloproteases act as pro-inflammatory agents in physiological wound healing pathways by stimulating cytokines including the interleukins, il6, il1a and il1b, and the tumor necrosis factor and transforming growth factor beta1. |
2017-01-31 |
2023-08-13 |
rat |
| Said Assou, Emilie Pourret, Marie Péquignot, Valérie Rigau, Vasiliki Kalatzis, Ounissa Aït-Ahmed, Samir Hamama. Cultured Cells from the Human Oocyte Cumulus Niche Are Efficient Feeders to Propagate Pluripotent Stem Cells. Stem cells and development. vol 24. issue 19. 2016-06-21. PMID:26153797. |
a comparative gene expression profile study of hcc and hff revealed significant differences (p < 0.05) in expression of cellular matrix components and an upregulation in hcc of genes known to be important players in cell proliferation such as interleukin 6 gene (il6). |
2016-06-21 |
2023-08-13 |
human |
| Marc Christian, Maury A Nussbau. An exploratory study of the effects of occupational exposure to physical demands on biomarkers of cartilage and muscle damage. Journal of occupational and environmental hygiene. vol 12. issue 2. 2015-08-26. PMID:25559147. |
serum levels of cartilage oligomeric matrix protein (comp), interleukin-6 (il6), and creatine kinase (ck)--which respectively indicate cartilage damage, muscle use, and muscle damage--were obtained,. |
2015-08-26 |
2023-08-13 |
human |
| Nijaguna B Prasad, Anne C Fischer, Alice Y Chuang, Jerry M Wright, Ting Yang, Hua-Ling Tsai, William H Westra, Nanette J Liegeois, Allan D Hess, Anthony P Tufar. Differential expression of degradome components in cutaneous squamous cell carcinomas. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 27. issue 7. 2015-02-21. PMID:24356192. |
the expression levels of some of these genes including matrix metallopeptidase 1 (mmp1), matrix metallopeptidase 10 (mmp10), parathyroid hormone-like hormone (pthlh), cyclin-dependent kinase inhibitor 2a (cdkn2a), a disintegrin and metalloproteinase with thrombospondin motifs 1 (adamts1), fbj osteosarcoma oncogene (fos), interleukin 6 (il6) and reversion-inducing-cysteine-rich protein with kazal motifs (reck) were significantly differentially expressed (p≤0.02) in squamous cell carcinoma compared with normal skin. |
2015-02-21 |
2023-08-12 |
Not clear |
| Anna Engler, Fabienne Niederer, Kerstin Klein, Renate E Gay, Diego Kyburz, Giovanni G Camici, Steffen Gay, Caroline Ospel. SIRT6 regulates the cigarette smoke-induced signalling in rheumatoid arthritis synovial fibroblasts. Journal of molecular medicine (Berlin, Germany). vol 92. issue 7. 2015-01-27. PMID:24638860. |
we demonstrated that stimulation with cigarette smoke extract (cse) enhances the pro-inflammatory and matrix-destructive potential of rasf by inducing the production of pro-inflammatory cytokine interleukin 8 (il8) and the matrix-destructive enzyme matrix metalloproteinase 1 (mmp1), but not of il6 and mmp3. |
2015-01-27 |
2023-08-12 |
mouse |
| Zhenzhen Zhan, Xuefeng Xie, Hao Cao, Xiaohui Zhou, Xu Dong Zhang, Huimin Fan, Zhongmin Li. Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination. Autophagy. vol 10. issue 2. 2014-11-12. PMID:24321786. |
this was mediated by the adaptor protein, toll-like receptor adaptor molecule 1 (ticam1/trif), and was required for tlr4- and tlr3-induced increases in the production of il6, ccl2/mcp-1 [chemokine (c-c motif) ligand 2], ccl20/mip-3α [chemokine (c-c motif) ligand 20], vegfa (vascular endothelial growth factor a), and mmp2 [matrix metallopeptidase 2 (gelatinase a, 72 kda gelatinase, 72 kda type iv collagenase)]. |
2014-11-12 |
2023-08-12 |
Not clear |
| Martha Lappa. NOD1 expression is increased in the adipose tissue of women with gestational diabetes. The Journal of endocrinology. vol 222. issue 1. 2014-09-28. PMID:24829218. |
in both omental and subcutaneous adipose tissues from ngt and gdm women, the nod1 ligand g-d-glutamyl-meso-diaminopimelic acid (ie-dap) significantly induced the expression and secretion of the pro-inflammatory cytokine interleukin 6 (il6) and chemokine il8; cox2 (ptgs2) gene expression and subsequent prostaglandin production; the expression and secretion of the extracellular matrix remodelling enzyme matrix metalloproteinase 9 (mmp9) and the gene expression and secretion of the adhesion molecules icam1 and vcam1. |
2014-09-28 |
2023-08-13 |
Not clear |
| Sophie Domhan, Christian Schwager, Quanxiang Wei, Stefan Muschal, Claudia Sommerer, Christian Morath, Wolfgang Wick, Christian Maercker, Jurgen Debus, Martin Zeier, Peter E Huber, Amir Abdollah. Deciphering the systems biology of mTOR inhibition by integrative transcriptome analysis. Current pharmaceutical design. vol 20. issue 1. 2014-09-15. PMID:23530502. |
among the rad001 downregulated genes, a transcriptional network was discovered enriched for genes related to angiogenesis processes and extracellular matrix remodeling, e.g., vegf, hif1a, cxcls, il6, fn, pai-1 or nrp1. |
2014-09-15 |
2023-08-12 |
human |
| Jonathan H Gooi, Ling Yeong Chia, Nicole C Walsh, Morten A Karsdal, Julian M W Quinn, T John Martin, Natalie A Sim. Decline in calcitonin receptor expression in osteocytes with age. The Journal of endocrinology. vol 221. issue 2. 2014-06-30. PMID:24516262. |
quantitative real-time pcr analysis of femoral metaphyses collected 1 and 4 h after a single pth injection confirmed a significant increase in mrna levels for interleukin 6 (il6) and ephrinb2 (efnb2), and a significant reduction in sost and dentin matrix protein-1 (dmp1) in response to pth. |
2014-06-30 |
2023-08-12 |
mouse |
| Mark A Carlson, Lynette M Smith, Crystal M Cordes, Jie Chao, James D Eud. Attachment-regulated signaling networks in the fibroblast-populated 3D collagen matrix. Scientific reports. vol 3. 2014-06-23. PMID:23697962. |
matrix stress-release was associated with modulation of signaling networks that involved il6, il8, nf-κb, tgf-β1, p53, interferon-γ, and other entities as central participants. |
2014-06-23 |
2023-08-12 |
human |
| Mark A Carlson, Lynette M Smith, Crystal M Cordes, Jie Chao, James D Eud. Attachment-regulated signaling networks in the fibroblast-populated 3D collagen matrix. Scientific reports. vol 3. 2014-06-23. PMID:23697962. |
perturbation of select networks in multiple fibroblast strains suggested that il6 and il8 secretion may have been involved in preservation of matrix cell population in the released matrix, though there was variability in testing results among the strains. |
2014-06-23 |
2023-08-12 |
human |
| Bo Gao, Wang Sun, Xianqi Wang, Xu Jia, Biao Ma, Yu Chang, Weihui Zhang, Dongbo Xu. Whole genome expression profiling and screening for differentially expressed cytokine genes in human bone marrow endothelial cells treated with humoral inhibitors in liver cirrhosis. International journal of molecular medicine. vol 32. issue 5. 2014-05-09. PMID:24043211. |
moreover, we screened and verified 21 differentially expressed cytokine genes [transforming growth factor (tgf)b1, tumor necrosis factor (tnf)b, tnf receptor superfamily, member 11b (tnfrsf11b), tnf (ligand) superfamily, member 13b (tnfsf13b), interleukin (il)1a, il6, il11, il17c, il24, family with sequence similarity 3, member b (fam3b), fas ligand (faslg), matrix metallopeptidase (mmp)3, mmp15, vitronectin (vtn), insulin-like growth factor 1 (igf1), fibroblast growth factor 22 (fgf22), slit homolog 2 (drosophila) (slit2), thrombospondin (thbs)2, thbs3, chemokine (c-c motif) ligand 28 (ccl28) and macrophage stimulating 1 (mst1)] from 97 cytokine genes in bmecs treated with serum from patients with lc. |
2014-05-09 |
2023-08-12 |
human |
| Ratana Lim, Gillian Barker, Martha Lappa. A novel role for FOXO3 in human labor: increased expression in laboring myometrium, and regulation of proinflammatory and prolabor mediators in pregnant human myometrial cells. Biology of reproduction. vol 88. issue 6. 2013-10-21. PMID:23636809. |
we found that the loss of foxo3 in myometrial cells was associated with a significant decrease in il1b-induced il6 and il8 expression and production, cyclooxygenase ([cox]-2, official symbol ptgs2) expression and subsequent prostaglandin (pge2 and pgf2alpha) release, and matrix metalloproteinase 9 (mmp9) and mrna expression and activity. |
2013-10-21 |
2023-08-12 |
human |
| Zu-Yau Lin, Wan-Long Chuan. Genes responsible for the characteristics of primary cultured invasive phenotype hepatocellular carcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 66. issue 6. 2013-01-30. PMID:22681909. |
for primary cultured invasive cells, differential expressions of several groups of common genes are known to have capacities to promote proliferation (cav1, il6, plat, rrad, srpx), remodeling of extracellular matrix (col1a1, col1a2, nid2, tnc, reln, sparc), migration (actg2, cav1, ccl2, ccl26, cdc42ep3, cnn1, phldb2, plat, rrad, srpx), implantation (il6), immune escape (cd70) and angiogenesis (ccl2, il6, il18, plat, slit3). |
2013-01-30 |
2023-08-12 |
human |
| Donna K Arnett, Robyn L McClelland, Alan Bank, David A Bluemke, Mary Cushman, Alexander J Szalai, Nishank Jain, Antoinette S Gomes, Susan R Heckbert, W Gregory Hundley, João A Lim. Biomarkers of inflammation and hemostasis associated with left ventricular mass: The Multiethnic Study of Atherosclerosis (MESA). International journal of molecular epidemiology and genetics. vol 2. issue 4. 2012-10-02. PMID:22200000. |
we studied relationships of c-reactive protein (crp), interleukin-6 (il6), d-dimer, soluble intercellular adhesion molecule-1 (sicam-1), plasminogen activator inhibitor 1 (pai-1), soluble thrombomodulin (stm), soluble tumor necrosis factor type 1 receptor (stnfr1), von willebrand factor (vwf), soluble e-selectin (se-selectin), factor viii, fibrinogen, matrix metalloproteinase 3 (mmp3), and matrix metalloproteinase 9 (mmp9) with lv mass in an asymptomatic population. |
2012-10-02 |
2023-08-12 |
human |
| S Yoon, S U Woo, J H Kang, K Kim, H-J Shin, H-S Gwak, S Park, Y-J Chwa. NF-κB and STAT3 cooperatively induce IL6 in starved cancer cells. Oncogene. vol 31. issue 29. 2012-09-25. PMID:22105366. |
the conditioned media from starved cancer cells contained various secretory factors, such as il6, il9, vwf (von willebrand factor), frem1 (fras1 related extracellular matrix 1), saa1 (serum amyloid a1), sdk1 (sidekick homolog 1) and adam12 (adam metallopeptidase domain 12), induced by nf-κb and stat3 and promoted clonogenic capacities of cancer cells, and proliferation and migration of human umbilical vein endothelial cells. |
2012-09-25 |
2023-08-12 |
human |
| Premkumar Vummidi Giridhar, Holly M Funk, Catherine A Gallo, Aleksey Porollo, Carol A Mercer, David R Plas, Angela F Dre. Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells. Clinical & experimental metastasis. vol 28. issue 8. 2012-01-10. PMID:21887537. |
moreover, adherence to plastic and to peritoneal extracellular matrix components was enhanced in tumor cells overexpressing il6 or il6rα. |
2012-01-10 |
2023-08-12 |
human |
| Elio Defilippi, Andrea Zitella, Alessandro Tizzan. [Alternative tests to PSA for prostate cancer diagnosis]. Urologia. vol 78. issue 2. 2011-12-16. PMID:21553390. |
we present a short review of the literature describing a selection of the most promising alternatives to psa being studied currently: pca3, serum kallikreins, serum detectable prostate specific membrane antigen, the nuclear matrix protein epca, epca-2, prostatic acid phosphatase, urine detectable gstp1, anti-amacr antibodies, sarcosine, plasminogen activating urokinase, igfbp, tgf beta 1,psp94, il6, plasmatic dna, serum autoantibodies, neuroendocrine markers, proteomic analysis. |
2011-12-16 |
2023-08-12 |
Not clear |