| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mingmin Wang, Shuangjie Yang, Mingyan Shao, Qian Zhang, Xiaoping Wang, Linghui Lu, Sheng Gao, Yong Wang, Wei Wan. Identification of Potential Bioactive Ingredients and Mechanisms of the Guanxin Suhe Pill on Angina Pectoris by Integrating Network Pharmacology and Molecular Docking. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-08-24. PMID:34422068. |
protein-protein interaction identified vegfa (vascular endothelial growth factor a), tnf (tumor necrosis factor), ccl2 (c-c motif chemokine ligand 2), fn1 (fibronectin 1), mmp9 (matrix metallopeptidase 9), ptgs2 (prostaglandin-endoperoxide synthase 2), il10 (interleukin 10), cxcl8 (c-x-c motif chemokine ligand 8), il6 (interleukin 6), and ins (insulin) as hub targets for gsp, which were involved in the inflammatory process, ecm proteolysis, glucose metabolism, and lipid metabolism. |
2021-08-24 |
2023-08-13 |
Not clear |
| Min Ji Han, Won Ji Lee, Joonhyuk Choi, Yean Ju Hong, Sang Jun Uhm, Youngsok Choi, Jeong Tae D. Inhibition of neural stem cell aging through the transient induction of reprogramming factors. The Journal of comparative neurology. vol 529. issue 3. 2021-07-26. PMID:32510600. |
in this study, we found that long-term in vitro culture of nscs resulted in aging-related upregulation of inflammatory- and endoplasmic reticulum (er) stress-related genes, including the proinflammatory cytokines interleukin (il)1β and il6, the senescence-associated enzyme matrix metallopeptidase 13 (mmp13), and the er stress-responsive transcription factor activating transcription factor 4 (atf4) and c/ebp homologous protein (chop). |
2021-07-26 |
2023-08-13 |
Not clear |
| Joakim Sandstedt, Karin Vargmar, Kristina Björkman, Ulla Ruetschi, Göran Bergström, Lillemor Mattsson Hultén, Eva Skiöldebran. COMP (Cartilage Oligomeric Matrix Protein) Neoepitope: A Novel Biomarker to Identify Symptomatic Carotid Stenosis. Arteriosclerosis, thrombosis, and vascular biology. vol 41. issue 3. 2021-03-15. PMID:33472398. |
when the concentration was compared between the stenosis and control groups, il-1ra (interleukin-1 receptor antagonist protein), il6 (interleukin-6), ren (renin), mmp1 (matrix metalloproteinase-1), trail-r2 (tumor necrosis factor-related apoptosis-inducing ligand receptor 2), itgb1bp2 (integrin beta 1 binding protein 2), and compneo were predictive of stenosis. |
2021-03-15 |
2023-08-13 |
human |
| Delsuz Rezaee, Mojgan Bandehpour, Bahram Kazemi, Mohammad Saleh. Role of intrauterine administration of transfected peripheral blood mononuclear cells by GM-CSF on embryo implantation and pregnancy rate in mice. Molecular human reproduction. vol 26. issue 2. 2021-02-03. PMID:31899496. |
attachment of mouse embryos and the mrna expression levels of leukemia inhibitory factor (lif), vascular endothelial growth factor (vegf), matrix metalloproteinase 9 (mmp9), gmcsf-receptor (gmcsf-r) and interleukin 6 (il6) in vitro were assessed by real-time pcr in endometrial cells. |
2021-02-03 |
2023-08-13 |
mouse |
| Heejei Yoon, Seung-Il Choi, Eung Kweon Ki. Uptake of cell debris and enhanced expression of inflammatory factors in response to dead cells in corneal fibroblast cells. Experimental eye research. vol 194. 2020-12-15. PMID:32217186. |
the corneal fibroblasts strongly expressed extracellular matrix molecules (fn and col1a1) and low or medium levels of macrophage markers (cd14, cd68, and cd36), inflammatory cytokines (il1a, il1b, and il6), and chemokines (il8 and ccl2), but not cd11b, suggesting that corneal fibroblasts are macrophage-like fibroblasts. |
2020-12-15 |
2023-08-13 |
Not clear |
| Binfeng Liu, Ang Li, Hongbo Wang, Jialin Wang, Gongwei Zhai, Haohao Ma, Shiqing Feng, Liyun Liu, Yanzheng Ga. Exploring the Key Genes and Pathways in the Formation of Corneal Scar Using Bioinformatics Analysis. BioMed research international. vol 2020. 2020-10-19. PMID:32016117. |
in total, 7 hub genes il6 (interleukin-6), mmp9 (matrix metallopeptidase 9), cxcl10 (c-x-c motif chemokine ligand 10), mapk8 (mitogen-activated protein kinase 8), tlr4 (toll-like receptor 4), hgf (hepatocyte growth factor), edn1 (endothelin 1) were selected. |
2020-10-19 |
2023-08-13 |
Not clear |
| Hamza Umut Karakurt, Pınar Pİ. Integration of transcriptomic profile of SARS-CoV-2 infected normal human bronchial epithelial cells with metabolic and protein-protein interaction networks. Turkish journal of biology = Turk biyoloji dergisi. vol 44. issue 3. 2020-09-28. PMID:32595353. |
our results are in accordance with the literature on response of il6 family of cytokines and their importance, in addition, we find that matrix metalloproteinase 2 (mmp2) and matrix metalloproteinase 9 (mmp9) with keratan sulfate synthesis pathway may play a key role in the infection. |
2020-09-28 |
2023-08-13 |
human |
| Prasad Tongaonkar, Vasu Punj, Akshay Subramanian, Dat Q Tran, Katie K Trinh, Justin B Schaal, Teresina Laragione, André J Ouellette, Percio S Gulko, Michael E Selste. RTD-1 therapeutically normalizes synovial gene signatures in rat autoimmune arthritis and suppresses proinflammatory mediators in RA synovial fibroblasts. Physiological genomics. vol 51. issue 12. 2020-07-07. PMID:31762409. |
upstream regulator analysis showed upregulation of gene expression pathways regulated by tnf, il1b, il6, proinflammatory cytokines, and matrix metalloproteases (mmps) involved in ra. |
2020-07-07 |
2023-08-13 |
human |
| Gordon A Ferns, Seyed Mahdi Hassanian, Mohammad-Hassan Arjman. Hyperglycaemia and the risk of post-surgical adhesion. Archives of physiology and biochemistry. 2020-06-15. PMID:32536284. |
high secretion of pro-inflammatory cytokines and growth factors, includes tumour necrosis factor α (tnf-α), interleukin 6 (il6), and transforming growth factor β (tgf-β) by persistent recruitment of immune cells and the inappropriate proliferated fibroblast/mesothelial cells can stimulate signalling pathways particularly tgf-β leads to the up-regulation of some pro-fibrotic genes that impair fibrinolytic activity and promote extracellular matrix (ecm) accumulation. |
2020-06-15 |
2023-08-13 |
Not clear |
| Yong-Gang Hong, Guo-Shu Xu, Guan-Yu Yu, Ji-Dian Zhou, Qi-Zhi Liu, Jun-Sheng Ni, Hong-Li Yan, Wei Zhang, Li-Qiang Ha. The RNA binding protein neuro-oncological ventral antigen 1 (NOVA1) regulates IL-6 mRNA stability to enhance JAK2-STAT3 signaling in CRC. Surgical oncology. vol 31. 2020-05-04. PMID:31541909. |
in further functional studies, we found that nova1 expression controlled the proliferation and invasive characteristics of crc cells via a mechanism wherein nova1 bound and stabilized the il6 mrna, enhancing il-6/jak2/stat3 signaling to in turn upregulate matrix metalloproteinases (mmps) 2, 7, and 9. |
2020-05-04 |
2023-08-13 |
Not clear |
| Eva Haltmayer, Iris Ribitsch, Simone Gabner, Julie Rosser, Sinan Gueltekin, Johannes Peham, Ulrich Giese, Marlies Dolezal, Monika Egerbacher, Florien Jenne. Co-culture of osteochondral explants and synovial membrane as in vitro model for osteoarthritis. PloS one. vol 14. issue 4. 2019-12-19. PMID:30939166. |
changes in the expression of extracellular matrix (ecm) genes (collagen type-1 (col1), col2, col10 and aggrecan) as well as presence and quantity of inflammatory marker genes (il6, matrix metalloproteinase-1 (mmp1), mmp3, mmp13, a disintegrin and metalloproteinase with-thrombospondin-motif-5 (adamts5) were analysed by immunohistochemistry, qpcr and elisa. |
2019-12-19 |
2023-08-13 |
Not clear |
| Hua Shen, Rohith Jayaram, Susumu Yoneda, Stephen W Linderman, Shelly E Sakiyama-Elbert, Younan Xia, Richard H Gelberman, Stavros Thomopoulo. The effect of adipose-derived stem cell sheets and CTGF on early flexor tendon healing in a canine model. Scientific reports. vol 8. issue 1. 2019-10-17. PMID:30038250. |
ctgf, either alone or with ascs, reduced inflammatory (il1b and il6) and matrix degrading (mmp3 and mmp13) gene expression, while increasing anti-inflammatory gene (il4) expression and collagen synthesis compared to control repairs. |
2019-10-17 |
2023-08-13 |
Not clear |
| Yuan Gao, En-Jie Liu, Wei-Jin Wang, Ya-Li Wang, Xiao-Guang Li, Xin Wang, Shi-Hong Li, Shu-Juan Zhang, Meng-Zhu Li, Qiu-Zhi Zhou, Xiao-Bing Long, Hua-Qiu Zhang, Jian-Zhi Wan. Microglia CREB-Phosphorylation Mediates Amyloid-β-Induced Neuronal Toxicity. Journal of Alzheimer's disease : JAD. vol 66. issue 1. 2019-09-19. PMID:30282353. |
inhibition of microglia activation by minocycline or creb phosphorylation by h89, an inhibitor of protein kinase a (pka), abolished aβ-induced microglia creb hyperphosphorylation with restoration of neuronal function and attenuation of inflammatory response, i.e., reduced levels of interleukin-6 (il6) and pcreb binding of matrix metalloproteinase-9 (mmp9) dna. |
2019-09-19 |
2023-08-13 |
mouse |
| Busra Gurel, Mehmet Cansev, Cansu Sevinc, Seda Kelestemur, Busra Ocalan, Aysen Cakir, Sami Aydin, Nevzat Kahveci, Mehmet Ozansoy, Ozlem Taskapilioglu, Ismail Hakki Ulus, Merve Karayel Başar, Betul Sahin, Mete Bora Tuzuner, Ahmet Tarik Bayka. Early Stage Alterations in CA1 Extracellular Region Proteins Indicate Dysregulation of IL6 and Iron Homeostasis in the 5XFAD Alzheimer's Disease Mouse Model. Journal of Alzheimer's disease : JAD. vol 61. issue 4. 2019-01-24. PMID:29376847. |
alterations in extracellular matrix proteins in addition to increasing amount of hippocampal il6 and iron in the early stages of ad may reveal inflammation-mediated iron dyshomeostasis in the early stages of neurodegeneration. |
2019-01-24 |
2023-08-13 |
mouse |
| Hossein Sendi, Ivy Mead, Meimei Wan, Marjan Mehrab-Mohseni, Kenneth Koch, Anthony Atala, Herbert L Bonkovsky, Colin E Bisho. miR-122 inhibition in a human liver organoid model leads to liver inflammation, necrosis, steatofibrosis and dysregulated insulin signaling. PloS one. vol 13. issue 7. 2019-01-22. PMID:30024933. |
this was associated with increase in inflammatory cytokines (il6, tnf), chemokines (ccl2, ccl3) and increase in a subset of matrix metaloproteinases (mmp8, mmp9). |
2019-01-22 |
2023-08-13 |
human |
| Julia Ettlin, Elena Clementi, Parisa Amini, Alexandra Malbon, Enni Markkane. Analysis of Gene Expression Signatures in Cancer-Associated Stroma from Canine Mammary Tumours Reveals Molecular Homology to Human Breast Carcinomas. International journal of molecular sciences. vol 18. issue 5. 2018-03-26. PMID:28531107. |
we found that col1a1 (collagen1α1), αsma (alpha smooth muscle actin), fap (fibroblast activation protein), pdgfrβ (platelet-derived growth factor receptor beta), and caveolin-1 were significantly upregulated in canine cas, and the expression of cxcl12 (stromal cell derived factor 1) significantly decreased, whereas mmp2 (matrix metalloproteinase 1) and il6 (interleukin 6) did not change. |
2018-03-26 |
2023-08-13 |
human |
| Patricia G Tremblay, Marc-André Sirar. Transcriptomic analysis of gene cascades involved in protein kinase A and C signaling in the KGN line of human ovarian granulosa tumor cells†. Biology of reproduction. vol 96. issue 4. 2018-03-12. PMID:28383663. |
gene associations with seven major ovarian functions were identified: prostaglandin- endoperoxide synthase 2 (ptgs2), interleukin 8 (il8), and interleukin 6 (il6) with inflammation; steroidogenic acute regulatory protein (star), cytochrome p450scc (cyp11a1), and cytochrome p450 family 19 subfamily a member 1 (cyp19a1) with steroidogenesis; vascular endothelial growth factor c (vegfc), vascular endothelial growth factor a (vegfa), and c-x-c chemokine receptor type 4 (cxcr4) with angiogenesis; amphiregulin (areg), epidermal growth factor receptor (egfr), and sprouty rtk signaling antagonist 2 (spry2) with differentiation, bcl2 associated x (bax), bcl2 like 12 (bcl2l12), and caspase 1(casp1) with apoptosis, cyclin d1 (ccnd1), cyclin b1 (ccnb1), and cyclin b2 (ccnb2) with division; and matrix metalloproteinase-1 (mmp1), matrix metallopeptidase 9 (mmp9), and timp metallopeptidase inhibitor 1 (timp1) with ovulation. |
2018-03-12 |
2023-08-13 |
human |
| Endin Nokik Stujanna, Nobuyuki Murakoshi, Kazuko Tajiri, DongZhu Xu, Taizo Kimura, Rujie Qin, Duo Feng, Saori Yonebayashi, Yukino Ogura, Fumi Yamagami, Akira Sato, Akihiko Nogami, Kazutaka Aonum. Rev-erb agonist improves adverse cardiac remodeling and survival in myocardial infarction through an anti-inflammatory mechanism. PloS one. vol 12. issue 12. 2018-01-04. PMID:29232411. |
moreover, the mrna expression levels of inflammatory-related molecules such as il6, mcp1, ly6g, cd11b, matrix metallopeptidase (mmp)9, and the protein expression levels of phosphorylated nf-κb p65, phosphorylated erk, and phosphorylated p38 were also significantly lower in mi+sr than in mi+v. |
2018-01-04 |
2023-08-13 |
mouse |
| Ammar T Qureshi, Devaveena Dey, Erin M Sanders, Jonathan G Seavey, Allison M Tomasino, Kaitlyn Moss, Benjamin Wheatley, David Cholok, Shawn Loder, John Li, Benjamin Levi, Thomas A Davi. Inhibition of Mammalian Target of Rapamycin Signaling with Rapamycin Prevents Trauma-Induced Heterotopic Ossification. The American journal of pathology. vol 187. issue 11. 2017-11-28. PMID:29029772. |
there was significant attenuation of 1) total new bone and soft tissue ectopic bone with 0.5 mg/kg (38.5% and 14.7%) and 2.5 mg/kg rapamycin (90.3% and 82.9%), respectively, 2) connective tissue progenitor cells, 3) platelet-derived growth factor receptor-α-positive cells, 4) α-smooth muscle actin-positive blood vessels, and 5) of key extracellular matrix remodeling (cd44, col1a1, integrins), osteogenesis (sp7, runx2, bmp2), inflammation (cxcl5, 10, il6, ccl2), and angiogenesis (angpt2) genes. |
2017-11-28 |
2023-08-13 |
rat |
| Beatrice Menicacci, Anna Laurenzana, Anastasia Chillà, Francesca Margheri, Silvia Peppicelli, Elisabetta Tanganelli, Gabriella Fibbi, Lisa Giovannelli, Mario Del Rosso, Alessandra Mocal. Chronic Resveratrol Treatment Inhibits MRC5 Fibroblast SASP-Related Protumoral Effects on Melanoma Cells. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 72. issue 9. 2017-09-22. PMID:28329136. |
in the present article, chronic treatment (5 weeks) with 5 µm resveratrol has been used to modulate senescence-related protumoral features of mrc5 fibroblasts, reducing sasp-related interleukins il1α, il1β, il6, and il8; transforming-growth-factor-β (tgfβ); matrix metallo-proteinases mmp3 and mmp2; urokinase plasminogen activator (upa); receptor proteins upar, il6r, insulin growth factor receptor-1 (igf-1r), tgfβ-r2, and cxcr4. |
2017-09-22 |
2023-08-13 |
Not clear |