| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shui-Wang Ying, Fan Jia, Syed Y Abbas, Franz Hofmann, Andreas Ludwig, Peter A Goldstei. Dendritic HCN2 channels constrain glutamate-driven excitability in reticular thalamic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 32. 2007-08-29. PMID:17687049. |
for example, dendritic expression of hcn1 normalizes somatic voltage responses and spike output in hippocampal and cortical neurons. |
2007-08-29 |
2023-08-12 |
mouse |
| Roland A Bender, Timo Kirschstein, Oliver Kretz, Amy L Brewster, Cristina Richichi, Christiane Rüschenschmidt, Ryuichi Shigemoto, Heinz Beck, Michael Frotscher, Tallie Z Bara. Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 17. 2007-05-15. PMID:17460082. |
localization of hcn1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. |
2007-05-15 |
2023-08-12 |
rat |
| Roland A Bender, Timo Kirschstein, Oliver Kretz, Amy L Brewster, Cristina Richichi, Christiane Rüschenschmidt, Ryuichi Shigemoto, Heinz Beck, Michael Frotscher, Tallie Z Bara. Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 17. 2007-05-15. PMID:17460082. |
here, we describe a novel developmental plasticity of hcn channel expression in axonal and presynaptic compartments: hcn1 channels were localized to axon terminals of the perforant path (the major hippocampal afferent pathway) of immature rats, where they modulated synaptic efficacy. |
2007-05-15 |
2023-08-12 |
rat |
| Roland A Bender, Timo Kirschstein, Oliver Kretz, Amy L Brewster, Cristina Richichi, Christiane Rüschenschmidt, Ryuichi Shigemoto, Heinz Beck, Michael Frotscher, Tallie Z Bara. Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 17. 2007-05-15. PMID:17460082. |
these findings support a novel developmentally regulated axonal transport of functional ion channels and suggest a role for hcn1 channel-mediated presynaptic i(h) in hippocampal maturation. |
2007-05-15 |
2023-08-12 |
rat |
| Amy L Brewster, Yuncai Chen, Roland A Bender, Amy Yeh, Ryuichi Shigemoto, Tallie Z Bara. Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus. Cerebral cortex (New York, N.Y. : 1991). vol 17. issue 3. 2007-04-18. PMID:16648453. |
in ca3, strong expression of hcn1 already neonatally supports the recently established role of this conductance in neonatal, age-specific, hippocampal oscillations (giant depolarizing potentials). |
2007-04-18 |
2023-08-12 |
rat |
| Roland A Bender, Rafael Galindo, Manuel Mameli, Rebeca Gonzalez-Vega, C Fernando Valenzuela, Tallie Z Bara. Synchronized network activity in developing rat hippocampus involves regional hyperpolarization-activated cyclic nucleotide-gated (HCN) channel function. The European journal of neuroscience. vol 22. issue 10. 2006-01-17. PMID:16307610. |
here we focus on hcn1, the prevalent hcn channel isoform in neonatal hippocampus, and demonstrate an hcn1 spatiotemporal expression pattern in both ca3 principal cells and interneurons that correlates with the developmental profile of gdps. |
2006-01-17 |
2023-08-12 |
rat |
| Takuya Notomi, Ryuichi Shigemot. Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain. The Journal of comparative neurology. vol 471. issue 3. 2004-05-03. PMID:14991560. |
immunoreactivity for hcn1 showed predominantly cortical distribution, being intense in the neocortex, hippocampus, superior colliculus, and cerebellum, whereas those for hcn3 and hcn4 exhibited subcortical distribution mainly concentrated in the hypothalamus and thalamus, respectively. |
2004-05-03 |
2023-08-12 |
rat |
| Takuya Notomi, Ryuichi Shigemot. Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain. The Journal of comparative neurology. vol 471. issue 3. 2004-05-03. PMID:14991560. |
double immunofluorescence revealed colocalization of immunoreactivity for hcn1 and hcn2 in distal dendrites of pyramidal cells in the hippocampus and neocortex. |
2004-05-03 |
2023-08-12 |
rat |
| Roland A Bender, Sheila V Soleymani, Amy L Brewster, Snow T Nguyen, Heinz Beck, Gary W Mathern, Tallie Z Bara. Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 17. 2003-09-03. PMID:12890777. |
hcn1 and hcn2 expression were measured using in situ hybridization and immunocytochemistry in hippocampi from three groups: tle with hippocampal sclerosis (hs; n = 17), epileptic hippocampi without hs, or non-hs (nhs; n = 10), and autopsy material (n = 10). |
2003-09-03 |
2023-08-12 |
human |
| Roland A Bender, Sheila V Soleymani, Amy L Brewster, Snow T Nguyen, Heinz Beck, Gary W Mathern, Tallie Z Bara. Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 17. 2003-09-03. PMID:12890777. |
in contrast, hcn1 mrna expression over the gc layer and in individual gcs from epileptic hippocampus was markedly increased once gc neuronal density was reduced by >50%. |
2003-09-03 |
2023-08-12 |
human |
| Roland A Bender, Sheila V Soleymani, Amy L Brewster, Snow T Nguyen, Heinz Beck, Gary W Mathern, Tallie Z Bara. Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 17. 2003-09-03. PMID:12890777. |
in contrast, in chronic epileptic hs hippocampus studied here, the profound loss of interneuronal and principal cell populations and consequent reduced inhibition, coupled with increased dendritic excitation of surviving gcs, might provoke a "compensatory" enhancement of hcn1 mrna and protein expression. |
2003-09-03 |
2023-08-12 |
human |
| Andrea Lörincz, Takuya Notomi, Gábor Tamás, Ryuichi Shigemoto, Zoltan Nusse. Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites. Nature neuroscience. vol 5. issue 11. 2002-12-05. PMID:12389030. |
light microscopy revealed graded hcn1 immunoreactivity in apical dendrites of hippocampal, subicular and neocortical layer-5 pyramidal cells. |
2002-12-05 |
2023-08-12 |
rat |
| A U Brãuer, N E Savaskan, M H Kole, M Plaschke, L M Monteggia, E J Nestler, E Simburger, R A Deisz, O Ninnemann, R Nitsc. Molecular and functional analysis of hyperpolarization-activated pacemaker channels in the hippocampus after entorhinal cortex lesion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 15. issue 14. 2002-01-15. PMID:11726545. |
differential display of hippocampal tissue after entorhinal cortex lesion (ecl) revealed decreases in mrna encoding the neuronal hyperpolarization-activated, cyclic nucleotide-gated channel hcn1. |
2002-01-15 |
2023-08-12 |
Not clear |
| A U Brãuer, N E Savaskan, M H Kole, M Plaschke, L M Monteggia, E J Nestler, E Simburger, R A Deisz, O Ninnemann, R Nitsc. Molecular and functional analysis of hyperpolarization-activated pacemaker channels in the hippocampus after entorhinal cortex lesion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 15. issue 14. 2002-01-15. PMID:11726545. |
in situ hybridization confirmed that hippocampal transcripts of hcn1, but not hcn2/3/4, are down-regulated after ecl. |
2002-01-15 |
2023-08-12 |
Not clear |
| A U Brãuer, N E Savaskan, M H Kole, M Plaschke, L M Monteggia, E J Nestler, E Simburger, R A Deisz, O Ninnemann, R Nitsc. Molecular and functional analysis of hyperpolarization-activated pacemaker channels in the hippocampus after entorhinal cortex lesion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 15. issue 14. 2002-01-15. PMID:11726545. |
hence, denervation of the hippocampus decreases hcn1 and concomitantly the ih activity in hilar neurons, and the recovery of h-current activation kinetics occurs parallel to postlesion sprouting. |
2002-01-15 |
2023-08-12 |
Not clear |
| S Chen, J Wang, S A Siegelbau. Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide. The Journal of general physiology. vol 117. issue 5. 2001-07-19. PMID:11331358. |
here, we report that hcn1 and hcn2, isoforms coexpressed in neocortex and hippocampus that differ markedly in their biophysical properties, coassemble to generate heteromultimeric channels with novel properties. |
2001-07-19 |
2023-08-12 |
xenopus_laevis |
| L M Monteggia, A J Eisch, M D Tang, L K Kaczmarek, E J Nestle. Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain. Brain research. Molecular brain research. vol 81. issue 1-2. 2001-02-01. PMID:11000485. |
hcn1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus; hcn2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body; hcn3 expression is most pronounced in supraoptic nucleus of hypothalamus; and hcn4 expression is most abundant in medial habenula and anterior and principal relay nuclei of the thalamus. |
2001-02-01 |
2023-08-12 |
mouse |
| S Moosmang, M Biel, F Hofmann, A Ludwi. Differential distribution of four hyperpolarization-activated cation channels in mouse brain. Biological chemistry. vol 380. issue 7-8. 1999-10-19. PMID:10494850. |
the expression of hcn1 was restricted to the olfactory bulb, cerebral cortex, hippocampus, superior colliculus and cerebellum. |
1999-10-19 |
2023-08-12 |
mouse |