| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan Pan, Sajag Bhattarai, Modestos Modestou, Arlene V Drack, Dane M Chetkovich, Sheila A Bake. TRIP8b is required for maximal expression of HCN1 in the mouse retina. PloS one. vol 9. issue 1. 2014-09-16. PMID:24409334. |
this is in contrast to hippocampal neurons where hcn1 is concentrated in a subset of dendrites. |
2014-09-16 |
2023-08-12 |
mouse |
| Wiebke Wilkars, Jessica Wollberg, Evita Mohr, Mieri Han, Dane M Chetkovich, Robert Bähring, Roland A Bende. Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 28. issue 5. 2014-06-16. PMID:24451387. |
we identified a py motif (l/ppxy), the characteristic binding motif for nedd4-2 in the c terminus of the hcn1 subunit, and showed that hcn1 and nedd4-2 interacted both in vivo (rat hippocampus, neocortex, and cerebellum) and in vitro [human embryonic kidney 293 (hek293) cells], resulting in increased hcn1 ubiquitination. |
2014-06-16 |
2023-08-12 |
human |
| Yoav Noam, Markus U Ehrengruber, Annie Koh, Paul Feyen, Erik M M Manders, Geoffrey W Abbott, Wytse J Wadman, Tallie Z Bara. Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons. The Journal of biological chemistry. vol 289. issue 9. 2014-04-25. PMID:24403084. |
filamin a promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (hcn1) channels and restricts ih in hippocampal neurons. |
2014-04-25 |
2023-08-12 |
Not clear |
| Yoav Noam, Markus U Ehrengruber, Annie Koh, Paul Feyen, Erik M M Manders, Geoffrey W Abbott, Wytse J Wadman, Tallie Z Bara. Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons. The Journal of biological chemistry. vol 289. issue 9. 2014-04-25. PMID:24403084. |
in hippocampal neurons, expression of a truncated dominant-negative flna enhances the expression of native hcn1. |
2014-04-25 |
2023-08-12 |
Not clear |
| Robert P Bonin, Agnieszka A Zurek, Jieying Yu, Douglas A Bayliss, Beverley A Orse. Hyperpolarization-activated current (In) is reduced in hippocampal neurons from Gabra5-/- mice. PloS one. vol 8. issue 3. 2013-09-17. PMID:23516534. |
finally, the expression of hcn1 protein that generates ih was reduced by 41% in the hippocampus of gabra5-/- mice. |
2013-09-17 |
2023-08-12 |
mouse |
| Yun-Jung Oh, Jongju Na, Ji-Heon Jeong, Dae-Kyoon Park, Kyung-Ho Park, Jeong-Sik Ko, Duk-So Ki. Alterations in hyperpolarization-activated cyclic nucleotidegated cation channel (HCN) expression in the hippocampus following pilocarpine-induced status epilepticus. BMB reports. vol 45. issue 11. 2013-08-06. PMID:23187002. |
although hcn1 immunoreactivity was observed in the hippocampus, its immunoreactivities were enhanced at 12 hrs following se. |
2013-08-06 |
2023-08-12 |
Not clear |
| Yun-Jung Oh, Jongju Na, Ji-Heon Jeong, Dae-Kyoon Park, Kyung-Ho Park, Jeong-Sik Ko, Duk-So Ki. Alterations in hyperpolarization-activated cyclic nucleotidegated cation channel (HCN) expression in the hippocampus following pilocarpine-induced status epilepticus. BMB reports. vol 45. issue 11. 2013-08-06. PMID:23187002. |
taken together, our findings suggest that altered expressions of hcn1 following se may be mainly involved in the imbalances of neurotransmissions to hippocampal circuits; thus, it is proposed that hcn1 may play an important role in the epileptogenic period as a compensatory response. |
2013-08-06 |
2023-08-12 |
Not clear |
| Chung Sub Kim, Payne Y Chang, Daniel Johnsto. Enhancement of dorsal hippocampal activity by knockdown of HCN1 channels leads to anxiolytic- and antidepressant-like behaviors. Neuron. vol 75. issue 3. 2012-10-18. PMID:22884333. |
enhancement of dorsal hippocampal activity by knockdown of hcn1 channels leads to anxiolytic- and antidepressant-like behaviors. |
2012-10-18 |
2023-08-12 |
mouse |
| Syed A Hussaini, Kimberly A Kempadoo, Sébastien J Thuault, Steven A Siegelbaum, Eric R Kande. Increased size and stability of CA1 and CA3 place fields in HCN1 knockout mice. Neuron. vol 72. issue 4. 2012-01-12. PMID:22099465. |
hcn1 is strongly expressed in ca1 neurons and in entorhinal cortex grid cells, which provide spatial information to the hippocampus. |
2012-01-12 |
2023-08-12 |
mouse |
| Rebecca Piskorowski, Bina Santoro, Steven A Siegelbau. TRIP8b splice forms act in concert to regulate the localization and expression of HCN1 channels in CA1 pyramidal neurons. Neuron. vol 70. issue 3. 2011-07-11. PMID:21555075. |
of the two remaining hippocampal trip8b isoforms, trip8b(1a-4) promoted hcn1 surface expression in dendrites, whereas trip8b(1a) suppressed hcn1 misexpression in axons. |
2011-07-11 |
2023-08-12 |
mouse |
| Yoav Noam, Qinqin Zha, Lise Phan, Rui-Lin Wu, Dane M Chetkovich, Wytse J Wadman, Tallie Z Bara. Trafficking and surface expression of hyperpolarization-activated cyclic nucleotide-gated channels in hippocampal neurons. The Journal of biological chemistry. vol 285. issue 19. 2010-06-11. PMID:20215108. |
taken together, the results reveal the highly dynamic nature of hcn1 channel trafficking in hippocampal neurons and provide a novel potential mechanism for rapid regulation of i(h), and hence of neuronal properties, via alterations of hcn1 trafficking and surface expression. |
2010-06-11 |
2023-08-12 |
Not clear |
| S Li, Z He, L Guo, L Huang, J Wang, W H. Behavioral alterations associated with a down regulation of HCN1 mRNA in hippocampal cornus ammon 1 region and neocortex after chronic incomplete global cerebral ischemia in rats. Neuroscience. vol 165. issue 3. 2010-03-08. PMID:19892002. |
behavioral alterations associated with a down regulation of hcn1 mrna in hippocampal cornus ammon 1 region and neocortex after chronic incomplete global cerebral ischemia in rats. |
2010-03-08 |
2023-08-12 |
rat |
| S Li, Z He, L Guo, L Huang, J Wang, W H. Behavioral alterations associated with a down regulation of HCN1 mRNA in hippocampal cornus ammon 1 region and neocortex after chronic incomplete global cerebral ischemia in rats. Neuroscience. vol 165. issue 3. 2010-03-08. PMID:19892002. |
in the in situ hybridization cytochemistry experiment, hcn1 mrna declined to 52.00% and 46.00% of the control values in the cornus ammon 1 (ca1) regions of hippocampus and neocortex separately after chronic cerebral ischemia. |
2010-03-08 |
2023-08-12 |
rat |
| Tursonjan Tokay, Marco Rohde, Sabine Krabbe, Mirko Rehberg, Roland A Bender, Rüdiger Köhling, Timo Kirschstei. HCN1 channels constrain DHPG-induced LTD at hippocampal Schaffer collateral-CA1 synapses. Learning & memory (Cold Spring Harbor, N.Y.). vol 16. issue 12. 2010-02-17. PMID:19940037. |
hcn1 channels constrain dhpg-induced ltd at hippocampal schaffer collateral-ca1 synapses. |
2010-02-17 |
2023-08-12 |
mouse |
| Bina Santoro, Rebecca A Piskorowski, Phillip Pian, Lei Hu, Haiying Liu, Steven A Siegelbau. TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain. Neuron. vol 62. issue 6. 2009-07-09. PMID:19555649. |
the hcn1 isoform regulates dendritic integration in cortical pyramidal neurons and provides an inhibitory constraint on both working memory in prefrontal cortex and spatial learning and memory in the hippocampus. |
2009-07-09 |
2023-08-12 |
Not clear |
| Alan S Lewis, Emily Schwartz, C Savio Chan, Yoav Noam, Minyoung Shin, Wytse J Wadman, D James Surmeier, Tallie Z Baram, Robert L Macdonald, Dane M Chetkovic. Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 19. 2009-05-28. PMID:19439603. |
in hippocampal neurons, coexpression of trip8b isoforms with hcn1 produced isoform-specific changes of hcn1 localization. |
2009-05-28 |
2023-08-12 |
Not clear |
| Xin Yu, Lianjun Guo, Guangfu Yin, Xiangang Zong, Yongxun A. Effect of non-specific HCN1 blocker CsCl on spatial learning and memory in mouse. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 26. issue 2. 2008-05-12. PMID:16850736. |
it has been suggested that hcn1 is primarily expressed in hippocampus, however little is known about its effects on spatial learning and memory. |
2008-05-12 |
2023-08-12 |
mouse |
| Xin Yu, Lianjun Guo, Guangfu Yin, Xiangang Zong, Yongxun A. Effect of non-specific HCN1 blocker CsCl on spatial learning and memory in mouse. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 26. issue 2. 2008-05-12. PMID:16850736. |
in hippocampal tissues, staining for the hcn1 mrna was stronger in the dg and ca1 region of the hippocampus (p <0.05, p<0.05, when cscl-administration group was compared with normal group). |
2008-05-12 |
2023-08-12 |
mouse |
| Qinqin Zha, Amy L Brewster, Cristina Richichi, Roland A Bender, Tallie Z Bara. Activity-dependent heteromerization of the hyperpolarization-activated, cyclic-nucleotide gated (HCN) channels: role of N-linked glycosylation. Journal of neurochemistry. vol 105. issue 1. 2008-04-28. PMID:17988239. |
thus, hippocampal hcn1 molecules have a significantly higher probability of being glycosylated after sa, and this might promote a stable heteromerization with hcn2. |
2008-04-28 |
2023-08-12 |
Not clear |
| Matthew F Nolan, Joshua T Dudman, Paul D Dodson, Bina Santor. HCN1 channels control resting and active integrative properties of stellate cells from layer II of the entorhinal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 46. 2007-12-19. PMID:18003822. |
these data suggest that hcn1 channels expressed by stellate neurons in layer ii of the entorhinal cortex are key molecular components in the processing of inputs to the hippocampal dentate gyrus, with distinct integrative roles during resting and active states. |
2007-12-19 |
2023-08-12 |
mouse |