| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ke Zhao, Yinchao Li, Huanling Lai, Ruili Niu, Huifeng Li, Shipei He, Zhengwei Su, Yue Gui, Lijie Ren, Xiaofeng Yang, Liemin Zho. Alterations in HCN1 expression and distribution during epileptogenesis in rats. Epilepsy research. vol 202. 2024-03-31. PMID:38555654. |
the hyperpolarization-activated cyclic nucleotide-gated cation channel (hcn1) is predominantly located in key regions associated with epilepsy, such as the neocortex and hippocampus. |
2024-03-31 |
2024-04-03 |
rat |
| Ke Zhao, Yinchao Li, Xiaofeng Yang, Liemin Zho. The Impact of Altered HCN1 Expression on Brain Function and Its Relationship with Epileptogenesis. Current neuropharmacology. 2023-06-27. PMID:37366350. |
hyperpolarization-activated cyclic nucleotide-gated cation channel 1 (hcn1) is predominantly expressed in neurons from the neocortex and hippocampus, two important regions related to epilepsy. |
2023-06-27 |
2023-08-14 |
Not clear |
| Karine Yu Sarkisova, Ekaterina A Fedosova, Alla B Shatskova, Margarita M Rudenok, Vera A Stanishevskaya, Petr A Slominsk. Maternal Methyl-Enriched Diet Increases DNMT1, HCN1, and TH Gene Expression and Suppresses Absence Seizures and Comorbid Depression in Offspring of WAG/Rij Rats. Diagnostics (Basel, Switzerland). vol 13. issue 3. 2023-02-11. PMID:36766503. |
disease-modifying effects of med were associated with increased expression of the dnmt1 and hcn1 genes in the ssc and hippocampus, as well as dnmt1, hcn1, and th genes in the nucleus accumbens. |
2023-02-11 |
2023-08-14 |
rat |
| Abdel-Azim Assi, Sara Abdelnabi, Abdelraheim Attaai, Rasha B Abd-Ellatie. Effect of ivabradine on cognitive functions of rats with scopolamine-induced dementia. Scientific reports. vol 12. issue 1. 2022-10-10. PMID:36216854. |
iva ameliorated the scopolamine-induced dysfunction, the hippocampus restored its normal healthy neurons, the amyloid plaques disappeared and the optical density of hcn1 immunoreactivity increased in hippocampal cells. |
2022-10-10 |
2023-08-14 |
rat |
| Pan Luo, Xiaopei Fu, Mujun Chang, Li Zhang, Lianjun Gu. Cerebral ischemia-reperfusion causes a down regulation of HCN1 expression via enhancing the nuclear NRSF-HDAC4 gathering that contributes to neuron damage. Brain research bulletin. vol 156. 2021-08-20. PMID:31923455. |
our data showed that i/r caused a strong decrease of hcn1 subunit in both hippocampus and cortex of rat. |
2021-08-20 |
2023-08-13 |
rat |
| Lianghui Ni, Yanling Xu, Sixuan Dong, Yujia Kong, Hong Wang, Guohua Lu, Yanyu Wang, Qi Li, Changjiang Li, Zhongde Du, Hongwei Sun, Lin Su. The potential role of the HCN1 ion channel and BDNF-mTOR signaling pathways and synaptic transmission in the alleviation of PTSD. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32198387. |
a series of behavioral tests and biochemical assessments of certain proteins (hcn1, bdnf, and pmtor) and synaptic ultrastructure in the prefrontal cortex (pfc) and hippocampus (hip) were then conducted. |
2021-06-18 |
2023-08-13 |
rat |
| Choong-Hyun Lee, Joon Ha Park, Moo-Ho Wo. Protein expression changes of HCN1 and HCN2 in hippocampal subregions of gerbils during the normal aging process. Iranian journal of basic medical sciences. vol 22. issue 11. 2020-09-28. PMID:32128096. |
protein expression changes of hcn1 and hcn2 in hippocampal subregions of gerbils during the normal aging process. |
2020-09-28 |
2023-08-13 |
Not clear |
| Choong-Hyun Lee, Joon Ha Park, Moo-Ho Wo. Protein expression changes of HCN1 and HCN2 in hippocampal subregions of gerbils during the normal aging process. Iranian journal of basic medical sciences. vol 22. issue 11. 2020-09-28. PMID:32128096. |
the objective of this study was to investigate age-related changes in hcn1 and hcn2 protein expressions in gerbil hippocampus at various ages. |
2020-09-28 |
2023-08-13 |
Not clear |
| Joon Ha Park, Dae Won Kim, Tae-Kyeong Lee, Cheol Woo Park, Young Eun Park, Ji Hyeon Ahn, Hyang-Ah Lee, Moo-Ho Won, Choong-Hyun Le. Improved HCN channels in pyramidal neurons and their new expression levels in pericytes and astrocytes in the gerbil hippocampal CA1 subfield following transient ischemia. International journal of molecular medicine. vol 44. issue 5. 2020-07-27. PMID:31573045. |
the present study investigated transient ischemia‑induced changes of hcn1 and hcn2 expressions in the cornu ammonis 1 (ca1) subfield of the hippocampus in gerbils subjected to 5 min transient global cerebral ischemia (tgci). |
2020-07-27 |
2023-08-13 |
Not clear |
| Daniel B McClatchy, Nam-Kyung Yu, Salvador Martínez-Bartolomé, Reesha Patel, Alexander R Pelletier, Mathieu Lavalle-Adam, Susan B Powell, Marisa Roberto, John R Yate. Structural Analysis of Hippocampal Kinase Signal Transduction. ACS chemical neuroscience. vol 9. issue 12. 2019-12-23. PMID:30053369. |
to demonstrate a functional relationship between the kinases and the network, pharmacological manipulation of akt in hippocampal slices was shown to regulate the activity of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel(hcn1), which was identified in the akt network. |
2019-12-23 |
2023-08-13 |
human |
| Zhi He, Chao Chen, Lin Huang, Shenghong Liu, Lianjun Gu. WITHDRAWN: Decreased HCN1 mRNA in hippocampal area CA1 and neocortex after chronic cerebral hypoperfusion. European journal of pharmacology. 2019-11-20. PMID:19073170. |
withdrawn: decreased hcn1 mrna in hippocampal area ca1 and neocortex after chronic cerebral hypoperfusion. |
2019-11-20 |
2023-08-12 |
Not clear |
| Mattia Bonzanni, Jacopo C DiFrancesco, Raffaella Milanesi, Giulia Campostrini, Barbara Castellotti, Annalisa Bucchi, Mirko Baruscotti, Carlo Ferrarese, Silvana Franceschetti, Laura Canafoglia, Francesca Ragona, Elena Freri, Angelo Labate, Antonio Gambardella, Cinzia Costa, Ilaria Rivolta, Cinzia Gellera, Tiziana Granata, Andrea Barbuti, Dario DiFrancesc. A novel de novo HCN1 loss-of-function mutation in genetic generalized epilepsy causing increased neuronal excitability. Neurobiology of disease. vol 118. 2019-09-09. PMID:29936235. |
among the four known isoforms, hcn1 is the most expressed in the neocortex and hippocampus and de novo hcn1 point mutations have been recently associated with early infantile epileptic encephalopathy. |
2019-09-09 |
2023-08-13 |
human |
| M Zhou, K Lin, Y Si, Q Ru, L Chen, H Xiao, C L. Downregulation of HCN1 channels in hippocampus and prefrontal cortex in methamphetamine re-exposed mice with enhanced working memory. Physiological research. vol 68. issue 1. 2019-06-24. PMID:30433806. |
downregulation of hcn1 channels in hippocampus and prefrontal cortex in methamphetamine re-exposed mice with enhanced working memory. |
2019-06-24 |
2023-08-13 |
mouse |
| M Zhou, K Lin, Y Si, Q Ru, L Chen, H Xiao, C L. Downregulation of HCN1 channels in hippocampus and prefrontal cortex in methamphetamine re-exposed mice with enhanced working memory. Physiological research. vol 68. issue 1. 2019-06-24. PMID:30433806. |
we found that meth re-exposure caused an enhancement of working memory, and a decrease in the hcn1 channels protein expression in both hippocampus and prefrontal cortex. |
2019-06-24 |
2023-08-13 |
mouse |
| Maurice Meseke, Florian Neumüller, Bianka Brunne, Xiaoyu Li, Max Anstötz, Theresa Pohlkamp, Meike M Rogalla, Joachim Herz, Gabriele M Rune, Roland A Bende. Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin. eNeuro. vol 5. issue 5. 2019-04-19. PMID:30406178. |
hcn1 compartmentalization in ca1 pyramidal cells, essential for hippocampal information processing, is believed to be controlled by the extracellular matrix protein reelin. |
2019-04-19 |
2023-08-13 |
Not clear |
| Aaron D Williams, Sangwook Jung, Nicholas P Poolo. Protein kinase C bidirectionally modulates Ih and hyperpolarization-activated cyclic nucleotide-gated (HCN) channel surface expression in hippocampal pyramidal neurons. The Journal of physiology. vol 593. issue 13. 2016-03-24. PMID:25820761. |
in the present study, we aimed to investigate phosphorylation as a mechanism controlling ih amplitude and hcn1 surface expression in hippocampal principal neurons under normal physiological conditions. |
2016-03-24 |
2023-08-13 |
Not clear |
| Aaron D Williams, Sangwook Jung, Nicholas P Poolo. Protein kinase C bidirectionally modulates Ih and hyperpolarization-activated cyclic nucleotide-gated (HCN) channel surface expression in hippocampal pyramidal neurons. The Journal of physiology. vol 593. issue 13. 2016-03-24. PMID:25820761. |
tyrosine phosphorylation decreased ih amplitude at maximal activation (maximal ih ), without altering hcn1 surface expression, in two classes of hippocampal principal neurons. |
2016-03-24 |
2023-08-13 |
Not clear |
| Aaron D Williams, Sangwook Jung, Nicholas P Poolo. Protein kinase C bidirectionally modulates Ih and hyperpolarization-activated cyclic nucleotide-gated (HCN) channel surface expression in hippocampal pyramidal neurons. The Journal of physiology. vol 593. issue 13. 2016-03-24. PMID:25820761. |
inhibition of serine/threonine protein phosphatases 1 and 2a decreased maximal ih and hcn1 surface expression in hippocampal principal neurons. |
2016-03-24 |
2023-08-13 |
Not clear |
| A Marie Phillips, Taehwan Kim, Ernesto Vargas, Steven Petrou, Christopher A Rei. Spike-and-wave discharge mediated reduction in hippocampal HCN1 channel function associates with learning deficits in a genetic mouse model of epilepsy. Neurobiology of disease. vol 64. 2014-11-12. PMID:24368169. |
spike-and-wave discharge mediated reduction in hippocampal hcn1 channel function associates with learning deficits in a genetic mouse model of epilepsy. |
2014-11-12 |
2023-08-12 |
mouse |
| A Marie Phillips, Taehwan Kim, Ernesto Vargas, Steven Petrou, Christopher A Rei. Spike-and-wave discharge mediated reduction in hippocampal HCN1 channel function associates with learning deficits in a genetic mouse model of epilepsy. Neurobiology of disease. vol 64. 2014-11-12. PMID:24368169. |
we conclude that swds reduce hippocampal hcn1 expression and function, and that the reduction associates with a spatial learning deficit. |
2014-11-12 |
2023-08-12 |
mouse |