| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinxin Ma, Junnian Hao, Jianrong Wu, Yuehua Li, Xiaojun Cai, Yuanyi Zhen. Prussian blue nanozyme as a pyroptosis inhibitor alleviates neurodegeneration. Advanced materials (Deerfield Beach, Fla.). 2022-02-10. PMID:35143076. |
both in vitro and in vivo results demonstrate that pbzyme reduces the activation of microglial nlrp3 inflammasomes and caspase-1 by scavenging reactive oxygen species, thereby downregulating gsdmd cleavage as well as inflammatory factor production, and eventually leading to the inhibition of microglia pyroptosis. |
2022-02-10 |
2023-08-13 |
mouse |
| Qian Jiang, Guo Tang, Xue-Min Zhong, Dan-Rui Ding, Hui Wang, Jia-Ni L. Role of Stat3 in NLRP3/caspase-1-mediated hippocampal neuronal pyroptosis in epileptic mice. Synapse (New York, N.Y.). 2021-12-27. PMID:34958692. |
subsequently, stat3, nod-like receptor protein 3 (nlrp3), cleaved-caspase-1, gasdermin d (gsdmd)-n, activated stat3 (p-stat3), and h3k9ac levels were detected in the mouse hippocampus and ht22 cells. |
2021-12-27 |
2023-08-13 |
mouse |
| Jiaxuan Wu, Wenfeng Cai, Ruiming Du, Haiyang Li, Bin Wang, Yanqiong Zhou, Daifei Shen, Huimin Shen, Yang Lan, Lesi Chen, Xiaoxia Zheng, Danmei Huang, Ganggang Sh. Sevoflurane Alleviates Myocardial Ischemia Reperfusion Injury by Inhibiting P2X7-NLRP3 Mediated Pyroptosis. Frontiers in molecular biosciences. vol 8. 2021-11-13. PMID:34765646. |
the protein expression of p2x7, nlrp3, apoptosis-associated speck-like protein (asc), cysteine aspartic acid specific protease-1(caspase-1), gasdermin-d (gsdmd), bcl-2 associated x protein (bax), b-cell lymphoma-2 (bcl-2) in myocardial tissue and cells were evaluated. |
2021-11-13 |
2023-08-13 |
rat |
| Dong Yuan, ShuangXian Guan, Zhen Wang, HongLiang Ni, DongLiang Ding, WenBo Xu, GuoMin L. HIF-1α aggravated traumatic brain injury by NLRP3 inflammasome-mediated pyroptosis and activation of microglia. Journal of chemical neuroanatomy. vol 116. 2021-11-10. PMID:34166779. |
the protein expressions of nlrp3, gsdmd, gsdmd-n, pro-caspase 1, and cleaved caspase 1 were markedly increased in the injured cortex, which were restored to normal levels by the interference of hif-1α. |
2021-11-10 |
2023-08-13 |
mouse |
| Rui Ding, Weiyang Ou, Chengwei Chen, Yaqi Liu, Haiyan Li, Xifang Zhang, Huihui Chai, Xiaowen Ding, Qiujing Wan. Endoplasmic reticulum stress and oxidative stress contribute to neuronal pyroptosis caused by cerebral venous sinus thrombosis in rats: Involvement of TXNIP/peroxynitrite-NLRP3 inflammasome activation. Neurochemistry international. vol 141. 2021-10-18. PMID:32980492. |
the levels of 3-nitrotyrosine (3-nt, as a footprint of peroxynitrite), nlrp3, caspase p20, il-1β, and gsdmd were distinctly elevated post-cvst and cellular localization of peroxynitrite, nlrp3, caspase p20, and il-1β was largely observed in neurons and/or microglia. |
2021-10-18 |
2023-08-13 |
rat |
| Dong-Xia Li, Chang-Nan Wang, Yan Wang, Chang-Lin Ye, Lai Jiang, Xiao-Yan Zhu, Yu-Jian Li. NLRP3 inflammasome-dependent pyroptosis and apoptosis in hippocampus neurons mediates depressive-like behavior in diabetic mice. Behavioural brain research. vol 391. 2021-10-05. PMID:32454054. |
it was found that stz treatment induced apoptotic and pyroptotic cell death in the hippocampus as evidenced by increases of cleaved caspase 3 positive hippocampal neurons, tunel-positive cells, protein levels of p53, bax, puma, and the cleaved gsdmd n-terminal fragment, all of which were decreased in nlrp3 deficient mice. |
2021-10-05 |
2023-08-13 |
mouse |
| Dan-Dan Tian, Min Wang, An Liu, Mei-Rong Gao, Chen Qiu, Wen Yu, Wen-Ju Wang, Kun Zhang, Le Yang, Yan-Yan Jia, Chang-Bin Yang, Yu-Mei W. Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway. Molecular neurobiology. vol 58. issue 2. 2021-09-01. PMID:33025508. |
the role of the pore-forming protein gasdermin d (gsdmd), a newly identified pyroptosis executioner downstream of nlrp3 inflammasome mediating inflammatory programmed cell death, in depression has not been well defined. |
2021-09-01 |
2023-08-13 |
mouse |
| Dan-Dan Tian, Min Wang, An Liu, Mei-Rong Gao, Chen Qiu, Wen Yu, Wen-Ju Wang, Kun Zhang, Le Yang, Yan-Yan Jia, Chang-Bin Yang, Yu-Mei W. Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway. Molecular neurobiology. vol 58. issue 2. 2021-09-01. PMID:33025508. |
we further demonstrated that pf administration inhibited the enhanced expression of gsdmd which mainly distributed in microglia, along with the proteins involved in pyroptosis signaling transduction including caspase (casp)-11, casp-1, nlrp3, and interleukin (il)-1β in the hippocampus of mice treated with reserpine. |
2021-09-01 |
2023-08-13 |
mouse |
| Junmei Zhang, Xuyuan Sun, Lingling Zhong, Bei She. IL-32 exacerbates adenoid hypertrophy via activating NLRP3-mediated cell pyroptosis, which promotes inflammation. Molecular medicine reports. vol 23. issue 3. 2021-05-04. PMID:33495843. |
il-32 (2, 10 and 50 ng/ml) also resulted in differing degrees of apoptosis, gsdmd activation, release of il-1β, il-6 and tnf-α, and increased protein expression levels of nlrp3, cleaved-caspase-1, activated gsdmd, nucleotide-binding oligomerization domain-containing protein (nod) 1/2 and toll-like receptor (tlr)4 in a concentration-dependent manner. |
2021-05-04 |
2023-08-13 |
human |
| Junmei Zhang, Xuyuan Sun, Lingling Zhong, Bei She. IL-32 exacerbates adenoid hypertrophy via activating NLRP3-mediated cell pyroptosis, which promotes inflammation. Molecular medicine reports. vol 23. issue 3. 2021-05-04. PMID:33495843. |
in addition, compared with the lps group, il-32 knockdown significantly inhibited lps-induced enhancement of cell proliferation, cell apoptosis, gsdmd activation and production of inflammatory cytokines, and reversed the increased protein expression of nlrp3, cleaved-caspase-1, activated gsdmd, nod1/2 and tlr4. |
2021-05-04 |
2023-08-13 |
human |
| Liwei Tan, Yeye Wang, Yu Jiang, Rong Wang, Jingzhi Zu, Rui Ta. Hydroxysafflor Yellow A Together with Blood-Brain Barrier Regulator Lexiscan for Cerebral Ischemia Reperfusion Injury Treatment. ACS omega. vol 5. issue 30. 2020-09-28. PMID:32775917. |
the down-regulative expression of cytokines, including nlrp3, asc, caspase-1, gsdmd, il-1β, il-18, ldh, nf-κb, and p-p56, suggested that hsya could both suppress pyroptosis and apoptosis pathway activation during the nerve injury. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xue-Peng Bian, Rui-Fang Ji, Bei-Bei Liu, Jing-Yun Hu, Ming-Ming Li, Xiang-Li Xue, Shu-Jie Lo. [Aerobic exercise reduces the expression of pyroptosis-related proteins and inflammatory factors in hippocampus of mice with insulin resistance]. Sheng li xue bao : [Acta physiologica Sinica]. vol 72. issue 4. 2020-09-24. PMID:32820308. |
compared with the ir group, progressive speed treadmill training significantly reduced the expression of nfκb, nlrp3, nek7, asc, pro-caspase-1, gsdmd, gsdmd-n, il-1β, and il-18 in the hippocampus of mice with ir. |
2020-09-24 |
2023-08-13 |
mouse |
| Liyan Hou, Jie Yang, Sheng Li, Ruixue Huang, Dongdong Zhang, Jie Zhao, Qingshan Wan. Glibenclamide attenuates 2,5-hexanedione-induced neurotoxicity in the spinal cord of rats through mitigation of NLRP3 inflammasome activation, neuroinflammation and oxidative stress. Toxicology letters. vol 331. 2020-07-23. PMID:32522579. |
glibenclamide, a sulfonylurea inhibitor of nlrp3 inflammasome, reduced hd-induced nlrp3 inflammasome activation, which was associated with mitigated gasdermin d (gsdmd) cleavage, neurofilament protein l (nf-l) reduction and demyelination as well as axon degeneration in the spinal cord of rats. |
2020-07-23 |
2023-08-13 |
rat |
| Stephanie W Lee, Shyam Gajavelli, Markus S Spurlock, Cody Andreoni, Juan Pablo de Rivero Vaccari, M Ross Bullock, Robert W Keane, W Dalton Dietric. Microglial Inflammasome Activation in Penetrating Ballistic-Like Brain Injury. Journal of neurotrauma. vol 35. issue 14. 2019-11-06. PMID:29439605. |
tissues were assessed by immunoblot analysis for expression of il-1β, il-18, and components of the inflammasome: apoptosis-associated speck-like protein containing a caspase-activation and recruitment domain (asc), caspase-1, x-linked inhibitor of apoptosis protein (xiap), nucleotide-binding oligomerization domain (nod)-like receptor protein 3 (nlrp3), and gasdermin-d (gsdmd). |
2019-11-06 |
2023-08-13 |
rat |
| Wangying Dai, Xingguo Wang, Honglin Teng, Chi Li, Bin Wang, Jing Wan. Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats. International immunopharmacology. vol 66. 2019-05-03. PMID:30472522. |
celastrol simultaneously reduced the activation of microglia (especially m1 microglia) in the spinal cord, inhibited the pyroptosis-related proteins (nlrp3 asc caspase-1 gsdmd), reduced the release of tnf-α il-1β and il-18 inflammatory factors, and increased the release of il10 cytokines. |
2019-05-03 |
2023-08-13 |
rat |
| Wan-ting He, Haoqiang Wan, Lichen Hu, Pengda Chen, Xin Wang, Zhe Huang, Zhang-Hua Yang, Chuan-Qi Zhong, Jiahuai Ha. Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion. Cell research. vol 25. issue 12. 2016-08-17. PMID:26611636. |
the induction of apoptosis required nlrp3 or other inflammasome receptors and asc, and caspase-1 may partially contribute to the activation of apoptotic caspases in gsdmd(-/-) cells. |
2016-08-17 |
2023-08-13 |
human |