| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fei Luan, Zi-Qin Lei, Li-Xia Peng, Zhi-Li Rao, Ruo-Cong Yang, Nan Zen. [Experimental study of cardioprotective effects of Cinnamomi Ramulus and Cinnamomi Cortex formula granules on myocardial ischemia/reperfusion injury in rats based on efficacy of "warming and coordinating heart Yang"]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 3. 2023-03-05. PMID:36872236. |
the gene expression levels of nucleotide-binding oligomerization domain-like receptor family pyrin domain protein 3(nlrp3) inflammasome, apoptosis-associated speck-like protein containing a card(asc), cysteinyl aspartate specific proteinase-1(caspase-1), gasdermin-d(gsdmd), interleukin-1β(il-1β), and interleukin-18(il-18) were determined by real-time quantitative polymerase chain reaction(rt-pcr). |
2023-03-05 |
2023-08-14 |
rat |
| Xiang Ao, Huan Yan, Mei Huang, Wei Xing, Luo-Quan Ao, Xiao-Feng Wu, Cheng-Xiu Pu, Bao-Yue Zhang, Xiang Xu, Hua-Ping Liang, Wei Gu. Lavender essential oil accelerates lipopolysaccharide-induced chronic wound healing by inhibiting caspase-11-mediated macrophage pyroptosis. The Kaohsiung journal of medical sciences. 2023-02-06. PMID:36744836. |
moreover, eo (lav) can down-regulate expression levels of il-1β, gsdmd, and nucleotide-binding oligomerization domain-like receptor protein 3 (nlrp3) in the caspase-11-related pyroptotic signaling pathway. |
2023-02-06 |
2023-08-14 |
Not clear |
| Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James M Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lanlan Geng, James E Vinc. Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal. 2023-01-17. PMID:36647737. |
neither caspase-3 and caspase-7-mediated activation of the pannexin-1 channel, or gsdmd loss, prevented nlrp3 inflammasome assembly and consequent caspase-1 and il-1β maturation downstream of xiap inhibition and caspase-8 activation, even though the pannexin-1 channel was required for nlrp3 triggering upon mitochondrial apoptosis. |
2023-01-17 |
2023-08-14 |
Not clear |
| Jia-Min Lyu, Ke-Feng Zhai, Hong Duan, Wei Wang, Cheng-Hui H. [Mechanism of total flavonoid extract from Dracocephalum moldavica on bleomycin-induced pulmonary fibrosis in mice based on pyroptosis pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 24. 2023-01-06. PMID:36604916. |
the protein expressions of type Ⅰ collagen(col-1), fibronectin 1(fn1), α-smooth muscle actin(α-sma), cysteinyl aspartate specific proteinase-1(caspase-1), gasdermin d(gsdmd), nod-like receptor thermal protein domain associated protein 3(nlrp3), p62, and apoptosis-associated speck-like protein containing a card(asc) in the lung tissues of mice with pf in the blm group were increased(p<0.01), whereas the protein expressions of autophagy-related 5(atg5) and beclin1 were decreased(p<0.01). |
2023-01-06 |
2023-08-14 |
mouse |
| Sebastiaan Moonen, Marta J Koper, Evelien Van Schoor, Jolien M Schaeverbeke, Rik Vandenberghe, Christine A F von Arnim, Thomas Tousseyn, Bart De Strooper, Dietmar Rudolf Tha. Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons. Acta neuropathologica. 2022-12-09. PMID:36481964. |
we investigated the presence of cleaved gasdermin d (gsdmd), the pyroptosis effector protein, as well as the nlrp3 inflammasome-forming proteins, in the medial temporal lobe of 23 symptomatic ad, 25 pathologically defined preclinical ad (p-pread) and 21 non-demented control cases. |
2022-12-09 |
2023-08-14 |
human |
| Mengyao Zhao, Boya Zhang, Linlin Deng, Liming Zha. Acrylamide Induces Neurotoxicity in SH-SY5Y Cells via NLRP3-mediated Pyroptosis. Molecular neurobiology. 2022-11-03. PMID:36324051. |
the results showed that acr treatment induced lytic cell death morphologically under both the canonical pyroptotic pathway (nod-like receptor protein 3 (nlrp3)-apoptosis-associated speck-like protein containing card (asc)-cysteinyl aspartate specific proteinase 1 (caspase-1)-gasdermin d (gsdmd)-interleukin-1β (il-1β)/interleukin-18 (il-18)) and an alternative pyroptotic pathway (cysteinyl aspartate specific proteinase 3 (caspase-3)-gasdermin e (gsdme)-il-1β/il-18) in sh-sy5y cells. |
2022-11-03 |
2023-08-14 |
Not clear |
| Mengran Yao, Zhuoran Wang, Leyu Jiang, Lingyan Wang, Yuqiao Yang, Quan Wang, Xi Qian, Weijun Zeng, Wei Yang, Rongbi Liang, Jinqiao Qia. Oxytocin ameliorates high glucose- and ischemia/reperfusion-induced myocardial injury by suppressing pyroptosis via AMPK signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076588. |
in addition, ot increased cell viability, decreased cell apoptosis and the expressions of il-18, il-1β, cleaved-caspase-1, nlrp3, and gsdmd following h/r. |
2022-09-09 |
2023-08-14 |
rat |
| Chenfeng Wang, Hongdao Ma, Bangke Zhang, Tong Hua, Haibin Wang, Liang Wang, Lin Han, Qisheng Li, Weiqing Wu, Yulin Sun, Haisong Yang, Xuhua L. Inhibition of IL1R1 or CASP4 attenuates spinal cord injury through ameliorating NLRP3 inflammasome-induced pyroptosis. Frontiers in immunology. vol 13. 2022-08-22. PMID:35990672. |
in the injured spinal cord, these three signatures were up-regulated and closely correlated with nlrp3 inflammasome formation and gasdermin d (gsdmd) -induced pyroptosis. |
2022-08-22 |
2023-08-14 |
rat |
| Chenfeng Wang, Hongdao Ma, Bangke Zhang, Tong Hua, Haibin Wang, Liang Wang, Lin Han, Qisheng Li, Weiqing Wu, Yulin Sun, Haisong Yang, Xuhua L. Inhibition of IL1R1 or CASP4 attenuates spinal cord injury through ameliorating NLRP3 inflammasome-induced pyroptosis. Frontiers in immunology. vol 13. 2022-08-22. PMID:35990672. |
in conclusion, our findings of the three targets shed new light on the pathogenesis of sci, and the use of immunosuppressive agents targeting these proteins exerted anti-inflammatory effects against spinal cord inflammation by inhibiting nf-kb and nlrp3 inflammasome activation, thus blocking gsdmd -induced pyroptosis and immune activation. |
2022-08-22 |
2023-08-14 |
rat |
| Hangfei Liang, Xiao Yang, Huilin Li, Xinhui Wang, Haiguo Su, Xuan Li, Jianing Tian, Chenghui Cai, Min Huang, Huichang B. Schisandrol B protects against cholestatic liver injury by inhibiting pyroptosis through pregnane X receptor. Biochemical pharmacology. 2022-08-21. PMID:35988735. |
further analysis revealed that both nod-like receptor protein 3 (nlrp3) inflammasome-induced canonical pyroptosis and apoptosis protease activating factor-1 (apaf-1) pyroptosome-induced noncanonical pyroptosis were significantly inhibited after solb pretreatment, as illustrated by the decreased expression levels of nlrp3, asc, caspase-1, and gsdmd and the levels of apaf-1, caspase-11 p20, caspase-3 p20, and gsdme. |
2022-08-21 |
2023-08-14 |
Not clear |
| Jiangbo Yan, Gangning Feng, Yong Yang, Dong Ding, Long Ma, Xin Zhao, Xiaolei Chen, Hui Wang, Zhirong Chen, Qunhua Ji. Autophagy attenuates osteoarthritis in mice by inhibiting chondrocyte pyroptosis and improving subchondral bone remodeling. Bosnian journal of basic medical sciences. 2022-07-26. PMID:35880352. |
mechanistically, activation of autophagy in cartilage increased the expression of type ii collagen (col ii), decreased the expression of matrix metalloproteinase 13 (mmp 13) and decreased the pyroptosis mediated by nod-like receptor protein 3 (nlrp3) inflammasome by decreasing the expression of nlrp3, caspase-1, gasdermin d (gsdmd), and il-1β. |
2022-07-26 |
2023-08-14 |
mouse |
| Yiping Chen, Chongyao Hao, Wenjie Chen, Wenjing Cheng, Peng Li, Junliang Shen, Tao Tong, Simin Yan, Shuqiong Huang, Tianwei He, Zhiyong Huang, Xianjun Men. Anti-depressant Effects of Acupuncture: the Insights from NLRP3 mediated Pyroptosis and Inflammation. Neuroscience letters. 2022-07-12. PMID:35820551. |
results showed that acupuncture significantly improved the depression-like behavior of cums rat, suppressed the expressions of nlrp3, asc, caspase-1, gsdmd, il-1β, il-18, hmgb1, ifn-γ, il-6 and tnf-α in the serum and hippocampus, restored the %area of microglia, astrocytes and neuronal cells in the hippocampus. |
2022-07-12 |
2023-08-14 |
rat |
| Fang Hua, Jing Ya Li, Meng Zhang, Peng Zhou, Liang Wang, Tie Jun Ling, Guan Hu Ba. Kaempferol-3-O-rutinoside exerts cardioprotective effects through NF-κB/NLRP3/Caspase-1 pathway in ventricular remodeling after acute myocardial infarction. Journal of food biochemistry. 2022-06-27. PMID:35758877. |
our results showed that kr had a good binding activity with nlrp3, caspase-1, and gsdmd, significantly improved cardiac function, alleviated cardiac pathological changes, reduced the excessive deposition of myocardial interstitial collagen, and inhibited cardiomyocyte apoptosis in ami rats. |
2022-06-27 |
2023-08-14 |
rat |
| Meng He, Jun Fan, Ruqin Zhou, Guanbin Gao, Ruoxi Li, YuFeng Zuo, Benben Li, Yanmei Li, Taolei Su. NLRP3/Caspase-1-Mediated Pyroptosis of Astrocytes Induced by Antipsychotics Is Inhibited by a Histamine H1 Receptor-Selective Agonist. Frontiers in aging neuroscience. vol 14. 2022-05-26. PMID:35615587. |
twenty-four hour treatment with olanzapine, quetiapine, risperidone, or haloperidol dose-dependently increased the protein expression of astrocytic nlrp3, nlrp6, caspase-1, caspase-4, and gsdmd. |
2022-05-26 |
2023-08-13 |
Not clear |
| Meng He, Jun Fan, Ruqin Zhou, Guanbin Gao, Ruoxi Li, YuFeng Zuo, Benben Li, Yanmei Li, Taolei Su. NLRP3/Caspase-1-Mediated Pyroptosis of Astrocytes Induced by Antipsychotics Is Inhibited by a Histamine H1 Receptor-Selective Agonist. Frontiers in aging neuroscience. vol 14. 2022-05-26. PMID:35615587. |
co-treatment with a histamine h1 receptor agonist, 2-(3-trifluoromethylphenyl) histamine (fmph), dose-dependently reduced the increased expression of nlrp3, caspase-1 and gsdmd induced by olanzapine, quetiapine, risperidone, or haloperidol. |
2022-05-26 |
2023-08-13 |
Not clear |
| Li Cai, Zeng-Yu Yao, Lu Yang, Xiu-Hong Xu, Meng Luo, Miao-Miao Dong, Guo-Ping Zho. Mechanism of Electroacupuncture Against Cerebral Ischemia-Reperfusion Injury: Reducing Inflammatory Response and Cell Pyroptosis by Inhibiting NLRP3 and Caspase-1. Frontiers in molecular neuroscience. vol 15. 2022-05-23. PMID:35600074. |
ea was conducted at acupoints chize (lu5), hegu (li4), sanyinjiao (sp6), and zusanli (st36) for 1.5 h after cerebral ischemia-reperfusion injury for 20 min, and observation was carried out after 24 h. neurological deficit scores evaluated the neurological function, cerebral infarction volume was observed by triphenyl tetrazolium chloride (ttc) staining, hematoxylin and eosin (h&e) staining, tunel and caspase-1 double-labeled fluorescence staining, and nlrp3 and caspase-1 double-labeled immunofluorescence staining that were used to observe the morphology of neurons in hippocampus, and the protein expression of nlrp3, pro-caspase-1, cleaved caspase-1 p20, pro-interleukin-1β (il-1β), cleaved il-1β, and gsdmd was detected by western blot assay. |
2022-05-23 |
2023-08-13 |
mouse |
| Li Cai, Zeng-Yu Yao, Lu Yang, Xiu-Hong Xu, Meng Luo, Miao-Miao Dong, Guo-Ping Zho. Mechanism of Electroacupuncture Against Cerebral Ischemia-Reperfusion Injury: Reducing Inflammatory Response and Cell Pyroptosis by Inhibiting NLRP3 and Caspase-1. Frontiers in molecular neuroscience. vol 15. 2022-05-23. PMID:35600074. |
results showed that ea could reduce the score of neurological deficit, reduce the volume of cerebral infarction and improve the degree of nerve cell injury, and inhibit nlrp3, pro-caspase-1, cleaved caspase-1 p20, pro-il-1β, cleaved il-1β, and gsdmd protein expression. |
2022-05-23 |
2023-08-13 |
mouse |
| Jia Liu, Qinyu Yao, Xinya Xie, Qi Cui, Tingting Jiang, Ziwei Zhao, Xiong Du, Baochang Lai, Lei Xiao, Nanping Wan. Procyanidin B2 Attenuates Nicotine-Induced Hepatocyte Pyroptosis through a PPARγ-Dependent Mechanism. Nutrients. vol 14. issue 9. 2022-05-14. PMID:35565726. |
here, we reported that nicotine promoted hepatocyte pyroptosis, as evidenced by the elevation of propidium iodide (pi)-positive cells, the activation of caspase-1 and gasdermin d (gsdmd), the enhanced expression of nod-like receptor containing pyrin domain 3 (nlrp3) and the increased release of lactate dehydrogenase (ldh), interleukin (il)-1β and il-18. |
2022-05-14 |
2023-08-13 |
mouse |
| Nadine A Kerr, Juliana Sanchez, Gregory O'Connor, Brant D Watson, Sylvia Daunert, Helen M Bramlett, W Dalton Dietric. Inflammasome-Regulated Pyroptotic Cell Death in Disruption of the Gut-Brain Axis After Stroke. Translational stroke research. 2022-03-20. PMID:35306629. |
we examined the time course of inflammasome protein expression in brain and intestinal lysate using western blot analysis at 1-, 3-, and 7-days post-injury for caspase-1, interleukin-1β, nod-like receptor protein 3 (nlrp3), and apoptosis speck-like protein containing a caspase-recruiting domain (asc) and gasdermin-d (gsdmd) cleavage. |
2022-03-20 |
2023-08-13 |
mouse |
| Jiangbo Yan, Dong Ding, Gangning Feng, Yong Yang, Yong Zhou, Long Ma, Haohui Guo, Zhidong Lu, Qunhua Ji. Metformin reduces chondrocyte pyroptosis in an osteoarthritis mouse model by inhibiting NLRP3 inflammasome activation. Experimental and therapeutic medicine. vol 23. issue 3. 2022-02-28. PMID:35222699. |
immunohistochemical staining was used to detect type ii collagen (col ii), matrix metalloproteinase 13 (mmp-13), nod-like receptor protein 3 (nlrp3), caspase-1, gasdermin d (gsdmd) and il-1β protein expression. |
2022-02-28 |
2023-08-13 |
mouse |