| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bing Wu, Cheng Xu, Changwu Xu, Liqiang Qiu, Ji-Xian Gao, Ming Li, Yuanguo Xiong, Hao Xia, Zhongyuan Xia, Xiaoxiong Li. Inhibition of Sema4D attenuates pressure overload-induced pathological myocardial hypertrophy via the MAPK/NF-\\xce\\xbaB/NLRP3 pathways. Biochimica et biophysica acta. Molecular basis of disease. 2023-11-12. PMID:37952827. |
further research indicated that myocardial hypertrophy induced by sema4d was closely related to the expression of the pyroptosis-related proteins pp65, nlrp3, caspase-1, asc, gsdmd, il-18 and il-1\xce\xb2. |
2023-11-12 |
2023-11-20 |
mouse |
| Peiting Huang, Zhanyu Zhang, Piao Zhang, Jiezhu Feng, Jianwei Xie, Yinjuan Zheng, Xiaomei Liang, Baoyu Zhu, Zhenzhen Chen, Shujun Feng, Lijuan Wang, Jiahong Lu, Yawei Liu, Yuhu Zhan. TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells. Molecular neurobiology. 2023-11-02. PMID:37917301. |
after trem2 knockdown, the number of activated microglia was significantly increased, and the expression of cleaved caspase-1, nlrp3 inflammasome, il-1\xce\xb2, gsdmd, and gsdmd-n was increased. |
2023-11-02 |
2023-11-08 |
mouse |
| Xi-Yun Liu, Ling-Yan Zhang, Xiao-Yu Wang, Shi-Chao Li, Yu-Yan Hu, Jing-Ge Zhang, Xiao-Hui Xian, Wen-Bin Li, Min Zhan. STAT4-Mediated Klotho Up-Regulation Contributes to the Brain Ischemic Tolerance by Cerebral Ischemic Preconditioning via Inhibiting Neuronal Pyroptosis. Molecular neurobiology. 2023-10-24. PMID:37875707. |
firstly, the expressions of pyroptosis-associated proteins (i.e., nlrp3, gsdmd, pro-caspase-1, and cleaved caspase-1) in hippocampal ca1 region were determined during the process of brain ischemic tolerance. |
2023-10-24 |
2023-11-08 |
Not clear |
| Tao Liu, Ziqian Ma, Liang Liu, Yilun Pei, Qichao Wu, Songjie Xu, Yadong Liu, Nan Ding, Yun Guan, Yan Zhang, Xueming Che. Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis. Neural regeneration research. vol 19. issue 5. 2023-10-20. PMID:37862215. |
we found that the conditioned medium effectively promoted the recovery of sensory and motor functions in rats with spinal cord injury, decreased expression of the microglial pyroptosis markers nlrp3, gsdmd, caspase-1, and interleukin-1\xce\xb2, promoted axonal and myelin regeneration, and inhibited the formation of glial scars. |
2023-10-20 |
2023-11-08 |
human |
| Gehua Wen, Xiaoni Zhan, Xiaoming Xu, Xi Xia, Shukun Jiang, Xinghua Ren, Weishu Ren, Haoyang Lou, Lei Lu, Anca Hermenean, Jun Yao, Lina Gao, Baoman Li, Yan Lu, Xu W. Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model. Molecular neurobiology. 2023-10-15. PMID:37840071. |
meanwhile, ketamine reduced the level of hippocampus nlrp3 and the expression of its downstream molecules in chronic unpredictable mild stress (cums) mice model by western blot and reduced the colocalization of gfap and gsdmd by nearly 25% via immunofluorescent staining. |
2023-10-15 |
2023-11-08 |
mouse |
| Daru Guo, Kang Cheng, Chao Song, Fei Liu, Weiye Cai, Jingwen Chen, Yongliang Mei, Daqian Zhou, Silong Gao, Guoyou Wang, Zongchao Li. Mechanisms of inhibition of nucleus pulposus cells pyroptosis through SDF1/CXCR4-NFkB-NLRP3 axis in the treatment of intervertebral disc degeneration by Duhuo Jisheng Decoction. International immunopharmacology. vol 124. issue Pt A. 2023-08-30. PMID:37647678. |
through bioinformatics, we found that nlrp3, gsdmd, il-1\xce\xb2and other hub proteins of pyroptosis were highly expressed in ivdd sd rats, and network pharmacology discovered that dhjsd may control cellular senescence, apoptosis, and pyroptosis in order to treat ivdd. |
2023-08-30 |
2023-09-07 |
rat |
| Lingyan Wang, Jin Liu, Zhuoran Wang, Xi Qian, Yu Zhao, Quan Wang, Na Dai, Yuhan Xie, Weijun Zeng, Wei Yang, Xiangfeng Bai, Yuqiao Yang, Jinqiao Qia. Dexmedetomidine abates myocardial ischemia reperfusion injury through inhibition of pyroptosis via regulation of miR-665/MEF2D/Nrf2 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-08-07. PMID:37549462. |
dex markedly augmented cell viability, while suppressing cell apoptosis and expressions of nlrp3, cleaved-caspase-1, asc, gsdmd, il-1\xce\xb2, and il-18 in h9c2 cells subjected to h/r injury. |
2023-08-07 |
2023-08-14 |
rat |
| Yan Li, Xing Wang, Wan-Qiu Zhang, Yu-Long Chen, Rui Zhan. [Effect of Gualou Xiebai Decoction on pulmonary fibrosis in rats based on pyroptosis pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 13. 2023-07-20. PMID:37474989. |
as compared with the control group, the level of tnf-\xce\xb1 in serum and balf of rats in the model group was significantly increased(p<0.01), the mrna expression levels of alpha smooth muscle actin(\xce\xb1-sma), collagen type \xe2\x85\xa0 alpha 1 chain(col1a1), caspase-1, il-1\xce\xb2, il-18, gasdermin d(gsdmd), and nod-like receptor thermal protein domain associated protein 3(nlrp3) in lung tissues were significantly increased(p<0.05, p<0.01), and the mrna expression level of e-cadherin was significantly decreased(p<0.01). |
2023-07-20 |
2023-08-14 |
rat |
| Shaoyong Shi, Chongyang Zhang, Jiaxiang Li. TIMP2 facilitates CIRI through activating NLRP3-mediated pyroptosis. Aging. vol 15. 2023-05-13. PMID:37178321. |
furthermore, the western blotting results demonstrated that the protein expression levels of timp2, p-erk1/2, t-erk1/2, nlrp3, il-1\xce\xb2, il-18, gsdmd, caspase-1, and asc in brain tissues and hippocampal neurons were significantly higher in the experimental groups than those in the control group. |
2023-05-13 |
2023-08-14 |
mouse |
| Fei Luan, Zi-Qin Lei, Li-Xia Peng, Zhi-Li Rao, Ruo-Cong Yang, Nan Zen. [Experimental study of cardioprotective effects of Cinnamomi Ramulus and Cinnamomi Cortex formula granules on myocardial ischemia/reperfusion injury in rats based on efficacy of "warming and coordinating heart Yang"]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 3. 2023-03-05. PMID:36872236. |
the gene expression levels of nucleotide-binding oligomerization domain-like receptor family pyrin domain protein 3(nlrp3) inflammasome, apoptosis-associated speck-like protein containing a card(asc), cysteinyl aspartate specific proteinase-1(caspase-1), gasdermin-d(gsdmd), interleukin-1\xce\xb2(il-1\xce\xb2), and interleukin-18(il-18) were determined by real-time quantitative polymerase chain reaction(rt-pcr). |
2023-03-05 |
2023-08-14 |
rat |
| Xiang Ao, Huan Yan, Mei Huang, Wei Xing, Luo-Quan Ao, Xiao-Feng Wu, Cheng-Xiu Pu, Bao-Yue Zhang, Xiang Xu, Hua-Ping Liang, Wei Gu. Lavender essential oil accelerates lipopolysaccharide-induced chronic wound healing by inhibiting caspase-11-mediated macrophage pyroptosis. The Kaohsiung journal of medical sciences. 2023-02-06. PMID:36744836. |
moreover, eo (lav) can down-regulate expression levels of il-1\xce\xb2, gsdmd, and nucleotide-binding oligomerization domain-like receptor protein 3 (nlrp3) in the caspase-11-related pyroptotic signaling pathway. |
2023-02-06 |
2023-08-14 |
Not clear |
| Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James M Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lanlan Geng, James E Vinc. Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1\\xce\\xb2 release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal. 2023-01-17. PMID:36647737. |
neither caspase-3 and caspase-7-mediated activation of the pannexin-1 channel, or gsdmd loss, prevented nlrp3 inflammasome assembly and consequent caspase-1 and il-1\xce\xb2 maturation downstream of xiap inhibition and caspase-8 activation, even though the pannexin-1 channel was required for nlrp3 triggering upon mitochondrial apoptosis. |
2023-01-17 |
2023-08-14 |
Not clear |
| Jia-Min Lyu, Ke-Feng Zhai, Hong Duan, Wei Wang, Cheng-Hui H. [Mechanism of total flavonoid extract from Dracocephalum moldavica on bleomycin-induced pulmonary fibrosis in mice based on pyroptosis pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 24. 2023-01-06. PMID:36604916. |
the protein expressions of type \xe2\x85\xa0 collagen(col-1), fibronectin 1(fn1), \xce\xb1-smooth muscle actin(\xce\xb1-sma), cysteinyl aspartate specific proteinase-1(caspase-1), gasdermin d(gsdmd), nod-like receptor thermal protein domain associated protein 3(nlrp3), p62, and apoptosis-associated speck-like protein containing a card(asc) in the lung tissues of mice with pf in the blm group were increased(p<0.01), whereas the protein expressions of autophagy-related 5(atg5) and beclin1 were decreased(p<0.01). |
2023-01-06 |
2023-08-14 |
mouse |
| Sebastiaan Moonen, Marta J Koper, Evelien Van Schoor, Jolien M Schaeverbeke, Rik Vandenberghe, Christine A F von Arnim, Thomas Tousseyn, Bart De Strooper, Dietmar Rudolf Tha. Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons. Acta neuropathologica. 2022-12-09. PMID:36481964. |
we investigated the presence of cleaved gasdermin d (gsdmd), the pyroptosis effector protein, as well as the nlrp3 inflammasome-forming proteins, in the medial temporal lobe of 23 symptomatic ad, 25 pathologically defined preclinical ad (p-pread) and 21 non-demented control cases. |
2022-12-09 |
2023-08-14 |
human |
| Mengyao Zhao, Boya Zhang, Linlin Deng, Liming Zha. Acrylamide Induces Neurotoxicity in SH-SY5Y Cells via NLRP3-mediated Pyroptosis. Molecular neurobiology. 2022-11-03. PMID:36324051. |
the results showed that acr treatment induced lytic cell death morphologically under both the canonical pyroptotic pathway (nod-like receptor protein 3 (nlrp3)-apoptosis-associated speck-like protein containing card (asc)-cysteinyl aspartate specific proteinase 1 (caspase-1)-gasdermin d (gsdmd)-interleukin-1\xce\xb2 (il-1\xce\xb2)/interleukin-18 (il-18)) and an alternative pyroptotic pathway (cysteinyl aspartate specific proteinase 3 (caspase-3)-gasdermin e (gsdme)-il-1\xce\xb2/il-18) in sh-sy5y cells. |
2022-11-03 |
2023-08-14 |
Not clear |
| Mengran Yao, Zhuoran Wang, Leyu Jiang, Lingyan Wang, Yuqiao Yang, Quan Wang, Xi Qian, Weijun Zeng, Wei Yang, Rongbi Liang, Jinqiao Qia. Oxytocin ameliorates high glucose- and ischemia/reperfusion-induced myocardial injury by suppressing pyroptosis via AMPK signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076588. |
in addition, ot increased cell viability, decreased cell apoptosis and the expressions of il-18, il-1\xce\xb2, cleaved-caspase-1, nlrp3, and gsdmd following h/r. |
2022-09-09 |
2023-08-14 |
rat |
| Chenfeng Wang, Hongdao Ma, Bangke Zhang, Tong Hua, Haibin Wang, Liang Wang, Lin Han, Qisheng Li, Weiqing Wu, Yulin Sun, Haisong Yang, Xuhua L. Inhibition of IL1R1 or CASP4 attenuates spinal cord injury through ameliorating NLRP3 inflammasome-induced pyroptosis. Frontiers in immunology. vol 13. 2022-08-22. PMID:35990672. |
in the injured spinal cord, these three signatures were up-regulated and closely correlated with nlrp3 inflammasome formation and gasdermin d (gsdmd) -induced pyroptosis. |
2022-08-22 |
2023-08-14 |
rat |
| Chenfeng Wang, Hongdao Ma, Bangke Zhang, Tong Hua, Haibin Wang, Liang Wang, Lin Han, Qisheng Li, Weiqing Wu, Yulin Sun, Haisong Yang, Xuhua L. Inhibition of IL1R1 or CASP4 attenuates spinal cord injury through ameliorating NLRP3 inflammasome-induced pyroptosis. Frontiers in immunology. vol 13. 2022-08-22. PMID:35990672. |
in conclusion, our findings of the three targets shed new light on the pathogenesis of sci, and the use of immunosuppressive agents targeting these proteins exerted anti-inflammatory effects against spinal cord inflammation by inhibiting nf-kb and nlrp3 inflammasome activation, thus blocking gsdmd -induced pyroptosis and immune activation. |
2022-08-22 |
2023-08-14 |
rat |
| Hangfei Liang, Xiao Yang, Huilin Li, Xinhui Wang, Haiguo Su, Xuan Li, Jianing Tian, Chenghui Cai, Min Huang, Huichang B. Schisandrol B protects against cholestatic liver injury by inhibiting pyroptosis through pregnane X receptor. Biochemical pharmacology. 2022-08-21. PMID:35988735. |
further analysis revealed that both nod-like receptor protein 3 (nlrp3) inflammasome-induced canonical pyroptosis and apoptosis protease activating factor-1 (apaf-1) pyroptosome-induced noncanonical pyroptosis were significantly inhibited after solb pretreatment, as illustrated by the decreased expression levels of nlrp3, asc, caspase-1, and gsdmd and the levels of apaf-1, caspase-11 p20, caspase-3 p20, and gsdme. |
2022-08-21 |
2023-08-14 |
Not clear |
| Jiangbo Yan, Gangning Feng, Yong Yang, Dong Ding, Long Ma, Xin Zhao, Xiaolei Chen, Hui Wang, Zhirong Chen, Qunhua Ji. Autophagy attenuates osteoarthritis in mice by inhibiting chondrocyte pyroptosis and improving subchondral bone remodeling. Bosnian journal of basic medical sciences. 2022-07-26. PMID:35880352. |
mechanistically, activation of autophagy in cartilage increased the expression of type ii collagen (col ii), decreased the expression of matrix metalloproteinase 13 (mmp 13) and decreased the pyroptosis mediated by nod-like receptor protein 3 (nlrp3) inflammasome by decreasing the expression of nlrp3, caspase-1, gasdermin d (gsdmd), and il-1\xce\xb2. |
2022-07-26 |
2023-08-14 |
mouse |