| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yao Wang, Yan-Chun Wang, Jun M. Effects of electroacupuncture on Sirt3/NLRP3/GSDMD signaling pathway in the substantia nigra of midbrain of rats with Parkinson's disease. Zhen ci yan jiu = Acupuncture research. vol 49. issue 4. 2024-04-22. PMID:38649206. |
to observe the effects on tyrosine hydroxylase (th), α-synaptic nucleoprotein (α-syn), sirtuin 3 (sirt3), nod-like receptor 3 (nlrp3) and gasdermin-d (gsdmd) in the substantia nigra of midbrain after electroacupuncture (ea) at "fengfu"(gv16), "taichong" (lr3) and "zusanli" (st36) in rats of parkinson's disease (pd), so as to explore the mechanism of ea in treatment of pd. |
2024-04-22 |
2024-04-26 |
rat |
| Xi Ma, YuZheng Yang, Hao Li, ZeHong Luo, QiuYi Wang, XueMing Yao, Fang Tang, Ying Huang, Yi Ling, WuKai M. Periplogenin inhibits pyroptosis of fibroblastic synoviocytes in rheumatoid arthritis through the NLRP3/Caspase-1/GSDMD signaling pathway. International immunopharmacology. vol 133. 2024-04-18. PMID:38636373. |
we discovered that ppn could inhibit the migration and invasion abilities of ra-fls and block their growth cycle, down-regulate the secretion and activation of nlrp3, caspase-1, gsdmd, il-1β, and il-18, and reduce the number of pyroptosis. |
2024-04-18 |
2024-04-21 |
Not clear |
| Jiasheng Deng, Le Qin, Sulang Qin, Ruisheng Wu, Guidong Huang, Yibin Fang, Lanlan Huang, Zhipin Zho. NcRNA Regulated Pyroptosis in Liver Diseases and Traditional Chinese Medicine Intervention: A Narrative Review. Journal of inflammation research. vol 17. 2024-04-08. PMID:38585470. |
pyroptosis is dependent on cysteine aspartate protein hydrolase (caspase)-mediated activation of gsdmd, nlrp3, and the release of pro-inflammatory cytokines, interleukin-1 (il-1β), and interleukin-18 (il-18), ultimately leading to cell death. |
2024-04-08 |
2024-04-10 |
Not clear |
| Ruonan Dang, Xuyang Hou, Xinglan Huang, Caifeng Huang, Xiaoqing Zhao, Xingrong Wang, Ning Zhang, Yuqi Yang, Nan Li, Sheng Liu, Peng Yan, Ping Fan, Xinghua Song, Suiying Zhang, Yuqiong Deng, Xiping Cheng, Xinhua Xi. Effects of the Glucocorticoid-Mediated Mitochondrial Translocation of Glucocorticoid Receptors on Oxidative Stress and Pyroptosis in BV-2 Microglia. Journal of molecular neuroscience : MN. vol 74. issue 1. 2024-03-13. PMID:38478195. |
bv-2 microglia were stimulated with dexamethasone (dex) and treated with either tubastatin-a or mitoquinone (mitoq) for 24 h. our results showed that dex increased the translocation of grs to mitochondria, and this effect was accompanied by decreases in the expression of mitochondrially encoded cytochrome c oxidase 1 (mt-co1) and mitochondrially encoded cytochrome c oxidase 3 (mt-co3) and increases in the expression of nod-like receptor thermal protein domain-associated protein 3 (nlrp3), caspase-1, and gasdermin d (gsdmd). |
2024-03-13 |
2024-03-16 |
Not clear |
| Hongzhu Zhang, Huimin Shi, Wan Xie, Meijuan Meng, Yan Wang, Nana Ma, Guangjun Chang, Xiangzhen She. Subacute ruminal acidosis induces pyroptosis via the mitophagy-mediated NLRP3 inflammasome activation in the livers of dairy cows fed a high-grain diet. Journal of dairy science. 2024-01-26. PMID:38278294. |
furthermore, western blot analysis showed that hg feeding led to increased expression of pyroptosis- and nlrp3 inflammasome-related proteins gsdmd n-terminal (gsdmd-nt; p = 0.006), il-1β (p < 0.001), il-18 (p = 0.076), cleaved-caspase-1 (p = 0.001), asc (p = 0.016), nlrp3 (p = 0.017), and cleaved-caspase-11 (p < 0.001) and upregulated expression of mitophagy-related proteins microtubule-associated protein 1 light chain 3 ii (map1lc3-ii; p = 0.001), beclin 1 (becn1; p = 0.001), parkin (p < 0.001), and pten induced kinase 1 (pink1; p = 0.006) in liver tissue. |
2024-01-26 |
2024-01-29 |
Not clear |
| Xin-Ying Fu, Tian-Song Sun, Cong-Xu Zhu, Shi-da Kuang, Jun Tan, Dan Chen, Qing-Hu He, Lu-Mei Li. [Effect of Polygonati Rhizoma in improving pyroptosis injury of diabetic macroangiopathy via NLRP3/caspase-1/GSDMD pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 24. 2024-01-11. PMID:38212030. |
this study aims to explore the influence of polygonati rhizoma on the pyroptosis in the rat model of diabetic macroangiopathy via the nod-like receptor thermal protein domain associated protein 3(nlrp3)/cysteinyl aspartate specific proteinase-1(caspase-1)/gasdermin d(gsdmd) pathway. |
2024-01-11 |
2024-01-14 |
rat |
| Kohei Takahashi, Kazuhiro Kurokawa, Lihua Hong, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuj. Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and co-occurring depressive-like behavior in ulcerative colitis model mice: Involvement of brain-gut autophagy. Experimental neurology. 2023-12-31. PMID:38160982. |
moreover, western blotting and immunohistochemical studies revealed that dss increased p-p70s6 kinase (thr389), p62, tumor necrosis factor-α, interleukin (il)-1β, il-18, nlr family pyrin domain containing 3 (nlrp3), cleaved caspase-1, cleaved gasdermin-d (gsdmd), and cleaved caspase-3 expression levels in the rectum and hippocampus, and increased cd40, inos, and kelch-like ech-associated protein 1 expression levels, and the number of iba1-positive cells in the hippocampus, and decreased p-ampk and lc3ii/i expression levels, and the number of nf-e2-related factor 2 (nrf2)-positive cells, and reduced neurogenesis in the hippocampus. |
2023-12-31 |
2024-01-05 |
mouse |
| Kohei Takahashi, Kazuhiro Kurokawa, Lihua Hong, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuj. Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and co-occurring depressive-like behavior in ulcerative colitis model mice: Involvement of brain-gut autophagy. Experimental neurology. 2023-12-31. PMID:38160982. |
moreover, nlrp3 staining was observed in the neurons and microglia, and cleaved gsdmd staining in neurons in the hippocampus of dss-treated mice. |
2023-12-31 |
2024-01-05 |
mouse |
| Xiao-Juan Wang, Yu-Lu Wang, Nan Shao, Ting Ye, Shu Ye, Hua-Wu Gao, Yan Wan. [Huangdi Anxiao Capsules-containing serum protects cell model from cognitive dysfunction in diabetes via inhibiting NLRP3-mediated pyroptosis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 19. 2023-12-19. PMID:38114121. |
western blot was employed to determine the protein levels of postsynaptic density protein 95(psd-95), nlrp3, apoptosis-associated speck-like protein containing a card(asc), gasdermin d(gsdmd), gsdmd-n, and cleaved cysteinyl aspartate specific proteinase-1(caspase-1), and rt-pcr to determine the mrna levels of nlrp3, asc, gsdmd, and caspase-1. |
2023-12-19 |
2023-12-23 |
rat |
| Lu Yu, Zuohui Zhang, Hao Chen, Miao Wang, Wenqi Mao, Jinxia Hu, Dandan Zuo, Bingchen Lv, Weifeng Wu, Suhua Qi, Guiyun Cu. Remote limb ischemic postconditioning inhibits microglia pyroptosis by modulating HGF after acute ischemia stroke. Bioengineering & translational medicine. vol 8. issue 6. 2023-12-01. PMID:38023701. |
we found that ripostc suppressed the activation of nlrp3 inflammasome to reduce the maturation of gsdmd, leading to decreased pyroptosis in microglia after ais. |
2023-12-01 |
2023-12-07 |
mouse |
| Lu Yu, Zuohui Zhang, Hao Chen, Miao Wang, Wenqi Mao, Jinxia Hu, Dandan Zuo, Bingchen Lv, Weifeng Wu, Suhua Qi, Guiyun Cu. Remote limb ischemic postconditioning inhibits microglia pyroptosis by modulating HGF after acute ischemia stroke. Bioengineering & translational medicine. vol 8. issue 6. 2023-12-01. PMID:38023701. |
we found that ripostc suppressed the activation of nlrp3 inflammasome to reduce the maturation of gsdmd, leading to decreased pyroptosis in microglia after ais. |
2023-11-29 |
2023-12-07 |
mouse |
| Bing Wu, Cheng Xu, Changwu Xu, Liqiang Qiu, Ji-Xian Gao, Ming Li, Yuanguo Xiong, Hao Xia, Zhongyuan Xia, Xiaoxiong Li. Inhibition of Sema4D attenuates pressure overload-induced pathological myocardial hypertrophy via the MAPK/NF-κB/NLRP3 pathways. Biochimica et biophysica acta. Molecular basis of disease. 2023-11-12. PMID:37952827. |
further research indicated that myocardial hypertrophy induced by sema4d was closely related to the expression of the pyroptosis-related proteins pp65, nlrp3, caspase-1, asc, gsdmd, il-18 and il-1β. |
2023-11-12 |
2023-11-20 |
mouse |
| Peiting Huang, Zhanyu Zhang, Piao Zhang, Jiezhu Feng, Jianwei Xie, Yinjuan Zheng, Xiaomei Liang, Baoyu Zhu, Zhenzhen Chen, Shujun Feng, Lijuan Wang, Jiahong Lu, Yawei Liu, Yuhu Zhan. TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells. Molecular neurobiology. 2023-11-02. PMID:37917301. |
after trem2 knockdown, the number of activated microglia was significantly increased, and the expression of cleaved caspase-1, nlrp3 inflammasome, il-1β, gsdmd, and gsdmd-n was increased. |
2023-11-02 |
2023-11-08 |
mouse |
| Xi-Yun Liu, Ling-Yan Zhang, Xiao-Yu Wang, Shi-Chao Li, Yu-Yan Hu, Jing-Ge Zhang, Xiao-Hui Xian, Wen-Bin Li, Min Zhan. STAT4-Mediated Klotho Up-Regulation Contributes to the Brain Ischemic Tolerance by Cerebral Ischemic Preconditioning via Inhibiting Neuronal Pyroptosis. Molecular neurobiology. 2023-10-24. PMID:37875707. |
firstly, the expressions of pyroptosis-associated proteins (i.e., nlrp3, gsdmd, pro-caspase-1, and cleaved caspase-1) in hippocampal ca1 region were determined during the process of brain ischemic tolerance. |
2023-10-24 |
2023-11-08 |
Not clear |
| Tao Liu, Ziqian Ma, Liang Liu, Yilun Pei, Qichao Wu, Songjie Xu, Yadong Liu, Nan Ding, Yun Guan, Yan Zhang, Xueming Che. Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis. Neural regeneration research. vol 19. issue 5. 2023-10-20. PMID:37862215. |
we found that the conditioned medium effectively promoted the recovery of sensory and motor functions in rats with spinal cord injury, decreased expression of the microglial pyroptosis markers nlrp3, gsdmd, caspase-1, and interleukin-1β, promoted axonal and myelin regeneration, and inhibited the formation of glial scars. |
2023-10-20 |
2023-11-08 |
human |
| Gehua Wen, Xiaoni Zhan, Xiaoming Xu, Xi Xia, Shukun Jiang, Xinghua Ren, Weishu Ren, Haoyang Lou, Lei Lu, Anca Hermenean, Jun Yao, Lina Gao, Baoman Li, Yan Lu, Xu W. Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model. Molecular neurobiology. 2023-10-15. PMID:37840071. |
meanwhile, ketamine reduced the level of hippocampus nlrp3 and the expression of its downstream molecules in chronic unpredictable mild stress (cums) mice model by western blot and reduced the colocalization of gfap and gsdmd by nearly 25% via immunofluorescent staining. |
2023-10-15 |
2023-11-08 |
mouse |
| Daru Guo, Kang Cheng, Chao Song, Fei Liu, Weiye Cai, Jingwen Chen, Yongliang Mei, Daqian Zhou, Silong Gao, Guoyou Wang, Zongchao Li. Mechanisms of inhibition of nucleus pulposus cells pyroptosis through SDF1/CXCR4-NFkB-NLRP3 axis in the treatment of intervertebral disc degeneration by Duhuo Jisheng Decoction. International immunopharmacology. vol 124. issue Pt A. 2023-08-30. PMID:37647678. |
through bioinformatics, we found that nlrp3, gsdmd, il-1βand other hub proteins of pyroptosis were highly expressed in ivdd sd rats, and network pharmacology discovered that dhjsd may control cellular senescence, apoptosis, and pyroptosis in order to treat ivdd. |
2023-08-30 |
2023-09-07 |
rat |
| Lingyan Wang, Jin Liu, Zhuoran Wang, Xi Qian, Yu Zhao, Quan Wang, Na Dai, Yuhan Xie, Weijun Zeng, Wei Yang, Xiangfeng Bai, Yuqiao Yang, Jinqiao Qia. Dexmedetomidine abates myocardial ischemia reperfusion injury through inhibition of pyroptosis via regulation of miR-665/MEF2D/Nrf2 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-08-07. PMID:37549462. |
dex markedly augmented cell viability, while suppressing cell apoptosis and expressions of nlrp3, cleaved-caspase-1, asc, gsdmd, il-1β, and il-18 in h9c2 cells subjected to h/r injury. |
2023-08-07 |
2023-08-14 |
rat |
| Yan Li, Xing Wang, Wan-Qiu Zhang, Yu-Long Chen, Rui Zhan. [Effect of Gualou Xiebai Decoction on pulmonary fibrosis in rats based on pyroptosis pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 13. 2023-07-20. PMID:37474989. |
as compared with the control group, the level of tnf-α in serum and balf of rats in the model group was significantly increased(p<0.01), the mrna expression levels of alpha smooth muscle actin(α-sma), collagen type Ⅰ alpha 1 chain(col1a1), caspase-1, il-1β, il-18, gasdermin d(gsdmd), and nod-like receptor thermal protein domain associated protein 3(nlrp3) in lung tissues were significantly increased(p<0.05, p<0.01), and the mrna expression level of e-cadherin was significantly decreased(p<0.01). |
2023-07-20 |
2023-08-14 |
rat |
| Shaoyong Shi, Chongyang Zhang, Jiaxiang Li. TIMP2 facilitates CIRI through activating NLRP3-mediated pyroptosis. Aging. vol 15. 2023-05-13. PMID:37178321. |
furthermore, the western blotting results demonstrated that the protein expression levels of timp2, p-erk1/2, t-erk1/2, nlrp3, il-1β, il-18, gsdmd, caspase-1, and asc in brain tissues and hippocampal neurons were significantly higher in the experimental groups than those in the control group. |
2023-05-13 |
2023-08-14 |
mouse |