| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Makoto Nishizawa, Hajime Nakabayashi, Keigo Uehara, Atsushi Nakagawa, Kenzo Uchida, Daisuke Koy. Intraportal GLP-1 stimulates insulin secretion predominantly through the hepatoportal-pancreatic vagal reflex pathways. American journal of physiology. Endocrinology and metabolism. vol 305. issue 3. 2013-10-17. PMID:23715725. |
under arterial isoglycemia across the groups, the physiological glp-1 infusion in sham augmented promptly and markedly arterial insulin levels, approximately twofold the levels in glucose alone infusion (p < 0.005), and insulin levels in vagox diminished apparently (p < 0.05). |
2013-10-17 |
2023-08-12 |
rat |
| Makoto Nishizawa, Hajime Nakabayashi, Keigo Uehara, Atsushi Nakagawa, Kenzo Uchida, Daisuke Koy. Intraportal GLP-1 stimulates insulin secretion predominantly through the hepatoportal-pancreatic vagal reflex pathways. American journal of physiology. Endocrinology and metabolism. vol 305. issue 3. 2013-10-17. PMID:23715725. |
intraportal pharmacological glp-1 infusion further augmented insulin secretion in both groups, but the nmc remained in 46% (ns; sham vs. vagox). |
2013-10-17 |
2023-08-12 |
rat |
| Makoto Nishizawa, Hajime Nakabayashi, Keigo Uehara, Atsushi Nakagawa, Kenzo Uchida, Daisuke Koy. Intraportal GLP-1 stimulates insulin secretion predominantly through the hepatoportal-pancreatic vagal reflex pathways. American journal of physiology. Endocrinology and metabolism. vol 305. issue 3. 2013-10-17. PMID:23715725. |
in contrast, "isoglycemic" intravenous glp-1 infusion (3 pmol·kg(-1)·min(-1)) evoked an equal insulin secretion in both groups. |
2013-10-17 |
2023-08-12 |
rat |
| Paul V Sabatini, Nicole A J Krentz, Bader Zarrouki, Clara Y Westwell-Roper, Cuilan Nian, Ryan A Uy, A M James Shapiro, Vincent Poitout, Francis C Lyn. Npas4 is a novel activity-regulated cytoprotective factor in pancreatic β-cells. Diabetes. vol 62. issue 8. 2013-10-01. PMID:23656887. |
npas4 tempers β-cell function through a direct inhibitory interaction with the insulin promoter and by blocking the potentiating effects of glp-1 without significantly reducing glucose-stimulated secretion. |
2013-10-01 |
2023-08-12 |
mouse |
| M A Abdul-Ghani, K Williams, M Kanat, Y Altuntas, R A DeFronz. Insulin vs GLP-1 analogues in poorly controlled Type 2 diabetic subjects on oral therapy: a meta-analysis. Journal of endocrinological investigation. vol 36. issue 3. 2013-09-30. PMID:22522662. |
insulin vs glp-1 analogues in poorly controlled type 2 diabetic subjects on oral therapy: a meta-analysis. |
2013-09-30 |
2023-08-12 |
human |
| M A Abdul-Ghani, K Williams, M Kanat, Y Altuntas, R A DeFronz. Insulin vs GLP-1 analogues in poorly controlled Type 2 diabetic subjects on oral therapy: a meta-analysis. Journal of endocrinological investigation. vol 36. issue 3. 2013-09-30. PMID:22522662. |
to compare insulin and glp-1 analogues therapy on glycemic control in poorly controlled type 2 diabetes (t2dm) subjects failing on oral therapy. |
2013-09-30 |
2023-08-12 |
human |
| Kazuo Sonoki, Masanori Iwase, Yutaka Takata, Tetsuji Nakamoto, Chihiro Masaki, Ryuji Hosokawa, Shigeki Murakami, Kaoru Chiwata, Hiromasa Inou. Effects of thirty-times chewing per bite on secretion of glucagon-like peptide-1 in healthy volunteers and type 2 diabetic patients. Endocrine journal. vol 60. issue 3. 2013-09-30. PMID:23138354. |
here, we examined the relationship between mastication and glp-1 secretion, along with postprandial blood glucose and insulin concentrations. |
2013-09-30 |
2023-08-12 |
human |
| Kazuo Sonoki, Masanori Iwase, Yutaka Takata, Tetsuji Nakamoto, Chihiro Masaki, Ryuji Hosokawa, Shigeki Murakami, Kaoru Chiwata, Hiromasa Inou. Effects of thirty-times chewing per bite on secretion of glucagon-like peptide-1 in healthy volunteers and type 2 diabetic patients. Endocrine journal. vol 60. issue 3. 2013-09-30. PMID:23138354. |
we compared the levels of blood glucose, serum insulin, and plasma active glp-1 concentrations after young healthy volunteers ate a test meal either by usual eating (control) or in one of three specified ways: 1. unilateral chewing, 2. quick eating, 3. |
2013-09-30 |
2023-08-12 |
human |
| Kazuo Sonoki, Masanori Iwase, Yutaka Takata, Tetsuji Nakamoto, Chihiro Masaki, Ryuji Hosokawa, Shigeki Murakami, Kaoru Chiwata, Hiromasa Inou. Effects of thirty-times chewing per bite on secretion of glucagon-like peptide-1 in healthy volunteers and type 2 diabetic patients. Endocrine journal. vol 60. issue 3. 2013-09-30. PMID:23138354. |
plasma active glp-1 concentrations did not change by unilateral chewing or quick eating, but did increase by the third method, without affecting the concentrations of blood glucose or serum insulin. |
2013-09-30 |
2023-08-12 |
human |
| Payal Shah, Amin Ardestani, Gitanjali Dharmadhikari, Svenja Laue, Desiree M Schumann, Julie Kerr-Conte, Francois Pattou, Thomas Klein, Kathrin Maedle. The DPP-4 inhibitor linagliptin restores β-cell function and survival in human isolated islets through GLP-1 stabilization. The Journal of clinical endocrinology and metabolism. vol 98. issue 7. 2013-09-30. PMID:23633194. |
inhibition of dipeptidyl peptidase-4 (dpp-4) is a potent strategy to increase glucose-dependent insulinotropic polypeptide and glucagon like peptide 1 (glp-1) induced insulin secretion in diabetes. |
2013-09-30 |
2023-08-12 |
human |
| Xavier Allirot, Laure Saulais, Kevin Seyssel, Julia Graeppi-Dulac, Hubert Roth, Anne Charrié, Jocelyne Drai, Joelle Goudable, Emilie Blond, Emmanuel Disse, Martine Lavill. An isocaloric increase of eating episodes in the morning contributes to decrease energy intake at lunch in lean men. Physiology & behavior. vol 110-111. 2013-09-24. PMID:23333553. |
blood sampling was performed to study the kinetics of ghrelin, glucagon-like peptide-1 (glp-1), glucose, insulin, triglycerides and non-esterified fatty acids (nefa). |
2013-09-24 |
2023-08-12 |
human |
| Lili Zhang, Mengliu Yang, Hong Ren, Huaidong Hu, Guenther Boden, Ling Li, Gangyi Yan. GLP-1 analogue prevents NAFLD in ApoE KO mice with diet and Acrp30 knockdown by inhibiting c-JNK. Liver international : official journal of the International Association for the Study of the Liver. vol 33. issue 5. 2013-09-23. PMID:23432843. |
liraglutide, a glucagon-like peptide-1(glp-1) analogue with 97% sequence identity to human glp-1, increases insulin secretion and insulin sensitivity. |
2013-09-23 |
2023-08-12 |
mouse |
| Shelley Elkinson, Gillian M Keatin. Lixisenatide: first global approval. Drugs. vol 73. issue 4. 2013-09-19. PMID:23558600. |
native glp-1 stimulates insulin secretion in a glucose-dependent manner, as well as suppressing glucagon production and slowing gastric emptying. |
2013-09-19 |
2023-08-12 |
Not clear |
| Rachael Lennox, David W Porter, Peter R Flatt, Victor A Gaul. (Val(8))GLP-1-Glu-PAL: a GLP-1 agonist that improves hippocampal neurogenesis, glucose homeostasis, and β-cell function in high-fat-fed mice. ChemMedChem. vol 8. issue 4. 2013-09-17. PMID:23138973. |
all glp-1 peptides significantly stimulated insulin secretion at 5.6 mm (1.3- to 4.9-fold, p<0.01 to p<0.001) and 16.7 mm glucose (1.5- to 2.3-fold, p<0.001). |
2013-09-17 |
2023-08-12 |
mouse |
| Rachael Lennox, David W Porter, Peter R Flatt, Victor A Gaul. (Val(8))GLP-1-Glu-PAL: a GLP-1 agonist that improves hippocampal neurogenesis, glucose homeostasis, and β-cell function in high-fat-fed mice. ChemMedChem. vol 8. issue 4. 2013-09-17. PMID:23138973. |
these data demonstrate that (val(8))glp-1-glu-pal is a long-acting glp-1 peptide that significantly improves hippocampal neurogenesis, glucose homeostasis, and insulin secretion in high-fat-fed mice. |
2013-09-17 |
2023-08-12 |
mouse |
| Yumei Xiong, Gayathri Swaminath, Qiong Cao, Li Yang, Qi Guo, Heather Salomonis, Jenny Lu, Jonathan B Houze, Paul J Dransfield, Yingcai Wang, Jiwen Jim Liu, Simon Wong, Ralf Schwandner, Franziska Steger, Helene Baribault, Lily Liu, Suzanne Coberly, Lynn Miao, Jane Zhang, Daniel C-H Lin, Margrit Schwar. Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1. Molecular and cellular endocrinology. vol 369. issue 1-2. 2013-09-16. PMID:23403053. |
ffa1 is expressed in pancreatic β-cells, where it regulates glucose-dependent insulin secretion, and gpr120 has been implicated in mediating glp-1 secretion. |
2013-09-16 |
2023-08-12 |
mouse |
| Yumei Xiong, Gayathri Swaminath, Qiong Cao, Li Yang, Qi Guo, Heather Salomonis, Jenny Lu, Jonathan B Houze, Paul J Dransfield, Yingcai Wang, Jiwen Jim Liu, Simon Wong, Ralf Schwandner, Franziska Steger, Helene Baribault, Lily Liu, Suzanne Coberly, Lynn Miao, Jane Zhang, Daniel C-H Lin, Margrit Schwar. Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1. Molecular and cellular endocrinology. vol 369. issue 1-2. 2013-09-16. PMID:23403053. |
we conclude that allosterism at ffa1 can contribute to postprandial glucose management by stimulating insulin secretion via an extrapancreatic mechanism of action, and that gpr120 in glp-1 secretion requires further investigation. |
2013-09-16 |
2023-08-12 |
mouse |
| Dimitris Papamargaritis, Carel W le Roux, Eleni Sioka, George Koukoulis, George Tzovaras, Dimitris Zacharouli. Changes in gut hormone profile and glucose homeostasis after laparoscopic sleeve gastrectomy. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. vol 9. issue 2. 2013-09-13. PMID:23183113. |
the objective of the present study was to assess the changes in glp-1, pyy, insulin, and glucose levels after laparoscopic sleeve gastrectomy (sg). |
2013-09-13 |
2023-08-12 |
Not clear |
| Xiaoquan Xiong, Weijuan Shao, Tianru Ji. New insight into the mechanisms underlying the function of the incretin hormone glucagon-like peptide-1 in pancreatic β-cells: the involvement of the Wnt signaling pathway effector β-catenin. Islets. vol 4. issue 6. 2013-09-10. PMID:23314611. |
glp-1 not only functions as an incretin hormone in stimulating insulin secretion in response to nutritional, hormonal and neuronal stimulations, but also acts as an "insulin-like" factor in β-cell and extra-pancreatic organs. |
2013-09-10 |
2023-08-12 |
Not clear |
| Hilary E Wilson-Pérez, Adam P Chambers, Karen K Ryan, Bailing Li, Darleen A Sandoval, Doris Stoffers, Daniel J Drucker, Diego Pérez-Tilve, Randy J Seele. Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency. Diabetes. vol 62. issue 7. 2013-09-09. PMID:23434938. |
glucagon-like peptide 1 (glp-1) is a peptide hormone that is released from the gut in response to nutrient ingestion and that has a range of metabolic effects, including enhancing insulin secretion and decreasing food intake. |
2013-09-09 |
2023-08-12 |
mouse |