| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Maccario, S Grottoli, M Procopio, S E Oleandri, R Rossetto, C Gauna, E Arvat, E Ghig. The GH/IGF-I axis in obesity: influence of neuro-endocrine and metabolic factors. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. vol 24 Suppl 2. 2000-10-10. PMID:10997620. |
it is well-known that gh secretion is deeply impaired in overweight patients: we reviewed the multiple mechanisms underlying this issue, considering either central (cns-related, such as impairment of ghrh tone or increased somatostatin release) or peripheral (ie metabolic: insulin, free fatty acids, glucose) factors. |
2000-10-10 |
2023-08-12 |
human |
| A J Cleare, S S Sookdeo, J Jones, V O'Keane, J P Miel. Integrity of the growth hormone/insulin-like growth factor system is maintained in patients with chronic fatigue syndrome. The Journal of clinical endocrinology and metabolism. vol 85. issue 4. 2000-05-01. PMID:10770178. |
we also performed 2 dynamic tests of gh function: a 100-microg ghrh test and an insulin stress test using 0.15 u/kg bw insulin. |
2000-05-01 |
2023-08-12 |
Not clear |
| A J Cleare, S S Sookdeo, J Jones, V O'Keane, J P Miel. Integrity of the growth hormone/insulin-like growth factor system is maintained in patients with chronic fatigue syndrome. The Journal of clinical endocrinology and metabolism. vol 85. issue 4. 2000-05-01. PMID:10770178. |
gh responses to both the ghrh test and the insulin stress test were no different in patients and controls. |
2000-05-01 |
2023-08-12 |
Not clear |
| C D McMahon, L T Chapin, K J Lookingland, R P Radcliff, H A Tucke. Feeding-induced increases in insulin do not suppress secretion of growth hormone. Domestic animal endocrinology. vol 17. issue 4. 2000-01-27. PMID:10628433. |
our objectives were to determine whether: 1) alloxan prevents concentrations of insulin from increasing after feeding steers; 2) concentrations of gh remain high after feeding alloxan-treated steers; and 3) gh-releasing hormone (ghrh) stimulates greater release of gh in alloxan-treated, than in control, steers after feeding. |
2000-01-27 |
2023-08-12 |
Not clear |
| R Lanzi, L Luzi, A Caumo, A C Andreotti, M F Manzoni, M E Malighetti, L P Sereni, A E Pontirol. Elevated insulin levels contribute to the reduced growth hormone (GH) response to GH-releasing hormone in obese subjects. Metabolism: clinical and experimental. vol 48. issue 9. 1999-09-28. PMID:10484056. |
0.9% nacl infusion and oral acipimox, an antilipolytic agent able to reduce ffa levels (250 mg at 6 and 2 hours before ghrh), and (3) euglycemic-hyperinsulinemic clamp (insulin infusion rate, 0.4 mu x kg(-1) x min(-1)). |
1999-09-28 |
2023-08-12 |
human |
| R Lanzi, L Luzi, A Caumo, A C Andreotti, M F Manzoni, M E Malighetti, L P Sereni, A E Pontirol. Elevated insulin levels contribute to the reduced growth hormone (GH) response to GH-releasing hormone in obese subjects. Metabolism: clinical and experimental. vol 48. issue 9. 1999-09-28. PMID:10484056. |
acipimox markedly reduced ffa levels and produced a mild reduction of insulin levels; under these conditions, the gh response to ghrh was increased in both groups, remaining lower in obese versus normal subjects (1,842 +/- 360 v 4,871 +/- 1,286 microg/l x 120 min, p < .05). |
1999-09-28 |
2023-08-12 |
human |
| R Lanzi, L Luzi, A Caumo, A C Andreotti, M F Manzoni, M E Malighetti, L P Sereni, A E Pontirol. Elevated insulin levels contribute to the reduced growth hormone (GH) response to GH-releasing hormone in obese subjects. Metabolism: clinical and experimental. vol 48. issue 9. 1999-09-28. PMID:10484056. |
in obese subjects, as previously reported in normals, the gh response to ghrh was inversely correlated with the mean serum insulin (r = -.70, p < .01). |
1999-09-28 |
2023-08-12 |
human |
| R Lanzi, L Luzi, A Caumo, A C Andreotti, M F Manzoni, M E Malighetti, L P Sereni, A E Pontirol. Elevated insulin levels contribute to the reduced growth hormone (GH) response to GH-releasing hormone in obese subjects. Metabolism: clinical and experimental. vol 48. issue 9. 1999-09-28. PMID:10484056. |
in conclusion, our data indicate that in the obese, as in normal subjects, the gh response to ghrh is a function of insulin levels. |
1999-09-28 |
2023-08-12 |
human |
| R Lanzi, L Luzi, A Caumo, A C Andreotti, M F Manzoni, M E Malighetti, L P Sereni, A E Pontirol. Elevated insulin levels contribute to the reduced growth hormone (GH) response to GH-releasing hormone in obese subjects. Metabolism: clinical and experimental. vol 48. issue 9. 1999-09-28. PMID:10484056. |
the finding that after both the acipimox treatment and the insulin clamp the obese still show higher insulin levels and a lower gh response to ghrh than normal subjects suggests that hyperinsulinemia is a major determinant of the reduced gh release associated with obesity. |
1999-09-28 |
2023-08-12 |
human |
| A Cai, J F Hyd. The human growth hormone-releasing hormone transgenic mouse as a model of modest obesity: differential changes in leptin receptor (OBR) gene expression in the anterior pituitary and hypothalamus after fasting and OBR localization in somatotrophs. Endocrinology. vol 140. issue 8. 1999-08-17. PMID:10433218. |
in conclusion, 1) the modest obesity in hghrh transgenic mice is associated with increases in leptin synthesis and secretion as well as insulin secretion; 2) gh and/or ghrh as well as leptin and insulin may differentially contribute to the changes in obr(l) gene expression in the anterior pituitary and the hypothalamus; 3) the response of obr(l) gene expression in the hypothalamus to fasting is absent in the modestly obese hghrh transgenic mice; and 4) somatotrophs are target cells for leptin, and the increase in obr(l) gene expression in the pituitary of hghrh transgenic mice is due at least in part to the increase in the number of cells expressing obr(l). |
1999-08-17 |
2023-08-12 |
mouse |
| A Cano, C Castelo-Branco, J J Tarí. Effect of menopause and different combined estradiol-progestin regimens on basal and growth hormone-releasing hormone-stimulated serum growth hormone, insulin-like growth factor-1, insulin-like growth factor binding protein (IGFBP)-1, and IGFBP-3 levels. Fertility and sterility. vol 71. issue 2. 1999-02-26. PMID:9988395. |
to determine the effects of menopause and three different formulations of e2 plus medroxyprogesterone acetate on serum concentrations of basal and growth hormone-releasing hormone (ghrh)-stimulated growth hormone (gh), insulin-like growth factor-1 (igf-1), insulin-like growth factor binding protein (igfbp)-1, igfbp-3, insulin, and c peptide. |
1999-02-26 |
2023-08-12 |
Not clear |
| T Tsushima, Y Katoh, Y Miyachi, K Chihara, A Teramoto, M Irie, Y Hashimot. Serum concentration of 20K human growth hormone (20K hGH) measured by a specific enzyme-linked immunosorbent assay. Study Group of 20K hGH. The Journal of clinical endocrinology and metabolism. vol 84. issue 1. 1999-02-03. PMID:9920101. |
the 20k ratio did not change after acute gh provocative tests, such as the insulin tolerance test and the ghrh test. |
1999-02-03 |
2023-08-12 |
human |
| G Aimaretti, G Corneli, P Razzore, S Bellone, C Baffoni, J Bellone, F Camanni, E Ghig. Usefulness of IGF-I assay for the diagnosis of GH deficiency in adults. Journal of endocrinological investigation. vol 21. issue 8. 1998-12-30. PMID:9801991. |
= 135, 61 women and 74 men; age, mean +/- se: 43.8 +/- 1.4 yr, range 20-80 yr) we studied igf-i levels, their reproducibility and association to peak gh response to ghrh + arginine (ghrh + arg) test and insulin tolerance test (itt). |
1998-12-30 |
2023-08-12 |
human |
| G Van den Berghe, P Wouters, L Carlsson, R C Baxter, R Bouillon, C Y Bower. Leptin levels in protracted critical illness: effects of growth hormone-secretagogues and thyrotropin-releasing hormone. The Journal of clinical endocrinology and metabolism. vol 83. issue 9. 1998-10-08. PMID:9745404. |
in contrast, gh-secretagogues elevated leptin levels within 12 h. infusion of ghrp-2 alone induced a maximal leptin increase of +87% after 24 h, whereas ghrh + ghrp-2 elevated leptin by up to +157% after 24 h. the increase in leptin within 12 h was related (r2 = 0.58) to the substantial rise in insulin. |
1998-10-08 |
2023-08-12 |
Not clear |
| A Iranmanesh, S South, A Y Liem, D Clemmons, M O Thorner, A Weltman, J D Veldhui. Unequal impact of age, percentage body fat, and serum testosterone concentrations on the somatotrophic, IGF-I, and IGF-binding protein responses to a three-day intravenous growth hormone-releasing hormone pulsatile infusion in men. European journal of endocrinology. vol 139. issue 1. 1998-09-04. PMID:9703380. |
ghrh infusion significantly increased the mean (24-h) serum gh concentration (0.3 +/- 0.1 basal vs 2.4 +/- 0.4 microg/l treatment; p = 0.0001), total daily pulsatile gh production rate (21 +/- 9.5 vs 97 +/- 17 microg/l/day; p = 0.01), gh secretory burst frequency (11 +/- 0.5 vs 17 +/- 0.3 events/day; p = <0.01), and mass of gh released per burst (1.1 +/- 0.4 vs 5.9 1 microg/l; p < 0.01), as well as serum igf-i (261 +/- 33 vs 436 +/- 37 microg/l; p = 0.005), insulin (45 +/- 13 vs 79 +/- 17 mu/l; p = 0.0002), and igf binding protein (igfbp)-3 (3320 +/- 107 vs 4320 +/- 114 microg/l; p = 0.001) concentrations, while decreasing igfbp-1 levels (16 +/- 1.2 vs 14 +/- 0.09 microg/l; p = 0.02). |
1998-09-04 |
2023-08-12 |
Not clear |
| P Limone, S E Oleandri, P Ajmone Catt, S Grottoli, C Frangioni, E Avogadri, M Perrin, M R Valetto, M Maccari. The inhibitory effect of glucose on growth hormone secretion is lost in obesity but not in hypertension. Journal of endocrinological investigation. vol 20. issue 10. 1998-02-09. PMID:9438920. |
aim of the present study was to verify the gh response to ghrh and the ability of glucose load to inhibit it in patients with essential hypertension in whom hyperinsulinism and insulin resistance are frequently present. |
1998-02-09 |
2023-08-12 |
human |
| P Limone, S E Oleandri, P Ajmone Catt, S Grottoli, C Frangioni, E Avogadri, M Perrin, M R Valetto, M Maccari. The inhibitory effect of glucose on growth hormone secretion is lost in obesity but not in hypertension. Journal of endocrinological investigation. vol 20. issue 10. 1998-02-09. PMID:9438920. |
in conclusion, this study demonstrates that, like in normal subjects but differently from in obese patients the gh response to ghrh is normal in patients with essential hypertension and it is normally inhibited by oral glucose load even when these patients show high insulin levels. |
1998-02-09 |
2023-08-12 |
human |
| R Lanzi, M F Manzoni, A C Andreotti, M E Malighetti, E Bianchi, L P Sereni, A Caumo, L Luzi, A E Pontirol. Evidence for an inhibitory effect of physiological levels of insulin on the growth hormone (GH) response to GH-releasing hormone in healthy subjects. The Journal of clinical endocrinology and metabolism. vol 82. issue 7. 1997-08-07. PMID:9215300. |
in the present study, the gh response to ghrh was evaluated during acute blockade of lipolysis obtained either by acipimox or by insulin at different infusion rates. |
1997-08-07 |
2023-08-12 |
human |
| R Lanzi, M F Manzoni, A C Andreotti, M E Malighetti, E Bianchi, L P Sereni, A Caumo, L Luzi, A E Pontirol. Evidence for an inhibitory effect of physiological levels of insulin on the growth hormone (GH) response to GH-releasing hormone in healthy subjects. The Journal of clinical endocrinology and metabolism. vol 82. issue 7. 1997-08-07. PMID:9215300. |
six healthy subjects (four men and two women, 25.8 +/- 1.9 yrs old, mean +/- se) underwent three ghrh tests (50 micrograms iv, at 1300 h) during: 1) iv 0.9% nacl infusion (1200-1500 h) after oral acipimox administration (250 mg) at 0700 h and at 1100 h; 2) 0.1 mu.kg-1.min-1 euglycemic insulin clamp (1200-1500 h) after oral acipimox administration (250 mg at 0700 h and at 1100 h); 3) 0.4 mu.kg-1.min-1 euglycemic insulin clamp (1200-1500 h) after oral placebo administration (at 0700 and 1100 h). |
1997-08-07 |
2023-08-12 |
human |
| R Lanzi, M F Manzoni, A C Andreotti, M E Malighetti, E Bianchi, L P Sereni, A Caumo, L Luzi, A E Pontirol. Evidence for an inhibitory effect of physiological levels of insulin on the growth hormone (GH) response to GH-releasing hormone in healthy subjects. The Journal of clinical endocrinology and metabolism. vol 82. issue 7. 1997-08-07. PMID:9215300. |
serum insulin (immunoreactive insulin) levels were significantly different in the three tests (12 +/- 2, 100 +/- 10, 194 +/- 19 pmol/l, p < 0.06), plasma ffa were low and similar (0.04 +/- 0.003, 0.02 +/- 0.005, 0.02 +/- 0.003, not significant), and the gh response to ghrh was progressively lower (4871 +/- 1286, 2414 +/- 626, 1076 +/- 207 micrograms/l 120 min), although only test 3 was significantly different from test 1 (p < 0.05). |
1997-08-07 |
2023-08-12 |
human |