| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manuel D Gahete, José Córdoba-Chacón, Qing Lin, Jens C Brüning, C Ronald Kahn, Justo P Castaño, Helen Christian, Raúl M Luque, Rhonda D Kinema. Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms. Endocrinology. vol 154. issue 7. 2013-08-28. PMID:23671263. |
however, comparison of the pattern of gh release, gh expression, somatotrope morphometry, and pituitary explant sensitivity to acute ghrh challenge in lean sirko and sigfrko mice strongly suggests the primary role of insulin in vivo is to suppress gh release, whereas igf-i serves to regulate gh synthesis. |
2013-08-28 |
2023-08-12 |
mouse |
| Yasuyuki Kinoshita, Atsushi Tominaga, Satoshi Usui, Kazunori Arita, Tetsuhiko Sakoguchi, Kazuhiko Sugiyama, Kaoru Kuris. The arginine and GHRP-2 tests as alternatives to the insulin tolerance test for the diagnosis of adult GH deficiency in Japanese patients: a comparison. Endocrine journal. vol 60. issue 1. 2013-07-22. PMID:23079545. |
the arginine + ghrh test has been established as an alternative to the insulin tolerance test (itt) for the diagnosis of adult gh deficiency (aghd). |
2013-07-22 |
2023-08-12 |
Not clear |
| Taísa A R Vicente, Ivina E S Rocha, Roberto Salvatori, Carla R P Oliveira, Rossana M C Pereira, Anita H O Souza, Viviane C Campos, Elenilde G Santos, Rachel D C Araújo Diniz, Eugênia H O Valença, Carlos C Epitácio-Pereira, Mario C P Oliveira, Andrea Mari, Manuel H Aguiar-Oliveir. Lifetime congenital isolated GH deficiency does not protect from the development of diabetes. Endocrine connections. vol 2. issue 2. 2013-06-25. PMID:23795286. |
adult subjects with untreated, lifetime, isolated gh deficiency (ighd) due to a homozygous ghrh receptor gene mutation (mut/mut) residing in itabaianinha, brazil, present with lower bmi, higher prevalence of impaired glucose tolerance (igt), increased insulin sensitivity (is), and reduced β-cell function (βcf) when compared with non-bmi-matched homozygous normal controls. |
2013-06-25 |
2023-08-12 |
human |
| Valentina Gasco, Guglielmo Beccuti, Chiara Baldini, Nunzia Prencipe, Stellina Di Giacomo, Alessandro Berton, Federica Guaraldi, Isabella Tabaro, Mauro Maccario, Ezio Ghigo, Silvia Grottol. Acylated ghrelin as a provocative test for the diagnosis of GH deficiency in adults. European journal of endocrinology. vol 168. issue 1. 2013-02-04. PMID:23082006. |
insulin tolerance test (itt) is the test of reference for the diagnosis of adult gh deficiency (ghd), although ghrh in combination with arginine (arg) or gh secretagogues are considered equally reliable tests. |
2013-02-04 |
2023-08-12 |
Not clear |
| G Balercia, L Giovannini, F Paggi, M Spaziani, N Tahani, M Boscaro, A Lenzi, A Radicion. Growth hormone deficiency in the transition period: body composition and gonad function. Journal of endocrinological investigation. vol 34. issue 9. 2012-07-16. PMID:21697646. |
retesting during the transition period, involving measurement of igf-i plus a provocative test (insulin tolerance test or ghrh + arginine test), is thus necessary to establish any persistent gh deficiency requiring additional replacement therapy. |
2012-07-16 |
2023-08-12 |
Not clear |
| Barbara Ludwig, Avi Rotem, Janine Schmid, Gordon C Weir, Clark K Colton, Mathias D Brendel, Tova Neufeld, Norman L Block, Karina Yavriyants, Anja Steffen, Stefan Ludwig, Triantafyllos Chavakis, Andreas Reichel, Dimitri Azarov, Baruch Zimermann, Shiri Maimon, Mariya Balyura, Tania Rozenshtein, Noa Shabtay, Pnina Vardi, Konstantin Bloch, Paul de Vos, Andrew V Schally, Stefan R Bornstein, Uriel Barka. Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 13. 2012-05-21. PMID:22393012. |
pretreatment with the growth hormone-releasing hormone (ghrh) agonist, ji-36, significantly enhanced graft function by improving glucose tolerance and increasing β-cell insulin reserve in rats thereby allowing for a reduction of the islet mass required for metabolic control. |
2012-05-21 |
2023-08-12 |
rat |
| Takara L Stanley, Cindy Y Chen, Karen L Branch, Hideo Makimura, Steven K Grinspoo. Effects of a growth hormone-releasing hormone analog on endogenous GH pulsatility and insulin sensitivity in healthy men. The Journal of clinical endocrinology and metabolism. vol 96. issue 1. 2011-02-04. PMID:20943777. |
the objective of this study was to determine the effects of a novel ghrh (ghrh(1-44)) analog, tesamorelin, on endogenous gh pulsatility and insulin sensitivity in healthy men. |
2011-02-04 |
2023-08-12 |
Not clear |
| Enrico Gabellieri, Luca Chiovato, Mary Lage, Ana I Castro, Felipe F Casanuev. Testing growth hormone deficiency in adults. Frontiers of hormone research. vol 38. 2010-09-07. PMID:20616504. |
insulin tolerance test is considered the diagnostic test of choice, however, the gh-releasing hormone (ghrh)+arginine, the ghrh+growth hormone-releasing peptide and the glucagon stimulation tests are well validated alternative tests in adults. |
2010-09-07 |
2023-08-12 |
Not clear |
| Philippe Chanson, Anne Cailleux-Bounacer, Jean-Marc Kuhn, Georges Weryha, Olivier Chabre, Françoise Borson-Chazot, Séverine Dubois, Caroline Vincent-Dejean, Thierry Brue, Christine Fedou, Jean-Louis Bresson, Pierre Demolis, Jean-Claude Souberbiell. Comparative validation of the growth hormone-releasing hormone and arginine test for the diagnosis of adult growth hormone deficiency using a growth hormone assay conforming to recent international recommendations. The Journal of clinical endocrinology and metabolism. vol 95. issue 8. 2010-08-24. PMID:20484474. |
the ghrh plus arginine (ghrh+arg) test is a promising alternative to the insulin tolerance test (itt) for diagnosis of adult gh deficiency (aghd). |
2010-08-24 |
2023-08-12 |
Not clear |
| Kevin C J Yuen, Beverly M K Biller, Mark E Molitch, David M Coo. Clinical review: Is lack of recombinant growth hormone (GH)-releasing hormone in the United States a setback or time to consider glucagon testing for adult GH deficiency? The Journal of clinical endocrinology and metabolism. vol 94. issue 8. 2009-08-25. PMID:19509104. |
the use of the combined ghrh and arginine (ghrh-arg) test has gained increasing acceptance in the united states as a reliable alternative test to the insulin tolerance test (itt) for diagnosing adult gh deficiency (ghd). |
2009-08-25 |
2023-08-12 |
Not clear |
| Ken H Darzy, Michael O Thorner, Stephen M Shale. Cranially irradiated adult cancer survivors may have normal spontaneous GH secretion in the presence of discordant peak GH responses to stimulation tests (compensated GH deficiency). Clinical endocrinology. vol 70. issue 2. 2009-08-18. PMID:18673465. |
we have previously demonstrated that spontaneous (physiological) gh secretion was entirely normal in cranially irradiated patients who had normal individual peak gh responses to the insulin tolerance test (itt) but reduced maximal somatotroph reserve as indicated by substantially reduced group gh responses to the ghrh + arginine stimulation test (ast). |
2009-08-18 |
2023-08-12 |
human |
| M Doga, S Bonadonna, M Gola, G Mazziotti, A Giustin. Growth hormone deficiency in the adult. Pituitary. vol 9. issue 4. 2009-06-11. PMID:17077947. |
insulin tolerance test (itt) has been considered the gold standard by the most important scientific societies, although alternative tests, in particular ghrh plus arginine have been proposed as valuable alternative to itt. |
2009-06-11 |
2023-08-12 |
human |
| H Shingu, K Hodate, S Kushibiki, E Touno, A Oshibe, Y Ueda, M Shinoda, S Ohash. Effects of growth hormone-releasing hormone treatment on milk production and plasma hormones and metabolites in lactating Japanese Black cows under negative energy balance. Journal of animal science. vol 87. issue 4. 2009-04-20. PMID:19098253. |
plasma gh, igf-1, insulin, and glucose concentrations increased (p<0.05) after ghrh treatment in both hed- and led-fed cows; ghrh treatment also induced an increase (p<0.05) in the net area under the curve of plasma insulin after glucose challenge in both hed- and led-fed cows. |
2009-04-20 |
2023-08-12 |
cattle |
| H Shingu, K Hodate, S Kushibiki, E Touno, A Oshibe, Y Ueda, M Shinoda, S Ohash. Effects of growth hormone-releasing hormone treatment on milk production and plasma hormones and metabolites in lactating Japanese Black cows under negative energy balance. Journal of animal science. vol 87. issue 4. 2009-04-20. PMID:19098253. |
we conclude that ghrh treatment of lactating japanese black cows stimulates endogenous gh and subsequent igf-1 secretion and might induce an increase in insulin resistance, irrespective of eb; however, compared with lactating dairy cows, both galactopoietic and lipolytic effects of ghrh might be insufficiently exerted under negative eb in lactating beef cows. |
2009-04-20 |
2023-08-12 |
cattle |
| Madhusmita Misra, Miriam A Bredella, Patrika Tsai, Nara Mendes, Karen K Miller, Anne Klibansk. Lower growth hormone and higher cortisol are associated with greater visceral adiposity, intramyocellular lipids, and insulin resistance in overweight girls. American journal of physiology. Endocrinology and metabolism. vol 295. issue 2. 2008-09-30. PMID:18544645. |
we hypothesized that low-peak gh on the gh-releasing hormone (ghrh)-arginine stimulation test and high cortisol in overweight adolescents would be associated with higher regional fat, insulin resistance, and lipids. |
2008-09-30 |
2023-08-12 |
Not clear |
| A Mazzola, C Meazza, P Travaglino, S Pagani, D Frattini, E Bozzola, G Corneli, G Aimaretti, M Bozzol. Unreliability of classic provocative tests for the diagnosis of growth hormone deficiency. Journal of endocrinological investigation. vol 31. issue 2. 2008-04-30. PMID:18362508. |
serum gh levels were measured by a time-resolved immunofluorimetric assay before and after 1 microg/kg body weight iv injection of ghrh, while serum prl, igf-i, and insulin were evaluated only in basal conditions using an automatic immunometric assay. |
2008-04-30 |
2023-08-12 |
human |
| H Sugihara, T Shibasaki, A Tatsuguchi, F Okajima, S Wakita, Y Nakajima, K Tanimura, H Tamura, S Ishii, J Kamegai, H Akasu, W Kitagawa, K Shimizu, Y Nakamura, E Uchida, T Tajiri, Z Naito, H Katakami, S Oikaw. A non-acromegalic case of multiple endocrine neoplasia type 1 accompanied by a growth hormone-releasing hormone-producing pancreatic tumor. Journal of endocrinological investigation. vol 30. issue 5. 2007-07-25. PMID:17598976. |
immunohistochemistry revealed positive immunoreactivity for ghrh, ss , insulin, glucagon, chromogranin a, and pancreatic polypeptide in the pancreatic tumor. |
2007-07-25 |
2023-08-12 |
Not clear |
| Raul M Luque, Rhonda D Kinema. Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function. Endocrinology. vol 147. issue 6. 2006-06-22. PMID:16513828. |
in addition, treating primary pituitary cell cultures from lean mice with insulin reduced gh release as well as gh, ghrh receptor, and ghrelin receptor mrna levels compared with vehicle-treated controls, where the magnitude of suppression of pituitary mrna levels was similar to that observed in the dio mouse. |
2006-06-22 |
2023-08-12 |
mouse |
| J Larry Jameso. Molecular mechanisms of end-organ resistance. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 14 Suppl A. 2005-10-18. PMID:15135777. |
mutations that cause hormone resistance have been described for most classes of hormones, including peptides like growth-hormone releasing hormone (ghrh); large proteins such as insulin and the glycoprotein hormones; steroid hormones; and even ions such as calcium. |
2005-10-18 |
2023-08-12 |
Not clear |
| H Shingu, K Hodate, S Kushibiki, Y Ueda, E Touno, M Shinoda, S Ohash. Hormonal and lactational responses to growth hormone-releasing hormone treatment in lactating Japanese Black cows. Journal of dairy science. vol 87. issue 6. 2005-04-14. PMID:15453480. |
treatment with ghrh analog induced higher basal plasma concentrations of growth hormone (gh), insulin-like growth factor-1 (igf-1), insulin, and glucose compared with saline-treated cows. |
2005-04-14 |
2023-08-12 |
cattle |