| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Cuboni, M Caputo, E Ghigo, G Aimaretti, V Gasc. Once upon a time: the glucagon stimulation test in diagnosing adult GH deficiency. Journal of endocrinological investigation. 2024-03-10. PMID:38461479. |
the insulin tolerance test (itt), ghrh + arginine test, glucagon stimulation test (gst), and, more recently, testing with macimorelin are all recognized as useful in diagnosing adult ghd. |
2024-03-10 |
2024-03-14 |
Not clear |
| Vanderlan O Batista, Michael Kellner, Roberto Salvatori, Walter Oliveira, André Faro, Lucas B Santos, Enaldo V Melo, Alecia Ao Santos, Carla R P Oliveira, Viviane C Campos, Cynthia S Barros-Oliveira, Elenilde G Santos, Nathalie O Santana, Keila R Villar-Gouy, Ângela C O Leal, Rivia S Amorim, Davi A Oliveira Simões, Manuel H Aguiar-Oliveir. Cognitive performance during senescence in untreated congenital isolated GH deficiency. Endocrine connections. 2023-11-29. PMID:38019109. |
individuals with untreated isolated gh deficiency (ighd) due to a mutation in the ghrh receptor gene from itabaianinha brazil have increased insulin sensitivity, normal life expectancy, and an extended healthspan, i.e., the period of life free from disabilities. |
2023-11-29 |
2023-12-07 |
human |
| A Tate Lasher, Liou Y Su. Distinct physiological characteristics and altered glucagon signaling in GHRH knockout mice: Implications for longevity. Aging cell. 2023-09-05. PMID:37667562. |
our previous research has demonstrated that mice lacking functional growth hormone-releasing hormone (ghrh) exhibit distinct physiological characteristics, including an extended lifespan, a preference for lipid utilization during rest, mild hypoglycemia, and heightened insulin sensitivity. |
2023-09-05 |
2023-09-07 |
mouse |
| Ruy A Louzada, Manuel Blandino-Rosano, Sebastian Flores, Camila Lubaczeuski, Tengjiao Cui, Wei Sha, Renzhi Cai, Andrew V Schally, Ernesto Bernal-Mizrach. GRHR agonist MR-409 protects β-cells from streptozotocin-induced diabetes. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 25. 2023-06-12. PMID:37307472. |
the assessment of the effects of ghrh agonist mr-409 in a model of t1d induced by low-dose streptozotocin showed that mice treated with mr-409 exhibited better glucose homeostasis, higher insulin levels, and preservation of β-cell mass. |
2023-06-12 |
2023-08-14 |
mouse |
| Holly D Cox, Graham N Knussmann, Chad Moore, Daniel Eichne. Detection of insulin analogues and large peptides > 2 kDa in urine. Drug testing and analysis. 2022-03-09. PMID:35261185. |
in addition to insulin analogues, the large peptides include a structurally diverse set of peptides including analogues of growth hormone releasing hormone (ghrh), insulin-like growth factor-1 (igf-1), and mechano-growth factor (mgf). |
2022-03-09 |
2023-08-13 |
Not clear |
| Valentina Gasco, Alice Ferrero, Alessandro Bisceglia, Nunzia Prencipe, Valeria Cambria, Fabio Bioletto, Ezio Ghigo, Mauro Maccario, Silvia Grottol. The Cut-off Limits of Growth Hormone Response to the Insulin Tolerance Test Related to Body Mass Index for the Diagnosis of Adult Growth Hormone Deficiency. Neuroendocrinology. vol 111. issue 5. 2021-11-17. PMID:32335555. |
the diagnosis of growth hormone deficiency (ghd) in adults is based on a reduced gh response to provocative tests, such as the insulin tolerance test (itt) and the gh-releasing hormone (ghrh) + arginine (arg) test. |
2021-11-17 |
2023-08-13 |
human |
| Karina Rodrigues-Dos-Santos, Gabriela M Soares, Dimitrius S P S F Guimarães, Thiago R Araújo, Jean F Vettorazzi, Lucas Zangerolamo, Emilio Marconato-Júnior, Renzhi Cai, Wei Sha, Andrew V Schally, Antônio C Boschero, Helena C L Barbos. Effects of growth hormone-releasing hormone agonistic analog MR-409 on insulin-secreting cells under cyclopiazonic acid-induced endoplasmic reticulum stress. Molecular and cellular endocrinology. vol 535. 2021-09-16. PMID:34252492. |
recently, the growth-hormone-releasing hormone (ghrh) action has been demonstrated in ins-1e cells, in which it increases cell proliferation and insulin secretion. |
2021-09-16 |
2023-08-13 |
Not clear |
| Fang Zhang, Mert Icyuz, Zhenghui Liu, Michael Fitch, Liou Y Su. Insulin sensitivity in long-lived growth hormone-releasing hormone knockout mice. Aging. vol 12. issue 18. 2021-04-02. PMID:32640420. |
our previous studies showed that loss-of-function mutation of growth hormone releasing hormone (ghrh) results in increased longevity and enhanced insulin sensitivity in mice. |
2021-04-02 |
2023-08-13 |
mouse |
| Showkat Ahmad Dar, Prem Prakash Srivastava, Mohd Ashraf Rather, Tincy Varghese, Sheikh Irfan Rasool, Subodh Gupt. Molecular and computational analysis of Ghrelin, growth hormone Secretagogues receptor and mRNA expression of Growth-related genes after exogenous administered ghrelin peptide in Labeo rohita. International journal of biological macromolecules. vol 142. 2020-06-12. PMID:31622719. |
the mrna expression level of ghrelin, leptin, ghsr, growth hormone releasing hormone (ghrh) and insulin growth factor-i (igf-1) revealed significant changes (p < 0.05), in the different treatments. |
2020-06-12 |
2023-08-13 |
Not clear |
| Pontirol. Peptide hormones: Review of current and emerging uses by nasal delivery. Advanced drug delivery reviews. vol 29. issue 1-2. 2019-11-20. PMID:10837581. |
luteinizing hormone releasing hormone, the analogues, desmopressin, oxytocin and salmon calcitonin are already marketed for intranasal administration; for salmon calcitonin, studies about bioavailability have been scanty in the past, but should be re-considered in order to fully explore its clinical benefit.intranasal peptide hormones not yet on the market are insulin, glucagon, growth hormone releasing hormone (ghrh) and ghrp, gh and somatostatin, but the scenario is likely to change in a short period of time. |
2019-11-20 |
2023-08-12 |
Not clear |
| Leonid E Fridlyand, Natalia A Tamarina, Andrew V Schally, Louis H Philipso. Growth Hormone-Releasing Hormone in Diabetes. Frontiers in endocrinology. vol 7. 2019-11-20. PMID:27777568. |
among the peripheral activities, recent studies demonstrate a novel ability of ghrh analogs to increase and preserve insulin secretion by beta-cells in isolated pancreatic islets, which makes them potentially useful for diabetes treatment. |
2019-11-20 |
2023-08-13 |
Not clear |
| Avinash Kharat, Bhawna Chandravanshi, Shashikant Gadre, Vikrant Patil, Ramesh Bhonde, Aparna Dubhash. IGF-1 and somatocrinin trigger islet differentiation in human amniotic membrane derived mesenchymal stem cells. Life sciences. vol 216. 2019-01-07. PMID:30444986. |
to induce differentiation of human amniotic membrane derived mesenchymal stem cells (hammscs) into insulin producing cells (ipcs) by treating with somatocrinin or growth hormone releasing hormone (ghrh) and insulin-like growth factor-1 (igf-1). |
2019-01-07 |
2023-08-13 |
human |
| Han Qiu, Jin-Kui Yang, Chen Che. Influence of insulin on growth hormone secretion, level and growth hormone signalling. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 5. 2018-08-29. PMID:29063103. |
insulin may exert positive or negative effects on the neurons expressing ghrh and ss and somatotropes under healthy and pathological conditions including obesity and diabetes. |
2018-08-29 |
2023-08-13 |
Not clear |
| Lyvianne Decourtye, Maud Clemessy, Erik Mire, Tatiana Ledent, Laurence Périn, Iain C Robinson, Yves Le Bouc, Laurent Kappele. Impact of insulin on primary arcuate neurons culture is dependent on early-postnatal nutritional status and neuronal subpopulation. PloS one. vol 13. issue 2. 2018-05-21. PMID:29466413. |
our data suggest that insulin failed to directly control axonal growth of arc neurons or influence specific igf-1-mediated effects on ghrh neurons. |
2018-05-21 |
2023-08-13 |
mouse |
| Carolina Di Somma, Alessandro Ciresi, Marco C Amato, Silvia Savastano, Maria Cristina Savanelli, Elisabetta Scarano, Annamaria Colao, Carla Giordan. Alteration of the growth hormone axis, visceral fat dysfunction, and early cardiometabolic risk in adults: the role of the visceral adiposity index. Endocrine. vol 49. issue 2. 2016-05-26. PMID:25381601. |
anthropometric measures, lipid profile, and glucose and insulin levels during oral glucose tolerance test, homa-ir and isi matsuda, igf-i and gh peak after ghrh plus arginine test were analyzed. |
2016-05-26 |
2023-08-13 |
human |
| Xianyang Zhang, Tengjiao Cui, Jinlin He, Haibo Wang, Renzhi Cai, Petra Popovics, Irving Vidaurre, Wei Sha, Janine Schmid, Barbara Ludwig, Norman L Block, Stefan R Bornstein, Andrew V Schall. Beneficial effects of growth hormone-releasing hormone agonists on rat INS-1 cells and on streptozotocin-induced NOD/SCID mice. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 44. 2016-03-02. PMID:26474831. |
in vitro treatment of ins-1 cells with ghrh agonists increased cell proliferation, the expression of cellular insulin, insulin-like growth factor-1 (igf1), and ghrh receptor, and also stimulated insulin secretion in response to glucose challenge. |
2016-03-02 |
2023-08-13 |
mouse |
| Xianyang Zhang, Tengjiao Cui, Jinlin He, Haibo Wang, Renzhi Cai, Petra Popovics, Irving Vidaurre, Wei Sha, Janine Schmid, Barbara Ludwig, Norman L Block, Stefan R Bornstein, Andrew V Schall. Beneficial effects of growth hormone-releasing hormone agonists on rat INS-1 cells and on streptozotocin-induced NOD/SCID mice. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 44. 2016-03-02. PMID:26474831. |
the maximal therapeutic benefits with respect to the efficiency of engraftment, ability to reach normoglycemia, gain in body weight, response to high glucose challenge, and induction of higher levels of serum insulin and igf1 were observed when diabetic mice were transplanted with rat islets preconditioned with ghrh agonist, mr-409, and received additional treatment with mr-409 posttransplantation. |
2016-03-02 |
2023-08-13 |
mouse |
| Liou Y Sun, Adam Spong, William R Swindell, Yimin Fang, Cristal Hill, Joshua A Huber, Jacob D Boehm, Reyhan Westbrook, Roberto Salvatori, Andrzej Bartk. Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice. eLife. vol 2. 2015-03-30. PMID:24175087. |
ghrh knockout mice are remarkably long-lived, exhibiting major shifts in the expression of genes related to xenobiotic detoxification, stress resistance, and insulin signaling. |
2015-03-30 |
2023-08-12 |
mouse |
| Deepti Nair, Vijay Ramesh, Richard C Li, Andrew V Schally, David Goza. Growth hormone releasing hormone (GHRH) signaling modulates intermittent hypoxia-induced oxidative stress and cognitive deficits in mouse. Journal of neurochemistry. vol 127. issue 4. 2014-01-06. PMID:23815362. |
here, we show that administration of the growth hormone releasing hormone (ghrh) agonist ji-34 attenuates ih-induced neurocognitive deficits, anxiety, and depression in mice along with reduction in oxidative stress markers such as mda and 8-hydroxydeoxyguanosine, and increases in hypoxia inducible factor-1α dna binding and up-regulation of insulin growth factor-1 and erythropoietin expression. |
2014-01-06 |
2023-08-12 |
mouse |
| Manuel D Gahete, José Córdoba-Chacón, Qing Lin, Jens C Brüning, C Ronald Kahn, Justo P Castaño, Helen Christian, Raúl M Luque, Rhonda D Kinema. Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms. Endocrinology. vol 154. issue 7. 2013-08-28. PMID:23671263. |
however, comparison of the pattern of gh release, gh expression, somatotrope morphometry, and pituitary explant sensitivity to acute ghrh challenge in lean sirko and sigfrko mice strongly suggests the primary role of insulin in vivo is to suppress gh release, whereas igf-i serves to regulate gh synthesis. |
2013-08-28 |
2023-08-12 |
mouse |