Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Zahra Sadat Aghili, Golnoosh Khoshnevisan, Rezvan Mostoli, Mehdi Alibaglouei, Sayyed Hamid Zarkesh-Esfahan. Growth hormone signaling and clinical implications: from molecular to therapeutic perspectives. Molecular biology reports. vol 52. issue 1. 2025-02-04. PMID:39904816. |
however, gh therapy requires close monitoring to prevent side effects like insulin resistance and metabolic complications. |
2025-02-04 |
2025-02-07 |
human |
Federico Gatto, Anna Arecco, Jessica Amarù, Marica Arvigo, Claudia Campana, Angelo Milioto, Daniela Esposito, Gudmundur Johannsson, Francesco Cocchiara, Davide Carlo Maggi, Diego Ferone, Alessandra Pudd. Differential Impact of Medical Therapies for Acromegaly on Glucose Metabolism. International journal of molecular sciences. vol 26. issue 2. 2025-01-25. PMID:39859181. |
elevated gh concentrations directly attenuate insulin signalling and stimulate lipolysis, decreasing glucose uptake in peripheral tissues, thus leading to the development of impaired glucose tolerance and dm. |
2025-01-25 |
2025-01-28 |
Not clear |
Parminder Singh, Anil Gautam, Marissa Trujillo, James Galligan, Lisa Hensley, Pankaj Kapahi, Andrzej Bartk. Growth Hormone Excess Drives Liver Aging via increased Glycation stress. bioRxiv : the preprint server for biology. 2025-01-20. PMID:39829894. |
intervention with glycation-lowering compounds effectively reversed the insulin resistance and aberrant transcriptomic signatures in the liver that are associated with elevated gh levels. |
2025-01-20 |
2025-01-23 |
mouse |
Betina Biagetti, Marta Araujo-Castro, Mónica Marazuela, Manel Puig-Doming. Treatment of acromegaly-induced diabetes: an updated proposal. Pituitary. vol 28. issue 1. 2024-12-31. PMID:39738706. |
acromegaly-induced diabetes presents unique features due to the direct effects of excess growth hormone (gh) and insulin-like growth factor 1 (igf-) on glucose metabolism, especially insulin resistance in association to low body fat content and water retention. |
2024-12-31 |
2025-01-03 |
Not clear |
Mariana R Tavares, Willian O Dos Santos, Andressa G Amaral, Edward O List, John J Kopchick, Guilherme A Alves, Renata Frazao, Jessica D M Dos Santos, Alessandra G Cruz, João Paulo Camporez, Jose Donat. Growth hormone receptor in VGLUT2 or Sim1 cells regulates glycemia and insulin sensitivity. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 52. 2024-12-19. PMID:39700135. |
for example, gh oversecretion induces insulin resistance and increases the risk of developing diabetes mellitus. |
2024-12-19 |
2024-12-22 |
Not clear |
Kevin C J Yuen, Rikke Hjortebjerg, Ashok Ainkaran Ganeshalingam, David R Clemmons, Jan Frysty. Growth hormone/insulin-like growth factor I axis in health and disease states: an update on the role of intra-portal insulin. Frontiers in endocrinology. vol 15. 2024-12-12. PMID:39665021. |
however, portal insulin delivery is also an essential co-player in the regulation of the gh/igf-i axis by affecting and regulating hepatic gh receptor synthesis, and subsequently altering hepatic gh sensitivity and igf-i generation. |
2024-12-12 |
2024-12-14 |
Not clear |
Kevin C J Yuen, Rikke Hjortebjerg, Ashok Ainkaran Ganeshalingam, David R Clemmons, Jan Frysty. Growth hormone/insulin-like growth factor I axis in health and disease states: an update on the role of intra-portal insulin. Frontiers in endocrinology. vol 15. 2024-12-12. PMID:39665021. |
disease states of gh excess (e.g., acromegaly) and gh deficiency (e.g., congenital isolated gh deficiency) are characterized by increased and decreased gh, igf-i and insulin levels, respectively, where the gh/igf-i relationship is reflected by a "primary association". |
2024-12-12 |
2024-12-14 |
Not clear |
Kevin C J Yuen, Rikke Hjortebjerg, Ashok Ainkaran Ganeshalingam, David R Clemmons, Jan Frysty. Growth hormone/insulin-like growth factor I axis in health and disease states: an update on the role of intra-portal insulin. Frontiers in endocrinology. vol 15. 2024-12-12. PMID:39665021. |
when intra-portal insulin levels are increased (e.g., obesity, cushing's syndrome, or due to treatment with glucocorticoids and glucagon-like peptide 1 receptor agonists) or decreased (e.g., malnutrition, anorexia nervosa and type 1 diabetes mellitus), these changes secondarily alter hepatic gh sensitivity resulting in a "secondary association" with discordant gh and igf-i levels (e.g., high gh/low igf-i levels or low gh/high igf-i levels, respectively). |
2024-12-12 |
2024-12-14 |
Not clear |
Kevin C J Yuen, Rikke Hjortebjerg, Ashok Ainkaran Ganeshalingam, David R Clemmons, Jan Frysty. Growth hormone/insulin-like growth factor I axis in health and disease states: an update on the role of intra-portal insulin. Frontiers in endocrinology. vol 15. 2024-12-12. PMID:39665021. |
through its effects on igfbp-1 and subsequently free igf-i, intra-portal insulin exerts its effects to influence endogenous gh secretion via the negative feedback loop. |
2024-12-12 |
2024-12-14 |
Not clear |
Umut Altunoglu, Gozde Tutku Turgut, Esin Karakılıç Özturan, Tuğba Kalaycı, Mert Kaya, Güven Toksoy, Firdevs Baş, Hülya Kayserili, Feyza Darendelile. Expanding the Clinical and Mutational Spectrum of Biallelic POC1A Variants: Characterization of Four Patients and a Comprehensive Review of POC1A-Related Phenotypes. Clinical genetics. 2024-12-11. PMID:39662966. |
endocrine abnormalities included insulin resistance and impaired glucose tolerance, dyslipidemia, gh deficiency, central hypothyroidism, and precocious puberty. |
2024-12-11 |
2024-12-14 |
human |
Tiphaine Carton, Coralie Thiry, Fleur Wolff, Bernard Corvilain, Agnès Burnia. Impact of sweet drink on pituitary response and subject comfort during insulin tolerance test. Scientific reports. vol 14. issue 1. 2024-12-02. PMID:39622921. |
the insulin tolerance test (itt) is the gold standard for the diagnosis of cortisol and growth hormone (gh) deficiencies. |
2024-12-02 |
2024-12-06 |
human |
Hasanain MohammedHuthaifa AbdlWhab, Araz Al-Saffar, Osama Abbas Mahdi, Rafid Badri Alamer. The impact of insulin resistance and glycaemic control on insulin-like growth factor-1 in patients with type 2 diabetes: a cross-sectional study. Clinical diabetes and endocrinology. vol 10. issue 1. 2024-11-23. PMID:39578883. |
these hormones, while interrelated, exert differential effects on glucose homeostasis; gh elevates blood glucose levels, whereas igf-1 sustains insulin secretion and augments insulin sensitivity. |
2024-11-23 |
2024-11-25 |
Not clear |
Igor A Suslin, Iakov V Efimenko, Ricardo Castrellon, Tarik M Husai. Abdominal Hypertrophy Syndrome: Characteristics and Potential Pathophysiology. Cureus. vol 16. issue 10. 2024-11-21. PMID:39569303. |
abdominal hypertrophy syndrome, known as steroid gut, is an uncommon condition affecting bodybuilders and athletes engaged in prolonged usage of growth hormone (gh), insulin, and other anabolic agents. |
2024-11-21 |
2024-11-23 |
human |
Igor A Suslin, Iakov V Efimenko, Ricardo Castrellon, Tarik M Husai. Abdominal Hypertrophy Syndrome: Characteristics and Potential Pathophysiology. Cureus. vol 16. issue 10. 2024-11-21. PMID:39569303. |
the available anecdotal data suggest that the prolonged use of high-dose anabolic steroids, particularly human gh and insulin, may contribute to the development of palumboism. |
2024-11-21 |
2024-11-23 |
human |
Seong Hwan Chang, Chan Jong Ki. Comparison of growth hormone stimulation tests in prepubertal children with short stature according to response to growth hormone replacement. Annals of pediatric endocrinology & metabolism. vol 29. issue 5. 2024-11-07. PMID:39506345. |
we aimed to compare l-dopa, insulin, and arginine-induced stimulation tests based on response to gh replacement. |
2024-11-07 |
2024-11-09 |
Not clear |
T Takahashi, K Kidachi, M Yukawa, Hachinohe, Y Takashima, M Fujimura, A Saito, D Soga, C Ota, E Niizuma, K Sato, H Ogasawara, Y Kuros. D-Aspartate Stimulates Growth Hormone Secretion in Wethers. Journal of animal science. 2024-10-21. PMID:39432441. |
blood gh, insulin, adrenaline, noradrenaline, non-esterified fatty acid (nefa), and glucose concentrations were evaluated in response to the intravenous infusion of a high-dose (0.1 mmol/kg/min) of d-asp for 20 min. |
2024-10-21 |
2024-10-24 |
Not clear |
Iulia Stefania Plotuna, Melania Balas, Ioana Golu, Daniela Amzar, Roxana Popescu, Ligia Petrica, Adrian Vlad, Daniel Luches, Daliborca Cristina Vlad, Mihaela Vla. The Use of Kidney Biomarkers, Nephrin and KIM-1, for the Detection of Early Glomerular and Tubular Damage in Patients with Acromegaly: A Case-Control Pilot Study. Diseases (Basel, Switzerland). vol 12. issue 9. 2024-09-27. PMID:39329880. |
high levels of gh and insulin growth factor-1 can lead to renal hypertrophy, as well as to diabetes mellitus and hypertension, which negatively impact kidney function. |
2024-09-27 |
2024-09-29 |
Not clear |
Joanna Kawalec, Wojciech Horzelski, Małgorzata Karbownik-Lewińska, Andrzej Lewiński, Krzysztof C Lewandowsk. Determination of glucose cut-off points for optimal performance of glucagon stimulation test. Frontiers in endocrinology. vol 15. 2024-09-12. PMID:39262672. |
we have endeavoured to explore the relationship between glucose and insulin fluctuations during gst and their impact on gh and cortisol secretion. |
2024-09-12 |
2024-09-14 |
Not clear |
Francesco Rossi, Thithawat Trakoolwilaiwan, Valeria Gigli, Cristina Tortolini, Andrea Lenzi, Andrea Maria Isidori, Nguyen Thi Kim Thanh, Riccarda Antiochi. Progress in nanoparticle-based electrochemical biosensors for hormone detection. Nanoscale. 2024-09-10. PMID:39254475. |
this review represents a critical comparison between different types of nanoparticle-based electrochemical biosensors for the detection of various hormones, namely cortisol, sex hormones (estradiol, progesterone, testosterone), insulin, thyroid-stimulating hormone (tsh) and growth hormone (gh). |
2024-09-10 |
2024-09-13 |
Not clear |
Maura Fanti, Valter Long. Nutrition, GH/IGF-I signaling, and cancer. Endocrine-related cancer. 2024-08-21. PMID:39166749. |
here we review the role of nutrition, cr, and fasting/fmd on cancer, focusing on the hypothesis that the modulation of gh, igf-i, and insulin signaling partly mediates the effect of these dietary interventions on cancer prevention. |
2024-08-21 |
2024-08-24 |
Not clear |