| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kanglu Li, Wenbo Yang, Xuanzuo Chen, Yihan Yu, Yiran Liu, Feifei Ni, Yan Xiao, Xiangcheng Qing, Sheng Liu, YuXin He, Baichuan Wang, Li Xu, Zengwu Shao, Lei Zhao, Yizhong Peng, Hui Li. A structured biomimetic nanoparticle as inflammatory factor sponge and autophagy-regulatory agent against intervertebral disc degeneration and discogenic pain. Journal of nanobiotechnology. vol 22. issue 1. 2024-08-14. PMID:39143545. |
in addition, tmnp@sr relieved mechanical and thermal hyperalgesia, reduced calcitonin gene-related peptide (cgrp) and substance p (sp) expression in the dorsal root ganglion, and downregulated gfap and c-fos signaling in the spinal cord in the rat idd model. |
2024-08-14 |
2024-08-17 |
rat |
| Jie Quan, Chun Jing He, Ji Yeon Kim, Jin Young Lee, Chang Jae Kim, Young Jae Jeon, Chang Woo Im, Do Kyung Lee, Ji Eun Kim, Hue Jung Par. Analgesic Effect of SKI306X on Chronic Postischemic Pain and Spinal Nerve Ligation-Induced Neuropathic Pain in Mice. Biomedicines. vol 12. issue 7. 2024-07-27. PMID:39061952. |
we also measured glial fibrillary acidic protein (gfap) levels in the spinal cord and dorsal root ganglia to confirm the change of ski306x administration. |
2024-07-27 |
2024-07-29 |
mouse |
| Lin-Li Chang, Yu-Ming Wu, Hung-Chen Wang, Kuang-Yi Tseng, Yi-Hsuan Wang, Yen-Mou Lu, Kuang-I Chen. Cilostazol Ameliorates Motor Dysfunction and Schwann Cell Impairment in Streptozotocin-Induced Diabetic Rats. International journal of molecular sciences. vol 25. issue 14. 2024-07-27. PMID:39063088. |
the sciatic nerve, l5 spinal cord, and spinal ventral root were collected to evaluate the expression of the glial fibrillary acidic protein (gfap), myelin protein zero (p0), and choline acetyltransferase (chat) by immunofluorescence and western blotting. |
2024-07-27 |
2024-07-29 |
rat |
| Megumi Sumizono, Yushin Yoshizato, Takaki Imai, Akira Tani, Kazuki Nakanishi, Nao Nojima, Shogo Kakimoto, Harutoshi Sakakim. Effects of Pain Relief Through Minimal Exercise Intervention in a Rat Model of Neuropathic Pain. Cureus. vol 16. issue 6. 2024-07-24. PMID:39044893. |
in the dorsal horn of the spinal cord, iba1 and gfap were significantly decreased in the ex group than in the no-ex group at five weeks post-cci. |
2024-07-24 |
2024-07-26 |
rat |
| Ruo-Mei Cui, Fu-Rong Fan, Shou-Hong Ma, Hua Li, Jin-Chun Li, Yu Wen, Ming-Wei Li. Autoimmune glial fibrillary acidic protein astrocytopathy with anti-NMDAR and sulfatide-IgG-positive encephalitis overlap syndrome: A case report and literature review. Medicine. vol 103. issue 28. 2024-07-12. PMID:38996095. |
autoimmune glial fibrillary acidic protein (gfap) astrocytopathy is a rare autoimmune disease of the central nervous system that affects the meninges, brain, spinal cord, and optic nerves. |
2024-07-12 |
2024-07-15 |
Not clear |
| Jenna B Honeycutt, Angela Wahl, Jacob K Files, Alexis F League, Barkha J Yadav-Samudrala, J Victor Garcia, Sylvia Fittin. In situ analysis of neuronal injury and neuroinflammation during HIV-1 infection. Retrovirology. vol 21. issue 1. 2024-06-30. PMID:38945996. |
to evaluate cns pathology during hiv-1 infection in the humanized bone marrow/liver/thymus (blt) mouse model, a histological analysis was conducted on five cns regions, including the frontal cortex, hippocampus, striatum, cerebellum, and spinal cord, to delineate the neuronal (map2ab, neun) and neuroinflammatory (gfap, iba-1) changes induced by two viral strains after 2 weeks and 8 weeks post-infection. |
2024-06-30 |
2024-07-03 |
mouse |
| Yongguo Zhang, Yinglin Xia, Jun Su. Probiotics and microbial metabolites maintain barrier and neuromuscular functions and clean protein aggregation to delay disease progression in TDP43 mutation mice. Gut microbes. vol 16. issue 1. 2024-06-11. PMID:38860943. |
we observed increased hmtdp43 and glial fibrillary acidic protein (gfap), and decreased expression of α-smooth muscle actin (α-sma), tight junction proteins (zo-1 and claudin-5) in the colon, spinal cord, and brain in tdp43 mice. |
2024-06-11 |
2024-06-14 |
mouse |
| Bheru D Charan, Shikha Priya, Vinay Goel, Pinky Chhatarpal, Savyasachi Jain, Anu Gupta, Ajay Gar. Unveiling Distinctive MRI Characteristics in the Diagnosis of GFAP Astrocytopathy: A Rare Autoimmune Neuroinflammatory Disorder. Annals of Indian Academy of Neurology. 2024-06-10. PMID:38856160. |
glial fibrillary acidic protein (gfap) astrocytopathy is a rare autoimmune inflammatory disorder affecting the central nervous system, involving the meninges, brain parenchyma, and spinal cord. |
2024-06-10 |
2024-06-14 |
Not clear |
| Hassan Reda Hassan Elsayed, Eyad Mohamed Tolba Ali, Mohammed Rami Rabei, Eman Mohamad El Nashar, Mansour Abdullah Alghamdi, Norah Saeed Al-Zahrani, Shaker Hassan Alshehri, Rashid A Aldahhan, Amira Ibrahim Mors. Angiotensin II Type 1 receptor blockade attenuates the neuropathological changes in the spinal cords of diabetic rats with modulation of nuclear factor erythroid 2-related factor 2/ heme oxygenase 1 system. Tissue & cell. vol 88. 2024-05-25. PMID:38795506. |
after two months, the pathological alteration in the spinal cord was investigated, and an immunohistochemical study was performed for neuronal, astrocytic, and microglial markers; nuclear protein (neun), glial fibrillary acidic protein (gfap), and ionized calcium-binding adaptor molecule 1 (iba1), respectively, and for an apoptosis marker; caspase-3, and the inflammatory marker; nuclear factor kappa b (nf-kb) signaling, heme oxygenase-1 (ho-1) and nuclear factor erythroid 2-related factor 2 (nrf2); physiological antioxidant system. |
2024-05-25 |
2024-05-31 |
rat |
| Shanglong Ning, Yang Chen, Jia Shao, Hui Zhu, Zepei Zhang, Jun Mia. The effects of acteoside on locomotor recovery after spinal cord injury - The role of autophagy and apoptosis signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 175. 2024-05-01. PMID:38692056. |
then, by preparing spinal cord cell homogenates, the expression levels of map1lc3a, map-2, glial fibrillary acidic protein (gfap), nrf2, keap-1, caspase 3 (casp3), bax, bcl-2, tnf-a, il-1b, reactive oxygen species (ros), and malondialdehyde (mda) were measured. |
2024-05-01 |
2024-05-04 |
rat |
| Caio Andrade Prins, Felipe Leite de Oliveira, Valeria de Mello Coelho, Emanuela Bezerra Dos Santos Ribeiro, Juliana Silva de Almeida, Natalia Moraes Bechelli Silva, Fernanda Martins Almeida, Ana Maria Blanco Martine. Galectin-3 absence alters lymphocytes populations dynamics behavior and promotes functional recovery after spinal cord injury in mice. Experimental neurology. 2024-04-26. PMID:38670250. |
at 42-day dpi immunohistochemistry analyses displayed reduced astrogliosis and greater axon preservation in galneg's spinal cord seem as a reduction of gfap immunostaining and an increase in nfh immunostaining, respectively. |
2024-04-26 |
2024-04-29 |
mouse |
| Zi-Jie Rong, Min Chen, Hong-Hua Cai, Gui-Hua Liu, Jin-Biao Chen, Hao Wang, Zhi-Wen Zhang, Yu-Liang Huang, Shuang-Fei N. Ursolic acid molecules dock MAPK1 to modulate gut microbiota diversity to reduce neuropathic pain. Neuropharmacology. 2024-04-03. PMID:38570065. |
additionally, immunofluorescent staining showed a decrease in gfap and iba1 intensity in the spinal cord along with an increase in neun following ursolic acid treatment. |
2024-04-03 |
2024-04-06 |
rat |
| Hongda Yi, Bin Zhu, Caihong Zheng, Zhenyang Ying, Mei Chen. CXCL13/CXCR5 promote chronic postsurgical pain and astrocyte activation in rats by targeting NLRP3. Neuroreport. 2024-03-25. PMID:38526919. |
the anti-cxcl13 antibody alleviated smir-induced decreased pwt and increased expression of gfap, cxcl13, cxcr5, nlrp3, and caspase-1 p20 in spinal cord tissues. |
2024-03-25 |
2024-03-28 |
rat |
| Chwan-Li Shen, Rui Wang, Julianna Maria Santos, Moamen M Elmassry, Emily Stephens, Nicole Kim, Volker Neugebaue. Ginger alleviates mechanical hypersensitivity and anxio-depressive behavior in rats with diabetic neuropathy through beneficial actions on gut microbiome composition, mitochondria, and neuroimmune cells of colon and spinal cord. Nutrition research (New York, N.Y.). vol 124. 2024-02-25. PMID:38402829. |
geg supplementation suppressed the dynamin-related protein 1 protein expression (colon) and gene expression (spinal cord), astrocytic marker gfap gene expression (colon and spinal cord), and tumor necrosis factor-α gene expression (colon, p < .05; spinal cord, p = .0974) in dnp rats. |
2024-02-25 |
2024-02-28 |
rat |
| Dea Gogishvili, Eva Illes-Toth, Matthew J Harris, Christopher Hopley, Charlotte E Teunissen, Sanne Abel. Structural flexibility and heterogeneity of recombinant human glial fibrillary acidic protein (GFAP). Proteins. 2023-12-27. PMID:38149328. |
glial fibrillary acidic protein (gfap) is a promising biomarker for brain and spinal cord disorders. |
2023-12-27 |
2023-12-29 |
human |
| Fernanda B de M Monte, Tadeu L Montagnoli, Bruno E Dematté, Fernanda Gubert, Vitória S Ventura, Jaqueline S da Silva, Margarete M Trachez, Rosalia Mendez-Otero, Gisele Zapata-Sud. Antinociceptive Effect of the Combination of a Novel α4β2* Agonist with Donepezil in a Chronic Pain Model. Biomedicines. vol 11. issue 12. 2023-12-23. PMID:38137470. |
the combination also modulated neuroinflammation by reducing astrocyte activation, evident in the decreased expression of glial fibrillary acidic protein (gfap) in the spinal cord. |
2023-12-23 |
2023-12-25 |
rat |
| Julianna M Santos, Rui Wang, Viren Bhakta, Zarek Driver, Yakhnitsa Vadim, Takaki Kiritoshi, Guangchen Ji, Volker Neugebauer, Chwan-Li She. Turmeric Bioactive Compounds Alleviate Spinal Nerve Ligation-Induced Neuropathic Pain by Suppressing Glial Activation and Improving Mitochondrial Function in Spinal Cord and Amygdala. Nutrients. vol 15. issue 20. 2023-10-30. PMID:37892476. |
the lumbosacral section of the spinal cord and the right amygdala (central nucleus) were collected to determine the mrna expression of genes (iba-1, cd11b, gfap, mfn1, drp1, fis1, pgc1α, pink, complex i, tlr4, and sod1) utilizing qrt-pcr. |
2023-10-30 |
2023-11-08 |
rat |
| Julianna M Santos, Rui Wang, Viren Bhakta, Zarek Driver, Yakhnitsa Vadim, Takaki Kiritoshi, Guangchen Ji, Volker Neugebauer, Chwan-Li She. Turmeric Bioactive Compounds Alleviate Spinal Nerve Ligation-Induced Neuropathic Pain by Suppressing Glial Activation and Improving Mitochondrial Function in Spinal Cord and Amygdala. Nutrients. vol 15. issue 20. 2023-10-30. PMID:37892476. |
increased mechanical hypersensitivity and increased gene expression of markers for microglial activation (iba-1 in the amygdala and cd11b in the spinal cord), astrocyte activation (gfap in the spinal cord), mitochondrial dysfunction (pgc1α in the amygdala), and oxidative stress (tlr4 in the spinal cord and amygdala) were found in untreated snl rats. |
2023-10-30 |
2023-11-08 |
rat |
| Julianna M Santos, Rui Wang, Viren Bhakta, Zarek Driver, Yakhnitsa Vadim, Takaki Kiritoshi, Guangchen Ji, Volker Neugebauer, Chwan-Li She. Turmeric Bioactive Compounds Alleviate Spinal Nerve Ligation-Induced Neuropathic Pain by Suppressing Glial Activation and Improving Mitochondrial Function in Spinal Cord and Amygdala. Nutrients. vol 15. issue 20. 2023-10-30. PMID:37892476. |
cur decreased cd11b and gfap gene expression in the spinal cord. |
2023-10-30 |
2023-11-08 |
rat |
| Julianna M Santos, Rui Wang, Viren Bhakta, Zarek Driver, Yakhnitsa Vadim, Takaki Kiritoshi, Guangchen Ji, Volker Neugebauer, Chwan-Li She. Turmeric Bioactive Compounds Alleviate Spinal Nerve Ligation-Induced Neuropathic Pain by Suppressing Glial Activation and Improving Mitochondrial Function in Spinal Cord and Amygdala. Nutrients. vol 15. issue 20. 2023-10-30. PMID:37892476. |
bdmc decreased iba-1 in the spinal cord and amygdala as well as cd11b and gfap in the spinal cord. |
2023-10-30 |
2023-11-08 |
rat |