| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiu-Qing Yan, Tian-Long Liu, Ling-Ling Liu, Yan-Su Wei, Yuan-Dan Zhao, Chao Yu, Zhen-Guo Zhong, Jin-Lan Huang, Deng-Pan W. Mitochondrial Treatment Improves Cognitive Impairment Induced by Lipopolysaccharide in Mice. Molecular neurobiology. 2024-07-22. PMID:39037529. |
additionally, mitochondrial therapy attenuated neuronal injury and down-regulated the expression of proinflammatory cytokines, including tnf-α and pro- and cleaved il-1β, and the expression of iba-1 and gfap in the hippocampus and cortex of lps-treated mice. |
2024-07-22 |
2024-07-24 |
mouse |
| Facundo Peralta, Ana Abril Vidal Escobedo, Juliette López Hanotte, Martino Avallone, Tomas Björklund, Paula Cecilia Reggiani, Joaquín Pard. Preventive cognitive protection based on AAV9 overexpression of IGF1 in hippocampal astrocytes. Neurobiology of disease. 2024-07-20. PMID:39032798. |
we overexpressed igf1 and the reporter tdtomato (tom) in hippocampal astrocytes with bicistronic adeno-associated virus (aav) harboring the glial fibrillary acidic protein (gfap) promoter and afterwards induced neurodegeneration by the intracerebroventricular (icv) injection of streptozotocin (stz), a rat model of behavioral impairment, neuroinflammation and shortening of hippocampal astrocytes. |
2024-07-20 |
2024-07-24 |
rat |
| Reham L Younis, Rehab M El-Gohary, Asmaa A Ghalwash, Islam Ibrahim Hegab, Maram M Ghabrial, Azza M Aboshanady, Raghad A Mostafa, Alaa H Abd El-Azeem, Eman E Farghal, Asmaa A E Belal, Haidy Khatta. Luteolin Mitigates D-Galactose-Induced Brain Ageing in Rats: SIRT1-Mediated Neuroprotection. Neurochemical research. 2024-07-10. PMID:38987448. |
hippocampal histopathological studies, along with gfap and ki67 immunoreactivity, were performed. |
2024-07-10 |
2024-07-13 |
rat |
| Jenna B Honeycutt, Angela Wahl, Jacob K Files, Alexis F League, Barkha J Yadav-Samudrala, J Victor Garcia, Sylvia Fittin. In situ analysis of neuronal injury and neuroinflammation during HIV-1 infection. Retrovirology. vol 21. issue 1. 2024-06-30. PMID:38945996. |
to evaluate cns pathology during hiv-1 infection in the humanized bone marrow/liver/thymus (blt) mouse model, a histological analysis was conducted on five cns regions, including the frontal cortex, hippocampus, striatum, cerebellum, and spinal cord, to delineate the neuronal (map2ab, neun) and neuroinflammatory (gfap, iba-1) changes induced by two viral strains after 2 weeks and 8 weeks post-infection. |
2024-06-30 |
2024-07-03 |
mouse |
| Hironori Oka, Takumi Nakamura, Takashi Sugawara, Kunihiko Ishizawa, Masakuni Amari, Takeshi Kawarabayashi, Koichi Okamoto, Masamitsu Takatama, Satoshi Nakata, Yuhei Yoshimoto, Ayako Yamazaki, Hideaki Yokoo, Akio Kimura, Takayoshi Shimohata, Yoshio Ikeda, Mikio Shoj. A case of chronic progressive autoimmune GFAP astrocytopathy with extensive meningoencephalomyelitis and contrast enhancement on MRI. eNeurologicalSci. vol 35. 2024-06-24. PMID:38911509. |
•we herein present a case of chronic progressive autoimmune gfap astrocytopathy.•symmetrical high-intensity signals on flair were observed in the white matter of the temporal and occipital lobes, lateral cerebral ventricle walls, hippocampus, amygdala, and occipital cortex, with extensive gd enhancement in radial perivascular lesions and the ependyma in the choroid plexus.•improvements were achieved by 4 courses of ivmp and one of ivig. |
2024-06-24 |
2024-06-26 |
Not clear |
| D K Avrova, L V Bayunova, N F Avrova, I O Zakharov. The Effect of Intranasal Administration of Gangliosides on the Viability of CA1 Hippocampal Neurons in Rat Two-Vessel Occlusion Model of Forebrain Ischemia/Reperfusion Injury. Bulletin of experimental biology and medicine. 2024-06-21. PMID:38907060. |
the immunohistochemical reaction of specific antibodies to marker proteins of activated microglia (iba1) and astrocytes (gfap) in hippocampal slices revealed the neuroprotective effect of exogenous gangliosides which can be mostly explained by their ability to suppress neuroinflammation and gliosis. |
2024-06-21 |
2024-06-24 |
rat |
| Sara Barsanti, João Filipe Viana, Alexandra Veiga, João Luís Machado, Daniela Sofia Abreu, José Duarte Dias, Susana Monteiro, Nuno A Silva, Luísa Pinto, João Filipe Oliveir. Assessing Different Histological Preparations for Reconstruction of Astrocyte Tridimensional Structure. Cells. vol 13. issue 11. 2024-06-19. PMID:38891101. |
for that, we explored different tissue processing protocols before gfap labeling to determine the most effective method for reconstructing astrocytic backbones in the mouse hippocampus. |
2024-06-19 |
2024-06-21 |
mouse |
| Oriana Mandolfo, Helen Parker, Èlia Aguado, Yuko Ishikawa Learmonth, Ai Yin Liao, Claire O'Leary, Stuart Ellison, Gabriella Forte, Jessica Taylor, Shaun Wood, Rachel Searle, Rebecca J Holley, Hervé Boutin, Brian W Bigge. Systemic immune challenge exacerbates neurodegeneration in a model of neurological lysosomal disease. EMBO molecular medicine. 2024-06-18. PMID:38890537. |
this was accompanied by an increase in caspase-1 activity within the brain of mps iiia mice with concomitant loss of hippocampal gfap and neun expression. |
2024-06-18 |
2024-06-21 |
mouse |
| Walaa G Abdelhamid, Noha A Mowaad, Gihan F Asaad, Asmaa F Galal, Sarah S Mohammed, Olfat E Mostafa, Doaa R Sadek, Lobna A Elkhate. The potential protective effect of Camellia Sinensis in mitigating monosodium glutamate-induced neurotoxicity: biochemical and histological study in male albino rats. Metabolic brain disease. 2024-06-13. PMID:38869783. |
msg administration resulted in significant neurotoxicity in rats that was revealed by the significant reduction of serum concentration of glutathione peroxidase (gpx) and nitric oxide (no), and the significant elevation of total antioxidant capacity (tac) accompanied by the significant reduction of levels of serum monoamines (dopamine, serotonin, and norepinephrine) and histological changes in the hippocampus area ca1, dentate gyrus, and cerebellar cortex and positive immunohistochemical staining of glial fibrillary acidic proteins (gfap) and calretinin. |
2024-06-13 |
2024-06-15 |
rat |
| Naveen Singh, RamaRao Golime, Abdhesh Kumar, Tuhin Ro. Attenuation of Nerve Agent Induced Neurodegenerative and Neuroinflammatory Changes in Rats with New Combination Treatment of Galantamine, Atropine and Midazolam. Molecular neurobiology. 2024-06-12. PMID:38867111. |
in rats, nod-like receptor family pyrin domain containing 3 (nlrp3), and glial fibrillary acidic protein (gfap) immunoreactivity levels were considerably increased in the hippocampus, piriform cortex, and amygdala areas after single subcutaneous soman exposure (90 µg/kg |
2024-06-12 |
2024-06-15 |
rat |
| Arianna Mazzoli, Maria Stefania Spagnuolo, Francesca De Palma, Natasha Petecca, Angela Di Porzio, Valentina Barrella, Antonio Dario Troise, Rosanna Culurciello, Sabrina De Pascale, Andrea Scaloni, Gianluigi Mauriello, Susanna Iossa, Luisa Ciglian. Limosilactobacillus reuteri DSM 17938 relieves inflammation, endoplasmic reticulum stress, and autophagy in hippocampus of western diet-fed rats by modulation of systemic inflammation. BioFactors (Oxford, England). 2024-05-27. PMID:38801155. |
interestingly, pro-inflammatory signaling pathway activation (increased nfkb phosphorylation, raised amounts of toll-like receptor-4, tumor necrosis factor-alpha, interleukin-6, gfap, and haptoglobin), as well as activation of ers (increased perk and eif2α phosphorylation, higher c/ebp-homologous protein amounts) and autophagy (increased beclin, p62-sequestosome-1, and lc3 ii) was revealed in hippocampus of western diet fed rats. |
2024-05-27 |
2024-05-31 |
rat |
| Cansu Bilister Egilmez, Burcu Azak Pazarlar, Mumin Alper Erdogan, Yiğit Uyanikgil, Oytun Erba. Choline chloride shows gender-dependent positive effects on social deficits, learning/memory impairments, neuronal loss and neuroinflammation in the lipopolysaccharide-induced rat model of autism. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2024-05-09. PMID:38721665. |
in addition, the number of hippocampal and cerebellar neurons and glial fibrillary acidic protein (gfap) expression were evaluated. |
2024-05-09 |
2024-05-27 |
rat |
| Jit Poddar, Suresh B Rangasamy, Kalipada Paha. Therapeutic efficacy of cinnamein, a component of balsam of Tolu/Peru, in controlled cortical impact mouse model of TBI. Neurochemistry international. 2024-04-19. PMID:38641028. |
oral delivery of cinnamein through gavage brought down the activation of microglia and astrocytes to decrease the expression of inducible nitric oxide synthase (inos), glial fibrillary acidic protein (gfap) and ionized calcium binding adaptor molecule 1 (iba1) in hippocampus and cortex of tbi mice. |
2024-04-19 |
2024-04-22 |
mouse |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
immunofluorescence was used to detect gfap, iba1, and nlrp3 expression in the hippocampus. |
2024-04-16 |
2024-04-18 |
rat |
| Ji-Yong Liu, Wen-Li Zhang, Jun Liao, Li-Juan Hu, Guo-Zuo Wang, Jin-Wen Ge, Zhi-Gang Me. [Effect of Naotaifang on microglial polarization and glial scar following cerebral ischemia reperfusion injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 4. 2024-04-15. PMID:38621906. |
compared with the sham, model 7 d and model 14 d groups showed cerebral infarction of different degrees, severe pathological injury of cerebral cortex and hippocampus, neurological impairment, reduced spatial learning and memory, cognitive dysfunction, severe anxiety, astrocyte hyperplasia, thickening penumbra glial scar, and up-regulated protein levels of il-1β, il-6, gfap, neurocan, phosphacan, cd206, and arg-1(p<0.01). |
2024-04-15 |
2024-04-18 |
rat |
| Zuolin Zhou, Yanhua Bi, Chunchun Zhi, Siqi Chen, Die Chen, Zhen Wei, Xiaoling Jian. Astroglial activation is exacerbated in a Down syndrome mouse model. Neuroscience. 2024-04-14. PMID:38615829. |
the expression of gfap in in vitro cultured dp16 astrocytes was not increased as it was in in vivo hippocampal tissue. |
2024-04-14 |
2024-04-17 |
mouse |
| Moses B Ekong, Anna Andrioli, Imaobong E Israel, Edemeka I Ifot, Samuel E Dickson, Ilaria Scambi, Paolo F Fabene, Giuseppe Bertini, Marina Bentivogli. Evaluation of prenatal calabash chalk geophagy on the developing brain of Wistar rats. IBRO neuroscience reports. vol 16. 2024-03-28. PMID:38544793. |
no hippocampal and somatosensory cortical cytoarchitectonic alterations and no significant signs of glial fibrillary acidic protein (gfap) activation were observed. |
2024-03-28 |
2024-03-30 |
rat |
| Miguel Farinha-Ferreira, Daniela M Magalhães, Mariana Neuparth-Sottomayor, Hugo Rafael, Catarina Miranda-Lourenço, Ana M Sebastiã. Unmoving and uninflamed: Characterizing neuroinflammatory dysfunction in the Wistar-Kyoto rat model of depression. Journal of neurochemistry. 2024-03-02. PMID:38430009. |
in a separate cohort, we assessed prefrontal cortex (pfc), hippocampus and amygdala levels of markers of astrocytic (gfap, s100a10) and microglial (iba1, cd86, ym1) activation status, as well as of three key proinflammatory cytokines (il-1β, il-6, tnf-α). |
2024-03-02 |
2024-03-04 |
rat |
| Amira A Kamel, Ahmed Y Nassar, Fatma Y Meligy, Yomna A Omar, Gamal A Y Nassar, Ghada M Ezza. Acetylated oligopeptide and N-acetylcysteine protect against iron overload-induced dentate gyrus hippocampal degeneration through upregulation of Nestin and Nrf2/HO-1 and downregulation of MMP-9/TIMP-1 and GFAP. Cell biochemistry and function. vol 42. issue 2. 2024-02-24. PMID:38396357. |
acetylated oligopeptide and n-acetylcysteine protect against iron overload-induced dentate gyrus hippocampal degeneration through upregulation of nestin and nrf2/ho-1 and downregulation of mmp-9/timp-1 and gfap. |
2024-02-24 |
2024-02-26 |
rat |
| Bharti Biswas, Valsamma Eapen, Margaret J Morris, Nicole M Jone. Combined Effect of Maternal Separation and Early-Life Immune Activation on Brain and Behaviour of Rat Offspring. Biomolecules. vol 14. issue 2. 2024-02-24. PMID:38397434. |
ms increased glial fibrillary acidic protein (gfap) and brain-derived neurotrophic factor expression in pfc and ionised calcium-binding adapter molecule-1 expression in male hippocampus. |
2024-02-24 |
2024-02-26 |
rat |