| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daopeng Luo, Baofei Sun, Wenjuan Wang, Aihua Zhan. The Role of the cGAS/STING Pathway in Arsenic-Induced Neurotoxicity: Insights from the Crosstalk Between Astrocytes and Neurons. Biological trace element research. 2024-12-18. PMID:39693001. |
specifically, markers of astrocyte activation, such as glial fibrillary acidic protein (gfap) and inducible nitric oxide synthase (inos), as well as the inflammatory cytokine interleukin (il)-1β, were significantly upregulated, and apoptosis was markedly increased, indicating neurotoxic damage. |
2024-12-18 |
2024-12-21 |
rat |
| Guodong Liu, Hui Li, Le Feng, Min Li, Peng Gao, Fang Wan. O-GlcNAcylation promotes astroglial-mesenchymal transition via the connexin43 pathway under high-glucose conditions. Experimental eye research. 2024-12-13. PMID:39672530. |
the levels of gfap and α-sma expressions were examined, while astrocyte proliferation was evaluated using the cck-8 assay, and migration was assessed through wound healing assays. |
2024-12-13 |
2024-12-21 |
rat |
| Jenni Ho, Suriyan Sukati, Tamara Taylor, Sherry Carter, Brittany Fuller, Amy Marmo, Caryn Sorge, John D'Orazio, D Allan Butterfield, Subbarao Bondada, Heidi Weiss, Daret K St Clair, Luksana Chaiswin. Extracellular vesicles released by ALL patients contain HNE-adducted proteins: implications of collateral damage. Free radical biology & medicine. 2024-12-06. PMID:39643137. |
evs were measured throughout the collection points for: 1) number of ev particles generated using nanoparticle tracking analysis (nta); 2) markers of neurons (neun), astrocyte activation (gfap), neuronal stability (bdnf), 3) markers of pre-b cell all (cd19 and cd22); and ) 4-hydroxy-2-nonenal (hne) adducted proteins. |
2024-12-06 |
2024-12-10 |
Not clear |
| Balazs Szeky, Veronika Jurakova, Eliska Fouskova, Anita Feher, Melinda Zana, Vivien Reka Karl, Janos Farkas, Maria Bodi-Jakus, Martina Zapletalova, Shashank Pandey, Radek Kucera, Jan Lochman, Andras Dinnye. Efficient derivation of functional astrocytes from human induced pluripotent stem cells (hiPSCs). PloS one. vol 19. issue 12. 2024-12-04. PMID:39630626. |
our hipsc-derived astrocytes expressed characteristic astrocyte markers, such as gfap, s100b, aldh1l1 and aqp4. |
2024-12-04 |
2024-12-07 |
human |
| Uliana De Simone, Francesca Caloni, Patrizia Pignatti, Carlo Gaetano, Carlo Alessandro Locatelli, Teresa Coccin. Human stromal cell-based protocol to generate astrocytes: a straightforward Toxicology mechanisms and methods. 2024-12-03. PMID:39626968. |
this methodology yields cells that display astrocyte morphology and express characteristic markers such as gfap and s100β. |
2024-12-03 |
2024-12-06 |
human |
| Jo Kamada, Tomohiro Hamanaka, Aya Oshimo, Hideo Sato, Tomonori Nishii, Marika Fujita, Yoshiharu Makiguchi, Miki Tanaka, Katsumi Aoyagi, Hisashi Nojim. Glial Fibrillary Acidic Protein's Usefulness as an Astrocyte Biomarker Using the Fully Automated LUMIPULSE Diagnostics (Basel, Switzerland). vol 14. issue 22. 2024-11-27. PMID:39594187. |
glial fibrillary acidic protein's usefulness as an astrocyte biomarker using the fully automated lumipulse glial fibrillary acidic protein (gfap) is an important biomarker for neuroinflammatory conditions. |
2024-11-27 |
2024-11-29 |
Not clear |
| Tahsin Nairuz, Jin-Chul Heo, Jong-Ha Le. Differential Glial Response and Neurodegenerative Patterns in CA1, CA3, and DG Hippocampal Regions of 5XFAD Mice. International journal of molecular sciences. vol 25. issue 22. 2024-11-27. PMID:39596222. |
moreover, the ca1 and ca3 regions showed higher vulnerability, with signs of reactive astrogliosis such as increased astrocyte density and elevated gfap expression. |
2024-11-27 |
2024-11-29 |
mouse |
| Adriana Fernanda K Vizuete, Fernanda Fróes, Marina Seady, Aline Castro Caurio, Osmar Vieira Ramires Junior, Ana Karla Oliveira Leite, Clarissa Penha Farias, Angela T S Wyse, Carlos-Alberto Gonçalve. Targeting glycolysis for neuroprotection in early LPS-induced neuroinflammation. Brain, behavior, & immunity - health. vol 42. 2024-11-25. PMID:39583162. |
additionally, mcc950 (an nlrp3 inhibitor) downregulated tlr4/akt/p38 mapk/nf-κb/stat3 signaling, expressions of cox2 and il-1β, and the astrocyte reactivity (decreasing gfap) induced by early neuroinflammation, resulting in low glucose uptake. |
2024-11-25 |
2024-11-27 |
Not clear |
| Xiaoxiao Feng, Liwei Zhang, Kangwei Jiao, Yunqing Li, Min Wu, Yu Xie, Libo Xia. Tracking astrocyte polarization in the retina in retinopathy of prematurity. Experimental eye research. 2024-11-22. PMID:39577607. |
immunofluorescence of ib4 and gfap staining was performed to observe changes in the vascular network and astrocyte pattern at different time points (p0, p7, p12, p17, and p21). |
2024-11-22 |
2024-11-25 |
mouse |
| Neža Žnidaršič, Neža Grgurevič, Alenka Nemec Svete, Anže Meden, Tomaž Sno. A comparison of cognitive decline in aged mice and mice treated with aftin-4. Scientific reports. vol 14. issue 1. 2024-11-16. PMID:39550500. |
in contrast, aged and aftin-4-treated male mice presented elevated levels of gfap, indicating astrocyte damage. |
2024-11-16 |
2024-11-20 |
mouse |
| Ying Zhang, Jun Wang, Haibo Zhang, Zhenkun Tan, Yingyan Zheng, Junjiao Ping, Jie Zhang, Jiali Luo, Linsen Li, Liming Lu, Xinxia Li. Elevated circulating levels of GFAP associated with reduced volumes in hippocampal subregions linked to mild cognitive impairment among community-dwelling elderly individuals. Frontiers in aging neuroscience. vol 16. 2024-11-14. PMID:39534430. |
the aim of this study is to investigate whether astrocyte activation is correlated with hippocampal atrophy, and to assess the potential of glial fibrillary acidic protein (gfap) as a biomarker for diagnosing mci among community-dwelling older individuals. |
2024-11-14 |
2024-11-17 |
Not clear |
| Kaushiki Mukherjee, Paul C Guest, Kolja Schiltz, Gabriela Meyer-Lotz, Henrik Dobrowolny, Katrin Borucki, Hans-Gert Bernstein, Thomas Nickl-Jockschat, Borna Relja, Johann Steine. Longitudinal analysis of astrocyte-derived protein levels in the blood of drug-naive and relapsed patients with schizophrenia. Journal of psychiatric research. vol 180. 2024-11-01. PMID:39486269. |
our findings suggest that lowered gfap and fabp7 may serve as trait markers of astrocyte pathology in schizophrenia, even prior to antipsychotic treatment. |
2024-11-01 |
2024-11-05 |
human |
| Manish Ravikumar, Brindha Durairaj, Deenathayalan Uvaraja. Necrostatin-1 as a Potential Anticonvulsant: Insights from Zebrafish Larvae Model of PTZ-Induced Seizures. Molecular neurobiology. 2024-10-28. PMID:39465486. |
additionally, c-fos expression was measured as an indicator of neuronal activation and analyzed mrna levels of the astrocyte activation marker (gfap) along with various inflammatory cytokines. |
2024-10-28 |
2024-10-30 |
human |
| Mateus Eduardo Herpich, Leonardo de Oliveira Guarnieri, Antônio Carlos Pinheiro de Oliveira, Márcio Flávio Dutra Morae. Bacterial Lipopolysaccharide Post-Conditioning in The kainic acid animal model of Temporal Lobe epilepsy. Epilepsy & behavior : E&B. vol 161. 2024-10-28. PMID:39467457. |
animals were euthanized on day 26, and hippocampal slices were analyzed using fluoro-jade staining for cell death and immunofluorescence staining for iba-1 (microglia) and gfap (astrocyte) labeling. |
2024-10-28 |
2024-10-31 |
rat |
| Janelle E Stanton, Sakshi Hans, Ioannis Zabetakis, Andreas M Grabrucke. Zinc signaling controls astrocyte-dependent synapse modulation via the PAF receptor pathway. Journal of neurochemistry. 2024-10-25. PMID:39450676. |
since zinc deficiency has been consistently linked to increased pro-inflammatory signaling, we aimed to identify cellular zinc-dependent signaling pathways that may lead to astrocyte activation using techniques such as immunocytochemistry and protein biochemistry to detect astrocyte gfap expression, fluorescent imaging to detect oxidative stress levels in activated astrocytes, cytokine profiling, and analysis of primary neurons subjected to astrocyte secretomes. |
2024-10-25 |
2024-10-28 |
Not clear |
| Regina Andressa Caetano, Joelma Alves, Thiago A Smaniotto, Francisco Daroda Dutra, Eduardo Z B de Assis, Luisa Soares Pedroso, Ariadni Peres, Alessandra G Machado, Rachel Krolow, Pauline Maciel August, Cristiane Matté, Marina Seady, Marina C Leite, Brenda G Machado, Carolina Marques, Laura Saraiva, Randriely Merscher Sobreira de Lima, Carla Dalma. Impacts of linseed oil diets on anxiety and memory extinction after early life stress: A sex-specific analysis of mitochondrial dysfunction, astrocytic markers, and inflammation in the amygdala. Brain research. 2024-10-07. PMID:39374840. |
amygdalae were evaluated for inflammatory cytokines (interleukin (il)-1beta, il-6, and tumor-necrose factor (tnf)-alpha), mitochondrial functionality, and astrocyte markers (glial fibrillary acidic protein - gfap, s100b, and glutamine synthetase activity). |
2024-10-07 |
2024-10-10 |
rat |
| Abhilasha Sood, Arpit Mehrotra, Devinder K Dhawan, Rajat Sandhi. Neuroprotective effects of Withania somnifera on ischemic stroke are mediated via anti-inflammatory response and modulation of neurotransmitter levels. Neurochemistry international. 2024-09-30. PMID:39349219. |
concomitantly, mrna and protein levels for astrocyte and microglial activation markers; gfap and iba-1, were increased in mcao animals. |
2024-09-30 |
2024-10-03 |
Not clear |
| Maria V Zakharova, Anna A Kovalenko, Olga E Zubareva, Alexander P Schwarz, Tatiana Y Postnikova, Alina M Trofimova, Aleksey V Zaitse. Pentylenetetrazole-Induced Seizures Cause Short-Term Changes in the Phenotype of Microglial and Astroglial Cells in the Hippocampus and Temporal Cortex of Young Male Wistar Rats. Journal of neuroscience research. vol 102. issue 9. 2024-09-21. PMID:39305083. |
an increase in the expression of the gfap, slc1a2, slc1a1, il1b, tnfa, bdnf, and fgf2 genes, and the a2 astrocyte condition marker s100a10, was observed. |
2024-09-21 |
2024-09-24 |
rat |
| Pei-Hao Lin, Hai-Yan Yao, Li Huang, Cong-Cong Fu, Xiao-Li Yao, Chun Lian, Shi-Feng Zhang, Wen-Dong Lai, Guan-Yan Lin, Sha Liao, Jie Yang, Zhi-Feng Mao, Ding Liu, Bao-Yi Long, Jia-Jia Yue, Cong Gao, You-Ming Lon. Autoimmune astrocytopathy double negative for AQP4-IgG and GFAP-IgG: Retrospective research of clinical practice, biomarkers, and pathology. CNS neuroscience & therapeutics. vol 30. issue 9. 2024-09-16. PMID:39279053. |
the objective of this study is to investigate the presence of astrocyte antibodies in patients, excluding aquaporin-4 or glial fibrillary acidic protein (gfap) antibodies, while evaluating associated biomarkers and pathologies. |
2024-09-16 |
2024-09-18 |
Not clear |
| Dianjun Liu, Xiangwen Yao, Hao Zhan. Effect of general anesthesia drugs on GFAP/Iba-1 expression: a meta-analysis. American journal of translational research. vol 16. issue 8. 2024-09-12. PMID:39262705. |
glial fibrillary acidic protein (gfap) is a marker associated with astrocyte activation and plays a role in various pathologic processes, including traumatic brain injury, stroke, and neurodegenerative diseases. |
2024-09-12 |
2024-09-14 |
Not clear |