| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Silvia J H Park, In-Jung Kim, Loren L Looger, Jonathan B Demb, Bart G Borghui. Excitatory synaptic inputs to mouse on-off direction-selective retinal ganglion cells lack direction tuning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 11. 2014-05-19. PMID:24623775. |
fluorescence measurements with the glutamate biosensor intensity-based glutamate-sensing fluorescent reporter (iglusnfr) conditionally expressed in on-off dsgcs showed that glutamate release in both on- and off-layer dendrites lacked ds, whereas simultaneously recorded excitatory currents showed apparent ds. |
2014-05-19 |
2023-08-12 |
mouse |
| Keisuke Yonehara, Karl Farrow, Alexander Ghanem, Daniel Hillier, Kamill Balint, Miguel Teixeira, Josephine Jüttner, Masaharu Noda, Rachael L Neve, Karl-Klaus Conzelmann, Botond Rosk. The first stage of cardinal direction selectivity is localized to the dendrites of retinal ganglion cells. Neuron. vol 79. issue 6. 2013-11-13. PMID:23973208. |
furthermore, the glutamate input to ds cells, recorded using a genetically encoded glutamate sensor, also lacked direction selectivity. |
2013-11-13 |
2023-08-12 |
Not clear |
| Amanda W Pong, Brianna R Geary, Kris M Engelstad, Ashwini Natarajan, Hong Yang, Darryl C De Viv. Glucose transporter type I deficiency syndrome: epilepsy phenotypes and outcomes. Epilepsia. vol 53. issue 9. 2012-11-16. PMID:22812641. |
glut 1 deficiency syndrome (ds) is defined by hypoglycorrhachia with normoglycemia, acquired microcephaly, episodic movements, and epilepsy refractory to standard antiepileptic drugs (aeds). |
2012-11-16 |
2023-08-12 |
Not clear |
| Amanda W Pong, Brianna R Geary, Kris M Engelstad, Ashwini Natarajan, Hong Yang, Darryl C De Viv. Glucose transporter type I deficiency syndrome: epilepsy phenotypes and outcomes. Epilepsia. vol 53. issue 9. 2012-11-16. PMID:22812641. |
our purpose is (1) to describe epilepsy phenotypes in a large glut 1 ds cohort, to facilitate diagnosis; and (2) to describe cases in which non-kd agents achieved seizure freedom (sf), highlighting potential adjunctive treatments. |
2012-11-16 |
2023-08-12 |
Not clear |
| Andrey V Dmitriev, Konstantin E Gavrikov, Stuart C Mange. GABA-mediated spatial and temporal asymmetries that contribute to the directionally selective light responses of starburst amacrine cells in retina. The Journal of physiology. vol 590. issue 7. 2012-08-07. PMID:22289910. |
employing a biophysically realistic, computational model of sacs, which incorporated experimental measurements of sac electrical properties and gaba and glutamate responses, we further investigated whether and how a [cl(−)](i) gradient along sac dendrites produces their ds responses. |
2012-08-07 |
2023-08-12 |
Not clear |
| Andrey V Dmitriev, Konstantin E Gavrikov, Stuart C Mange. GABA-mediated spatial and temporal asymmetries that contribute to the directionally selective light responses of starburst amacrine cells in retina. The Journal of physiology. vol 590. issue 7. 2012-08-07. PMID:22289910. |
the combination of these two specific gaba-associated spatial and temporal asymmetries, in conjunction with symmetric glutamate excitation, may underlie the opposite polarity, ds light responses of sacs. |
2012-08-07 |
2023-08-12 |
Not clear |
| Frederic Ambroggi, Ali Ghazizadeh, Saleem M Nicola, Howard L Field. Roles of nucleus accumbens core and shell in incentive-cue responding and behavioral inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 18. 2011-08-05. PMID:21543612. |
using a discriminative stimulus (ds) task in rats and inactivating the nac by blocking excitatory inputs with glutamate antagonists, we dissociated core and shell contributions to task performance. |
2011-08-05 |
2023-08-12 |
rat |
| Germán A Enciso, Michael Rempe, Andrey V Dmitriev, Konstantin E Gavrikov, David Terman, Stuart C Mange. A model of direction selectivity in the starburst amacrine cell network. Journal of computational neuroscience. vol 28. issue 3. 2011-01-11. PMID:20524107. |
in this paper we present a model of strong ds behavior of sacs which relies on the gaba-mediated communication within a tightly interconnected network of these cells and on the glutamate signal that the sacs receive from bipolar cells (a presynaptic cell that receives input from cones). |
2011-01-11 |
2023-08-12 |
rabbit |
| Cara J Westmark, Pamela R Westmark, James S Malte. Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures. Journal of Alzheimer's disease : JAD. vol 20. issue 4. 2010-10-12. PMID:20413855. |
we demonstrate that ad (tg2576) and ds (ts65dn) mice exhibit audiogenic seizures, which can be attenuated with antagonists to metabotropic glutamate receptor 5 (mglur5) or by passive immunization with anti-amyloid-beta antibody. |
2010-10-12 |
2023-08-12 |
mouse |
| Debarati Ghosh, Swagata Sinha, Anindita Chatterjee, Krishnadas Nandagopa. A study of GluK1 kainate receptor polymorphisms in Down syndrome reveals allelic non-disjunction at 1173(C/T). Disease markers. vol 27. issue 2. 2010-01-12. PMID:19893199. |
accordingly, we sought evidence for allelic non-disjunction in the gluk1 gene that encodes the critical kainite-binding glutamate receptor subunit-5, maps to chromosome 21q22.1 in the ds critical region and is expressed in brain regions responsible for learning and memory. |
2010-01-12 |
2023-08-12 |
Not clear |
| Oh-Ju Kwon, Moon-Sook Kim, Tae-Jin Kim, Chang-Jin Jeo. Identification of synaptic pattern of kainate glutamate receptor subtypes on direction-selective retinal ganglion cells. Neuroscience research. vol 58. issue 3. 2007-10-19. PMID:17466402. |
in this article we investigate the distributions of kainate glutamate receptor subtypes glur5-7 and ka1, 2 on the dendritic arbors of direction-selective (ds) retinal ganglion cells (rgcs) of the rabbit retina to search for anisotropies, which might contribute to a directional preference of ds rgcs. |
2007-10-19 |
2023-08-12 |
rabbit |
| J Lipski, C K Wan, J Z Bai, R Pi, D Li, D Donnell. Neuroprotective potential of ceftriaxone in in vitro models of stroke. Neuroscience. vol 146. issue 2. 2007-08-15. PMID:17363173. |
recently, rothstein et al., [rothstein jd, patel s, regan mr, haenggeli c, huang yh, bergles de, jin l, dykes hoberg m, vidensky s, chung ds, toan sv, bruijn li, su zz, gupta p, fisher pb (2005) beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. |
2007-08-15 |
2023-08-12 |
rat |
| Yvonne Klaue, Annika M Källman, Michael Bonin, Wolfgang Nellen, Marie Ohma. Biochemical analysis and scanning force microscopy reveal productive and nonproductive ADAR2 binding to RNA substrates. RNA (New York, N.Y.). vol 9. issue 7. 2003-08-27. PMID:12810917. |
the natural selectively edited r/g site from glutamate receptor subunit b (glur-b) was inserted into an rna backbone molecule consisting of a completely double-stranded (ds) central part and incompletely paired ends derived from potato spindle tuber viroid (pstvd). |
2003-08-27 |
2023-08-12 |
Not clear |
| Barbara Begni, Laura Brighina, Lorenzo Fumagalli, Simona Andreoni, Enrico Castelli, Claudia Francesconi, Roberto Del Bo, Nereo Bresolin, Carlo Ferrares. Altered glutamate uptake in peripheral tissues from Down syndrome patients. Neuroscience letters. vol 343. issue 2. 2003-08-07. PMID:12759167. |
since alterations of app metabolism and oxidative damage are systemic, we investigated glutamate uptake in platelets and fibroblasts from ds patients to explore whether abnormalities in this process are inherent properties of ds cells and not secondary to neurodegeneration. |
2003-08-07 |
2023-08-12 |
Not clear |
| Barbara Begni, Laura Brighina, Lorenzo Fumagalli, Simona Andreoni, Enrico Castelli, Claudia Francesconi, Roberto Del Bo, Nereo Bresolin, Carlo Ferrares. Altered glutamate uptake in peripheral tissues from Down syndrome patients. Neuroscience letters. vol 343. issue 2. 2003-08-07. PMID:12759167. |
glutamate uptake was significantly decreased in platelets (p<0.005 vs. control) and fibroblasts (p<0.001 vs. control) from ds patients, particularly in those with free trisomy and with mitochondrial point mutations. |
2003-08-07 |
2023-08-12 |
Not clear |
| Barbara Begni, Laura Brighina, Lorenzo Fumagalli, Simona Andreoni, Enrico Castelli, Claudia Francesconi, Roberto Del Bo, Nereo Bresolin, Carlo Ferrares. Altered glutamate uptake in peripheral tissues from Down syndrome patients. Neuroscience letters. vol 343. issue 2. 2003-08-07. PMID:12759167. |
systemic impairment of glutamate uptake in ds is suggested, probably related to app overexpression and mitochondrial dysfunction. |
2003-08-07 |
2023-08-12 |
Not clear |
| S Ito, K Komatsu, K Tsukamoto, A F Sve. Tonic excitatory input to the rostral ventrolateral medulla in Dahl salt-sensitive rats. Hypertension (Dallas, Tex. : 1979). vol 37. issue 2. 2001-05-17. PMID:11230246. |
glutamate and the eaa antagonist kynurenic acid were microinjected into the rvlm of chloralose-anesthetized ds and dr rats maintained on diets containing either 0.3% nacl or 8.0% nacl. |
2001-05-17 |
2023-08-12 |
rat |
| R Seidl, N Cairns, N Singewald, S T Kaehler, G Lube. Differences between GABA levels in Alzheimer's disease and Down syndrome with Alzheimer-like neuropathology. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218066. |
a number of amino acids [glutamate, aspartate, gamma-aminobutyrate (gaba), glycine, taurine, glutamine, serine, arginine] were investigated in post-mortem tissue samples from temporal, occipital cortex, thalamus, caudate nucleus, and cerebellum of adult patients with down syndrome (ds) exhibiting alzheimer-like neuropatholgy, alzheimer's disease (ad) and from controls by use of high performance liquid chromatography (hplc). |
2001-05-03 |
2023-08-12 |
human |
| S Ito, K Komatsu, K Tsukamoto, A F Sve. Tonic excitatory input to the rostral ventrolateral medulla in Dahl salt-sensitive rats. Hypertension (Dallas, Tex. : 1979). vol 37. issue 2 Pt 2. 2001-04-26. PMID:11230357. |
glutamate and the eaa antagonist kynurenic acid were microinjected into the rvlm of chloralose-anesthetized ds and dr rats maintained on diets containing either 0.3% nacl or 8.0% nacl. |
2001-04-26 |
2023-08-12 |
rat |
| P Boulenguez, S L Peters, S N Mitchell, J Chauveau, J A Gray, M H Josep. Dopamine release in the nucleus accumbens and latent inhibition in the rat following microinjections of a 5-HT1B agonist into the dorsal subiculum: implications for schizophrenia. Journal of psychopharmacology (Oxford, England). vol 12. issue 3. 2000-09-15. PMID:10958252. |
in the presence of dizocilpine in the n. acc, microinjection of s-cm-gtnh2 into the ds could still increase dopac and hva, but da levels were not further changed, whereas in the presence of cnqx, microinjection of s-cm-gtnh2 into the ds still increased not only dopac and hva, but also da levels in a way similar to that in the absence of glutamate antagonist. |
2000-09-15 |
2023-08-12 |
human |