| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joelle Robinson, Nidhi Chawla, Shreya Patel, Eliana Spey, Olivia McNulty, Gurjinder Kau. Neurodevelopmental Abnormalities in Down Syndrome: Assessing Structural and Functional Deficits. Cureus. vol 16. issue 12. 2025-01-23. PMID:39845250. |
reduced glutamate transmission and decreased amyloid precursor protein metabolism contribute to synaptic plasticity deficits and behavioral changes in ds. |
2025-01-23 |
2025-01-25 |
Not clear |
| Ling Hu, Xuemei Lv, Yunxiu Zhang, Wanying Du, Shoujin Fan, Lingan Kon. Transcriptomic and Metabolomic Profiling of Root Tissue in Drought-Tolerant and Drought-Susceptible Wheat Genotypes in Response to Water Stress. International journal of molecular sciences. vol 25. issue 19. 2024-10-16. PMID:39408761. |
the integrated analysis of the transcriptome and metabolome showed that in dt, the kegg pathways, including flavonoid biosynthesis and arginine and proline metabolism, were shared by differentially accumulated metabolites (dams) and degs at 6 h after treatment (hat) and pathways including alanine, aspartate, glutamate metabolism and carbon metabolism were shared at 48 hat, while in ds, the kegg pathways shared by dams and degs only included arginine and proline metabolism at 6 hat and the biosynthesis of amino acids at 48 hat. |
2024-10-16 |
2024-10-18 |
Not clear |
| Amir Attallah, Maryvonne Ardourel, Fabien Lesne, Anthony De Oliveira, Chloé Felgerolle, Sylvain Briault, Isabelle Ranchon-Cole, Olivier Perch. Dietary Supplement Enriched in Antioxidants and Omega-3 Promotes Retinal Glutamine Synthesis. Experimental eye research. 2024-06-08. PMID:38851478. |
only one in-vivo preclinical study demonstrated that dietary supplementation (ds) prevents the retina from light-induced retinal degeneration; and only one in-vitro study on müller cells culture showed that glutamate metabolism cycle was key in oxidative stress response. |
2024-06-08 |
2024-06-11 |
Not clear |
| Amir Attallah, Maryvonne Ardourel, Fabien Lesne, Anthony De Oliveira, Chloé Felgerolle, Sylvain Briault, Isabelle Ranchon-Cole, Olivier Perch. Dietary Supplement Enriched in Antioxidants and Omega-3 Promotes Retinal Glutamine Synthesis. Experimental eye research. 2024-06-08. PMID:38851478. |
therefore, we raised the question about the in-vivo effect of ds on glutamate metabolism in the retina. |
2024-06-08 |
2024-06-11 |
Not clear |
| Sunil Srivastav, Xiaoying Cui, Roger Bitencourt Varela, James P Kesby, Darryl Eyle. Increasing dopamine synthesis in nigrostriatal circuits increases phasic dopamine release and alters dorsal striatal connectivity: implications for schizophrenia. Schizophrenia (Heidelberg, Germany). vol 9. issue 1. 2023-10-05. PMID:37798312. |
alongside changes in da systems, we also show increased density of vesicular glutamate transporter 1 (vglut1) synapses in the edips ds suggesting changes in cortical connectivity. |
2023-10-05 |
2023-10-07 |
rat |
| Mustafa Q Hameed, Benjamin Hui, Rui Lin, Paul C MacMullin, Andres Pascual-Leone, Sheryl Anne D Vermudez, Alexander Rotenber. Depressed glutamate transporter 1 expression in a mouse model of Dravet syndrome. Annals of clinical and translational neurology. 2023-07-14. PMID:37452008. |
here, we demonstrate reduced expression of the rodent glutamate transporter type 1 (glt-1) in a ds mouse model, and in wild type mouse strains where scn1a haploinsufficiency is most likely to cause epilepsy, indicating that glt-1 depression may play a role in ds seizures. |
2023-07-14 |
2023-08-14 |
mouse |
| Qing-Ling Zhao, Min Sun, Wen Lin, Ai-Xia Ren, Zhi-Xin Wang, Rong-Rong Zhang, Lei Li, Zhi-Qiang Ga. Effects of sowing modes on soil water dynamics and grain protein formation in dryland wheat. Ying yong sheng tai xue bao = The journal of applied ecology. vol 32. issue 11. 2021-12-13. PMID:34898114. |
compared with ds, the glutamine synthetase (gs) activity of grains at 15-35 days after anthesis was significantly increased by fs and wss, while the glutamate synthase (gogat) activity of flag leaves and grains at 5-35 days after anthesis was significantly increased by fs in the dry year. |
2021-12-13 |
2023-08-13 |
Not clear |
| Mintu Chandra, Amy K Kendall, Lauren P Jackso. Toward Understanding the Molecular Role of SNX27/Retromer in Human Health and Disease. Frontiers in cell and developmental biology. vol 9. 2021-05-04. PMID:33937239. |
snx27/retromer downregulation is strongly linked to down's syndrome (ds) via glutamate receptor dysfunction and to alzheimer's disease (ad) through increased intracellular production of amyloid peptides from amyloid precursor protein (app) breakdown. |
2021-05-04 |
2023-08-13 |
human |
| Robert D Cole, Matty Zimmerman, Anastasia Matchanova, Munir Gunes Kutlu, Thomas J Gould, Vinay Parik. Cognitive rigidity and BDNF-mediated frontostriatal glutamate neuroadaptations during spontaneous nicotine withdrawal. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 5. 2021-03-30. PMID:31752015. |
bdnf-evoked glutamate release and synapsin phosphorylation was attenuated within ds synapses, but enhanced in the nucleus accumbens, suggesting a dichotomous role of bdnf signaling in striatal regions. |
2021-03-30 |
2023-08-13 |
mouse |
| Kumar, Shah, Dube. Salinity induced behavioural changes in malate dehydrogenase and glutamate dehydrogenase activities in rice seedlings of differing salt tolerance. Plant science : an international journal of experimental plant biology. vol 156. issue 1. 2020-09-30. PMID:10908802. |
the activities of malate dehydrogenase in whole tissue extract (nad(+)-mdh) as well as in mitochondrial (nad(+)-mdh) and chloroplastic (nadp(+)-mdh) preparations of aminating (nadh-gdh) and deaminating(nad(+)-gdh) glutamate dehydrogenases were studied in two sets of rice cultivars differing in salt tolerance grown under moderate (7 ds m(-1)) and high (14 ds m(-1)) nacl salinity levels. |
2020-09-30 |
2023-08-12 |
Not clear |
| Macarena Gómez de Salazar, Cristina Grau, Francisco Ciruela, Xavier Altafa. Phosphoproteomic Alterations of Ionotropic Glutamate Receptors in the Hippocampus of the Ts65Dn Mouse Model of Down Syndrome. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:30140203. |
the phenotypic assessment and pharmacotherapy interventions in ds murine models strongly pointed out glutamatergic neurotransmission alterations (specially affecting ionotropic glutamate receptors [iglurs]) that might contribute to ds pathophysiology, which is in agreement with ds condition. |
2020-09-30 |
2023-08-13 |
mouse |
| Lin Chen, Zhiliang Wei, Kannie W Y Chan, Shuhui Cai, Guanshu Liu, Hanzhang Lu, Philip C Wong, Peter C M van Zijl, Tong Li, Jiadi X. Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI. NeuroImage. vol 188. 2020-01-21. PMID:30553917. |
phantom studies of glutamate solution, protein (egg white) and hair conditioner show the capability of the proposed scheme to minimize the contributions from amine protons, ds, and mtc, respectively. |
2020-01-21 |
2023-08-13 |
mouse |
| Jun-Seok Lee, Hang-Gu Kim, Chang-Jin Jeo. Identification of synaptic pattern of NMDA receptor subunits upon direction-selective retinal ganglion cells in developing and adult mouse retina. Acta histochemica. vol 119. issue 5. 2017-11-16. PMID:28545760. |
these ds rgcs are sensitive to glutamate, which is secreted from bipolar cells. |
2017-11-16 |
2023-08-13 |
mouse |
| Sheng-Chuan Liu, Ji-Qiang Jin, Jian-Qiang Ma, Ming-Zhe Yao, Chun-Lei Ma, Chun-Fang Li, Zhao-Tang Ding, Liang Che. Transcriptomic Analysis of Tea Plant Responding to Drought Stress and Recovery. PloS one. vol 11. issue 1. 2016-08-11. PMID:26788738. |
proline was probably mainly biosynthesized from glutamate under ds and rc. |
2016-08-11 |
2023-08-13 |
Not clear |
| Takahiko Chimura, Thomas Launey, Nobuaki Yoshid. Calpain-Mediated Degradation of Drebrin by Excitotoxicity In vitro and In vivo. PloS one. vol 10. issue 4. 2016-04-21. PMID:25905636. |
it was suggested that excitotoxic neuronal death caused by overactivation of nmda-type glutamate receptors (nmdars) occurs in ad and ds; however, the relationship between excitotoxicity and drebrin loss is unknown. |
2016-04-21 |
2023-08-13 |
Not clear |
| Xin Wang, Timothy Huang, Yingjun Zhao, Qiuyang Zheng, Robert C Thompson, Guojun Bu, Yun-wu Zhang, Wanjin Hong, Huaxi X. Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity. Cell reports. vol 9. issue 3. 2015-07-23. PMID:25437557. |
we have recently found that overexpression of a chromosome 21-encoded microrna-155 results in decreased levels of the membrane trafficking component, snx27, diminishing glutamate receptor recycling and thereby impairing synaptic functions in ds. |
2015-07-23 |
2023-08-13 |
mouse |
| Mathieu D Santin, Romain Valabrègue, Isabelle Rivals, Romain Pénager, Raphaël Paquin, Luce Dauphinot, Christelle Albac, Benoit Delatour, Marie-Claude Potie. In vivo 1H MRS study in microlitre voxels in the hippocampus of a mouse model of Down syndrome at 11.7 T. NMR in biomedicine. vol 27. issue 10. 2015-05-18. PMID:25088227. |
thus, the excitation-inhibition imbalance described in ds does not appear to be related to a radical change in the levels of either gaba or glutamate in the hippocampus. |
2015-05-18 |
2023-08-13 |
mouse |
| Giles My Tan, Felix Beacher, Eileen Daly, Jamie Horder, Verinder Prasher, Maria-Luisa Hanney, Robin Morris, Simon Lovestone, Kieran C Murphy, Andrew Simmons, Declan Gm Murph. Hippocampal glutamate-glutamine (Glx) in adults with Down syndrome: a preliminary study using in vivo proton magnetic resonance spectroscopy ((1)H MRS). Journal of neurodevelopmental disorders. vol 6. issue 1. 2015-05-04. PMID:25937842. |
the biological associates of both id and ad in ds are poorly understood, but glutamate has been proposed to play a key role. |
2015-05-04 |
2023-08-13 |
Not clear |
| Giles My Tan, Felix Beacher, Eileen Daly, Jamie Horder, Verinder Prasher, Maria-Luisa Hanney, Robin Morris, Simon Lovestone, Kieran C Murphy, Andrew Simmons, Declan Gm Murph. Hippocampal glutamate-glutamine (Glx) in adults with Down syndrome: a preliminary study using in vivo proton magnetic resonance spectroscopy ((1)H MRS). Journal of neurodevelopmental disorders. vol 6. issue 1. 2015-05-04. PMID:25937842. |
however, the concentration of hippocampal glutamate in ds individuals with and without dementia has not previously been directly investigated. |
2015-05-04 |
2023-08-13 |
Not clear |
| Francesca Rossi, Ida Marabese, Maria De Chiaro, Serena Boccella, Livio Luongo, Francesca Guida, Danilo De Gregorio, Catia Giordano, Vito de Novellis, Enza Palazzo, Sabatino Maion. Dorsal striatum metabotropic glutamate receptor 8 affects nocifensive responses and rostral ventromedial medulla cell activity in neuropathic pain conditions. Journal of neurophysiology. vol 111. issue 11. 2015-01-24. PMID:24304862. |
the present study investigated the role of metabotropic glutamate receptor subtype 8 (mglur8) in the dorsal striatum (ds) in modulating thermonociception and rostral ventromedial medulla (rvm) on and off cell activities in conditions of neuropathic pain induced by spared nerve injury (sni) of the sciatic nerve in rats. |
2015-01-24 |
2023-08-12 |
rat |