| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wan Long Pan, Michael Chopp, Baoyan Fan, Ruilan Zhang, Xinli Wang, Jiani Hu, Xiao Ming Zhang, Zheng Gang Zhang, Xian Shuang Li. Ablation of the microRNA-17-92 cluster in neural stem cells diminishes adult hippocampal neurogenesis and cognitive function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 4. 2020-01-13. PMID:30668139. |
compared with wild-type mice, ablation of the mir-17-92 cluster significantly reduced the number of proliferating nscs and neuroblasts and neuronal differentiation in the dentate gyrus (dg) of the hippocampus and significantly impaired hippocampal-dependent learning and memory, as assayed by social recognition memory, novel object recognition, and morris water-maze tests. |
2020-01-13 |
2023-08-13 |
mouse |
| Karim A Alkadh. Cellular and Molecular Differences Between Area CA1 and the Dentate Gyrus of the Hippocampus. Molecular neurobiology. vol 56. issue 9. 2020-01-13. PMID:30874972. |
a distinct feature of the hippocampus of the brain is its unidirectional tri-synaptic pathway originating from the entorhinal cortex and projecting to the dentate gyrus (dg) then to area ca3 and subsequently, area ca1 of the ammon's horn. |
2020-01-13 |
2023-08-13 |
Not clear |
| Bangrong Cai, Kyung-Joo Seong, Sun-Woong Bae, Min Suk Kook, Changju Chun, Jin Ho Lee, Won-Seok Choi, Ji-Yeon Jung, Won-Jae Ki. Water-Soluble Arginyl-Diosgenin Analog Attenuates Hippocampal Neurogenesis Impairment Through Blocking Microglial Activation Underlying NF-κB and JNK MAPK Signaling in Adult Mice Challenged by LPS. Molecular neurobiology. vol 56. issue 9. 2020-01-09. PMID:30740619. |
microglia-mediated neuroinflammatory responses are well known to inhibit neurogenesis in the dentate gyrus (dg) of the adult hippocampus, and growing evidence indicates that therapeutic intervention to suppress microglial activation could be an effective strategy for restoring the impaired neurogenesis and memory performance. |
2020-01-09 |
2023-08-13 |
mouse |
| Sarah Houben, Karelle Leroy, Kunie Ando, Zehra Yilmaz, Cyprien Widomski, Luc Buée, Jean-Pierre Brio. Genetic ablation of tau in postnatal neurons rescues decreased adult hippocampal neurogenesis in a tauopathy model. Neurobiology of disease. vol 127. 2020-01-09. PMID:30818066. |
the volume of the granular layer, the number of granule cells and of neuronal precursors expressing the immature markers dcx or 3r-tau were analyzed in the dentate gyrus (dg) using unbiased stereological methods. |
2020-01-09 |
2023-08-13 |
mouse |
| Mahshid Hosseinzadeh, Hamid Gholami Pourbadie, Fariba Khodagholi, Mahtab Daftari, Nima Naderi, Fereshteh Motamed. Preconditioning with toll-like receptor agonists attenuates seizure activity and neuronal hyperexcitability in the pilocarpine rat model of epilepsy. Neuroscience. vol 408. 2020-01-09. PMID:31026566. |
24 h after seizure induction, the hippocampal level of pro/anti-inflammatory mediators and electrophysiological properties of the dentate gyrus (dg) granular cells were investigated by western blot and whole cell patch clamp techniques, respectively. |
2020-01-09 |
2023-08-13 |
rat |
| Chrysoula Dioli, Patrícia Patrício, Nuno Sousa, Nikolaos Kokras, Christina Dalla, Sara Guerreiro, Miguel A Santos-Silva, Ana Cristina Rego, Luísa Pinto, Elisabete Ferreiro, Ioannis Sotiropoulo. Chronic stress triggers divergent dendritic alterations in immature neurons of the adult hippocampus, depending on their ultimate terminal fields. Translational psychiatry. vol 9. issue 1. 2020-01-09. PMID:31028242. |
although many studies show that stressful conditions reduce the number of newborn neurons in the adult dentate gyrus (dg), little is known about whether and how stress impacts on dendritic development and structural maturation of these newborn neurons. |
2020-01-09 |
2023-08-13 |
Not clear |
| Fang Tong, Yijuan Zou, Yue Liang, Hao Lei, Tenzin Lopsong, Yuluo Liu, Jehane Michael Le Grange, Guanglong He, Yiwu Zho. The Water Diffusion of Brain Following Hypoglycemia in Rats - A Study with Diffusion Weighted Imaging and Neuropathologic Analysis. Neuroscience. vol 409. 2020-01-09. PMID:31034973. |
in the acute hypoglycemia group, the apparent diffusion coefficient (adc) of the dentate gyrus (dg) and the hypothalamus was increased, while the adc of the somatosensory cortex (ssc), subcortex and striatum (str) was decreased. |
2020-01-09 |
2023-08-13 |
rat |
| Véronique Deroche-Gamonet, Jean-Michel Revest, Jean-François Fiancette, Eric Balado, Muriel Koehl, Noëlle Grosjean, Djoher Nora Abrous, Pier-Vincenzo Piazz. Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior. Molecular psychiatry. vol 24. issue 2. 2020-01-06. PMID:29507372. |
the hippocampus is the main locus for adult dentate gyrus (dg) neurogenesis. |
2020-01-06 |
2023-08-13 |
mouse |
| Yoo Jin Shin, Yeon Tae Chun, Sun Woo Lim, Kang Luo, Yi Quan, Sheng Cui, Eun Jeong Ko, Byung Ha Chung, Jiyeong Lee, Seongno Hong, Mun Yong Lee, Hee Gyoo Kang, Chul Woo Yan. Influence of Tacrolimus on Depressive-Like Behavior in Diabetic Rats Through Brain-Derived Neurotrophic Factor Regulation in the Hippocampus. Neurotoxicity research. vol 36. issue 2. 2020-01-02. PMID:31201731. |
bdnf expression in the hippocampus was examined in the dentate gyrus (dg) and ca3 region using immunohistochemistry. |
2020-01-02 |
2023-08-13 |
rat |
| Rebecca K West, Jessica I Wooden, Emily A Barton, J Leigh Leasur. Recurrent binge ethanol is associated with significant loss of dentate gyrus granule neurons in female rats despite concomitant increase in neurogenesis. Neuropharmacology. vol 148. 2019-12-27. PMID:30659841. |
using stereology, we quantified the number and/or size of neurons in the medial prefrontal cortex (mpfc) and hippocampal dentate gyrus (dg), as well as the number and activation state of microglia. |
2019-12-27 |
2023-08-13 |
rat |
| James E Delorme, Varna Kodoth, Sara J Ato. Sleep loss disrupts Arc expression in dentate gyrus neurons. Neurobiology of learning and memory. vol 160. 2019-12-24. PMID:29635031. |
using in situ hybridization (together with behavioral observation to quantify sleep amounts), we find that in the dorsal hippocampus, sd minimally affects arc mrna expression, and decreases the number of dentate gyrus (dg) granule cells expressing arc. |
2019-12-24 |
2023-08-13 |
mouse |
| Claire E Manning, Andrew L Eagle, Christine C Kwiatkowski, Ridouane Achargui, Hillary Woodworth, Emily Potter, Yoshinori Ohnishi, Gina M Leinninger, A J Robiso. Hippocampal Subgranular Zone FosB Expression Is Critical for Neurogenesis and Learning. Neuroscience. vol 406. 2019-12-24. PMID:30902680. |
neural proliferation in the dentate gyrus (dg) is closely linked with learning and memory, but the transcriptional programming that drives adult proliferation remains incompletely understood. |
2019-12-24 |
2023-08-13 |
mouse |
| Stanislau Hrybouski, Melanie MacGillivray, Yushan Huang, Christopher R Madan, Rawle Carter, Peter Seres, Nikolai V Malykhi. Involvement of hippocampal subfields and anterior-posterior subregions in encoding and retrieval of item, spatial, and associative memories: Longitudinal versus transverse axis. NeuroImage. vol 191. 2019-12-20. PMID:30742981. |
the hippocampus can be segmented into three major anteroposterior sections, called head, body and tail, and into the cornu ammonis (ca), dentate gyrus (dg), and subiculum (sub) subfields based on its transverse axis. |
2019-12-20 |
2023-08-13 |
human |
| Xu-Yi Li, Wei-Wei Qi, Yuan-Xiang Zhang, Si-Yan Jiang, Bin Yang, Lei Xiong, Jiu-Cui Ton. Helicid Ameliorates Learning and Cognitive Ability and Activities cAMP/PKA/CREB Signaling in Chronic Unpredictable Mild Stress Rats. Biological & pharmaceutical bulletin. vol 42. issue 7. 2019-12-19. PMID:31257291. |
immunohistochemistry showed that administration of helicid could promoted the proliferation of neurons in the hippocampal ca1 and dentate gyrus (dg) regions. |
2019-12-19 |
2023-08-13 |
rat |
| Nasrin Hamidi, Abdollah Nozad, Hamid Sheikhkanloui Milan, Mohammad Aman. Okadaic acid attenuates short-term and long-term synaptic plasticity of hippocampal dentate gyrus neurons in rats. Neurobiology of learning and memory. vol 158. 2019-12-17. PMID:30630043. |
the aim of this study was to examine the effect of oka on electrophysiological characteristics of hippocampal dentate gyrus (dg) neurons in vivo. |
2019-12-17 |
2023-08-13 |
rat |
| Rubén D Castro-Torres, Jon Landa, Marina Rabaza, Oriol Busquets, Jordi Olloquequi, Miren Ettcheto, Carlos Beas-Zarate, Jaume Folch, Antoni Camins, Carme Auladell, Ester Verdague. JNK Isoforms Are Involved in the Control of Adult Hippocampal Neurogenesis in Mice, Both in Physiological Conditions and in an Experimental Model of Temporal Lobe Epilepsy. Molecular neurobiology. vol 56. issue 8. 2019-12-17. PMID:30685843. |
neurogenesis in the adult dentate gyrus (dg) of the hippocampus allows the continuous generation of new neurons. |
2019-12-17 |
2023-08-13 |
mouse |
| Minhui Gao, Peili Hu, Zixuan Cai, Yue Wu, Dan Wang, Wenfeng Hu, Xing Xu, Yaru Zhang, Xu Lu, Dongjian Chen, Zhuo Chen, Kai Ma, Jie Wen, Hui Wang, Chao Huan. Identification of a microglial activation-dependent antidepressant effect of amphotericin B liposome. Neuropharmacology. vol 151. 2019-12-10. PMID:30954529. |
immunofluorescence analysis showed that amphotericin b liposome reversed the cus-induced decline in dentate gyrus (dg) microglia, and inhibition or ablation of microglia in the hippocampus by minocycline (40 mg/kg) or plx3397 pre-treatment (290 mg/kg) abrogated the antidepressant effect of the amphotericin b liposome in cus-treated mice. |
2019-12-10 |
2023-08-13 |
mouse |
| Victor M Luna, Christoph Anacker, Nesha S Burghardt, Hameda Khandaker, Valentine Andreu, Amira Millette, Paige Leary, Rebecca Ravenelle, Jessica C Jimenez, Alessia Mastrodonato, Christine A Denny, Andre A Fenton, Helen E Scharfman, Rene He. Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus. Science (New York, N.Y.). vol 364. issue 6440. 2019-12-10. PMID:31073064. |
young adult-born granule cells (abgcs) in the dentate gyrus (dg) have a profound impact on cognition and mood. |
2019-12-10 |
2023-08-13 |
Not clear |
| Lily Wan, Tian Tu, Qi-Lei Zhang, Juan Jiang, Xiao-Xin Ya. Pregnancy Promotes Maternal Hippocampal Neurogenesis in Guinea Pigs. Neural plasticity. vol 2019. 2019-12-10. PMID:31097956. |
adult neurogenesis in the hippocampal dentate gyrus (dg) modulates cognition and behavior in mammals, while motherhood is associated with cognitive and behavioral changes essential for the care of the young. |
2019-12-10 |
2023-08-13 |
mouse |
| Elif Tunc-Ozcan, Chian-Yu Peng, Yiwen Zhu, Sara R Dunlop, Anis Contractor, John A Kessle. Activating newborn neurons suppresses depression and anxiety-like behaviors. Nature communications. vol 10. issue 1. 2019-12-09. PMID:31434877. |
the neurogenic hypothesis proposes that mdd is linked to impairments of adult neurogenesis in the hippocampal dentate gyrus (dg), while the effects of antidepressants are mediated by increased neurogenesis. |
2019-12-09 |
2023-08-13 |
mouse |