| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' P Kramata, I Votruba, B Otov\\xc3\\xa1, A Hol\\xc3\\xb. Different inhibitory potencies of acyclic phosphonomethoxyalkyl nucleotide analogs toward DNA polymerases alpha, delta and epsilon. Molecular pharmacology. vol 49. issue 6. 1996-07-19. PMID:8649338.' |
of the nucleotide analogs tested, 9-(2-phosphonomethoxyethyl) guanine diphosphate is the most efficient inhibitor of polymerases alpha and epsilon, whereas the diphosphate of 9-(2-phosphonomethoxyethyl) adenine, the therapeutically important agent adefovir, inhibits polymerases alpha and epsilon relatively poorly and exerts only moderate inhibition of polymerase delta. |
1996-07-19 |
2023-08-12 |
rat |
| P C Liu, M A Phillips, F Matsumur. Alteration by 2,3,7,8-Tetrachlorodibenzo-p-dioxin of CCAAT/enhancer binding protein correlates with suppression of adipocyte differentiation in 3T3-L1 cells. Molecular pharmacology. vol 49. issue 6. 1996-07-19. PMID:8649359. |
analysis of mrna for three isoforms of the ccaat/enhancer binding protein (c/ebp) revealed that tcdd (5 nm) selectively inhibited the induction of c/ebp alpha mrna but did not block the induction of c/ebp beta and c/ebp delta in response to differentiation inducers. |
1996-07-19 |
2023-08-12 |
Not clear |
| T Zlotkin, G Kaufmann, Y Jiang, M Y Lee, L Uitto, J Syväoja, I Dornreiter, E Fanning, T Nethane. DNA polymerase epsilon may be dispensable for SV40- but not cellular-DNA replication. The EMBO journal. vol 15. issue 9. 1996-07-18. PMID:8641295. |
only dna polymerases alpha and delta were detectably photolabelled by nascent sv40 dna, whether synthesized in soluble viral chromatin or within nuclei isolated from sv40-infected cells. |
1996-07-18 |
2023-08-12 |
Not clear |
| T Zlotkin, G Kaufmann, Y Jiang, M Y Lee, L Uitto, J Syväoja, I Dornreiter, E Fanning, T Nethane. DNA polymerase epsilon may be dispensable for SV40- but not cellular-DNA replication. The EMBO journal. vol 15. issue 9. 1996-07-18. PMID:8641295. |
mitogenic stimulation enhanced the photolabelling of the polymerases in the alpha>delta>epsilon order of preference. |
1996-07-18 |
2023-08-12 |
Not clear |
| T Zlotkin, G Kaufmann, Y Jiang, M Y Lee, L Uitto, J Syväoja, I Dornreiter, E Fanning, T Nethane. DNA polymerase epsilon may be dispensable for SV40- but not cellular-DNA replication. The EMBO journal. vol 15. issue 9. 1996-07-18. PMID:8641295. |
the data agree with the notion that dna polymerases alpha and delta catalyse the principal dna polymerisation reactions at the replication fork of sv40 and, perhaps, also of nuclear chromosomes. |
1996-07-18 |
2023-08-12 |
Not clear |
| F P Schwarz, S Misquith, A Suroli. Effect of substituent on the thermodynamics of D-glucopyranoside binding to concanavalin A, pea (Pisum sativum) lectin and lentil (Lens culinaris) lectin. The Biochemical journal. vol 316 ( Pt 1). 1996-07-18. PMID:8645193. |
the binding enthalpies, delta h0b, and entropies, delta s0b, determined from the measurements were compared with the same thermodynamic binding parameters for glu, d-mannopyranoside and methyl-alpha- d-glucopyranoside (alpha meoglu). |
1996-07-18 |
2023-08-12 |
Not clear |
| C E van Beijsterveldt, P C Molenaar, E J de Geus, D I Boomsm. Heritability of human brain functioning as assessed by electroencephalography. American journal of human genetics. vol 58. issue 3. 1996-07-16. PMID:8644716. |
the averaged heritabilites for the delta, theta, alpha and beta frequencies was 76%, 89%, 89%, and 86%, respectively. |
1996-07-16 |
2023-08-12 |
human |
| D J Mozzherin, P A Fishe. Human DNA polymerase epsilon: enzymologic mechanism and gap-filling synthesis. Biochemistry. vol 35. issue 11. 1996-07-15. PMID:8639508. |
competitive inhibition studies indicate that like dna polymerases alpha and delta (pol alpha and pol delta, respectively), free pol epsilon binds single-stranded but not double-stranded dna. |
1996-07-15 |
2023-08-12 |
human |
| D J Mozzherin, P A Fishe. Human DNA polymerase epsilon: enzymologic mechanism and gap-filling synthesis. Biochemistry. vol 35. issue 11. 1996-07-15. PMID:8639508. |
enzymologic studies suggest that in contrast to both pol alpha and pol delta, pol epsilon functions more efficiently as gap size decreases. |
1996-07-15 |
2023-08-12 |
human |
| D Sabbert, S Engelbrecht, W Jung. Intersubunit rotation in active F-ATPase. Nature. vol 381. issue 6583. 1996-07-09. PMID:8637601. |
solubilized f1 is composed of five different subunits, (alpha beta)3 gamma delta epsilon, and is active as an atpase. |
1996-07-09 |
2023-08-12 |
Not clear |
| J Dietrich, A Neisig, X Hou, A M Wegener, M Gajhede, C Geisle. Role of CD3 gamma in T cell receptor assembly. The Journal of cell biology. vol 132. issue 3. 1996-07-05. PMID:8636209. |
the t cell receptor (tcr) consists of the ti alpha beta heterodimer and the associated cd3 gamma delta epsilon and zeta 2 chains. |
1996-07-05 |
2023-08-12 |
human |
| H Tsuda, S Yamada, Y Yamane, K Yoshida, J J Hopwood, K Sugahar. Structures of five sulfated hexasaccharides prepared from porcine intestinal heparin using bacterial heparinase. Structural variants with apparent biosynthetic precursor-product relationships for the antithrombin III-binding site. The Journal of biological chemistry. vol 271. issue 18. 1996-07-01. PMID:8631846. |
the five hexa- or heptasulfated hexasaccharides share the common core pentasulfated structure delta hexa(2s) alpha 1-4glcn-(ns, 6s) alpha 1-4idoa alpha/glca beta 1-4glcn(6s) alpha 1-4glca beta 1-4glcn (ns) with one or two additional sulfate groups (delta hexa, glcn, idoa, and glca represent 4-deoxy-alpha-l-threo-hex-4-enepyranosyluronic acid, d-glucosamine, l-iduronic acid, and d-glucuronic acid, whereas 2s, 6s and ns stand for 2-o-, 6-o-, and 2-n-sulfate, respectively). |
1996-07-01 |
2023-08-12 |
Not clear |
| H Tsuda, S Yamada, Y Yamane, K Yoshida, J J Hopwood, K Sugahar. Structures of five sulfated hexasaccharides prepared from porcine intestinal heparin using bacterial heparinase. Structural variants with apparent biosynthetic precursor-product relationships for the antithrombin III-binding site. The Journal of biological chemistry. vol 271. issue 18. 1996-07-01. PMID:8631846. |
three components have the following hitherto unreported structures: delta hexa(2s) alpha 1-4glcn(ns, 6s) alpha 1-4glca beta 1-4glcn(ns, 6s) alpha 1-4glca beta 1-4glcn(ns,6s), delta hexa(2s) alpha 1-4glcn(ns, 6s) alpha 1-4idoa alpha 1-4glcnac(6s)-alpha 1-4glca beta 1-4glcn(ns, 3s), and delta hexa(2s) alpha 1-4glcn-(ns,6s) alpha 1-4idoa (2s) alpha 1-4glcnac(6s) alpha 1-4glca beta 1-4glcn(ns, 6s). |
1996-07-01 |
2023-08-12 |
Not clear |
| P Beauparlant, R Lin, J Hiscot. The role of the C-terminal domain of I kappa B alpha in protein degradation and stabilization. The Journal of biological chemistry. vol 271. issue 18. 1996-07-01. PMID:8631876. |
deletion studies demonstrated that the last c-terminal 30 amino acids (amino acids (aa) 288 to aa 317, deleted in i kappa b alpha delta 3), including most of the pest domain, were dispensable for i kappa b alpha function. |
1996-07-01 |
2023-08-12 |
human |
| P Beauparlant, R Lin, J Hiscot. The role of the C-terminal domain of I kappa B alpha in protein degradation and stabilization. The Journal of biological chemistry. vol 271. issue 18. 1996-07-01. PMID:8631876. |
however, deletions from aa 261 to 317 or aa 269 to 317 (i kappa b alpha delta 1 and i kappa b alpha delta 2 respectively), lacked the ability to dissociate nf-kappa b/dna complexes in vitro and were unable to inhibit nf-kappa b dependent transcription. |
1996-07-01 |
2023-08-12 |
human |
| P Beauparlant, R Lin, J Hiscot. The role of the C-terminal domain of I kappa B alpha in protein degradation and stabilization. The Journal of biological chemistry. vol 271. issue 18. 1996-07-01. PMID:8631876. |
moreover, i kappa b alpha delta 1 and i kappa b alpha delta 2 mutants were resistant to inducer-mediated degradation. |
1996-07-01 |
2023-08-12 |
human |
| P Beauparlant, R Lin, J Hiscot. The role of the C-terminal domain of I kappa B alpha in protein degradation and stabilization. The Journal of biological chemistry. vol 271. issue 18. 1996-07-01. PMID:8631876. |
analysis of i kappa b alpha deletions in the presence of protein synthesis inhibitors revealed that, independently of stimulation, i kappa b alpha delta 1 and i kappa b alpha delta 2 had a half-life four times shorter than wild type i kappa b alpha and the interaction of i kappa b alpha delta 1 and i kappa b alpha delta 2 with p65 was dramatically decreased in vivo as measured by co-immunoprecipitation. |
1996-07-01 |
2023-08-12 |
human |
| P Beauparlant, R Lin, J Hiscot. The role of the C-terminal domain of I kappa B alpha in protein degradation and stabilization. The Journal of biological chemistry. vol 271. issue 18. 1996-07-01. PMID:8631876. |
interestingly, protease inhibitors which blocked inducer-mediated degradation of i kappa b alpha also stabilized the turnover of i kappa b alpha delta 1 and i kappa b alpha delta 2. |
1996-07-01 |
2023-08-12 |
human |
| J García-Colunga, R Miled. Serotonergic modulation of muscle acetylcholine receptors of different subunit composition. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 9. 1996-07-01. PMID:8633003. |
judging by the amplitudes of accho currents generated, the levels of functional receptor expression were: alpha beta gamma delta > alpha beta delta > alpha beta gamma > alpha gamma delta. |
1996-07-01 |
2023-08-12 |
xenopus_laevis |
| J García-Colunga, R Miled. Serotonergic modulation of muscle acetylcholine receptors of different subunit composition. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 9. 1996-07-01. PMID:8633003. |
the alpha beta gamma delta and alpha beta delta acchor subtypes were strongly blocked by 5ht, whereas the alpha beta gamma receptor was blocked only slightly. |
1996-07-01 |
2023-08-12 |
xenopus_laevis |