| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masahiro Nezu, Yosuke Hirotsu, Kenji Amemiya, Toru Tateno, Soichi Takizawa, Masaharu Inoue, Hitoshi Mochizuki, Kyoko Hosaka, Constance Chik, Toshio Oyama, Masao Omat. Paraganglioma with High Levels of Dopamine, Dopa Decarboxylase Suppression, Dopamine β-hydroxylase Upregulation and Intra-tumoral Melanin Accumulation: A Case Report with a Literature Review. Internal medicine (Tokyo, Japan). 2022-11-17. PMID:36384901. |
in this condition, intratumoral dopamine β-hydroxylase (dbh), which controls the conversion of norepinephrine from dopamine, is impaired, resulting in suppressed norepinephrine and epinephrine production. |
2022-11-17 |
2023-08-14 |
Not clear |
| Steven Lehrer, Peter H Rheinstei. α-synuclein enfolds tyrosine hydroxylase and dopamine ß-hydroxylase, potentially reducing dopamine and norepinephrine synthesis. Journal of proteins and proteomics. vol 13. issue 2. 2022-10-24. PMID:36277464. |
a third enzyme, dopamine ß-hydroxylase (dbh), catalyzes the conversion of dopamine to norepinephrine. |
2022-10-24 |
2023-08-14 |
Not clear |
| Ato O Aikins, Joel T Little, Nataliya Rybalchenko, J Thomas Cunningha. Norepinephrine Innervation of the Supraoptic Nucleus Contributes to Increased Copeptin and Dilutional Hyponatremia in Male Rats. American journal of physiology. Regulatory, integrative and comparative physiology. 2022-10-03. PMID:36189988. |
brains were processed for delta fosb, dopamine β-hydroxylase (dbh) and avp immunohistochemistry. |
2022-10-03 |
2023-08-14 |
rat |
| Z Pidsudko, J Godlewski, K Wąsowic. The distribution and chemical coding of urinary bladder trigone-projecting neurons in testicular and aorticorenal ganglia in male pigs. Polish journal of veterinary sciences. vol 25. issue 3. 2022-09-26. PMID:36155594. |
the expression of tyrosine hydroxylase (th) or dopamine beta-hydroxylase (dbh), neuropeptide y (npy), somatostatin (som), galanin (gal), nitric oxide synthase (nos) and vesicular acetylcholine transporter (vacht) were investigated. |
2022-09-26 |
2023-08-14 |
Not clear |
| Ayumi Sato, Takehiro Yajima, Daisuke Tachiya, Hiroyuki Ichikawa, Tadasu Sat. Innervation of the human minor salivary glands; immunohistochemical study for neurochemical substances. Tissue & cell. vol 79. 2022-09-20. PMID:36126414. |
distributions of choline acetyltransferase (chat), vasoactive intestinal polypeptide (vip), dopamine β-hydroxylase (dbh), tyrosine hydroxylase (th), neuropeptide y (npy) and the transient receptor potential cation channel subfamily v member 2 (trpv2) were examined in the human minor salivary glands. |
2022-09-20 |
2023-08-14 |
human |
| Agata Szlaga, Patryk Sambak, Anna Gugula, Aleksandra Trenk, Andrew L Gundlach, Anna Blasia. Catecholaminergic innervation and D2-like dopamine receptor-mediated modulation of brainstem nucleus incertus neurons in the rat. Neuropharmacology. 2022-08-16. PMID:35973599. |
our immunohistochemical and viral-based retrograde tract-tracing studies revealed a dense innervation of the ni area by fibers containing the catecholaminergic biosynthesis enzymes, tyrosine hydroxylase (th) and dopamine β-hydroxylase (dbh), and indicated the major sources of the catecholaminergic innervation of the ni as the darkschewitsch, raphe and hypothalamic a13 nuclei. |
2022-08-16 |
2023-08-14 |
rat |
| Sobhika Agarwala, Keun-Young Kim, Sebastien Phan, Saeyeon Ju, Ye Eun Kong, Guillaume A Castillon, Eric A Bushong, Mark H Ellisman, Owen J Tampli. Defining the ultrastructure of the hematopoietic stem cell niche by correlative light and electron microscopy. eLife. vol 11. 2022-08-09. PMID:35943143. |
our approach also allowed us to identify dopamine beta-hydroxylase (dbh) positive ganglion cells as a previously uncharacterized functional cell type in the hspc niche. |
2022-08-09 |
2023-08-14 |
zebrafish |
| Manisha Saini, Sanjay K Dey, Suman Kund. Anti-hypertensive effect of BPM4 on spontaneously hypertensive rats that antagonizes Dopamine βeta hydroxylase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556580. |
a non-conventional target whose inhibition can regulate hypertension is dopamine βeta hydroxylase (dbh). |
2022-05-13 |
2023-08-13 |
rat |
| Hao Xie, Christoph Heier, Xia Meng, Latifa Bakiri, Isabella Pototschnig, Zhiyuan Tang, Silvia Schauer, Vanessa J Baumgartner, Gernot F Grabner, Gernot Schabbauer, Heimo Wolinski, Graham R Robertson, Gerald Hoefler, Wenwen Zeng, Erwin F Wagner, Martina Schweiger, Rudolf Zechne. An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 9. 2022-02-25. PMID:35210363. |
1) interleukin-4 receptor deficiency impeded the alternative activation of macrophages, reduced sympathetic activity, and restrained wat browning, and 2) reduced catecholamine synthesis in peripheral dopamine β-hydroxylase (dbh)-deficient mice prevented cancer-induced wat browning and adipose atrophy. |
2022-02-25 |
2023-08-13 |
mouse |
| Justyna Barut, Katarzyna Rafa-Zabłocka, Agnieszka M Jurga, Monika Bagińska, Irena Nalepa, Rosanna Parlato, Grzegorz Kreine. Genetic lesions of the noradrenergic system trigger induction of oxidative stress and inflammation in the ventral midbrain. Neurochemistry international. 2022-02-12. PMID:35150790. |
to this end, we selectively ablated the transcription initiation factor-ia (tif-ia) in neurons expressing dopamine β-hydroxylase (dbh) by the cre-loxp system. |
2022-02-12 |
2023-08-13 |
mouse |
| Xinyi Li, Dushyant Kshatriya, Nicholas T Bell. Weight-gain propensity and morphine withdrawal alters locomotor behavior and regional norepinephrine-related gene expression in male and female mice. Pharmacology, biochemistry, and behavior. 2022-01-10. PMID:35007656. |
for males, expression of dopamine beta-hydroxylase (dbh), alpha-adrenergic receptor 2 a (adra2a), and orexin receptor 1 (orx1) were increased in the locus coeruleus (lc) region of op mice, regardless of treatment. |
2022-01-10 |
2023-08-13 |
mouse |
| Khulekani Mncube, Marisa Möller, Brian H Harve. Post-weaning Social Isolated Flinders Sensitive Line Rats Display Bio-Behavioural Manifestations Resistant to Fluoxetine: A Model of Treatment-Resistant Depression. Frontiers in psychiatry. vol 12. 2021-12-07. PMID:34867504. |
post-mortem cortico-hippocampal norepinephrine (ne), serotonin (5-ht), and dopamine (da), as well as plasma interleukin 6 (il-6), tumour necrosis factor alpha (tnf-α), corticosterone (cort), and dopamine-beta-hydroxylase (dbh) levels were assayed. |
2021-12-07 |
2023-08-13 |
rat |
| Kui Cui, Fan Yang, Turan Tufan, Muhammad U Raza, Yanqiang Zhan, Yan Fan, Fei Zeng, Russell W Brown, Jennifer B Price, Thomas C Jones, Gary W Miller, Meng-Yang Zh. Restoration of Noradrenergic Function in Parkinson's Disease Model Mice. ASN neuro. vol 13. 2021-11-30. PMID:33940943. |
biochemical analysis showed that microinjection of lentiviral expression cassettes into the lc significantly increased mrna levels of phox2a, and phox2b, which were accompanied by parallel increases of mrna and proteins of dopamine β-hydroxylase (dbh) and tyrosine hydroxylase (th) in the lc. |
2021-11-30 |
2023-08-13 |
mouse |
| Mutsuko Kawashima, Takehiro Yajima, Daisuke Tachiya, Souichi Kokubun, Hiroyuki Ichikawa, Tadasu Sat. Parasympathetic neurons in the human submandibular ganglion. Tissue & cell. vol 70. 2021-11-29. PMID:33517097. |
in this study, immunohistochemistry for vasoactive intestinal polypeptide (vip), neuropeptide y (npy), choline acetyltransferase (chat), dopamine β-hydroxylase (dbh), tyrosine hydroxylase (th), and the transient receptor potential cation channel subfamily v members 1 (trpv1) and 2 (trpv2) was performed on the human smg. |
2021-11-29 |
2023-08-13 |
human |
| Małgorzata Frankowska, Paulina Surówka, Agata Suder, Renata Pieniążek, Renata Pukło, Joanna Jastrzębska, Władysława A Daniel, Małgorzata Filip, Magdalena Zadrożny-Bujalska, Patrycja Kleczkowsk. Treatment with dopamine β-hydroxylase (DBH) inhibitors prevents morphine use and relapse-like behavior in rats. Pharmacological reports : PR. vol 73. issue 6. 2021-11-25. PMID:34236605. |
treatment with dopamine β-hydroxylase (dbh) inhibitors prevents morphine use and relapse-like behavior in rats. |
2021-11-25 |
2023-08-13 |
rat |
| Małgorzata Frankowska, Paulina Surówka, Agata Suder, Renata Pieniążek, Renata Pukło, Joanna Jastrzębska, Władysława A Daniel, Małgorzata Filip, Magdalena Zadrożny-Bujalska, Patrycja Kleczkowsk. Treatment with dopamine β-hydroxylase (DBH) inhibitors prevents morphine use and relapse-like behavior in rats. Pharmacological reports : PR. vol 73. issue 6. 2021-11-25. PMID:34236605. |
recently, several studies have led to promising results with disulfiram (dsf), a dopamine β-hydroxylase (dbh) inhibitor, showing that it is a potent agent against not only alcohol but also addiction to various drugs. |
2021-11-25 |
2023-08-13 |
rat |
| Noriko Kimura, Kiyoto Shiga, Ken-Ichi Kaneko, Yutaka Oki, Chiho Sugisawa, Jun Saito, Seiich Tawara, Hiroshi Akahori, Susumu Sogabe, Takafumi Yamashita, Kazuhiro Takekoshi, Mitsuhide Naruse, Takayuki Katabam. Immunohistochemical Expression of Choline Acetyltransferase and Catecholamine-Synthesizing Enzymes in Head-and-Neck and Thoracoabdominal Paragangliomas and Pheochromocytomas. Endocrine pathology. vol 32. issue 4. 2021-11-23. PMID:34743284. |
to determine the phenotypic features of these pgls, we performed an immunohistochemical study using specific antibodies against choline acetyltransferase (chat), an enzyme involved in acetylcholine synthesis, and enzymes for the catecholamine-synthesis, tyrosine hydroxylase (th), and dopamine beta-hydroxylase (dbh), in 34 hnpgls from 31 patients, 12 thoracoabdominal pgls from 12 patients, and 26 pheochromocytomas from 22 patients. |
2021-11-23 |
2023-08-13 |
Not clear |
| Raquel Martinho, Gabriela Correia, Rafaela Seixas, Ana Oliveira, Soraia Silva, Paula Serrão, Carlos Fernandes-Lopes, Cristina Costa, Mónica Moreira-Rodrigue. Treatment With Nepicastat Decreases Contextual Traumatic Memories Persistence in Post-traumatic Stress Disorder. Frontiers in molecular neuroscience. vol 14. 2021-10-12. PMID:34630037. |
dopamine-β-hydroxylase (dbh) catalyzes the conversion of dopamine to noradrenaline and consequently, dbh inhibition reduces catecholamines. |
2021-10-12 |
2023-08-13 |
mouse |
| Hayden Torres, Clara Huesing, David H Burk, Adrien J R Molinas, Winfried L Neuhuber, Hans-Rudolf Berthoud, Heike Münzberg, Andrei V Derbenev, Andrea Zsombo. Sympathetic innervation of the mouse kidney and liver arising from prevertebral ganglia. American journal of physiology. Regulatory, integrative and comparative physiology. vol 321. issue 3. 2021-09-16. PMID:34231420. |
we used tyrosine hydroxylase (th) and dopamine β-hydroxylase (dbh) reporter mice to visualize abdominal prevertebral ganglia. |
2021-09-16 |
2023-08-13 |
mouse |
| Tessa Wassenberg, Jaap Deinum, Frans J van Ittersum, Erik-Jan Kamsteeg, Maartje Pennings, Marcel M Verbeek, Ron A Wevers, Mirjam E van Albada, Ido P Kema, Jorie Versmissen, Ton van den Meiracker, Jacques W M Lenders, Leo Monnens, Michèl A Willemse. Clinical presentation and long-term follow-up of dopamine beta hydroxylase deficiency. Journal of inherited metabolic disease. vol 44. issue 3. 2021-09-03. PMID:33034372. |
dopamine beta hydroxylase (dbh) deficiency is an extremely rare autosomal recessive disorder with severe orthostatic hypotension, that can be treated with l-threo-3,4-dihydroxyphenylserine (l-dops). |
2021-09-03 |
2023-08-13 |
Not clear |