| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shir Confino, Yair Wexler, Adar Medvetzky, Yotam Elazary, Zohar Ben-Moshe, Joel Reiter, Talya Dor, Simon Edvardson, Gali Prag, Tamar Harel, Yoav Gothil. A deleterious variant of INTS1 leads to disrupted sleep-wake cycles. Disease models & mechanisms. vol 17. issue 8. 2024-08-27. PMID:39189071. |
furthermore, ints1-deficent larvae exhibited elevated levels of dopamine β-hydroxylase (dbh) mrna in the locus coeruleus, a wakefulness-inducing brainstem center. |
2024-08-27 |
2024-08-30 |
human |
| Antonio Verduzco-Mendoza, Daniel Mota-Rojas, Adriana Olmos-Hernández, Alberto Avila-Luna, Karla García-García, Arturo Gálvez-Rosas, Alberto Hidalgo-Bravo, Camilo Ríos, Carmen Parra-Cid, Sergio Montes, Julieta García-López, Laura E Ramos-Languren, Francisca Pérez-Severiano, Rigoberto González-Piña, Antonio Bueno-Nav. Changes in Noradrenergic Synthesis and Dopamine Beta-Hydroxylase Activity in Response to Oxidative Stress after Iron-induced Brain Injury. Neurochemical research. 2024-08-06. PMID:39105899. |
the present study investigated whether iron-induced cortical injury modulated noradrenergic synthesis and dopamine beta-hydroxylase (dbh) activity in response to oxidative stress in the brain cortex, pons and cerebellum of the rat. |
2024-08-06 |
2024-08-08 |
rat |
| Antonio Verduzco-Mendoza, Daniel Mota-Rojas, Adriana Olmos-Hernández, Alberto Avila-Luna, Karla García-García, Arturo Gálvez-Rosas, Alberto Hidalgo-Bravo, Camilo Ríos, Carmen Parra-Cid, Sergio Montes, Julieta García-López, Laura E Ramos-Languren, Francisca Pérez-Severiano, Rigoberto González-Piña, Antonio Bueno-Nav. Changes in Noradrenergic Synthesis and Dopamine Beta-Hydroxylase Activity in Response to Oxidative Stress after Iron-induced Brain Injury. Neurochemical research. 2024-08-06. PMID:39105899. |
on the 3rd and 20th days, the rats were euthanized to measure oxidative stress indicators (reactive oxygen species (ros), reduced glutathione (gsh) and oxidized glutathione (gssg)) and catecholamines (na, dopamine (da)), plus dbh mrna and protein levels. |
2024-08-06 |
2024-08-08 |
rat |
| Jingwei Yu, Shuqin Ji, Huixin Tao, Xiaochun Shan, Yu Yan, Xiangzhou Sun, Xiang'an Tu, Lei Li, Chunhua Den. Cell-specific expression of Cre recombinase in rat noradrenergic neurons via CRISPR-Cas9 system. Neuroscience. 2024-07-27. PMID:39067682. |
in this study, we successfully generated a transgenic rat strain capable of expressing cre recombinase under the control of the dopamine beta-hydroxylase (dbh) gene promoter using the crispr-cas9 system. |
2024-07-27 |
2024-08-02 |
rat |
| Richard B McCosh, Michael J Kreisman, Katherine Tian, Steven A Thomas, Kellie M Bree. Norepinephrine Neurons in the Nucleus of the Solitary Tract Suppress Luteinizing Hormone Secretion in Female Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-07-22. PMID:39038954. |
here, we investigated a population of catecholamine neurons in the nucleus of the solitary tract (nts), marked by expression of the enzyme dopamine beta-hydroxylase (dbh), in female mice. |
2024-07-22 |
2024-07-25 |
mouse |
| Anna Kaplinsky, Reut Halperin, Gadi Shlomai, Amit Tiros. Role of epigenetic regulation on catecholamine synthesis in pheochromocytoma and paraganglioma. Cancer. 2024-06-14. PMID:38872410. |
catecholamines are synthesized by several enzymes: phenylalanine hydroxylase (encoded by pah), tyrosine hydroxylase (th), aromatic l-amino acid decarboxylase (ddc), dopamine β-hydroxylase (dbh), and phenylethanolamine n-methyltransferase (pnmt). |
2024-06-14 |
2024-06-16 |
Not clear |
| Qiaoling Sun, Heng Li, Jing Lv, Weilin Shi, Yanfeng Bai, Ke Pan, Alice Che. Dopamine β-hydroxylase shapes intestinal inflammation through modulating T cell activation. Cellular immunology. vol 401-402. 2024-06-08. PMID:38850753. |
however, the role of dopamine beta-hydroxylase (dbh), an enzyme converting dopamine into norepinephrine, in modulating intestinal inflammation is not well defined. |
2024-06-08 |
2024-06-11 |
Not clear |
| Tao Wang, Jianmin Zeng, Weijie Huang, Xiong Xiong, Li S. Right thalamic volume mediates impact of the dopamine beta-hydroxylase gene on the endowment effect. Behavioural brain research. vol 469. 2024-05-25. PMID:38761858. |
previous studies showed a strong relation between the dopamine beta-hydroxylase (dbh) gene and the endowment effect (ee), and a link between ee and task-based functional mri activation in multiple brain regions. |
2024-05-25 |
2024-05-27 |
human |
| Aisha Nasir Hashmi, Raees Ahmed Dharejo, Usama Bin Zubair, Netasha Khan, Iqra Kashif, Muhammad Ajmal, Rizwan Taj, Raheel Qamar, Maleeha Aza. Association of dopamine β-hydroxylase polymorphism rs1611115 and serum levels with psychiatric disorders in Pakistani population. The International journal of neuroscience. 2024-02-16. PMID:36120985. |
dopamine β-hydroxylase (dbh) is a copper-containing enzyme that has an important role in maintaining the cellular homeostasis between the two neurotransmitters, dopamine (da) and nor-adrenaline (na). |
2024-02-16 |
2024-02-19 |
Not clear |
| Yoshiaki Soejima, Nahoko Iwata, Koichiro Yamamoto, Atsuhito Suyama, Yasuhiro Nakano, Fumio Otsuk. Mutual Effects of Orexin and Bone Morphogenetic Proteins on Catecholamine Regulation Using Adrenomedullary Cells. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338864. |
orexin a treatment reduced the mrna levels of key enzymes for catecholamine synthesis, including tyrosine hydroxylase (th), 3,4-dihydroxyphenylalanie decarboxylase (ddc) and dopamine β-hydroxylase (dbh), in a concentration-dependent manner. |
2024-02-10 |
2024-02-12 |
rat |
| Marta Louçano, Ana Coelho, Sílvia Sousa Chambel, Cristina Prudêncio, Célia Duarte Cruz, Isaura Tavare. Noradrenergic Pathways Involved in Micturition in an Animal Model of Hydrocephalus-Implications for Urinary Dysfunction. Biomedicines. vol 12. issue 1. 2024-01-23. PMID:38255319. |
since our previous characterization of the lc in hydrocephalic animals showed increased levels of noradrenaline, we then evaluated the noradrenergic innervation of the spinal cord's onuf's nucleus by measuring levels of dopamine β-hydroxylase (dbh). |
2024-01-23 |
2024-01-25 |
rat |
| Lais Oliveira Dellacqua, Paula Magalhães Gomes, Julia Santos Batista, Lisete Compagno Michelini, Vagner Roberto Antune. Exercise-induced neuroplasticity in autonomic nuclei restores the cardiac vagal tone and baroreflex dysfunction in aged hypertensive rats. Journal of applied physiology (Bethesda, Md. : 1985). 2023-12-07. PMID:38059293. |
therefore, male 22 month-old spontaneously hypertensive rats (shr) and age-matched wistar kyoto (wky) submitted to moderate-intensity exercise training (t) or kept sedentary (s) for 8 weeks were evaluated for hemodynamic/autonomic parameters, baroreflex sensitivity, cardiac sympathetic/parasympathetic tone and analysis of dopamine β-hydroxylase (dbh) and oxytocin (ot) pathways of autonomic brain nuclei. |
2023-12-07 |
2023-12-10 |
rat |
| Toshiharu Nagats. Catecholamines and Parkinson's disease: tyrosine hydroxylase (TH) over tetrahydrobiopterin (BH4) and GTP cyclohydrolase I (GCH1) to cytokines, neuromelanin, and gene therapy: a historical overview. Journal of neural transmission (Vienna, Austria : 1996). 2023-08-28. PMID:37638996. |
the author identified the genes and proteins of human enzymes involved in the biosynthesis of catecholamines (dopamine, norepinephrine, epinephrine) and tetrahydrobiopterin (bh4): tyrosine hydroxylase (th), aromatic l-amino acid decarboxylase (aadc), dopamine β-hydroxylase (dbh), phenylethanolamine n-methyltransferase (pnmt), and gtp cyclohydrolase i (gch1). |
2023-08-28 |
2023-09-07 |
human |
| Toyanji Joseph Punchaichira, Prachi Kukshal, Triptish Bhatia, Smita Neelkanth Deshpande, B K Thelm. Effect of rs1108580 of DBH and rs1006737 of CACNA1C on Cognition and Tardive Dyskinesia in a North Indian Schizophrenia Cohort. Molecular neurobiology. 2023-07-26. PMID:37493923. |
we aimed to test the association of a functional splice variant each in dopamine β-hydroxylase (dbh; rs1108580) and calcium voltage-gated channel subunit alpha1 c (cacna1c; rs1006737) genes in these pathways with schizophrenia (506 cases, 443 controls); abnormal involuntary movement scale (aims) scores in subjects assessed for tardive dyskinesia (76 td-positive, 95 td-negative) and penn computerized neurocognitive battery (penncnb) scores (334 cases, 234 controls). |
2023-07-26 |
2023-08-14 |
human |
| William Sha. Inhibition of the Beta-oxidation Pathway of Fatty Acids and Dopamine- Beta-hydroxylase by Phenyl Derivatives of Short- Chain Fatty Acids from Gastrointestinal Clostridia Bacteria is a (the) Major Cause of Autism. Integrative medicine (Encinitas, Calif.). vol 22. issue 2. 2023-06-27. PMID:37363147. |
a the author's comprehensive evaluation of the biochemical metabolomic literature over more than 40 years discusses multiple studies documenting abnormal elevations of the neurotransmitter dopamine and its metabolites as well as inhibitors of dopamine beta hydroxylase (dbh) from clostridia bacteria in urine samples and cerebrospinal fluid samples of children with autism. |
2023-06-27 |
2023-08-14 |
Not clear |
| Teresa Juárez-Cedillo, Nancy Martínez-Rodríguez, José Manuel Fragoso, Valentin Islas-Pérez, Amara López-Martínez, Antonio Valle-Medin. Multifactor Dimensionality Reduction Analysis to Evaluate the Association of Dopamine Beta-Hydroxylase (DΒH) Polymorphisms with Susceptibility to Dementia (SADEM Study). Molecular neurobiology. 2023-05-06. PMID:37148523. |
the aim of this study was to evaluate the association between single-nucleotide polymorphism (snp) in the dopamine b-hydroxylase (dbh gene (rs1611115) and their interactions with environmental factors and the dementia risk. |
2023-05-06 |
2023-08-14 |
Not clear |
| Ellen Tedford, Norhidayah Binti Badya, Conor Laing, Nozomi Asaoka, Shuji Kaneko, Beatrice Maria Filippi, Glenn Alan McConke. Infection-induced extracellular vesicles evoke neuronal transcriptional and epigenetic changes. Scientific reports. vol 13. issue 1. 2023-04-27. PMID:37106020. |
tinev (toxoplasma-induced neuronal extracellular vesicles) isolated from infected noradrenergic cells down-regulated dopamine ß-hydroxylase (dbh) gene expression in human and rodent cells. |
2023-04-27 |
2023-08-14 |
human |
| Elsa Isingrini, Chloé Guinaudie, Léa Perret, Elisa Guma, Victor Gorgievski, Ian D Blum, Jessica Colby-Milley, Maryia Bairachnaya, Sébastien Mella, Antoine Adamantidis, Kai-Florian Storch, Bruno Giro. Behavioral and Transcriptomic Changes Following Brain-Specific Loss of Noradrenergic Transmission. Biomolecules. vol 13. issue 3. 2023-03-29. PMID:36979445. |
we engineered vmat2 gene splicing and ne depletion by crossing floxed vmat2 mice with mice expressing the cre-recombinase under the dopamine β-hydroxylase (dbh) gene promotor. |
2023-03-29 |
2023-08-14 |
mouse |
| Xia-Jing Zhang, Zhi-Bin Xiao, Jun-Xiang Gu, Kun Chen, Jian Wang, Sheng-Long Xu, Ke-Ke Xing, Tao Che. Investigating the molecular mechanisms of delirium-like neuropsychiatric disorder induced by electromagnetic pulse based on bioinformatics analysis. Molecular brain. vol 16. issue 1. 2023-02-08. PMID:36750928. |
lncrna aabr07042999.1 and mrna tph2, slc6a4, dbh and th were upregulated, and the contents of serotonin, dopamine and norepinephrine were increased in both pfc and hip after emp exposure. |
2023-02-08 |
2023-08-14 |
rat |
| Mehmet Evren Öztürk, Anıl Yirün, Selinay Başak Erdemli-Köse, Aylin Balcı-Özyurt, Deniz Arca Çakır, Didem Oral, Pınar Erkekoğl. Evaluation of the toxic effects of thimerosal and/or aluminum hydroxide in SH-SY5Y cell line. Human & experimental toxicology. vol 41. 2022-11-21. PMID:36411272. |
nuclear factor erythroid 2-associated factor 2 (nrf2), norepinephrine (ne), dopamine transporter (dat) and dopamine beta β-hydroxylase (dbh) levels were measured by sandwich elisa kits while 8-hydroxy deoxyguanosine (8-ohdg) and dopamine levels were determined by competitive elisa kits. |
2022-11-21 |
2023-08-14 |
Not clear |