| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erin S Calipari, Mark J Ferris, Cody A Siciliano, Sara R Jone. Differential influence of dopamine transport rate on the potencies of cocaine, amphetamine, and methylphenidate. ACS chemical neuroscience. vol 6. issue 1. 2015-09-10. PMID:25474655. |
dopamine transporter (dat) levels vary across brain regions and individuals, and are altered by drug history and disease states; however, the impact of altered dat expression on psychostimulant effects in brain has not been systematically explored. |
2015-09-10 |
2023-08-13 |
Not clear |
| Erin S Calipari, Mark J Ferris, Cody A Siciliano, Sara R Jone. Differential influence of dopamine transport rate on the potencies of cocaine, amphetamine, and methylphenidate. ACS chemical neuroscience. vol 6. issue 1. 2015-09-10. PMID:25474655. |
using fast scan cyclic voltammetry, we measured the effects of elevated dat levels on presynaptic dopamine parameters as well as the uptake inhibition potency of the blockers cocaine and methylphenidate (mph) and the releaser amphetamine (amph) in the nucleus accumbens core. |
2015-09-10 |
2023-08-13 |
Not clear |
| Yasemin Karabacak, Sunetra Sase, Yogesh D Aher, Ajinkya Sase, Sivaprakasam R Saroja, Ana Cicvaric, Harald Höger, Michael Berger, Vasiliy Bakulev, Harald H Sitte, Johann Leban, Francisco J Monje, Gert Lube. The effect of modafinil on the rat dopamine transporter and dopamine receptors D1-D3 paralleling cognitive enhancement in the radial arm maze. Frontiers in behavioral neuroscience. vol 9. 2015-09-08. PMID:26347626. |
modafinil was binding to the dat but insignificantly to sert or net and dopamine reuptake was blocked specifically (ic50 = 11.11 μm; sert 1547 μm; net 182 μm). |
2015-09-08 |
2023-08-13 |
rat |
| Ágnes Fehér, Anna Juhász, Magdolna Pákáski, János Kálmán, Zoltán Jank. Association between the 9 repeat allele of the dopamine transporter 40bp variable tandem repeat polymorphism and Alzheimer's disease. Psychiatry research. vol 220. issue 1-2. 2015-09-01. PMID:25130782. |
a case-control study was performed to investigate the association between the dopamine transporter (dat) gene (slc6a3) rs28363170 polymorphism and the risk for alzheimer's disease (ad). |
2015-09-01 |
2023-08-13 |
Not clear |
| Daniel Jenson, Kechun Yang, Alexandra Acevedo-Rodriguez, Amber Levine, John I Broussard, Jianrong Tang, John A Dan. Dopamine and norepinephrine receptors participate in methylphenidate enhancement of in vivo hippocampal synaptic plasticity. Neuropharmacology. vol 90. 2015-08-20. PMID:25445492. |
our hypothesis was that mph affects hippocampal synaptic plasticity underlying learning because mph boosts catecholamine signaling by blocking the dopamine and norepinephrine transporters (dat and net respectively). |
2015-08-20 |
2023-08-13 |
mouse |
| Thomas Steinkellner, Therese R Montgomery, Tina Hofmaier, Oliver Kudlacek, Jae-Won Yang, Mattias Rickhag, Gangsoo Jung, Gert Lubec, Ulrik Gether, Michael Freissmuth, Harald H Sitt. Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 21. 2015-08-20. PMID:26019340. |
amphetamine-induced transport reversal at the closely related dopamine transporter (dat) has been shown previously to be contingent upon modulation by calmodulin kinase iiα (αcamkii). |
2015-08-20 |
2023-08-13 |
mouse |
| Yoshitoshi Shingai, Amane Tateno, Ryosuke Arakawa, Takeshi Sakayori, WooChan Kim, Hidenori Suzuki, Yoshiro Okub. Age-related decline in dopamine transporter in human brain using PET with a new radioligand [¹⁸F]FE-PE2I. Annals of nuclear medicine. vol 28. issue 3. 2015-08-19. PMID:24385293. |
dopamine transporter (dat) density is considered as a marker of pre-synaptic function. |
2015-08-19 |
2023-08-12 |
human |
| Suja Sadasivan, Joseph H Friedma. Experience with DaTscan at a tertiary referral center. Parkinsonism & related disorders. vol 21. issue 1. 2015-08-19. PMID:25465746. |
functional imaging of the dopamine transporter (dat) defines integrity of the striatal dopaminergic system and provides a marker for presynaptic neuronal degeneration. |
2015-08-19 |
2023-08-13 |
Not clear |
| Peter S Hasenhuetl, Klaus Schicker, Xaver Koenig, Yang Li, Subhodeep Sarker, Thomas Stockner, Sonja Sucic, Harald H Sitte, Michael Freissmuth, Walter Sandtne. Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction. Molecular pharmacology. vol 88. issue 1. 2015-08-11. PMID:25873594. |
the membrane transporters for the monoamines serotonin (sert) and dopamine (dat) are prominent targets of various psychoactive substances, including competitive inhibitors, such as tricyclic antidepressants, methylphenidate, and cocaine. |
2015-08-11 |
2023-08-13 |
Not clear |
| C Ortez, S T Duarte, A Ormazábal, M Serrano, A Pérez, R Pons, M Pineda, Z Yapici, E Fernández-Álvarez, R Domingo-Jiménez, P De Castro, R Artuch, A García-Cazorl. Cerebrospinal fluid synaptic proteins as useful biomarkers in tyrosine hydroxylase deficiency. Molecular genetics and metabolism. vol 114. issue 1. 2015-08-07. PMID:25468651. |
dopamine transporter (dat), d2-receptor and vesicular monoamine transporter (vmat2) were measured in the csf of 10 subjects with th deficiency by western blot analysis. |
2015-08-07 |
2023-08-13 |
human |
| David J Heal, Jane Gosden, Sharon L Smit. Dopamine reuptake transporter (DAT) "inverse agonism"--a novel hypothesis to explain the enigmatic pharmacology of cocaine. Neuropharmacology. vol 87. 2015-08-04. PMID:24953830. |
dopamine reuptake transporter (dat) "inverse agonism"--a novel hypothesis to explain the enigmatic pharmacology of cocaine. |
2015-08-04 |
2023-08-13 |
human |
| David J Heal, Jane Gosden, Sharon L Smit. Dopamine reuptake transporter (DAT) "inverse agonism"--a novel hypothesis to explain the enigmatic pharmacology of cocaine. Neuropharmacology. vol 87. 2015-08-04. PMID:24953830. |
we describe the experimental findings which suggest cocaine serves as a negative allosteric modulator to alter the function of the dopamine reuptake transporter (dat) and reverse its direction of transport. |
2015-08-04 |
2023-08-13 |
human |
| David J Heal, Jane Gosden, Sharon L Smit. Dopamine reuptake transporter (DAT) "inverse agonism"--a novel hypothesis to explain the enigmatic pharmacology of cocaine. Neuropharmacology. vol 87. 2015-08-04. PMID:24953830. |
because the physiological role of dat is to remove dopamine from the synapse and the action of cocaine is the opposite of this, we have postulated that cocaine's effect is analogous to an inverse agonist. |
2015-08-04 |
2023-08-13 |
human |
| Julien Vezoli, Kwamivi Dzahini, Nicolas Costes, Charles R E Wilson, Karim Fifel, Howard M Cooper, Henry Kennedy, Emmanuel Procy. Increased DAT binding in the early stage of the dopaminergic lesion: a longitudinal [11C]PE2I binding study in the MPTP-monkey. NeuroImage. vol 102 Pt 2. 2015-08-03. PMID:25108180. |
we measured the binding potential of the selective dopamine active transporter (dat) radiotracer [(11)c]pe2i in mptp-treated macaque monkeys, thus establishing a detailed profile of the nigrostriatal da status following mptp intoxication and its relation to induced motor and non-motor symptoms. |
2015-08-03 |
2023-08-13 |
monkey |
| Zongchang Li, Ying He, Jinsong Tang, Xiaofen Zong, Maolin Hu, Xiaogang Che. Molecular imaging of striatal dopamine transporters in major depression--a meta-analysis. Journal of affective disorders. vol 174. 2015-08-03. PMID:25497470. |
increasing studies have revealed the dopamine transporter (dat) availability altered in striatum associated with major depression. |
2015-08-03 |
2023-08-13 |
Not clear |
| Manuela C Matesan, Donna J Cross, David H Lewis, Satoshi Minoshim. Differential alterations of dopamine transporter in the striatum and midbrain in patients with parkinsonian syndrome. Clinical nuclear medicine. vol 40. issue 3. 2015-07-30. PMID:25546191. |
in this study, we examined dopamine transporter (dat) density in the striatum versus midbrain (mb) in patients with nigrostriatal denervation. |
2015-07-30 |
2023-08-13 |
Not clear |
| Jason R Richardson, Michele M Taylor, Stuart L Shalat, Thomas S Guillot, W Michael Caudle, Muhammad M Hossain, Tiffany A Mathews, Sara R Jones, Deborah A Cory-Slechta, Gary W Mille. Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 5. 2015-07-30. PMID:25630971. |
mice exposed to the pyrethroid pesticide deltamethrin during development exhibit several features reminiscent of adhd, including elevated dopamine transporter (dat) levels, hyperactivity, working memory and attention deficits, and impulsive-like behavior. |
2015-07-30 |
2023-08-13 |
mouse |
| Kai-Chun Yang, Shyh-Jen Wang, Wen-Chi Hsieh, Jiing-Feng Lirng, Chen-Chang Yang, Jou-Fang Deng, Chun-Lung Lin, Yuan-Hwa Cho. Longitudinal changes in the dopamine transporter and cognition in suicide attempters with charcoal burning. Psychiatry research. vol 231. issue 2. 2015-07-29. PMID:25572798. |
this study was designed to elucidate associations between changes in the dopamine transporter (dat) and cognitive function in patients following co poisoning during a follow-up period of 6 months. |
2015-07-29 |
2023-08-13 |
human |
| Stephen J Kohut, Takato Hiranita, Soo-Kyung Hong, Aaron L Ebbs, Valeria Tronci, Jennifer Green, Linda Garcés-Ramírez, Lauren E Chun, Maddalena Mereu, Amy H Newman, Jonathan L Katz, Gianluigi Tand. Preference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic dopamine. Biological psychiatry. vol 76. issue 10. 2015-07-27. PMID:24853388. |
subjective effects of cocaine are mediated primarily by dopamine (da) transporter (dat) blockade. |
2015-07-27 |
2023-08-13 |
Not clear |
| Mariana Raineri, Betina González, Celeste Rivero-Echeto, Javier A Muñiz, María Laura Gutiérrez, Carolina I Ghanem, Jean Lud Cadet, Edgar García-Rill, Francisco J Urbano, Veronica Bisagn. Differential effects of environment-induced changes in body temperature on modafinil's actions against methamphetamine-induced striatal toxicity in mice. Neurotoxicity research. vol 27. issue 1. 2015-07-27. PMID:25261212. |
brains were dissected out 6 days after treatments and processed for tyrosine hydroxylase (th), dopamine transporter (dat), gfap and c-fos immunohistochemistry. |
2015-07-27 |
2023-08-13 |
mouse |