| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Takamatsu, Y Hagino, A Sato, T Takahashi, S Y Nagasawa, Y Kubo, M Mizuguchi, G R Uhl, I Sora, K Iked. Improvement of learning and increase in dopamine level in the frontal cortex by methylphenidate in mice lacking dopamine transporter. Current molecular medicine. vol 15. issue 3. 2016-02-12. PMID:25817856. |
recent studies have drawn attention to altered dopamine-mediated neurotransmission in adhd, particularly reuptake by the dopamine transporter (dat). |
2016-02-12 |
2023-08-13 |
mouse |
| Y Kasahara, Y Arime, F S Hall, G R Uhl, I Sor. Region-specific dendritic spine loss of pyramidal neurons in dopamine transporter knockout mice. Current molecular medicine. vol 15. issue 3. 2016-02-12. PMID:25817859. |
dopamine transporter (dat) knockout (ko) mice show numerous behavioral alterations, including hyperlocomotion, cognitive deficits, impulsivity and impairment of prepulse inhibition of the startle reflex (ppi), phenotypes that may be relevant to frontostriatal disorders such as schizophrenia. |
2016-02-12 |
2023-08-13 |
mouse |
| Aida Niñerola-Baizán, Santiago Rojas, Núria Roé-Vellvé, Francisco Lomeña, Domènec Ros, Javier Paví. Dopamine transporter imaging in the aged rat: a [¹²³I]FP-CIT SPECT study. Nuclear medicine and biology. vol 42. issue 4. 2016-02-09. PMID:25624150. |
one of the results of this susceptibility is a decline in striatal dopamine transporter (dat) availability. |
2016-02-09 |
2023-08-13 |
rat |
| Christian Pifl, Harald Reither, Oleh Hornykiewic. The profile of mephedrone on human monoamine transporters differs from 3,4-methylenedioxymethamphetamine primarily by lower potency at the vesicular monoamine transporter. European journal of pharmacology. vol 755. 2016-02-09. PMID:25771452. |
we therefore compared their effects on the human monoamine transporters using human cell lines stably expressing the human noradrenaline, dopamine and serotonin transporter (net, dat and sert); preparations of synaptic vesicles from human striatum in uptake experiments; and a superfusion system where releasing effects can be reliably measured. |
2016-02-09 |
2023-08-13 |
human |
| Yasir H Ahmed-Braimah, Andrea L Sweigar. A single gene causes an interspecific difference in pigmentation in Drosophila. Genetics. vol 200. issue 1. 2016-02-08. PMID:25769982. |
the mapped interval includes only the first exon and regulatory region(s) of the dopamine n-acetyltransferase gene (dat). |
2016-02-08 |
2023-08-13 |
drosophila_melanogaster |
| Frank Scott Hall, Ichiro Sora, René Hen, George R Uh. Serotonin/dopamine interactions in a hyperactive mouse: reduced serotonin receptor 1B activity reverses effects of dopamine transporter knockout. PloS one. vol 9. issue 12. 2016-02-04. PMID:25514162. |
knockout (ko) mice that lack the dopamine transporter (sl6a3; dat) display increased locomotion that can be attenuated, under some circumstances, by administration of drugs that normally produce psychostimulant-like effects, such as amphetamine and methylphenidate. |
2016-02-04 |
2023-08-13 |
mouse |
| Frank Scott Hall, Ichiro Sora, René Hen, George R Uh. Serotonin/dopamine interactions in a hyperactive mouse: reduced serotonin receptor 1B activity reverses effects of dopamine transporter knockout. PloS one. vol 9. issue 12. 2016-02-04. PMID:25514162. |
these findings of complementation of the locomotor effects of dat ko by reducing 5-ht1b receptor activity underscore roles for interactions between specific 5-ht receptors and dopamine (da) systems in basal and cocaine-stimulated locomotion and support evaluation of 5-ht1b antagonists as potential, non-stimulant adhd therapeutics. |
2016-02-04 |
2023-08-13 |
mouse |
| J Renard, M Citeri, L Zanollo, C Guerrer, L Rizzato, L Frediani, C E Iselin, M Spinell. Can Dopamine Depletion at DAT Scan in a Non Parkinson Patient be the Cause a Refractory Overactive Bladder? Urology case reports. vol 3. issue 6. 2016-01-21. PMID:26793549. |
can dopamine depletion at dat scan in a non parkinson patient be the cause a refractory overactive bladder? |
2016-01-21 |
2023-08-13 |
Not clear |
| J Renard, M Citeri, L Zanollo, C Guerrer, L Rizzato, L Frediani, C E Iselin, M Spinell. Can Dopamine Depletion at DAT Scan in a Non Parkinson Patient be the Cause a Refractory Overactive Bladder? Urology case reports. vol 3. issue 6. 2016-01-21. PMID:26793549. |
dat scan was finally performed showing clear reduction in dopamine secretion without diagnosis of any neurological condition. |
2016-01-21 |
2023-08-13 |
Not clear |
| Eline R Zaaijer, Lonneke van Dijk, Kora de Bruin, Anna E Goudriaan, Laureen A Lammers, Maarten W J Koeter, Wim van den Brink, Jan Booi. Effect of extended-release naltrexone on striatal dopamine transporter availability, depression and anhedonia in heroin-dependent patients. Psychopharmacology. vol 232. issue 14. 2016-01-19. PMID:25757673. |
however, naltrexone treatment of opioid-dependent patients may reduce striatal dopamine transporter (dat) availability and cause depression and anhedonia. |
2016-01-19 |
2023-08-13 |
Not clear |
| Lan-Ting Lee, Hsin Chun Tsai, Mei Hung Chi, Wei Hung Chang, Kao Chin Chen, I Hui Lee, Po See Chen, Wei Jen Yao, Nan Tsing Chiu, Yen Kuang Yan. Lower availability of striatal dopamine transporter in generalized anxiety disorder: a preliminary two-ligand SPECT study. International clinical psychopharmacology. vol 30. issue 3. 2016-01-15. PMID:25647452. |
the aims of this study were to examine the availabilities of the striatal dopamine transporter (dat) and the midbrain serotonin transporter (sert) in patients with gad. |
2016-01-15 |
2023-08-13 |
human |
| George Khelashvili, Milka Doktorova, Michelle A Sahai, Niklaus Johner, Lei Shi, Harel Weinstei. Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2 -containing membranes. Proteins. vol 83. issue 5. 2016-01-15. PMID:25739722. |
the dopamine transporter (dat) is a transmembrane protein belonging to the family of neurotransmitter:sodium symporters (nss). |
2016-01-15 |
2023-08-13 |
human |
| Fabíola Trevizol, Verônica T Dias, Katiane Roversi, Raquel C S Barcelos, Fábio T Kuhn, Karine Roversi, Camila S Pase, Ronaldo Golombieski, Juliana C Veit, Jaqueline Piccolo, Tatiana Emanuelli, João B T Rocha, Marilise E Bürge. Cross-generational trans fat intake modifies BDNF mRNA in the hippocampus: Impact on memory loss in a mania animal model. Hippocampus. vol 25. issue 5. 2016-01-13. PMID:25394793. |
fo supplementation was associated with lower reactive species (rs) generation and protein carbonyl (pc) levels and increased dopamine transporter (dat) levels, while hvf increased rs and pc levels, thus decreasing catalase (cat) activity and dat levels in hippocampus after amph treatment. |
2016-01-13 |
2023-08-13 |
rat |
| Ying-Shan Piao, Frank Scott Hall, Yuki Moriya, Miki Ito, Arihisa Ohara, Ruri Kikura-Hanajiri, Yukihiro Goda, Klaus-Peter Lesch, Dennis L Murphy, George R Uhl, Ichiro Sor. Methylone-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters. Behavioural pharmacology. vol 26. issue 4. 2016-01-13. PMID:25794333. |
methylone has been assumed to induce hyperthermic effects through inhibition of serotonin and/or dopamine transporters (sert and dat, respectively). |
2016-01-13 |
2023-08-13 |
mouse |
| Rafael Godoy, Sandra Noble, Kevin Yoon, Hymie Anisman, Marc Ekke. Chemogenetic ablation of dopaminergic neurons leads to transient locomotor impairments in zebrafish larvae. Journal of neurochemistry. vol 135. issue 2. 2016-01-11. PMID:26118896. |
to determine the impact of a controlled loss of dopaminergic neurons on locomotor function, we generated transgenic zebrafish, tg(dat:cfp-ntr), expressing a cyan fluorescent protein-nitroreductase fusion protein (cfp-ntr) under the control of dopamine transporter (dat) cis-regulatory elements. |
2016-01-11 |
2023-08-13 |
zebrafish |
| Javier Castro-Hernández, Domingo Afonso-Oramas, Ignacio Cruz-Muros, Josmar Salas-Hernández, Pedro Barroso-Chinea, Rosario Moratalla, Mark J Millan, Tomás González-Hernánde. Prolonged treatment with pramipexole promotes physical interaction of striatal dopamine D3 autoreceptors with dopamine transporters to reduce dopamine uptake. Neurobiology of disease. vol 74. 2016-01-06. PMID:25511804. |
the dopamine (da) transporter (dat), a membrane glycoprotein expressed in dopaminergic neurons, clears da from extracellular space and is regulated by diverse presynaptic proteins like protein kinases, α-synuclein, d2 and d3 autoreceptors. |
2016-01-06 |
2023-08-13 |
mouse |
| Francisco Molinet-Dronda, Belén Gago, Ana Quiroga-Varela, Carlos Juri, María Collantes, Mercedes Delgado, Elena Prieto, Margarita Ecay, Elena Iglesias, Concepció Marín, Iván Peñuelas, José A Obes. Monoaminergic PET imaging and histopathological correlation in unilateral and bilateral 6-hydroxydopamine lesioned rat models of Parkinson's disease: a longitudinal in-vivo study. Neurobiology of disease. vol 77. 2016-01-06. PMID:25681534. |
behavior was characterized by rotational, catalepsy and limb-use asymmetry tests and dopaminergic striatal denervation was validated post-mortem by immunostaining of the dopamine transporter (dat). |
2016-01-06 |
2023-08-13 |
rat |
| F Sakloth, R Kolanos, P D Mosier, J S Bonano, M L Banks, J S Partilla, M H Baumann, S S Negus, R A Glenno. Steric parameters, molecular modeling and hydropathic interaction analysis of the pharmacology of para-substituted methcathinone analogues. British journal of pharmacology. vol 172. issue 9. 2016-01-05. PMID:25522019. |
specifically, the steric character (taft's steric es ) of the 4-position substituent affected in vitro potency to induce monoamine release via dopamine and 5-ht transporters (dat and sert) and in vivo modulation of intracranial self-stimulation (icss). |
2016-01-05 |
2023-08-13 |
Not clear |
| Oleg Kovtun, Dhananjay Sakrikar, Ian D Tomlinson, Jerry C Chang, Xochitl Arzeta-Ferrer, Randy D Blakely, Sandra J Rosentha. Single-quantum-dot tracking reveals altered membrane dynamics of an attention-deficit/hyperactivity-disorder-derived dopamine transporter coding variant. ACS chemical neuroscience. vol 6. issue 4. 2016-01-04. PMID:25747272. |
the presynaptic, cocaine- and amphetamine-sensitive dopamine (da) transporter (dat, slc6a3) controls the intensity and duration of synaptic dopamine signals by rapid clearance of da back into presynaptic nerve terminals. |
2016-01-04 |
2023-08-13 |
Not clear |
| Andrzej Jasiewicz, Błażej Rubiś, Jerzy Samochowiec, Iwona Małecka, Aleksandra Suchanecka, Marcin Jabłoński, Anna Grzywac. DAT1 methylation changes in alcohol-dependent individuals vs. controls. Journal of psychiatric research. vol 64. 2016-01-04. PMID:25862379. |
dopamine transporter (dat) gene is also supposed to be differentially methylated in alcohol-dependent patients than in controls. |
2016-01-04 |
2023-08-13 |
Not clear |