| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dmitrii S Traktirov, Ilya R Nazarov, Valeria S Artemova, Raul R Gainetdinov, Nina S Pestereva, Marina N Karpenk. Alterations in Serotonin Neurotransmission in Hyperdopaminergic Rats Lacking the Dopamine Transporter. Biomedicines. vol 11. issue 11. 2023-11-25. PMID:38001881. |
in this article we showed that knockout of the gene encoding dat leads not only to a profound dysregulation of dopamine neurotransmission in the striatum but also in the midbrain, prefrontal cortex, hippocampus, medulla oblongata and spinal cord. |
2023-11-25 |
2023-11-28 |
rat |
| Felix P Mayer, Adele Stewart, Randy D Blakel. Leaky lessons learned: Efflux prone dopamine transporter variant DAT Val559 reveals sex and circuit specific contributions of D2 receptor signaling to neuropsychiatric disease. Basic & clinical pharmacology & toxicology. 2023-11-21. PMID:37987120. |
leaky lessons learned: efflux prone dopamine transporter variant dat val559 reveals sex and circuit specific contributions of d2 receptor signaling to neuropsychiatric disease. |
2023-11-21 |
2023-11-29 |
mouse |
| Yong-Qing Zhang, Hyun Kyu Min, Eunchong Hong, Eunhye Yu, Sun Mi Gu, Seong Shoon Yoon, Dohyun Lee, Jaejun Lee, Jin Tae Hong, Jaesuk Yu. Abused drug-induced intracranial self-stimulation is correlated with the alteration of dopamine transporter availability in the medial prefrontal cortex and nucleus accumbens of mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 169. 2023-11-10. PMID:37948992. |
we determined dopamine transporter (dat) availability in the medial prefrontal cortex (mpfc), striatum, and nucleus accumbens (nac) after drug treatment. |
2023-11-10 |
2023-11-20 |
mouse |
| Nicole Burkert, Shoumik Roy, Max Häusler, Dominik Wuttke, Sonja Müller, Johanna Wiemer, Helene Hollmann, Marvin Oldrati, Jorge Ramirez-Franco, Julia Benkert, Michael Fauler, Johanna Duda, Jean-Marc Goaillard, Christina Pötschke, Moritz Münchmeyer, Rosanna Parlato, Birgit Lis. Deep learning-based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra. Communications biology. vol 6. issue 1. 2023-11-10. PMID:37950046. |
using dlap, we identified a small subpopulation of th-positive neurons (~5%), mainly located in the very lateral substantia nigra (sn), that was immunofluorescence-negative for the plasmalemmal dopamine transporter (dat), with ~40% smaller cell bodies. |
2023-11-10 |
2023-11-20 |
mouse |
| Hyomin Ahn, Kichul Park, Dongyoung Kim, Sung-Gil Chi, Kee-Hyun Choi, Seo-Jung Han, Chiman Son. Implications for Combination Therapy of Selective Monoamine Reuptake Inhibitors on Dopamine Transporters. Biomedicines. vol 11. issue 10. 2023-10-30. PMID:37893219. |
monoamine transporters, including dopamine, norepinephrine, and serotonin transporters (dat, net, and sert, respectively), are important therapeutic targets due to their essential roles in the brain. |
2023-10-30 |
2023-11-08 |
Not clear |
| Maddison Reed, Wen Pan, Lina Musa, Stefania Arlotta, Jan A Mennigen, Michael G Jon. A role for dopamine in control of the hypoxic ventilatory response via D The Journal of comparative neurology. 2023-10-14. PMID:37837632. |
we further identified dopamine active transporter (dat) and vesicular monoamine transporter (vmat2) expression in neurons of the gill filaments using transgenic lines. |
2023-10-14 |
2023-11-08 |
zebrafish |
| Romain Geelhand de Merxem, Sandrine Launay, Catherine Hana. Association Between Bipolar Disorder and Parkinson's Disease. Psychiatria Danubina. vol 35. issue Suppl 2. 2023-10-06. PMID:37800205. |
dopamine transporter (dat) scans can aid in making a differential diagnosis. |
2023-10-06 |
2023-10-07 |
Not clear |
| Mei Tian, Chuantao Zuo, A Cahid Civelek, Ignasi Carrio, Yasuyoshi Watanabe, Keon Wook Kang, Koji Murakami, John O Prior, Yan Zhong, Xiaofeng Dou, Congcong Yu, Chentao Jin, Rui Zhou, Fengtao Liu, Xinyi Li, Jiaying Lu, Hong Zhang, Jian Wan. International consensus on clinical use of presynaptic dopaminergic positron emission tomography imaging in parkinsonism. European journal of nuclear medicine and molecular imaging. 2023-10-03. PMID:37789188. |
the pet tracers most commonly used at the present time mainly target dopamine transporters (dat), aromatic amino acid decarboxylase (aadc), and vesicular monoamine type 2 (vmat2). |
2023-10-03 |
2023-10-07 |
Not clear |
| Gioia Zanfino, Concetto Puzzo, Vincenzo de Laurenzi, Walter Adrian. Characterization of Behavioral Phenotypes in Heterozygous DAT Rat Based on Pedigree. Biomedicines. vol 11. issue 9. 2023-09-28. PMID:37761006. |
reuptake is carried out by the dopamine transporter (dat; |
2023-09-28 |
2023-10-07 |
rat |
| Li He, Huihui Zheng, Jilong Qiu, Hong Chen, Huan Li, Yuejiao Ma, Yingying Wang, Qianjin Wang, Yuzhu Hao, Yueheng Liu, Qian Yang, Xin Wang, Manyun Li, Huixue Xu, Pu Peng, Zejun Li, Yanan Zhou, Qiuxia Wu, Shubao Chen, Xiaojie Zhang, Tieqiao Li. Effects of Multiple High-Dose Methamphetamine Administration on Enteric Dopaminergic Neurons and Intestinal Motility in the Rat Model. Neurotoxicity research. 2023-09-27. PMID:37755670. |
the edns were assessed by measuring the expression of two dopaminergic neuronal markers, dopamine transporter (dat) and tyrosine hydroxylase (th), at the transcriptional and protein levels. |
2023-09-27 |
2023-10-07 |
rat |
| R Schumacher, M F Rossetti, G Canesini, L Gaydou, A P Garcia, G P Lazzarino, P R Fernandez, C Stoker, M J Carrió, M F Andreoli, J G Ramo. Neonatal overfeeding alters the functioning of the mesolimbic dopaminergic circuitry involving changes in DNA methylation and effects on feeding behavior. The Journal of nutritional biochemistry. 2023-09-25. PMID:37748623. |
sl-pnd21 animals presented increased expression levels of tyrosine hydroxylase and dopamine receptor d2 in vta, decreased expression levels of dopamine active transporter (dat) in vta, and higher expression levels of dat in nacc. |
2023-09-25 |
2023-10-07 |
rat |
| Jie Chen, Xufang Gao, Chengyou Zheng, Chen Zhang, Peimao Li, Kaiwu He, Gongping Liu, Xinfeng Huang, Jianjun Liu, Yongmei Xie, Xifei Yan. Low-dose Cu exposure enhanced α-synuclein accumulation associates with mitochondrial impairments in mice model of Parkinson's disease. Toxicology letters. 2023-09-17. PMID:37717680. |
proteomics revealed changes in neurodevelopment, transport function, and mitochondrial membrane-related function in cu-treated wt mice, which were associated with reduced expression of mitochondrial complex (ndufa10, atp5a), dopamine neurons (th), and dopamine transporter (dat). |
2023-09-17 |
2023-10-07 |
mouse |
| Pengju Yan, Ningning Li, Ming Ma, Zhaoli Liu, Huicui Yang, Jinnan Li, Chunlei Wan, Shuliu Gao, Shuai Li, Longtai Zheng, John L Waddington, Lin Xu, Xuechu Zhe. Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis. Signal transduction and targeted therapy. vol 8. issue 1. 2023-09-17. PMID:37718358. |
additionally, the elevation of hif-1α enhanced hepcidin/ferroportin 1 (fpn1)-mediated iron efflux and resulted in cellular iron deficiency, which led to the functional accumulation of the dopamine transporter (dat) in plasma membranes due to iron deficiency-impaired ubiquitin degradation. |
2023-09-17 |
2023-10-07 |
mouse |
| Felix P Mayer, Marco Niello, Simon Bulling, Yuan-Wei Zhang, Yang Li, Oliver Kudlacek, Marion Holy, Fatemeh Kooti, Walter Sandtner, Gary Rudnick, Diethart Schmid, Harald H Sitt. Mephedrone induces partial release at human dopamine transporters but full release at human serotonin transporters. Neuropharmacology. 2023-09-13. PMID:37703919. |
the stimulating properties are believed to arise from the ability of mephedrone to interact with the high-affinity transporters for dopamine (da) (dat) and norepinephrine (net), whereas the entactogenic effect presumably relies on its activity at the serotonin (5-ht) transporter (sert). |
2023-09-13 |
2023-10-07 |
human |
| Norasma Amira Binti Zainudin, Nurul Nadiah Zulkifli, Khadijah Abdul Hamid, Hazlin Hashim, Syahir Manso. A Pilot Study of the Striatal Dopamine Transporter Levels in Kratom-Dependent and Normal Subjects Using 99mTc-TRODAT-1 Single Photon Emission Computed Tomography-Computed Tomography (SPECT-CT). Cureus. vol 15. issue 8. 2023-09-11. PMID:37692587. |
the study aims to elucidate the effects of kratom addiction on dopamine transporter (dat) using [2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]ethanethiolato(3-)-n2,n20,s2,s20]oxo-[1r-(exo-exo)]-[ |
2023-09-11 |
2023-10-07 |
human |
| Maged M Harra. Selective dopaminergic vulnerability in Parkinson's disease: new insights into the role of DAT. Frontiers in neuroscience. vol 17. 2023-09-11. PMID:37694119. |
several mechanisms, previously considered in isolation, have been proposed to contribute to the pathophysiology of dopaminergic degeneration: dopamine oxidation-mediated neurotoxicity, high dopamine transporter (dat) expression density per neuron, and autophagy-lysosome pathway (alp) dysfunction. |
2023-09-11 |
2023-10-07 |
Not clear |
| Maged M Harra. Selective dopaminergic vulnerability in Parkinson's disease: new insights into the role of DAT. Frontiers in neuroscience. vol 17. 2023-09-11. PMID:37694119. |
i propose that autophagy modulates dopamine reuptake by selectively degrading dat. |
2023-09-11 |
2023-10-07 |
Not clear |
| Maged M Harra. Selective dopaminergic vulnerability in Parkinson's disease: new insights into the role of DAT. Frontiers in neuroscience. vol 17. 2023-09-11. PMID:37694119. |
in pd, alp dysfunction could increase dat density per neuron, and enhance dopamine reuptake, oxidation, and neurotoxicity, potentially contributing to the progressive loss of dopaminergic neurons. |
2023-09-11 |
2023-10-07 |
Not clear |
| Tao Ke, Ganesh Ambigapathy, Thanh Ton, Archana Dhasarathy, Lucia Carvell. Long-Lasting Epigenetic Changes in the Dopamine Transporter in Adult Animals Exposed to Amphetamine during Embryogenesis: Investigating Behavioral Effects. International journal of molecular sciences. vol 24. issue 17. 2023-09-09. PMID:37685899. |
the dopamine transporter (dat) is an integral member of the dopaminergic system and is responsible for the release and reuptake of dopamine from the synaptic space into the dopaminergic neurons. |
2023-09-09 |
2023-10-07 |
Not clear |
| Jan Booij, Sem P Tellier, John Seibyl, Chris Vrien. Dopamine Transporter Availability in Early Parkinson's Disease is Dependent on Sunlight Exposure. Movement disorders : official journal of the Movement Disorder Society. 2023-09-06. PMID:37670567. |
preliminary studies suggested seasonality of dopaminergic functioning, but it is unknown whether dopamine transporter (dat) expression in humans is also dependent on the seasons. |
2023-09-06 |
2023-10-07 |
Not clear |