| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yatao Du, Qin Li, Guangdi Zhou, Zhenzhen Cai, Qiuhong Man, Weiye Charles Wan. Early-life perfluorooctanoic acid exposure disrupts the function of dopamine transporter protein with glycosylation changes implicating the links between decreased dopamine levels and disruptive behaviors in larval zebrafish. The Science of the total environment. 2024-01-28. PMID:38281643. |
taken together, we can deduce that glycosylation changes in dat lead to dysfunction of dat to regulate dopamine levels, which in turn alters behavior in larval zebrafish. |
2024-01-28 |
2024-01-31 |
human |
| Efthalia Angelopoulou, Anastasia Bougea, Alexandros Hatzimanolis, Leonidas Stefanis, Nikolaos Scarmeas, Sokratis Papageorgio. Mild Behavioral Impairment in Parkinson's Disease: An Updated Review on the Clinical, Genetic, Neuroanatomical, and Pathophysiological Aspects. Medicina (Kaunas, Lithuania). vol 60. issue 1. 2024-01-23. PMID:38256375. |
neuroimaging studies have revealed that mbi in patients with pd may be related todistinct patterns of brain atrophy, altered neuronal connectivity, and distribution of dopamine transporter (dat) depletion, shedding more light on its pathophysiological background. |
2024-01-23 |
2024-01-25 |
Not clear |
| Ralph Buchert, Balazs Szabo, Akos Kovacs, Thomas Buddenkotte, Franziska Mathies, Amir Karimzadeh, Wencke Lehnert, Susanne Klutmann, Attila Forgacs, Ivayla Apostolov. Dopamine Transporter SPECT with 12-Minute Scan Duration Using Multiple-Pinhole Collimators. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2024-01-18. PMID:38238040. |
this study evaluated the potential to reduce the scan duration in dopamine transporter (dat) spect when using a second-generation multiple-pinhole (mph) collimator designed for brain spect with improved count sensitivity and improved spatial resolution compared with parallel-hole and fanbeam collimators. |
2024-01-18 |
2024-01-21 |
Not clear |
| Jose Medina-Luque, Patrick Piechocinski, Paul Feyen, Carmelo Sgobio, Jochen Herm. Striatal dopamine neurotransmission is altered in age- and region-specific manner in a Parkinson's disease transgenic mouse. Scientific reports. vol 14. issue 1. 2024-01-03. PMID:38167878. |
structurally, dopamine transporter (dat) was found to be redistributed in larger dat-positive clumps only in the dls of 3- and 12-month-old mice. |
2024-01-03 |
2024-01-06 |
mouse |
| Maggy Yu Hei Lau, Sana Gadiwalla, Susan Jones, Elisa Gallian. Different electrophysiological profiles of genetically labelled dopaminergic neurons in the mouse midbrain and olfactory bulb. The European journal of neuroscience. 2024-01-03. PMID:38169095. |
after confirming the penetrance and specificity of the dopamine transporter (dat) cre line, we compared soma shape, passive membrane properties, voltage sags and action potential (ap) firing across midbrain and forebrain bulbar da subtypes. |
2024-01-03 |
2024-01-06 |
mouse |
| Tarique Bagalkot, Alexander Sorki. Amphetamine induces sex-dependent loss of the striatal dopamine transporter in sensitized mice. eNeuro. 2024-01-02. PMID:38164591. |
dopamine transporter (dat) controls dopamine signaling in the brain through the reuptake of synaptically released dopamine. |
2024-01-02 |
2024-01-05 |
mouse |
| Tarique Bagalkot, Alexander Sorki. Amphetamine induces sex-dependent loss of the striatal dopamine transporter in sensitized mice. eNeuro. 2024-01-02. PMID:38164591. |
acute amph administration leads to transient dat endocytosis which among other amph effects on dopaminergic neurons elevates extracellular dopamine. |
2024-01-02 |
2024-01-05 |
mouse |
| Lauren R Fitzgerald, Brenda M Gannon, Donna Walther, Antonio Landavazo, Takato Hiranita, Bruce E Blough, Michael H Baumann, William E Fantegross. Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones. Neuropharmacology. 2023-12-28. PMID:38154512. |
automated photobeam analysis was used to evaluate effects of drugs on ambulatory activity in mice, whereas in vitro assays were used to determine activities at transporters for dopamine (dat), norepinephrine (net), and 5-ht (sert) in rat brain synaptosomes. |
2023-12-28 |
2023-12-31 |
mouse |
| Duncan J Noble, Aida Mohammadkhani, Min Qiao, Stephanie L Borglan. Characterization of dopaminergic projections from the ventral tegmental area and the dorsal raphe nucleus to the orbital frontal cortex. The European journal of neuroscience. 2023-12-28. PMID:38155094. |
male and female adult dopamine transporter (dat) |
2023-12-28 |
2023-12-31 |
Not clear |
| Jun Sung Park, Riaz Ahmad, Kyonghwan Choe, Min Hwa Kang, Tae Ju Park, Myeong Ok Ki. Immunization Effects of a Novel α-Synuclein-Based Peptide Epitope Vaccine in Parkinson's Disease-Associated Pathology. Vaccines. vol 11. issue 12. 2023-12-23. PMID:38140224. |
furthermore, vaccinated groups, especially ova and klh groups, showed decrease in α-syn levels and increased dopamine-related markers, i.e., tyrosine hydroxylase (th), vesicle monoamine transporter 2 (vmat2), and dopamine transporter (dat), and autophagy activities in the striatum and snpc. |
2023-12-23 |
2023-12-25 |
mouse |
| Thomas Budenkotte, Ivayla Apostolova, Roland Opfer, Julia Krüger, Susanne Klutmann, Ralph Bucher. Automated identification of uncertain cases in deep learning-based classification of dopamine transporter SPECT to improve clinical utility and acceptance. European journal of nuclear medicine and molecular imaging. 2023-12-22. PMID:38133688. |
deep convolutional neural networks (cnn) are promising for automatic classification of dopamine transporter (dat)-spect images. |
2023-12-22 |
2023-12-24 |
Not clear |
| Amarachi V Okorom, Gisela Andrea Camacho-Hernandez, Kristine Salomon, Kuo Hao Lee, Therese C Ku, Jianjing Cao, Sung Joon Won, Jacob Friedman, Jenny Lam, James Paule, Rana Rais, Benjamin Klein, Zheng-Xiong Xi, Lei Shi, Claus J Loland, Amy Hauck Newma. Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile. Journal of medicinal chemistry. 2023-12-20. PMID:38117239. |
atypical dopamine transporter (dat) inhibitors have shown therapeutic potential in the preclinical models of psychostimulant use disorders (psud). |
2023-12-20 |
2023-12-23 |
rat |
| Madhur Shetty, Danielle E Bolland, Joshua Morrell, Bryon D Grove, James D Foster, Roxanne A Vaugha. Dopamine transporter membrane mobility is bidirectionally regulated by phosphorylation and palmitoylation. Current research in physiology. vol 6. 2023-12-19. PMID:38107792. |
the primary regulator of dopamine availability in the brain is the dopamine transporter (dat), a plasma membrane protein that drives reuptake of released dopamine from the extracellular space into the presynaptic neuron. |
2023-12-19 |
2023-12-21 |
Not clear |
| Yuliya Piatkova, Matthieu Doyen, Sébastien Heyer, Ayaz Tahmazov, Solene Frismand, Lucie Hopes, Laetitia Imbert, Antoine Verge. Effects of medication on dopamine transporter imaging using [ European journal of nuclear medicine and molecular imaging. 2023-12-19. PMID:38114618. |
effects of medication on dopamine transporter imaging using [ dopamine transporter (dat) imaging is used to support the diagnosis of neurodegenerative parkinsonian disorders. |
2023-12-19 |
2023-12-23 |
Not clear |
| Mengfei Bu, Jordan Follett, Isaac Deng, Igor Tatarnikov, Shannon Wall, Dylan Guenther, Melissa Maczis, Genevieve Wimsatt, Austen Milnerwood, Mark S Moehle, Habibeh Khoshbouei, Matthew J Farre. Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine physiology in VPS35 p.D620N knock-in mice. NPJ Parkinson's disease. vol 9. issue 1. 2023-12-18. PMID:38110354. |
while striatal dopamine transporter (dat) expression and function is similarly impaired in both vki and haplo mice, that physiology is normalized in vki by treatment with the lrrk2 kinase inhibitor, mli-2. |
2023-12-18 |
2023-12-21 |
mouse |
| Mengfei Bu, Jordan Follett, Isaac Deng, Igor Tatarnikov, Shannon Wall, Dylan Guenther, Melissa Maczis, Genevieve Wimsatt, Austen Milnerwood, Mark S Moehle, Habibeh Khoshbouei, Matthew J Farre. Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine physiology in VPS35 p.D620N knock-in mice. NPJ Parkinson's disease. vol 9. issue 1. 2023-12-18. PMID:38110354. |
taken together, these data show vps35 p.d620n confers a gain-of-function with respect to lrrk2 kinase activity, and that vps35 and lrrk2 functionally interact to regulate dat function and striatal dopamine transmission. |
2023-12-18 |
2023-12-21 |
mouse |
| Aleksandr Veshchitskii, Polina Shkorbatova, Aleksandr Mikhalkin, Zoja Fesenko, Evgeniya V Efimova, Raul R Gainetdinov, Natalia Merkulyev. Activation of the spinal and brainstem locomotor networks during free treadmill stepping in rats lacking dopamine transporter. Frontiers in molecular neuroscience. vol 16. 2023-12-11. PMID:38076209. |
extracellular dopamine levels are controlled by the membrane dopamine transporter (dat), and animals lacking dat (dat-ko) are characterized by hyperdopaminergia and several alterations of locomotion including hyperactivity. |
2023-12-11 |
2023-12-17 |
rat |
| Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Ki. Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum. Frontiers in public health. vol 11. 2023-12-01. PMID:38026429. |
furthermore, compared to the control group, the metal mixture exposure group showed a significantly lower expression level of tyrosine hydroxylase (th) and significantly higher expression levels of dopamine transporter (dat), tryptophan hydroxylase 1 (tph1), and serotonin reuptake transporter (sert). |
2023-12-01 |
2023-12-10 |
mouse |
| Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Ki. Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum. Frontiers in public health. vol 11. 2023-12-01. PMID:38026429. |
these findings suggest that the key proteins involved in the synthesis and reuptake of dopamine (th and dat, respectively), as well as in the synthesis and reuptake of serotonin (tph1 and sert, respectively), play crucial roles in the neurotoxic effects associated with exposure to metal mixtures. |
2023-12-01 |
2023-12-10 |
mouse |
| Min Seung Kim, Dong Gueu Park, In Ja Shin, Young Sil An, Jung Han Yoo. The Role of Dual-Phase 18F-FP-CIT PET to Early Diagnosis of Corticobasal Syndrome. Clinical nuclear medicine. 2023-11-28. PMID:38015725. |
this study was performed to delineate the specific patterns of cortical hypoperfusion, dopamine transporter (dat) uptake using dual-phase fp-cit pet in discriminating between cbs and ipd at early stage. |
2023-11-28 |
2023-12-07 |
Not clear |