| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Bäckström, Magdalena Eriksson Domellöf, Gabriel Granåsen, Jan Linder, Sofia Mayans, Eva Elgh, Susanna Jakobson Mo, Lars Forsgre. PITX3 genotype and risk of dementia in Parkinson's disease: A population-based study. Journal of the neurological sciences. vol 381. 2018-06-11. PMID:28991698. |
this study investigates whether a common polymorphism in the pitx3 gene (rs2281983), which is of importance for the function of dopaminergic neurons, affects the risk of developing dementia in pd and whether it affects dopamine transporter (dat) uptake. |
2018-06-11 |
2023-08-13 |
Not clear |
| Koji Kamagata, Tomoya Nakatsuka, Ryuji Sakakibara, Yohei Tsuyusaki, Tomohiro Takamura, Kanako Sato, Michimasa Suzuki, Masaaki Hori, Kanako K Kumamaru, Tsutomu Inaoka, Shigeki Aoki, Hitoshi Terad. Diagnostic imaging of dementia with Lewy bodies by susceptibility-weighted imaging of nigrosomes versus striatal dopamine transporter single-photon emission computed tomography: a retrospective observational study. Neuroradiology. vol 59. issue 1. 2018-06-08. PMID:28035426. |
assessment of dopamine uptake in the striatum using dopamine transporter (dat) single-photon emission computed tomography (spect) is the gold standard for diagnosing dlb; however, this modality is expensive, time consuming and involves radiation exposure. |
2018-06-08 |
2023-08-13 |
Not clear |
| Gwynne L Davis, Adele Stewart, Gregg D Stanwood, Raajaram Gowrishankar, Maureen K Hahn, Randy D Blakel. Functional coding variation in the presynaptic dopamine transporter associated with neuropsychiatric disorders drives enhanced motivation and context-dependent impulsivity in mice. Behavioural brain research. vol 337. 2018-06-08. PMID:28964912. |
in keeping with studies suggesting dopaminergic contributions to attention-deficit hyperactivity disorder (adhd), bipolar disorder (bpd) and autism spectrum disorder (asd), subjects with these diagnoses have been found to express a rare, functional coding substitution in the dopamine (da) transporter (dat), ala559val. |
2018-06-08 |
2023-08-13 |
mouse |
| Elina Mäkinen, Juho Joutsa, Tero Vahlberg, Valtteri Kaasine. Survival in Parkinson's disease in relation to striatal dopamine transporter binding. Parkinsonism & related disorders. vol 42. 2018-06-07. PMID:28662820. |
to investigate whether dopamine transporter (dat) binding, as measured with single photon emission computed tomography (spect), can be used to predict mortality in patients with parkinson's disease (pd). |
2018-06-07 |
2023-08-13 |
Not clear |
| Mattia Volta, Dayne A Beccano-Kelly, Sarah A Paschall, Stefano Cataldi, Sarah E MacIsaac, Naila Kuhlmann, Chelsie A Kadgien, Igor Tatarnikov, Jesse Fox, Jaskaran Khinda, Emma Mitchell, Sabrina Bergeron, Heather Melrose, Matthew J Farrer, Austen J Milnerwoo. Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice. eLife. vol 6. 2018-05-29. PMID:28930069. |
in young gki mice, dopamine transients are slower, independent of dopamine transporter (dat), increasing the lifetime of extracellular dopamine. |
2018-05-29 |
2023-08-13 |
mouse |
| Shou-Yang Yu, Wei-Feng Bai, Ping Tu, Cheng-Kai Qiu, Pei-Run Yang, Su-Yuan Lu. [Effect of Corydalis Rhizoma and L-tetrahydropalmatine on dopamine system of hippocampus and striatum in morphine-induced conditioned place preference rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 19. 2018-05-24. PMID:28925162. |
to investigate the effects of corydalis rhizoma and l-tetrahydropalma-tine (l-thp) on the levels of dopamine neurotransmitter (da), dopamine transporter (dat) and the second dopamine receptor (d2r) in learning and memory-related brain areas, hippocampus and striatum, the da, dat and d2r were detected in conditioned place preference (cpp) rats suffered from morphine. |
2018-05-24 |
2023-08-13 |
rat |
| Shou-Yang Yu, Wei-Feng Bai, Ping Tu, Cheng-Kai Qiu, Pei-Run Yang, Su-Yuan Lu. [Effect of Corydalis Rhizoma and L-tetrahydropalmatine on dopamine system of hippocampus and striatum in morphine-induced conditioned place preference rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 19. 2018-05-24. PMID:28925162. |
compared with the ns treatment group and the model group, the higher values including in the contents of neurotransmitter dopamine were detected of hippocampus and striatum (p<0.01, p<0.05), the dat and d2r protein expression of corydalis rhizoma (2, 1 g•kg⁻¹) and l-thp (3.76, 1.88 mg•kg⁻¹) increased in hippocampus and striatum (p<0.01). |
2018-05-24 |
2023-08-13 |
rat |
| Shou-Yang Yu, Wei-Feng Bai, Ping Tu, Cheng-Kai Qiu, Pei-Run Yang, Su-Yuan Lu. [Effect of Corydalis Rhizoma and L-tetrahydropalmatine on dopamine system of hippocampus and striatum in morphine-induced conditioned place preference rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 19. 2018-05-24. PMID:28925162. |
the similar effects were observed on the neurotransmitter dopamine, dat and d2r in learning and memory-related brain areas, hippocampus and striatum of the morphine- dependent rats. |
2018-05-24 |
2023-08-13 |
rat |
| Edith Miville-Godbout, Mélanie Bourque, Marc Morissette, Sara Al-Sweidi, Tara Smith, Dushmanthi Jayasinghe, Shawn Ritchie, Thérèse Di Paol. Plasmalogen precursor mitigates striatal dopamine loss in MPTP mice. Brain research. vol 1674. 2018-05-22. PMID:28830769. |
in addition, ppi-1025 treatment prevented the mptp-induced decrease of the striatal dopamine transporter (dat) and vesicular monoamine transporter 2 (vmat2) specific binding. |
2018-05-22 |
2023-08-13 |
mouse |
| E Jaakkola, J Joutsa, E Mäkinen, J Johansson, V Kaasine. Ventral striatal dopaminergic defect is associated with hallucinations in Parkinson's disease. European journal of neurology. vol 24. issue 11. 2018-05-21. PMID:28834102. |
the aim of this study was to investigate the dopaminergic mechanisms of vhs and specifically whether the degree of striatal dopamine transporter (dat) function or extrastriatal serotonin transporter (sert) function can predict the appearance of vhs in patients with pd. |
2018-05-21 |
2023-08-13 |
Not clear |
| Walter Adriani, Emilia Romano, Mariangela Pucci, Esterina Pascale, Luca Cerniglia, Silvia Cimino, Renata Tambelli, Paolo Curatolo, Oleg Granstrem, Mauro Maccarrone, Giovanni Laviola, Claudio D'Addari. Potential for diagnosis versus therapy monitoring of attention deficit hyperactivity disorder: a new epigenetic biomarker interacting with both genotype and auto-immunity. European child & adolescent psychiatry. vol 27. issue 2. 2018-05-18. PMID:28822049. |
in view of the need for easily accessible biomarkers, we evaluated in adhd children the epigenetic status of the 5'-untranslated region (utr) in the slc6a3 gene, coding for human dopamine transporter (dat). |
2018-05-18 |
2023-08-13 |
human |
| Walter Adriani, Emilia Romano, Mariangela Pucci, Esterina Pascale, Luca Cerniglia, Silvia Cimino, Renata Tambelli, Paolo Curatolo, Oleg Granstrem, Mauro Maccarrone, Giovanni Laviola, Claudio D'Addari. Potential for diagnosis versus therapy monitoring of attention deficit hyperactivity disorder: a new epigenetic biomarker interacting with both genotype and auto-immunity. European child & adolescent psychiatry. vol 27. issue 2. 2018-05-18. PMID:28822049. |
methylation levels at six-selected cpg sites (among which, a cggcggcgg and a cgcg motif), alone or in combination with serum titers in auto-antibodies against dopamine transporter (dat aabs), were analysed for correlation with cgas scores (by clinicians) and conners' scales (by parents), collected at recruitment and after 6 weeks. |
2018-05-18 |
2023-08-13 |
human |
| Liping Huang, Minzhen Deng, Sheng Zhang, Shiyao Lu, Xuehong Gui, Yongqi Fan. β-asarone and levodopa coadministration increases striatal levels of dopamine and levodopa and improves behavioral competence in Parkinson's rat by enhancing dopa decarboxylase activity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-15. PMID:28787702. |
neurotransmitters, dopa decarboxylase (ddc), tyrosine hydroxylase (th), catechol-o-methyltransferase (comt), monoamine oxidase b (mao-b) and dopamine transporter (dat) levels were detected. |
2018-05-15 |
2023-08-13 |
rat |
| Alexis J Haas, Yann Le Page, Maxim Zhadobov, Ronan Sauleau, Yves Le Dréan, Christian Saligau. Effect of acute millimeter wave exposure on dopamine metabolism of NGF-treated PC12 cells. Journal of radiation research. vol 58. issue 4. 2018-05-14. PMID:28339776. |
impact of exposure on the dopamine transporter (dat) expression was also assessed by immunocytochemistry. |
2018-05-14 |
2023-08-13 |
Not clear |
| Alexis J Haas, Yann Le Page, Maxim Zhadobov, Ronan Sauleau, Yves Le Dréan, Christian Saligau. Effect of acute millimeter wave exposure on dopamine metabolism of NGF-treated PC12 cells. Journal of radiation research. vol 58. issue 4. 2018-05-14. PMID:28339776. |
neither dopamine turnover nor dat protein expression level were impacted by mmw exposure. |
2018-05-14 |
2023-08-13 |
Not clear |
| James D Foster, Roxanne A Vaugha. Phosphorylation mechanisms in dopamine transporter regulation. Journal of chemical neuroanatomy. vol 83-84. 2018-05-11. PMID:27836487. |
the dopamine transporter (dat) is a plasma membrane phosphoprotein that actively translocates extracellular dopamine (da) into presynaptic neurons. |
2018-05-11 |
2023-08-13 |
Not clear |
| Danielle E Rastedt, Roxanne A Vaughan, James D Foste. Palmitoylation mechanisms in dopamine transporter regulation. Journal of chemical neuroanatomy. vol 83-84. 2018-05-11. PMID:28115272. |
synaptic da homeostasis is controlled by the dopamine transporter (dat) which transports extracellular da into the presynaptic neuron after release and regulates its availability to receptors. |
2018-05-11 |
2023-08-13 |
Not clear |
| Aparna Shekar, Jenny I Aguilar, Greta Galli, Nicholas V Cozzi, Simon D Brandt, Arnold E Ruoho, Michael H Baumann, Heinrich J G Matthies, Aurelio Gall. Atypical dopamine efflux caused by 3,4-methylenedioxypyrovalerone (MDPV) via the human dopamine transporter. Journal of chemical neuroanatomy. vol 83-84. 2018-05-11. PMID:28163218. |
the past ten years of research on the common constituent of bath salts, mdpv (the synthetic cathinone 3,4-methylenedioxypyrovalerone), has aided the understanding of how synthetic cathinones act at the dopamine (da) transporter (dat). |
2018-05-11 |
2023-08-13 |
human |
| Caline S Karam, Namita Sen, Jonathan A Javitc. Phospho-specific antibodies targeting the amino terminus of the human dopamine transporter. Journal of chemical neuroanatomy. vol 83-84. 2018-05-11. PMID:28571709. |
the dopamine transporter (dat), which mediates the inactivation of released dopamine through its reuptake, is the primary molecular target for the actions of psychostimulants. |
2018-05-11 |
2023-08-13 |
human |
| Patrick Neiens, Georg Höfner, Klaus T Wanne. Determination of the enantiomeric purity of the selective dopamine transporter inhibitor (+)-R,R-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol. Chirality. vol 29. issue 6. 2018-05-10. PMID:28437017. |
(+)-r,r-d-84 ((+)-r,r-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol) is a promising pharmacological tool for the dopamine transporter (dat), due to its high affinity and selectivity for this target. |
2018-05-10 |
2023-08-13 |
Not clear |