| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amy Hauck Newman, Jianjing Cao, Jacqueline D Keighron, Chloe J Jordan, Guo-Hua Bi, Ying Liang, Ara M Abramyan, Alicia J Avelar, Christopher W Tschumi, Michael J Beckstead, Lei Shi, Gianluigi Tanda, Zheng-Xiong X. Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 8. 2020-03-31. PMID:30858517. |
efforts to develop potential pharmacotherapies have led to the identification of a promising lead molecule, jjc8-091, that demonstrates a novel binding mode at the dopamine transporter (dat). |
2020-03-31 |
2023-08-13 |
mouse |
| Heeyoung Kim, Minyoung Oh, Jungsu S Oh, Hyojeong Moon, Sun Ju Chung, Chong Sik Lee, Jae Seung Ki. Association of striatal dopaminergic neuronal integrity with cognitive dysfunction and cerebral cortical metabolism in Parkinson's disease with mild cognitive impairment. Nuclear medicine communications. vol 40. issue 12. 2020-03-27. PMID:31584466. |
we investigated the association of striatal dopamine transporter (dat) loss with cognitive function and cerebral cortical metabolism in pd. |
2020-03-27 |
2023-08-13 |
Not clear |
| Emma A Honkanen, Nina Kemppainen, Tommi Noponen, Marko Seppänen, Juho Joutsa, Valtteri Kaasine. Bupropion Causes Misdiagnosis in Brain Dopamine Transporter Imaging for Parkinsonism. Clinical neuropharmacology. vol 42. issue 5. 2020-03-23. PMID:31361666. |
the objective of this study was to report long-lasting effects of bupropion on brain dopamine transporter (dat) in a patient with depression and parkinsonism. |
2020-03-23 |
2023-08-13 |
Not clear |
| June P Kampangkaew, Catherine J Spellicy, Ellen M Nielsen, Mark J Harding, An Ye, Sara C Hamon, Thomas R Kosten, David A Nielse. Pharmacogenetic role of dopamine transporter (SLC6A3) variation on response to disulfiram treatment for cocaine addiction. The American journal on addictions. vol 28. issue 4. 2020-03-20. PMID:31087723. |
patients with two slc6a3 (dat1) rs28363170 10-repeat alleles who have with genetically high dopamine transporter (dat) levels may benefit from increased dopamine levels resulting from disulfiram treatment. |
2020-03-20 |
2023-08-13 |
Not clear |
| Ruru Li, Jianzong Che. Salidroside Protects Dopaminergic Neurons by Enhancing PINK1/Parkin-Mediated Mitophagy. Oxidative medicine and cellular longevity. vol 2019. 2020-03-20. PMID:31583052. |
moreover, sal diminished mptp-induced degeneration of nigrostriatal da neurons as evidenced by upregulated th-positive neurons in the substantia nigra, increased dat expression, and high dopamine and metabolite levels in the striatum. |
2020-03-20 |
2023-08-13 |
Not clear |
| Naoko Kuzumaki, Yukari Suda, Chizuru Iwasawa, Michiko Narita, Takefumi Sone, Moe Watanabe, Aya Maekawa, Takuya Matsumoto, Wado Akamatsu, Katsuhide Igarashi, Hideki Tamura, Hideyuki Takeshima, Vivianne L Tawfik, Toshikazu Ushijima, Nobutaka Hattori, Hideyuki Okano, Minoru Narit. Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease. Brain : a journal of neurology. vol 142. issue 6. 2020-03-12. PMID:31135049. |
in dopamine transporter (dat)-cre mice, overexpression of comt, specifically in dopaminergic neurons of the substantia nigra, produced cataleptic behaviours associated with impaired motor coordination. |
2020-03-12 |
2023-08-13 |
mouse |
| Merve Çapkın Yurtsever, Arlin Kiremitci, Menemşe Gümüşderelioğl. Dopaminergic induction of human dental pulp stem cells by photobiomodulation: comparison of 660nm laser light and polychromatic light in the nir. Journal of photochemistry and photobiology. B, Biology. vol 204. 2020-03-11. PMID:31982670. |
real time rt-qpcr analysis indicated that expressions of brain derived neurotrophic factor (bdnf), glial cell line derived neurotropic factor (gndf), matrix associated protein 2 (map2), nuclear receptor related 1 protein (nurr1) and dopamine transporter (dat) were increased, especially in the first 7 days of dopaminergic induction when 660 nm laser light was applied with a total energy density of 1.6 j/cm |
2020-03-11 |
2023-08-13 |
human |
| Cheng-Tsung Liu, Li-Ting Kao, Jui-Hu Shih, Wu-Chien Chien, Chuang-Hsin Chiu, Kuo-Hsing Ma, Yuahn-Sieh Huang, Cheng-Yi Cheng, Chyng-Yann Shiue, I-Hsun L. The effect of dextromethorphan use in Parkinson's disease: A 6-hydroxydopamine rat model and population-based study. European journal of pharmacology. vol 862. 2020-03-05. PMID:31491406. |
the availability of dopamine transporter (dat) and serotonin transporter (sert) in the striatum of the rat brain was measured using positron emission tomography. |
2020-03-05 |
2023-08-13 |
human |
| Martin O Job, Jonathan L Kat. A behavioral economic analysis of the effects of rimcazole on reinforcing effects of cocaine injection and food presentation in rats. Psychopharmacology. vol 236. issue 12. 2020-03-03. PMID:31399853. |
rimcazole, a σ-receptor antagonist with affinity for the dopamine transporter (dat), decreases rates of cocaine self-administration at doses lower than those that affect food-reinforced responding. |
2020-03-03 |
2023-08-13 |
rat |
| Molly A Kwiatkowski, Gerhard Hellemann, Catherine A Sugar, Zackary A Cope, Arpi Minassian, William Perry, Mark A Geyer, Jared W Youn. Dopamine transporter knockdown mice in the behavioral pattern monitor: A robust, reproducible model for mania-relevant behaviors. Pharmacology, biochemistry, and behavior. vol 178. 2020-02-25. PMID:29289701. |
we have repeatedly assessed the behavioral effects of reduced dopamine transporter (dat) expression in the bpm using a dat knockdown (kd) mouse line (~10% normal expression). |
2020-02-25 |
2023-08-13 |
mouse |
| Juliet Richetto, Marcello Polesel, Ulrike Weber-Stadlbaue. Effects of light and dark phase testing on the investigation of behavioural paradigms in mice: Relevance for behavioural neuroscience. Pharmacology, biochemistry, and behavior. vol 178. 2020-02-25. PMID:29782942. |
in addition, animals tested in the light phase also exhibit increased locomotor response to systemic amphetamine treatment, which is paralleled by alterations in the expression patterns of tyrosine hydroxylase (th) and dopamine transporter (dat) in the nucleus accumbens (nac) and/or midbrain (mid). |
2020-02-25 |
2023-08-13 |
mouse |
| Lucas B Thal, Ian D Tomlinson, Meagan A Quinlan, Oleg Kovtun, Randy D Blakely, Sandra J Rosentha. Single Quantum Dot Imaging Reveals PKCβ-Dependent Alterations in Membrane Diffusion and Clustering of an Attention-Deficit Hyperactivity Disorder/Autism/Bipolar Disorder-Associated Dopamine Transporter Variant. ACS chemical neuroscience. vol 10. issue 1. 2020-02-18. PMID:30153408. |
the dopamine transporter (dat) is a transmembrane protein that terminates dopamine signaling in the brain by driving rapid dopamine reuptake into presynaptic nerve terminals. |
2020-02-18 |
2023-08-13 |
Not clear |
| Lucas B Thal, Ian D Tomlinson, Meagan A Quinlan, Oleg Kovtun, Randy D Blakely, Sandra J Rosentha. Single Quantum Dot Imaging Reveals PKCβ-Dependent Alterations in Membrane Diffusion and Clustering of an Attention-Deficit Hyperactivity Disorder/Autism/Bipolar Disorder-Associated Dopamine Transporter Variant. ACS chemical neuroscience. vol 10. issue 1. 2020-02-18. PMID:30153408. |
indeed, individuals with these disorders have been found to express the rare, functional dat coding variant val559, which confers anomalous dopamine efflux (ade) in vitro and in vivo. |
2020-02-18 |
2023-08-13 |
Not clear |
| Lucas B Thal, Ian D Tomlinson, Meagan A Quinlan, Oleg Kovtun, Randy D Blakely, Sandra J Rosentha. Single Quantum Dot Imaging Reveals PKCβ-Dependent Alterations in Membrane Diffusion and Clustering of an Attention-Deficit Hyperactivity Disorder/Autism/Bipolar Disorder-Associated Dopamine Transporter Variant. ACS chemical neuroscience. vol 10. issue 1. 2020-02-18. PMID:30153408. |
these findings further demonstrate a functional impact of dat val559 and suggest that changes in transporter localization and lateral mobility may sustain ade and contribute to alterations in dopamine signaling underlying multiple neuropsychiatric disorders. |
2020-02-18 |
2023-08-13 |
Not clear |
| Donna Walther, Abdelrahman R Shalabi, Michael H Baumann, Richard A Glenno. Systematic Structure-Activity Studies on Selected 2-, 3-, and 4-Monosubstituted Synthetic Methcathinone Analogs as Monoamine Transporter Releasing Agents. ACS chemical neuroscience. vol 10. issue 1. 2020-02-18. PMID:30354055. |
to formulate structure-activity relationship (sar) generalities, we examined the releasing ability of several simple methcathinone analogs at the three monoamine transporters (i.e., the dopamine, norepinephrine, and serotonin transporters, dat, net, and sert, respectively) using in vitro assay methods. |
2020-02-18 |
2023-08-13 |
Not clear |
| Juliana C Cotrin, Leonardo F Fontenelle, Fabiana B Kohlrausc. Association analyses reveal gender-specific associations of DAT1 40-bp VNTR and -839C/T polymorphisms with obsessive-compulsive disorder and obsessive-compulsive symptoms. Molecular biology reports. vol 46. issue 5. 2020-02-17. PMID:31325142. |
the dopamine transporter (dat) is involved in dopamine signaling and distribution, controlling dopamine concentrations and contributing to several central nervous system disorders. |
2020-02-17 |
2023-08-13 |
Not clear |
| Anna Rickli, Marius C Hoener, Matthias E Liecht. Pharmacological profiles of compounds in preworkout supplements ("boosters"). European journal of pharmacology. vol 859. 2020-01-28. PMID:31265842. |
we investigated whether substances that are contained in commercially available athletic multiple-ingredient preworkout supplements exert amphetamine-type activity at norepinephrine, dopamine, and serotonin transporters (net, dat, and sert, respectively). |
2020-01-28 |
2023-08-13 |
human |
| Jordan M Buck, Kelsey N Sanders, Charles R Wageman, Valerie S Knopik, Jerry A Stitzel, Heidi C O'Neil. Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice. Neuropharmacology. vol 149. 2020-01-27. PMID:30742847. |
pharmacological characterization of nicotinic and dopaminergic systems in striatum and frontal cortex reveals altered expression and dysfunction of nicotinic acetylcholine receptors (nachrs), hypersensitivity to nicotine-induced nachr-mediated dopamine release, and impaired dopamine transporter (dat) function in dne mice. |
2020-01-27 |
2023-08-13 |
mouse |
| Diana V Atigari, Rajendra Uprety, Gavril W Pasternak, Susruta Majumdar, Bronwyn M Kivel. MP1104, a mixed kappa-delta opioid receptor agonist has anti-cocaine properties with reduced side-effects in rats. Neuropharmacology. vol 150. 2020-01-21. PMID:30768946. |
the anti-cocaine effects exerted by mp1104 are in part due to increased dopamine (da) uptake by the dopamine transporter (dat) in the dorsal striatum (dstr) and nucleus accumbens (nac). |
2020-01-21 |
2023-08-13 |
rat |
| Merijn Joling, Chris Vriend, Pieter G H M Raijmakers, Jessica J van der Zande, Afina W Lemstra, Henk W Berendse, Jan Booij, Odile A van den Heuve. Striatal DAT and extrastriatal SERT binding in early-stage Parkinson's disease and dementia with Lewy bodies, compared with healthy controls: An NeuroImage. Clinical. vol 22. 2020-01-17. PMID:30884365. |
we aimed to study degeneration of terminals with dopamine and serotonin transporter (dat and sert, respectively) in patients with early-stage pd and dlb relative to healthy controls, using |
2020-01-17 |
2023-08-13 |
Not clear |