| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dareia S Roos, Jos W R Twisk, Pieter G H M Raijmakers, Richard L Doty, Henk W Berends. Hyposmia as a marker of (non-)motor disease severity in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 126. issue 11. 2020-08-24. PMID:31515655. |
in a subgroup of patients (n = 155) with a dopamine transporter (dat) spect scan, a similar statistical analysis was performed, now including striatal dat binding. |
2020-08-24 |
2023-08-13 |
Not clear |
| Jin Cheng, Siyi Wang, Weiwei Lin, Nan Wu, Yuanqiang Wang, Maozi Chen, Xiang-Qun Xie, Zhiwei Fen. Computational Systems Pharmacology-Target Mapping for Fentanyl-Laced Cocaine Overdose. ACS chemical neuroscience. vol 10. issue 8. 2020-08-18. PMID:31257858. |
sequentially, we looked into the detail of (1) the addiction to cocaine and fentanyl by binding to the dopamine transporter and the μ opioid receptor (dat and μor, respectively), (2) the potential drug-drug interaction of cocaine and fentanyl via p-glycoprotein (p-gp) efflux, (3) the metabolism of cocaine and fentanyl in cyp3a4, and (4) the physiologically based pharmacokinetic (pbpk) model for two drugs and their drug-drug interaction at the absorption, distribution, metabolism, and excretion (adme) level. |
2020-08-18 |
2023-08-13 |
Not clear |
| Adithya Gopinath, Andria Doty, Phillip M Mackie, Basil Hashimi, Madison Francis, Leila Saadatpour, Kaustuv Saha, Gerry Shaw, Adolfo Ramirez-Zamora, Michael S Okun, Wolfgang J Streit, Habibeh Khoshboue. A novel approach to study markers of dopamine signaling in peripheral immune cells. Journal of immunological methods. vol 476. 2020-08-17. PMID:31634479. |
human monocytes express known markers of dopamine synthesis, storage and clearance, including dopamine transporter (dat), tyrosine hydroxylase (th), all subtypes of dopamine receptors and vesicular monoamine transporter 2 (vmat2). |
2020-08-17 |
2023-08-13 |
human |
| Adithya Gopinath, Andria Doty, Phillip M Mackie, Basil Hashimi, Madison Francis, Leila Saadatpour, Kaustuv Saha, Gerry Shaw, Adolfo Ramirez-Zamora, Michael S Okun, Wolfgang J Streit, Habibeh Khoshboue. A novel approach to study markers of dopamine signaling in peripheral immune cells. Journal of immunological methods. vol 476. 2020-08-17. PMID:31634479. |
the use of dopamine signaling could also be explored as a technique to monitor therapeutic interventions particularly those targeting dat and th in the periphery. |
2020-08-17 |
2023-08-13 |
human |
| Amanda L Blaker, Eric A Rodriguez, Bryan K Yamamot. Neurotoxicity to dopamine neurons after the serial exposure to alcohol and methamphetamine: Protection by COX-2 antagonism. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31228610. |
these effects preceded the activation of cleaved caspase-3 in dopamine cell bodies, as well as decreases in tyrosine hydroxylase (th) immunoreactivity in the substantia nigra and dopamine transporter (dat) immunoreactivity in the striatum measured at 7 days after meth. |
2020-08-14 |
2023-08-13 |
rat |
| Meixing Zhang, Dong Zhang, Jingbo Dai, Yong Cao, Wangjie Xu, Guang He, Zhaoxia Wang, Lianyu Wang, Runsheng Li, Zhongdong Qia. Paternal nicotine exposure induces hyperactivity in next-generation via down-regulating the expression of DAT. Toxicology. vol 431. 2020-08-14. PMID:31945395. |
then these epigenetic modifications reduced the expression of dat in the brain of the offspring, resulting in a rise in the level of extracellular dopamine. |
2020-08-14 |
2023-08-13 |
mouse |
| Can Peng, Yijin Yan, Veronica J Kim, Staci E Engle, Jennifer N Berry, J Michael McIntosh, Rachael L Neve, Ryan M Drena. Gene editing vectors for studying nicotinic acetylcholine receptors in cholinergic transmission. The European journal of neuroscience. vol 50. issue 3. 2020-08-07. PMID:29779223. |
finally, the mouse β2 nachr gene was successfully targeted in dopamine transporter (dat)-positive neurons via crispr/cas9. |
2020-08-07 |
2023-08-13 |
mouse |
| Shaili Aggarwal, Xiaonan Liu, Caitlyn Rice, Paul Menell, Philip J Clark, Nicholas Paparoidamis, You-Cai Xiao, Joseph M Salvino, Andréia C K Fontana, Rodrigo A España, Sandhya Kortagere, Ole V Mortense. Identification of a Novel Allosteric Modulator of the Human Dopamine Transporter. ACS chemical neuroscience. vol 10. issue 8. 2020-08-07. PMID:31184115. |
the dopamine transporter (dat) serves a pivotal role in controlling dopamine (da)-mediated neurotransmission by clearing da from synaptic and perisynaptic spaces and controlling its action at postsynaptic da receptors. |
2020-08-07 |
2023-08-13 |
human |
| Anthony Klambatsen, Stephanie K Nygard, Anna J Chang, Vanya Quinones, Shirzad Jena. Sex differences in memory and intracellular signaling after methamphetamine binge treatment. Brain research. vol 1711. 2020-08-04. PMID:30629943. |
we did not find a significant effect of methamphetamine on the dopamine neuron markers tyrosine hydroxylase (th) or dopamine transporter (dat) 7 days after methamphetamine administrations. |
2020-08-04 |
2023-08-13 |
rat |
| Giulia Castellani, Gabriella Contarini, Maddalena Mereu, Ennio Albanesi, Céline Devroye, Claudio D'Amore, Valentina Ferretti, Sara De Martin, Francesco Papale. Dopamine-mediated immunomodulation affects choroid plexus function. Brain, behavior, and immunity. vol 81. 2020-08-04. PMID:31175999. |
we performed a peripheral and cerebral immunophenotyping in mice bearing dopaminergic alteration produced by genetic liability (hypofunction of the dopamine transporter dat) and psychostimulant (amphetamine) administration. |
2020-08-04 |
2023-08-13 |
mouse |
| Jaskaren Randhawa, Raja Mehann. Drug induced parkinsonism: Symptomatic beyond 22 months. Parkinsonism & related disorders. vol 66. 2020-08-04. PMID:31471121. |
we report 2 cases of drug induced parkinsonism followed longitudinally that remained symptomatic 22 and 27 months after stopping causative agents with normal dopamine ioflupane iodine-123 (dat) single-photon emission computed tomography (spect) scans at 8 and 16 months. |
2020-08-04 |
2023-08-13 |
Not clear |
| Mauro Pettorruso, Giovanni Martinotti, Fabrizio Cocciolillo, Luisa De Risio, Annarita Cinquino, Marco Di Nicola, Giovanni Camardese, Giuseppe Migliara, Lorenzo Moccia, Eliana Conte, Luigi Janiri, Daniela Di Giud. Striatal presynaptic dopaminergic dysfunction in gambling disorder: A Addiction biology. vol 24. issue 5. 2020-08-03. PMID:30226290. |
the action of dopamine in the synapses is regulated by the dopamine transporter (dat). |
2020-08-03 |
2023-08-13 |
human |
| Mauro Pettorruso, Daniela Di Giuda, Giovanni Martinotti, Fabrizio Cocciolillo, Luisa De Risio, Chiara Montemitro, Giovanni Camardese, Marco Di Nicola, Luigi Janiri, Massimo di Giannantoni. Dopaminergic and clinical correlates of high-frequency repetitive transcranial magnetic stimulation in gambling addiction: a SPECT case study. Addictive behaviors. vol 93. 2020-08-03. PMID:30798016. |
at baseline and after rtms treatment the patient underwent a spect examination with (123)i-fp-cit tracer, to test changes in dopamine transporter (dat) availability. |
2020-08-03 |
2023-08-13 |
Not clear |
| Kyoungjune Pak, Heeyoung Kim, Ju Won Seok, Myung Jun Lee, Seunghyeon Shin, Keunyoung Kim, Jae Meen Lee, Youngduk Seo, Bum Soo Kim, Sungmin Jun, In Joo Ki. Prediction of future weight change with dopamine transporter in patients with Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 126. issue 6. 2020-07-27. PMID:31102003. |
we hypothesised that striatal dopamine transporter (dat) density at the time of diagnosis might play an important role in weight regulation in patients with pd. |
2020-07-27 |
2023-08-13 |
Not clear |
| Jyoti C Patel, Melissa A Stouffer, Maria Mancini, Charles Nicholson, Kenneth D Carr, Margaret E Ric. Interactions between insulin and diet on striatal dopamine uptake kinetics in rodent brain slices. The European journal of neuroscience. vol 49. issue 6. 2020-07-22. PMID:29791756. |
however, insulin also acts directly on dopamine axons to increase dopamine uptake by promoting dopamine transporter (dat) surface expression, counteracting enhanced dopamine release. |
2020-07-22 |
2023-08-13 |
mouse |
| Jyoti C Patel, Melissa A Stouffer, Maria Mancini, Charles Nicholson, Kenneth D Carr, Margaret E Ric. Interactions between insulin and diet on striatal dopamine uptake kinetics in rodent brain slices. The European journal of neuroscience. vol 49. issue 6. 2020-07-22. PMID:29791756. |
here, we determined the functional consequences of acute insulin exposure and chronic diet-induced changes in insulin on dat activity after evoked dopamine release in striatal slices from adult ad-libitum fed (al) rats and mice, and food-restricted (fr) or high-fat/high-sugar obesogenic (ob) diet rats. |
2020-07-22 |
2023-08-13 |
mouse |
| Lisa Proebstl, Felicia Kamp, Kirsi Manz, Daniela Krause, Kristina Adorjan, Oliver Pogarell, Gabi Koller, Michael Soyka, Peter Falkai, Joseph Kambeit. Effects of stimulant drug use on the dopaminergic system: A systematic review and meta-analysis of in vivo neuroimaging studies. European psychiatry : the journal of the Association of European Psychiatrists. vol 59. 2020-07-15. PMID:30981746. |
imaging studies show that these changes are most apparent in dopamine transporter (dat) or receptor availability within the striatum. |
2020-07-15 |
2023-08-13 |
Not clear |
| David Bartolomé-Martín, Ignacio Ibáñez, Dolores Piniella, Elena Martínez-Blanco, Sara G Pelaz, Francisco Zafr. Identification of potassium channel proteins Kv7.2/7.3 as common partners of the dopamine and glutamate transporters DAT and GLT-1. Neuropharmacology. vol 161. 2020-07-14. PMID:30885609. |
identification of potassium channel proteins kv7.2/7.3 as common partners of the dopamine and glutamate transporters dat and glt-1. |
2020-07-14 |
2023-08-13 |
Not clear |
| David Bartolomé-Martín, Ignacio Ibáñez, Dolores Piniella, Elena Martínez-Blanco, Sara G Pelaz, Francisco Zafr. Identification of potassium channel proteins Kv7.2/7.3 as common partners of the dopamine and glutamate transporters DAT and GLT-1. Neuropharmacology. vol 161. 2020-07-14. PMID:30885609. |
dopamine and glutamate transporters (dat and glt-1, respectively) share some biophysical characteristics, as both are secondary active carriers coupled to electrochemical ion gradients. |
2020-07-14 |
2023-08-13 |
Not clear |
| Marco Niello, Daniela Cintulova, Eva Hellsberg, Kathrin Jäntsch, Marion Holy, Leila H Ayatollahi, Nicholas V Cozzi, Michael Freissmuth, Walter Sandtner, Gerhard F Ecker, Marko D Mihovilovic, Harald H Sitt. para-Trifluoromethyl-methcathinone is an allosteric modulator of the serotonin transporter. Neuropharmacology. vol 161. 2020-07-14. PMID:31028773. |
the transporters for dopamine (dat) and serotonin (sert) are important targets in the treatment of psychiatric disorders including major depression, anxiety and attention-deficit hyperactivity disorder. |
2020-07-14 |
2023-08-13 |
Not clear |