| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kristin M Wilcox, Heather L Kimmel, Kimberly P Lindsey, John R Votaw, Mark M Goodman, Leonard L Howel. In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys. Synapse (New York, N.Y.). vol 58. issue 4. 2006-01-18. PMID:16206183. |
similar to cocaine, other local anesthetics bind to the dopamine transporter (dat) and inhibit da uptake in rodent and monkey brain. |
2006-01-18 |
2023-08-12 |
human |
| Michael F Salvatore, Brent Fisher, Stewart P Surgener, Greg A Gerhardt, Tracey Rouaul. Neurochemical investigations of dopamine neuronal systems in iron-regulatory protein 2 (IRP-2) knockout mice. Brain research. Molecular brain research. vol 139. issue 2. 2006-01-17. PMID:16051392. |
to further characterize the dopamine (da) systems of irp-2 -/- mice, we harvested cns tissue from age-matched wild type and irp-2 -/- (16-19 months) and analyzed the protein levels of tyrosine hydroxylase (th), dopamine transporter (dat), vesicular monoamine transporter (vmat2), and da levels in dorsal striatum, ventral striatum (including the core and shell of nucleus accumbens), and midbrain. |
2006-01-17 |
2023-08-12 |
mouse |
| A Winogrodzka, J Booij, E Ch Wolter. Disease-related and drug-induced changes in dopamine transporter expression might undermine the reliability of imaging studies of disease progression in Parkinson's disease. Parkinsonism & related disorders. vol 11. issue 8. 2006-01-17. PMID:16257254. |
dopamine transporter (dat) scintigraphy with single photon emission computed tomography (spect) has been used to assess the dopaminergic function in pd. |
2006-01-17 |
2023-08-12 |
Not clear |
| Sharadsrikar V Kotturi, Songchun Jiang, An-Chih Chang, Philip Abraham, Hernán A Navarro, Michael J Kuhar, F Ivy Carrol. Synthesis and monoamine transporter binding properties of 2,3-diaryltropanes. Journal of medicinal chemistry. vol 48. issue 23. 2006-01-17. PMID:16279803. |
the compounds were evaluated for inhibition of radioligand binding at the dopamine, norepinephrine, and serotonin transporters (dat, net, and 5-htt, respectively). |
2006-01-17 |
2023-08-12 |
Not clear |
| Vera C Campbell, Theresa A Kopajtic, Amy Hauck Newman, Jonathan L Kat. Assessment of the influence of histaminergic actions on cocaine-like effects of 3alpha-diphenylmethoxytropane analogs. The Journal of pharmacology and experimental therapeutics. vol 315. issue 2. 2006-01-12. PMID:16055673. |
previous studies demonstrated that analogs of benztropine (bzt) possess high affinity for the dopamine (da) transporter (dat) but generally have behavioral effects different from those of cocaine, suggesting either unique actions at the da transporter or that another action of these drugs interferes with cocaine-like effects. |
2006-01-12 |
2023-08-12 |
rat |
| Y Itzhak, J L Martin, S F Al. Comparison between the role of the neuronal and inducible nitric oxide synthase in methamphetamine-induced neurotoxicity and sensitization. Annals of the New York Academy of Sciences. vol 914. 2006-01-04. PMID:11085313. |
administration of meth to nnos(-/-) mice had no significant effect on the level of striatal dopamine, 3,4-dihydroxyphenylacetic acid (dopac), homovanillic acid (hva), or dopamine transporter (dat) binding sites. |
2006-01-04 |
2023-08-12 |
mouse |
| Hubert P Vanbilloen, Davy Kieffer, Bernard J Cleynhens, Guy Bormans, Luc Mortelmans, Alfons M Verbrugge. Development and biological evaluation of 99mTc-BAT-tropane esters. Nuclear medicine and biology. vol 32. issue 6. 2006-01-04. PMID:16026707. |
two (99m)tc-bat-tropane conjugates, i.e., technetium(v)-oxo-3-[n-(2-mercaptoethyl), n-(n'-(2-mercaptoethyl)-2-aminoethyl)]-aminopropyl 3beta-(4-chlorophenyl)-8-methyl-8-azabicyclo [3.2.1]octane-2beta-carboxylate and the corresponding norchloro derivative, were prepared and evaluated as potential imaging agents for the central nervous dopamine transporter (dat) system. |
2006-01-04 |
2023-08-12 |
mouse |
| Colin N Haile, Xiang Yang Zhang, F Ivy Carroll, Therese A Koste. Cocaine self-administration and locomotor activity are altered in Lewis and F344 inbred rats by RTI 336, a 3-phenyltropane analog that binds to the dopamine transporter. Brain research. vol 1055. issue 1-2. 2006-01-03. PMID:16095575. |
compared to f344 rats, lewis rats have lower d2 receptor and dopamine transporter (dat) levels in nucleus accumbens (nac). |
2006-01-03 |
2023-08-12 |
rat |
| Swen Hesse, Ulrich Müller, Thomas Lincke, Henryk Barthel, Thomas Villmann, Matthias C Angermeyer, Osama Sabri, Katarina Stengler-Wenzk. Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder. Psychiatry research. vol 140. issue 1. 2006-01-03. PMID:16213689. |
we applied [123i]-2beta-carbomethoxy-3beta-(4-idiophenyl)tropane (beta-cit) and a brain-dedicated high-resolution single photon emission computed tomography (spect) system to quantify dopamine transporter (dat) and serotonin transporter (sert) availability. |
2006-01-03 |
2023-08-12 |
Not clear |
| Oliver Pogarell, Gabriele Poepperl, Christoph Mulert, Christine Hamann, Nikolai Sadowsky, Michael Riedel, Hans-Juergen Moeller, Ulrich Hegerl, Klaus Tatsc. SERT and DAT availabilities under citalopram treatment in obsessive-compulsive disorder (OCD). European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 15. issue 5. 2005-12-30. PMID:16139170. |
serotonin and dopamine transporter (sert, dat) availabilities have prospectively been investigated using [123i]beta-cit and single photon emission computed tomography in subjects with obsessive-compulsive disorder under treatment with the selective serotonin reuptake inhibitor citalopram. |
2005-12-30 |
2023-08-12 |
human |
| Jill B Rhoden, Maud Bouvet, Sari Izenwasser, Dean Wade, Stacey A Lomenzo, Mark L Trudel. Structure-activity studies of 3'-4'-dichloro-meperidine analogues at dopamine and serotonin transporters. Bioorganic & medicinal chemistry. vol 13. issue 19. 2005-12-23. PMID:15993612. |
the structure-activity relationships of 3',4'-dichloro-meperidine were investigated at dopamine (dat) and serotonin transporters (sert). |
2005-12-23 |
2023-08-12 |
Not clear |
| S Jourdain, M Morissette, N Morin, T Di Paol. Oestrogens prevent loss of dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) in substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice. Journal of neuroendocrinology. vol 17. issue 8. 2005-12-23. PMID:16011487. |
oestrogens prevent loss of dopamine transporter (dat) and vesicular monoamine transporter (vmat2) in substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice. |
2005-12-23 |
2023-08-12 |
mouse |
| S Jourdain, M Morissette, N Morin, T Di Paol. Oestrogens prevent loss of dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) in substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice. Journal of neuroendocrinology. vol 17. issue 8. 2005-12-23. PMID:16011487. |
dopamine transporter (dat) and vesicular monoamine transporter (vmat2) specific binding were measured by autoradiography. |
2005-12-23 |
2023-08-12 |
mouse |
| Nicola Berretta, Peter S Freestone, Ezia Guatteo, Denis de Castro, Raffaella Geracitano, Giorgio Bernardi, Nicola B Mercuri, Janusz Lipsk. Acute effects of 6-hydroxydopamine on dopaminergic neurons of the rat substantia nigra pars compacta in vitro. Neurotoxicology. vol 26. issue 5. 2005-12-22. PMID:15890406. |
cell membrane current and ca2+ responses were not prevented by blocking dopamine transporter (dat). |
2005-12-22 |
2023-08-12 |
rat |
| Kazunori Yukawa, Tetsuji Tanaka, Kyoko Owada-Makabe, Yuji Tsubota, Tao Bai, Masanobu Maeda, Kiyoshi Takeda, Shizuo Akira, Hiroyuki Is. Reduced prepulse inhibition of startle in STAT6-deficient mice. International journal of molecular medicine. vol 16. issue 4. 2005-12-21. PMID:16142403. |
we recently showed that stat6-deficient mice displayed increased locomotor activities and had reduced levels of dopamine transporter (dat) expression in the striatum. |
2005-12-21 |
2023-08-12 |
mouse |
| Manuel Miranda, Christine C Wu, Tatiana Sorkina, Davin R Korstjens, Alexander Sorki. Enhanced ubiquitylation and accelerated degradation of the dopamine transporter mediated by protein kinase C. The Journal of biological chemistry. vol 280. issue 42. 2005-12-13. PMID:16109712. |
enhanced ubiquitylation and accelerated degradation of the dopamine transporter mediated by protein kinase c. dopamine transporter (dat) localization in dopaminergic neurons plays an important role in regulating dopamine signaling. |
2005-12-13 |
2023-08-12 |
human |
| Jean Logan, Yu-Shin Ding, Kuo-Shyan Lin, Deborah Pareto, Joanna Fowler, Anat Biego. Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region. Nuclear medicine and biology. vol 32. issue 5. 2005-12-07. PMID:15982584. |
the development of positron emission tomography (pet) ligands for the norepinephrine transporter (net) has been slow compared to the development of radiotracers for others systems, such as the dopamine (dat) or the serotonin transporters (sert). |
2005-12-07 |
2023-08-12 |
Not clear |
| C L Parish, J Nunan, D I Finkelstein, F N McNamara, J Y Wong, J L Waddington, R M Brown, A J Lawrence, M K Horne, J Drag. Mice lacking the alpha4 nicotinic receptor subunit fail to modulate dopaminergic neuronal arbors and possess impaired dopamine transporter function. Molecular pharmacology. vol 68. issue 5. 2005-11-28. PMID:16077034. |
in addition, although synaptosome da uptake studies showed that the interaction of the d2 da receptor and the dopamine transporter (dat) was preserved in alpha4(-/-) mice, dat function was found to be impaired. |
2005-11-28 |
2023-08-12 |
mouse |
| Amy K Wagner, Xiangbai Chen, Anthony E Kline, Youming Li, Ross D Zafonte, C Edward Dixo. Gender and environmental enrichment impact dopamine transporter expression after experimental traumatic brain injury. Experimental neurology. vol 195. issue 2. 2005-11-21. PMID:16023635. |
the dopamine transporter (dat) plays a crucial role in regulating da transmission, and previous work shows that dat is decreased after tbi in males. |
2005-11-21 |
2023-08-12 |
rat |
| Elzbieta Lorenc-Koci, Krystyna Gołembiowska, Jadwiga Warda. 1,2,3,4-Tetrahydroisoquinoline protects terminals of dopaminergic neurons in the striatum against the malonate-induced neurotoxicity. Brain research. vol 1051. issue 1-2. 2005-11-15. PMID:16004976. |
injection of malonate at a dose of 3 mumol unilaterally into the rat left medial forebrain bundle resulted in the 54% decrease in dopamine (da) concentration in the ipsilateral striatum and, depending on the examined striatum regions, caused 24-44% reduction in [3h]gbr12,935 binding to the dopamine transporter (dat). |
2005-11-15 |
2023-08-12 |
rat |