| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julie Kniazeff, Claus Juul Loland, Naomi Goldberg, Matthias Quick, Shonit Das, Harald H Sitte, Jonathan A Javitch, Ulrik Gethe. Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16129457. |
it was not possible, however, to transfer to tnat binding sites for another metal ion, zn(2+), that we previously engineered in the dopamine (dat) and gaba (gat-1) transporters between tm 7 and 8. |
2006-03-10 |
2023-08-12 |
Not clear |
| Michelle S Mazei-Robison, R Steven Couch, Richard C Shelton, Mark A Stein, Randy D Blakel. Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16171832. |
the activity of the presynaptic dopamine (da) transporter (dat) is critical in mediating the magnitude and duration of dopaminergic signaling in the brain. |
2006-03-10 |
2023-08-12 |
human |
| Balachandra K Gorentla, Roxanne A Vaugha. Differential effects of dopamine and psychoactive drugs on dopamine transporter phosphorylation and regulation. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16181646. |
the dopamine transporter (dat) is a phosphoprotein whose activity and phosphorylation state are acutely regulated by both protein kinase c (pkc) and substrate transport. |
2006-03-10 |
2023-08-12 |
Not clear |
| Balachandra K Gorentla, Roxanne A Vaugha. Differential effects of dopamine and psychoactive drugs on dopamine transporter phosphorylation and regulation. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16181646. |
to examine these issues we subjected rdat llc-pk(1) cells to acute in vitro pretreatments with the endogenous, psychostimulant, and therapeutic compounds dopamine (da), (-)-cocaine, 2 beta-carbomethoxy-3beta-(4-fluorophenyl)tropane (beta-cft), gbr 12909, mazindol, and methylphenidate (mph), in the presence or absence of the pkc activator phorbol 12 myristate 13 acetate (pma), followed by analysis of dat metabolic phosphorylation and transport activity. |
2006-03-10 |
2023-08-12 |
Not clear |
| L'aurelle A Johnson, Cheryse A Furman, Minjia Zhang, Bipasha Guptaroy, Margaret E Gneg. Rapid delivery of the dopamine transporter to the plasmalemmal membrane upon amphetamine stimulation. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16212991. |
the dopamine transporter, dat, is a primary regulator of dopamine (da) signaling at the synapse. |
2006-03-10 |
2023-08-12 |
rat |
| M Le Saux, T Di Paol. Influence of oestrogenic compounds on monoamine transporters in rat striatum. Journal of neuroendocrinology. vol 18. issue 1. 2006-03-09. PMID:16451217. |
oestrogens have been reported to modulate rat membrane (dat) and vesicular (vmat(2)) dopamine transporters. |
2006-03-09 |
2023-08-12 |
rat |
| Sangeeta Raje, Jennifer Cornish, Amy H Newman, Jianjing Cao, Jonathan L Katz, Natalie D Eddingto. Pharmacodynamic assessment of the benztropine analogues AHN-1055 and AHN-2005 using intracerebral microdialysis to evaluate brain dopamine levels and pharmacokinetic/pharmacodynamic modeling. Pharmaceutical research. vol 22. issue 4. 2006-03-07. PMID:15846468. |
the benztropine (bzt) analogues bind with high affinity to the dopamine transporter (dat) and demonstrate a behavioral and pharmacokinetic profile unlike that of cocaine. |
2006-03-07 |
2023-08-12 |
Not clear |
| Trent J Volz, James O Schen. A comprehensive atlas of the topography of functional groups of the dopamine transporter. Synapse (New York, N.Y.). vol 58. issue 2. 2006-03-06. PMID:16088952. |
the neuronal dopamine transporter (dat) is a transmembrane transporter that clears da from the synaptic cleft. |
2006-03-06 |
2023-08-12 |
human |
| Mark A Cervinski, James D Foster, Roxanne A Vaugha. Psychoactive substrates stimulate dopamine transporter phosphorylation and down-regulation by cocaine-sensitive and protein kinase C-dependent mechanisms. The Journal of biological chemistry. vol 280. issue 49. 2006-03-06. PMID:16204245. |
the dopamine transport blocker (-)-cocaine did not affect dat phosphorylation but prevented the phosphorylation increase induced by meth. |
2006-03-06 |
2023-08-12 |
rat |
| Kevin B Freeman, Kenner C Rice, Anthony L Rile. Assessment of monoamine transporter inhibition in the mediation of cocaine-induced conditioned taste aversion. Pharmacology, biochemistry, and behavior. vol 82. issue 3. 2006-03-02. PMID:16337262. |
using the conditioned taste aversion (cta) preparation, the present study examined the role of monoamine uptake inhibition in cocaine's aversive effects by comparing cocaine to three reuptake inhibitors with relative specificity for the transporters of dopamine (dat; gbr 12909), norepinephrine (net; desipramine) and serotonin (sert; clomipramine). |
2006-03-02 |
2023-08-12 |
rat |
| S Horschitz, R Hummerich, T Lau, M Rietschel, P Schlos. A dopamine transporter mutation associated with bipolar affective disorder causes inhibition of transporter cell surface expression. Molecular psychiatry. vol 10. issue 12. 2006-03-01. PMID:16103889. |
the dopamine transporter (dat) plays a crucial role in dopaminergic neurotransmission as it clears the extracellular space of dopamine (da) and thus controls the concentration of active neurotransmitter. |
2006-03-01 |
2023-08-12 |
human |
| M Plotkin, H Amthauer, S Klaffke, A Kühn, L Lüdemann, G Arnold, K-D Wernecke, A Kupsch, R Felix, S Ven. Combined 123I-FP-CIT and 123I-IBZM SPECT for the diagnosis of parkinsonian syndromes: study on 72 patients. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 5. 2006-02-16. PMID:15375677. |
72 consecutive patients with suspected parkinsonian syndromes (ps) were studied by dopamine transporter (dat) and d2 receptor spect in order to evaluate the accuracy of combined spect imaging. |
2006-02-16 |
2023-08-12 |
Not clear |
| Joo Hwan Cha, Mu-Fa Zou, Erika M Adkins, Søren G F Rasmussen, Claus Juul Loland, Bernhard Schoenenberger, Ulrik Gether, Amy Hauck Newma. Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter. Journal of medicinal chemistry. vol 48. issue 24. 2006-02-09. PMID:16302792. |
novel fluorescent ligands were synthesized to identify a high-affinity probe that would enable visualization of the dopamine transporter (dat) in living cells. |
2006-02-09 |
2023-08-12 |
Not clear |
| Gilberto Gerra, Luciano Garofano, Caterina Pellegrini, Silvano Bosari, Amir Zaimovic, Gabriele Moi, Paola Avanzini, Enrica Talarico, Federica Gardini, Claudia Donnin. Allelic association of a dopamine transporter gene polymorphism with antisocial behaviour in heroin-dependent patients. Addiction biology. vol 10. issue 3. 2006-02-08. PMID:16109590. |
polymorphism of a variable number of tandem repeats (vntr) in the 3' untranslated region of exon 15 of the slc6a3 gene, coding for the dopamine transporter (dat), was analysed to test whether length variation contributes to differences in the individual susceptibility to aggressive - criminal behaviour and liability to heroin dependence. |
2006-02-08 |
2023-08-12 |
human |
| Walter Koch, Christine Hamann, Julia Welsch, Gabriele Pöpperl, Perry E Radau, Klaus Tatsc. Is iterative reconstruction an alternative to filtered backprojection in routine processing of dopamine transporter SPECT studies? Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 46. issue 11. 2006-02-03. PMID:16269593. |
in general, striatal dopamine transporter (dat) binding is assessed by use of data reconstructed by filtered backprojection (fbp). |
2006-02-03 |
2023-08-12 |
Not clear |
| John R Adams, Hinke van Netten, Michael Schulzer, Edwin Mak, Jessamyn Mckenzie, Audrey Strongosky, Vesna Sossi, Thomas J Ruth, Chong S Lee, Matthew Farrer, Thomas Gasser, Ryan J Uitti, Donald B Calne, Zbigniew K Wszolek, A Jon Stoess. PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation. Brain : a journal of neurology. vol 128. issue Pt 12. 2006-01-26. PMID:16081470. |
fifteen family members underwent pet using: 18f-6-fluoro-l-dopa (18f-dopa) to assess dopamine (da) synthesis and storage, 11c-(+/-)-dihydrotetrabenazine (11c-dtbz) for the vesicular monoamine transporter, and 11c-d-threo-methylphenidate (11c-mp) for the membrane dopamine transporter (dat). |
2006-01-26 |
2023-08-12 |
Not clear |
| Kent C Berridge, J Wayne Aldridge, Kimberly R Houchard, Xiaoxi Zhuan. Sequential super-stereotypy of an instinctive fixed action pattern in hyper-dopaminergic mutant mice: a model of obsessive compulsive disorder and Tourette's. BMC biology. vol 3. 2006-01-25. PMID:15710042. |
knockdown mutation of the dopamine transporter gene (dat) causes extracellular dopamine levels in the neostriatum of these adult mutant mice to rise to 170% of wild-type control levels. |
2006-01-25 |
2023-08-12 |
mouse |
| Annabelle M Belcher, Steven J O'Dell, John F Marshal. Impaired object recognition memory following methamphetamine, but not p-chloroamphetamine- or d-amphetamine-induced neurotoxicity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 11. 2006-01-24. PMID:15900317. |
after behavioral testing, the specificity of monoaminergic lesions was determined by postmortem [125i]rti-55 binding to dopamine (dat) and serotonin (sert) transporter proteins. |
2006-01-24 |
2023-08-12 |
rat |
| J Jankovic, S Chen, W D L. The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Progress in neurobiology. vol 77. issue 1-2. 2006-01-20. PMID:16243425. |
nurr1 interacts with other factors critical for the survival of mensencephalic dopaminergic neurons and it appears to regulate the expression of tyrosine hydroxylase (th), dopamine transporter (dat), vesicular monoamine transporter 2 (vmat2), and l-aromatic amino acid decarboxylase (aadc), all of which are important in the synthesis and storage of dopamine. |
2006-01-20 |
2023-08-12 |
mouse |
| Sidney H VanNess, Michael J Owens, Clinton D Kilt. The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density. BMC genetics. vol 6. 2006-01-20. PMID:16309561. |
a 40-bp variable number of tandem repeats (vntr) polymorphism exists in the 15th exon of dat1, the gene encoding the human dopamine transporter (dat). |
2006-01-20 |
2023-08-12 |
human |