| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathelijne Peremans, Ingeborg Goethals, Filip De Vos, A Dobbeleir, Hamphrey Ham, Henri Van Bree, Cees Van Heeringen, Kurt Audenaer. Serotonin transporter and dopamine transporter imaging in the canine brain. Nuclear medicine and biology. vol 33. issue 7. 2007-01-09. PMID:17045171. |
functional imaging with specific sert and dopamine transporter (dat) ligands contributes to the study of the ssri-transporter interaction. |
2007-01-09 |
2023-08-12 |
Not clear |
| Aurelija Jucaite, Ikuo Odano, Hans Olsson, Stefan Pauli, Christer Halldin, Lars Fard. Quantitative analyses of regional [11C]PE2I binding to the dopamine transporter in the human brain: a PET study. European journal of nuclear medicine and molecular imaging. vol 33. issue 6. 2007-01-05. PMID:16514530. |
the dopamine transporter (dat) is a plasma membrane protein of central interest in the pathophysiology of neuropsychiatric disorders and is known to be a target for psychostimulant drugs. |
2007-01-05 |
2023-08-12 |
human |
| Satoshi Fuke, Natsumi Minami, Hiroki Kokubo, Ayumu Yoshikawa, Hiroshi Yasumatsu, Noboru Sasagawa, Yumiko Saga, Toshifumi Tsukahara, Shoichi Ishiur. Hesr1 knockout mice exhibit behavioral alterations through the dopaminergic nervous system. Journal of neuroscience research. vol 84. issue 7. 2007-01-03. PMID:16998899. |
several dopamine-related genes, such as dat, dopamine receptors d1, d2, d4, and d5, were significantly upregulated. |
2007-01-03 |
2023-08-12 |
mouse |
| Yu-Shin Ding, Kuo-Shyan Lin, Jean Loga. PET imaging of norepinephrine transporters. Current pharmaceutical design. vol 12. issue 30. 2007-01-03. PMID:17073682. |
the fact that all three monoamine (dopamine, norepinephrine, and serotonin) transporters (dat, net and sert) are involved in various neurological and psychiatric diseases further emphasizes the need to develop suitable net ligands so that researchers will be able to probe the contributions of each monoamine transporter system to specific cns disorders. |
2007-01-03 |
2023-08-12 |
Not clear |
| Leslie Iverse. Neurotransmitter transporters and their impact on the development of psychopharmacology. British journal of pharmacology. vol 147 Suppl 1. 2006-12-27. PMID:16402124. |
the dopamine transporter (dat) is a key target for amphetamine and methylphenidate, used in the treatment of attention deficit hyperactivity disorder. |
2006-12-27 |
2023-08-12 |
Not clear |
| Cindy Casteels, Peter Vermaelen, Johan Nuyts, Annemie Van Der Linden, Veerle Baekelandt, Luc Mortelmans, Guy Bormans, Koen Van Laer. Construction and evaluation of multitracer small-animal PET probabilistic atlases for voxel-based functional mapping of the rat brain. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 47. issue 11. 2006-12-26. PMID:17079820. |
we have mapped metabolic ((18)f-fdg), dopamine transporter (dat) (2'-(18)f-fluoroethyl(1r-2-exo-3-exe)-8-methyl-3-(4-chlorophenyl)-8-azabicyclo[3.2.1]-octane-2-carboxylate [(18)f-fect]), and dopaminergic d(2) receptor ((11)c-raclopride) small-animal pet data onto a 3-dimensional t2-weighted mri rat brain template oriented according to the rat brain paxinos atlas. |
2006-12-26 |
2023-08-12 |
rat |
| Johanna Krause, Stefan H Dresel, Klaus-Henning Krause, Christian La Fougère, Peter Zill, Manfred Ackenhei. Striatal dopamine transporter availability and DAT-1 gene in adults with ADHD: no higher DAT availability in patients with homozygosity for the 10-repeat allele. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 7. issue 3. 2006-12-22. PMID:16861140. |
striatal dopamine transporter availability and dat-1 gene in adults with adhd: no higher dat availability in patients with homozygosity for the 10-repeat allele. |
2006-12-22 |
2023-08-12 |
Not clear |
| Johanna Krause, Stefan H Dresel, Klaus-Henning Krause, Christian La Fougère, Peter Zill, Manfred Ackenhei. Striatal dopamine transporter availability and DAT-1 gene in adults with ADHD: no higher DAT availability in patients with homozygosity for the 10-repeat allele. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 7. issue 3. 2006-12-22. PMID:16861140. |
in 29 adults with attention deficit hyperactivity disorder (adhd) striatal dopamine transporter (dat) availability was assessed by [(99m)tc]trodat-1 spect and correlated with 3' vntr polymorphism of the dat gene on chromosome 5p15.3. |
2006-12-22 |
2023-08-12 |
Not clear |
| Jan Booij, Kora de Bruin, W Boudewijn Gunnin. Repeated administration of D-amphetamine induces loss of [123I]FP-CIT binding to striatal dopamine transporters in rat brain: a validation study. Nuclear medicine and biology. vol 33. issue 3. 2006-12-18. PMID:16631090. |
in recent years, several pet and spect studies have shown loss of striatal dopamine transporter (dat) binding in amphetamine (amph) users. |
2006-12-18 |
2023-08-12 |
rat |
| Hubert P Vanbilloen, Davy M Kieffer, Bernard J Cleynhens, Guy M Bormans, Luc Mortelmans, Alfons M Verbrugge. Evaluation of (99m)Tc-labeled tropanes with alkyl substituents on the 3beta-phenyl ring as potential dopamine transporter tracers. Nuclear medicine and biology. vol 33. issue 3. 2006-12-18. PMID:16631091. |
technetium(v)-oxo-3beta-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-yl[n-(2-mercaptoethyl), n-(n'-(2-mercaptoethyl)-2-aminoethyl)]-aminomethyl ((99m)tc-trodat-1) and three derivatives with one or two substituents on the 3beta-phenyl ring (4-methylphenyl, 4-ethylphenyl and 2,4-dimethylphenyl) were prepared and evaluated as potential imaging agents for the central nervous dopamine transporter (dat). |
2006-12-18 |
2023-08-12 |
mouse |
| Zhuang-wei Xiao, Chu-yu Cao, Zhao-xin Wang, Jun-xiong Li, Hai-yong Liao, Xue-xin Zhan. Changes of dopamine transporter function in striatum during acute morphine addiction and its abstinence in rhesus monkey. Chinese medical journal. vol 119. issue 21. 2006-12-13. PMID:17097035. |
although dopamine transporter (dat) is essential for addiction, the effect of additive drugs on dat function is still controversial, especially for opiates. |
2006-12-13 |
2023-08-12 |
monkey |
| Marco Sarchiapone, Vladimir Carli, Giovanni Camardese, Chiara Cuomo, Daniela Di Giuda, Maria-Lucia Calcagni, C Focacci, Sergio De Risi. Dopamine transporter binding in depressed patients with anhedonia. Psychiatry research. vol 147. issue 2-3. 2006-12-07. PMID:16952448. |
the dopamine transporter (dat) is a predominantly presynaptic receptor that may play a critical role in the pathophysiology of dopaminergic transmission. |
2006-12-07 |
2023-08-12 |
human |
| Marco Sarchiapone, Vladimir Carli, Giovanni Camardese, Chiara Cuomo, Daniela Di Giuda, Maria-Lucia Calcagni, C Focacci, Sergio De Risi. Dopamine transporter binding in depressed patients with anhedonia. Psychiatry research. vol 147. issue 2-3. 2006-12-07. PMID:16952448. |
these findings suggest an alteration in dat density in depressed patients with anhedonia that may be a primary susceptibility factor or a secondary phenomenon to reduced dopamine concentration in the synaptic cleft. |
2006-12-07 |
2023-08-12 |
human |
| Amy Hauck Newman, Joo Hwan Cha, Jianjing Cao, Theresa Kopajtic, Jonathan L Katz, M Laura Parnas, Roxanne Vaughan, John R Leve. Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2beta-carbomethoxy-3beta-biphenyltropane. Journal of medicinal chemistry. vol 49. issue 22. 2006-12-05. PMID:17064081. |
tropane-based photoaffinity ligands covalently bind to discrete points of attachment on the dopamine transporter (dat). |
2006-12-05 |
2023-08-12 |
Not clear |
| Bertha K Madras, Zhihua Xie, Zhicheng Lin, Amy Jassen, Helen Panas, Laurie Lynch, Ryan Johnson, Eli Livni, Thomas J Spencer, Ali A Bonab, Gregory M Miller, Alan J Fischma. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16885432. |
we postulated that modafinil enhances wakefulness by modulating dopamine (dat), norepinephrine (net), or serotonin (sert) transporter activities. |
2006-12-04 |
2023-08-12 |
human |
| Bertha K Madras, Zhihua Xie, Zhicheng Lin, Amy Jassen, Helen Panas, Laurie Lynch, Ryan Johnson, Eli Livni, Thomas J Spencer, Ali A Bonab, Gregory M Miller, Alan J Fischma. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16885432. |
in vitro, modafinil inhibited [(3)h]dopamine (ic(50) = 6.4 microm), [(3)h]norepinephrine (ic(50) = 35.6 microm), and [(3)h]serotonin (ic(50) > 500 microm) transport via the human dat, net, and sert. |
2006-12-04 |
2023-08-12 |
human |
| Bertha K Madras, Michele A Fahey, Martin Goulet, Zhicheng Lin, Jacob Bendor, Claudia Goodrich, Peter C Meltzer, David R Elmaleh, Eli Livni, Ali A Bonab, Alan J Fischma. Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16885433. |
dopamine transporter (dat) inhibitors alleviate specific parkinsonian deficits in monkeys: association with dat occupancy in vivo. |
2006-12-04 |
2023-08-12 |
monkey |
| Bertha K Madras, Michele A Fahey, Martin Goulet, Zhicheng Lin, Jacob Bendor, Claudia Goodrich, Peter C Meltzer, David R Elmaleh, Eli Livni, Ali A Bonab, Alan J Fischma. Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16885433. |
viable dopamine neurons in parkinson's disease express the dopamine transporter (dat) and release dopamine (da). |
2006-12-04 |
2023-08-12 |
monkey |
| Bertha K Madras, Michele A Fahey, Martin Goulet, Zhicheng Lin, Jacob Bendor, Claudia Goodrich, Peter C Meltzer, David R Elmaleh, Eli Livni, Ali A Bonab, Alan J Fischma. Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16885433. |
we postulated that potent dat inhibitors, with low affinity for the serotonin transporter (sert), may elevate endogenously released extracellular dopamine levels to provide therapeutic benefit. |
2006-12-04 |
2023-08-12 |
monkey |
| Mu-Fa Zou, Jianjing Cao, Theresa Kopajtic, Rajeev I Desai, Jonathan L Katz, Amy Hauck Newma. Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation. Journal of medicinal chemistry. vol 49. issue 21. 2006-12-04. PMID:17034144. |
most of these analogues demonstrated high affinity binding to the dopamine transporter (dat; k(i) = 1.8-40 nm), and selectivity over the other monoamine transporters and muscarinic m(1) receptors. |
2006-12-04 |
2023-08-12 |
human |