| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongbin Yuan, Pavel A Petukho. Improved 3D-QSAR CoMFA of the dopamine transporter blockers with multiple conformations using the genetic algorithm. Bioorganic & medicinal chemistry letters. vol 16. issue 24. 2007-02-16. PMID:17027270. |
a 3d-qsar/comfa was performed for a series of 42 piperidine-based dopamine transporter (dat) blockers. |
2007-02-16 |
2023-08-12 |
Not clear |
| Christian la Fougère, Johanna Krause, Klaus-Henning Krause, Franz Josef Gildehaus, Marcus Hacker, Walter Koch, Klaus Hahn, Klaus Tatsch, Stefan Drese. Value of 99mTc-TRODAT-1 SPECT to predict clinical response to methylphenidate treatment in adults with attention deficit hyperactivity disorder. Nuclear medicine communications. vol 27. issue 9. 2007-02-12. PMID:16894328. |
in a previous study, binding of tc-trodat-1 to the dopamine transporter (dat) was found to be higher in patients with attention deficit hyperactivity disorder (adhd) as compared to healthy controls. |
2007-02-12 |
2023-08-12 |
Not clear |
| Erik Ryding, Jan-Anders Ahnlide, Mats Lindström, Ingmar Rosén, Lil Träskman-Bend. Regional brain serotonin and dopamine transporter binding capacity in suicide attempters relate to impulsiveness and mental energy. Psychiatry research. vol 148. issue 2-3. 2007-02-12. PMID:17085020. |
to study different aspects of regional pre-synaptic brain (123)i-beta-cit uptake on serotonin and dopamine re-uptake sites in drug-free suicide attempters in comparison with age- and sex matched control subjects, single photon emission computed tomography (spect) measurements were analysed for regional serotonin re-uptake (5htt) and dopamine re-uptake (dat) capacity (binding potential, bp()) after i.v. |
2007-02-12 |
2023-08-12 |
human |
| P T Redman, B S Jefferson, C B Ziegler, O V Mortensen, G E Torres, E S Levitan, E Aizenma. A vital role for voltage-dependent potassium channels in dopamine transporter-mediated 6-hydroxydopamine neurotoxicity. Neuroscience. vol 143. issue 1. 2007-01-26. PMID:17027171. |
6-hydroxydopamine (6-ohda), a neurotoxic substrate of the dopamine transporter (dat), is widely used in parkinson's disease models. |
2007-01-26 |
2023-08-12 |
rat |
| P T Redman, B S Jefferson, C B Ziegler, O V Mortensen, G E Torres, E S Levitan, E Aizenma. A vital role for voltage-dependent potassium channels in dopamine transporter-mediated 6-hydroxydopamine neurotoxicity. Neuroscience. vol 143. issue 1. 2007-01-26. PMID:17027171. |
we tested whether ectopic expression of dat induces sensitivity to 6-ohda in non-dopaminergic rat cortical neurons and evaluated the contribution of voltage-dependent potassium channel (kv)-dependent apoptosis to the toxicity of this compound in rat cortical and midbrain dopamine neurons. |
2007-01-26 |
2023-08-12 |
rat |
| P T Redman, B S Jefferson, C B Ziegler, O V Mortensen, G E Torres, E S Levitan, E Aizenma. A vital role for voltage-dependent potassium channels in dopamine transporter-mediated 6-hydroxydopamine neurotoxicity. Neuroscience. vol 143. issue 1. 2007-01-26. PMID:17027171. |
cortical neurons expressing dat accumulated dopamine and were highly vulnerable to 6-ohda. |
2007-01-26 |
2023-08-12 |
rat |
| P T Redman, B S Jefferson, C B Ziegler, O V Mortensen, G E Torres, E S Levitan, E Aizenma. A vital role for voltage-dependent potassium channels in dopamine transporter-mediated 6-hydroxydopamine neurotoxicity. Neuroscience. vol 143. issue 1. 2007-01-26. PMID:17027171. |
we conclude that native dat expression accounts for the dopamine neuron specific toxicity of 6-ohda. |
2007-01-26 |
2023-08-12 |
rat |
| Wadad Saba, Héric Valette, Marie-Anne Schöllhorn-Peyronneau, Christine Coulon, Michele Ottaviani, Sylvie Chalon, Frédéric Dolle, Patrick Emond, Christer Halldin, Julie Helfenbein, Jean-Claude Madelmont, Jean-Bernard Deloye, Denis Guilloteau, Michel Bottlaende. [11C]LBT-999: a suitable radioligand for investigation of extra-striatal dopamine transporter with PET. Synapse (New York, N.Y.). vol 61. issue 1. 2007-01-26. PMID:17068778. |
a new tropane derivative, (e)-n-(4-fluorobut-2-enyl)-2beta-carbomethoxy-3beta-(4'-tolyl)nortropane (lbt-999), was evaluated in baboons as a carbon-11 radioligand for studies of the dopamine transporter (dat) using positron emission tomography (pet). |
2007-01-26 |
2023-08-12 |
Not clear |
| Maren Carbon, David Eidelber. Functional imaging of sequence learning in Parkinson's disease. Journal of the neurological sciences. vol 248. issue 1-2. 2007-01-23. PMID:16753182. |
in healthy subjects dopamine transporter (dat) binding correlated with learning-related brain activation in prefrontal, premotor and cingulate cortices, and in the thalamus. |
2007-01-23 |
2023-08-12 |
human |
| L Li, Y Su, C Zhao, H Zhao, G Liu, J Wang, Q X. The role of Ret receptor tyrosine kinase in dopaminergic neuron development. Neuroscience. vol 142. issue 2. 2007-01-23. PMID:16879925. |
the dopamine transporter (dat) gene was clearly induced in rat embryonic neural precursors that had been transfected with ret. |
2007-01-23 |
2023-08-12 |
rat |
| Jeffrey S Stehouwer, Nachwa Jarkas, Fanxing Zeng, Ronald J Voll, Larry Williams, Michael J Owens, John R Votaw, Mark M Goodma. Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. Journal of medicinal chemistry. vol 49. issue 23. 2007-01-19. PMID:17154506. |
2beta-carbomethoxy-3beta-(3'-((z)-2-iodoethenyl)phenyl)nortropane (mzient, 1) and 2beta-carbomethoxy-3beta-(3'-((z)-2-bromoethenyl)phenyl)nortropane (mzbrent, 2) were synthesized and evaluated for binding to the human serotonin, dopamine, and norepinephrine transporters (sert, dat, and net, respectively) using transfected cells. |
2007-01-19 |
2023-08-12 |
human |
| Anne Larsson, Michael Ljungberg, Susanna Jakobson Mo, Katrine Riklund, Lennart Johansso. Correction for scatter and septal penetration using convolution subtraction methods and model-based compensation in 123I brain SPECT imaging-a Monte Carlo study. Physics in medicine and biology. vol 51. issue 22. 2007-01-17. PMID:17068363. |
the corrections are evaluated for a dopamine transporter (dat) study and a study of the regional cerebral blood flow (rcbf), performed with 123i. |
2007-01-17 |
2023-08-12 |
Not clear |
| Lin Zhang, Yukihiko Shirayama, Eiji Shimizu, Masaomi Iyo, Kenji Hashimot. Protective effects of minocycline on 3,4-methylenedioxymethamphetamine-induced neurotoxicity in serotonergic and dopaminergic neurons of mouse brain. European journal of pharmacology. vol 544. issue 1-3. 2007-01-12. PMID:16859675. |
the repeated administration of mdma (10 mg/kg x 3, 3-h intervals, s.c.) significantly decreased the contents of the dopamine and the density of the dopamine transporter (dat) in the striatum, but not the frontal cortex. |
2007-01-12 |
2023-08-12 |
mouse |
| Lin Zhang, Yukihiko Shirayama, Eiji Shimizu, Masaomi Iyo, Kenji Hashimot. Protective effects of minocycline on 3,4-methylenedioxymethamphetamine-induced neurotoxicity in serotonergic and dopaminergic neurons of mouse brain. European journal of pharmacology. vol 544. issue 1-3. 2007-01-12. PMID:16859675. |
significantly attenuated the reduction of 5-ht and dopamine as well as the density of 5-htt and dat in the mouse brain by the repeated administration of mdma. |
2007-01-12 |
2023-08-12 |
mouse |
| Xu-Feng Huang, Katerina Zavitsanou, Xin Huang, Yinghua Yu, HongQin Wang, Feng Chen, Andrew J Lawrence, Chao Den. Dopamine transporter and D2 receptor binding densities in mice prone or resistant to chronic high fat diet-induced obesity. Behavioural brain research. vol 175. issue 2. 2007-01-11. PMID:17000016. |
this study examined the density of dopamine transporter (dat) and d2 receptors in the brains of chronic high-fat diet-induced obese (cdio), obese-resistant (cdr) and low-fat-fed (lf) control mice. |
2007-01-11 |
2023-08-12 |
mouse |
| Shaji Theodore, Stephanie Stolberg, Wayne A Cass, William F Marago. Human immunodeficiency virus-1 protein tat and methamphetamine interactions. Annals of the New York Academy of Sciences. vol 1074. 2007-01-10. PMID:17105916. |
in previous studies, we demonstrated that coexposure to these two toxins caused a synergistic loss of striatal dopamine and binding to the dopamine transporter (dat), suggesting a loss of dopamine terminals. |
2007-01-10 |
2023-08-12 |
human |
| Shaji Theodore, Stephanie Stolberg, Wayne A Cass, William F Marago. Human immunodeficiency virus-1 protein tat and methamphetamine interactions. Annals of the New York Academy of Sciences. vol 1074. 2007-01-10. PMID:17105916. |
because the loss of dopamine and dat, however, do not necessarily reflect dopamine terminal degeneration, we have used silver staining and th immunohistochemistry to further examine this issue. |
2007-01-10 |
2023-08-12 |
human |
| Karen L Anderson, Yossef Itzha. Methamphetamine-induced selective dopaminergic neurotoxicity is accompanied by an increase in striatal nitrate in the mouse. Annals of the New York Academy of Sciences. vol 1074. 2007-01-10. PMID:17105919. |
administration of meth (5 mg/kg x 3) to swiss webster mice resulted in marked depletion of dopamine (da) and da transporter (dat) binding sites but no change in 5-hydroxytryptamine (5-ht) and 5-ht transporter (5-htt) binding sites in the striatum, amygdala, frontal cortex, and hippocampus, suggesting that meth causes selective neurotoxicity to da nerve terminals. |
2007-01-10 |
2023-08-12 |
mouse |
| Yukio Takamatsu, Hideko Yamamoto, Yasukazu Ogai, Yoko Hagino, Athina Markou, Kazutaka Iked. Fluoxetine as a potential pharmacotherapy for methamphetamine dependence: studies in mice. Annals of the New York Academy of Sciences. vol 1074. 2007-01-10. PMID:17105925. |
interestingly, the rewarding effects of cocaine are retained in dopamine transporter (dat) knockout (ko) mice, while serotonin transporter (sert) and dat double ko mice do not exhibit conditioned place preference (cpp) to cocaine. |
2007-01-10 |
2023-08-12 |
mouse |
| Chin-Bin Yeh, Chiang-Hsuan Lee, Yuan-Hwa Chou, Chia-Jung Chang, Kuo-Hsing Ma, Wen-Sheng Huan. Evaluating dopamine transporter activity with 99mTc-TRODAT-1 SPECT in drug-naive Tourette's adults. Nuclear medicine communications. vol 27. issue 10. 2007-01-09. PMID:16969259. |
findings on imaging of dopamine transporter (dat) activity in patients with tourette's syndrome remain inconclusive. |
2007-01-09 |
2023-08-12 |
Not clear |