| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Diana Martinez, Nina Urban, Alex Grassetti, Dinissa Chang, Mei-Chen Hu, Abraham Zangen, Frances R Levin, Richard Foltin, Edward V Nune. Transcranial Magnetic Stimulation of Medial Prefrontal and Cingulate Cortices Reduces Cocaine Self-Administration: A Pilot Study. Frontiers in psychiatry. vol 9. 2021-06-08. PMID:29615935. |
previous studies have shown that repetitive transcranial magnetic stimulation (rtms) to the dorsolateral prefrontal cortex may serve as a potential treatment for cocaine use disorder (cud), which remains a public health problem that is refractory to treatment. |
2021-06-08 |
2023-08-13 |
human |
| Diana Martinez, Nina Urban, Alex Grassetti, Dinissa Chang, Mei-Chen Hu, Abraham Zangen, Frances R Levin, Richard Foltin, Edward V Nune. Transcranial Magnetic Stimulation of Medial Prefrontal and Cingulate Cortices Reduces Cocaine Self-Administration: A Pilot Study. Frontiers in psychiatry. vol 9. 2021-06-08. PMID:29615935. |
in the self-administration sessions, cud participants chose between cocaine and an alternative reinforcer (money) in order to directly measure cocaine-seeking behavior. |
2021-06-08 |
2023-08-13 |
human |
| Margaret Haney, Eric Rubin, Rebecca K Denson, Richard W Folti. Modafinil reduces smoked cocaine self-administration in humans: effects vary as a function of cocaine 'priming' and cost. Drug and alcohol dependence. vol 221. 2021-06-08. PMID:33610094. |
the absence of an fda-approved medication for the treatment of cocaine use disorder (cud) may, in part, reflect the varying conditions present when the decision to use cocaine is made, with one medication unlikely to work under all conditions. |
2021-06-08 |
2023-08-13 |
human |
| Karen D Ersche, Tsen Vei Lim, Alexander G Murley, Catarina Rua, Matilde M Vaghi, Tara L White, Guy B Williams, Trevor W Robbin. Reduced Glutamate Turnover in the Putamen Is Linked With Automatic Habits in Human Cocaine Addiction. Biological psychiatry. vol 89. issue 10. 2021-06-02. PMID:33581835. |
the balance between goal-directed behavior and habits has been hypothesized to be biased toward the latter in individuals with cocaine use disorder (cud), suggesting possible neurochemical changes in the putamen, which may contribute to their compulsive behavior. |
2021-06-02 |
2023-08-13 |
human |
| Noelle C Anastasio, Dennis J Sholler, Robert G Fox, Sonja J Stutz, Christina R Merritt, James M Bjork, F Gerard Moeller, Kathryn A Cunningha. Suppression of cocaine relapse-like behaviors upon pimavanserin and lorcaserin co-administration. Neuropharmacology. vol 168. 2021-05-27. PMID:32145488. |
cocaine use disorder (cud) is a major public health challenge for which there are no pharmacotherapeutics approved by the united states food and drug administration (fda). |
2021-05-27 |
2023-08-13 |
Not clear |
| Fiene Marie Kuijper, Uma V Mahajan, Seul Ku, Daniel A N Barbosa, Sheila M Alessi, Sherman C Stein, Kyle M Kampman, Brandon S Bentzley, Casey H Halper. Deep Brain Stimulation Compared With Contingency Management for the Treatment of Cocaine Use Disorders: A Threshold and Cost-Effectiveness Analysis. Neuromodulation : journal of the International Neuromodulation Society. 2021-05-24. PMID:34028131. |
cocaine is the second most frequently used illicit drug worldwide (after cannabis), and cocaine use disorder (cud) related deaths increased globally by 80% from 1990 to 2013. |
2021-05-24 |
2023-08-13 |
Not clear |
| Florence Vorspan, Romain Icick, Nawel Mekdad, Cindie Courtin, Vanessa Bloch, Frank Bellivier, Jean-Louis Laplanche, Nathalie Prince, Dmitry Pishalin, Cyril Firmo, Corinne Blugeon, Bruno Mégarbane, Cynthia Marie-Claire, Nadia Benturqui. Translational study of the whole transcriptome in rats and genetic polymorphisms in humans identifies LRP1B and VPS13A as key genes involved in tolerance to cocaine-induced motor disturbances. Translational psychiatry. vol 10. issue 1. 2021-05-18. PMID:33159041. |
in a 5-day protocol measuring motor tolerance to cocaine in rats (n = 40), modeling the motor response to cocaine in patients, whole-genome rna sequencing was conducted on the ventral and dorsal striatum to prioritize a genetic association study in 225 patients with severe cud who underwent thorough phenotypic (cocaine-induced hyperlocomotion, cih; and cocaine-induced stereotypies, cis) and genotypic [571,000 polymorphisms (snps)] characterization. |
2021-05-18 |
2023-08-13 |
human |
| Florence Vorspan, Romain Icick, Nawel Mekdad, Cindie Courtin, Vanessa Bloch, Frank Bellivier, Jean-Louis Laplanche, Nathalie Prince, Dmitry Pishalin, Cyril Firmo, Corinne Blugeon, Bruno Mégarbane, Cynthia Marie-Claire, Nadia Benturqui. Translational study of the whole transcriptome in rats and genetic polymorphisms in humans identifies LRP1B and VPS13A as key genes involved in tolerance to cocaine-induced motor disturbances. Translational psychiatry. vol 10. issue 1. 2021-05-18. PMID:33159041. |
using hypothesis-free prioritization of candidate genes along with thorough methodology in both the preclinical and human analysis pipelines, we provide reliable evidence that lrp1b and vps13a are involved in the motor tolerance to cocaine in cud patients, in line with their known pathophysiology. |
2021-05-18 |
2023-08-13 |
human |
| Peter U Hámor, Mariola J Edelmann, Christina Gobin, Marek Schwend. Long-term Changes in the Central Amygdala Proteome in Rats with a History of Chronic Cocaine Self-administration. Neuroscience. vol 443. 2021-05-14. PMID:32540363. |
this study suggests that chronic cocaine self-administration, followed by a prolonged abstinence results in reorganization of specific protein signaling networks within the cea that may underlie incubated cocaine craving and identifies potential novel 'druggable' targets for the treatment of cocaine use disorder (cud). |
2021-05-14 |
2023-08-13 |
rat |
| Bao-Zhu Yang, Iris M Balodis, Hedy Kober, Patrick D Worhunsky, Cheryl M Lacadie, Joel Gelernter, Marc N Potenz. GABAergic polygenic risk for cocaine use disorder is negatively correlated with precuneus activity during cognitive control in African American individuals. Addictive behaviors. vol 114. 2021-05-14. PMID:33153773. |
impaired cognitive control has been implicated in cocaine use disorder (cud). |
2021-05-14 |
2023-08-13 |
human |
| Robert Suchting, Charlotte L Beard, Joy M Schmitz, Heather E Soder, Jin H Yoon, Khader M Hasan, Ponnada A Narayana, Scott D Lan. A meta-analysis of tract-based spatial statistics studies examining white matter integrity in cocaine use disorder. Addiction biology. vol 26. issue 2. 2021-04-21. PMID:32267062. |
tract-based spatial statistics (tbss) of diffusion tensor imaging (dti) studies have consistently shown diminished white matter (wm) integrity for individuals with cocaine use disorder (cud). |
2021-04-21 |
2023-08-13 |
Not clear |
| Natalie A Hadad, Marek Schwendt, Lori A Knacksted. Hypothalamic-pituitary-adrenal axis activity in post-traumatic stress disorder and cocaine use disorder. Stress (Amsterdam, Netherlands). vol 23. issue 6. 2021-03-24. PMID:32835581. |
post-traumatic stress disorder (ptsd) is often comorbid with cocaine use disorder (cud), but little is known about hypothalamic-pituitary-adrenal (hpa) axis function in ptsd + cud. |
2021-03-24 |
2023-08-13 |
rat |
| Natalie A Hadad, Marek Schwendt, Lori A Knacksted. Hypothalamic-pituitary-adrenal axis activity in post-traumatic stress disorder and cocaine use disorder. Stress (Amsterdam, Netherlands). vol 23. issue 6. 2021-03-24. PMID:32835581. |
conversely, increased cort levels are found in cud patients during the first 2 weeks of cocaine abstinence. |
2021-03-24 |
2023-08-13 |
rat |
| Natalie A Hadad, Marek Schwendt, Lori A Knacksted. Hypothalamic-pituitary-adrenal axis activity in post-traumatic stress disorder and cocaine use disorder. Stress (Amsterdam, Netherlands). vol 23. issue 6. 2021-03-24. PMID:32835581. |
future studies should aim to reconcile the differences in pre-clinical and clinical basal cort levels during cocaine and assess hpa axis function in both rodent models of cud that consider stress-susceptibility and in ptsd + cud individuals. |
2021-03-24 |
2023-08-13 |
rat |
| Natalie A Hadad, Marek Schwendt, Lori A Knacksted. Hypothalamic-pituitary-adrenal axis activity in post-traumatic stress disorder and cocaine use disorder. Stress (Amsterdam, Netherlands). vol 23. issue 6. 2021-03-24. PMID:32835581. |
lay summary post-traumatic stress disorder (ptsd) is often comorbid with cocaine use disorder (cud), but little is known about the hypothalamic-pituitary-adrenal (hpa) axis function in ptsd + cud. |
2021-03-24 |
2023-08-13 |
rat |
| Natalie A Hadad, Marek Schwendt, Lori A Knacksted. Hypothalamic-pituitary-adrenal axis activity in post-traumatic stress disorder and cocaine use disorder. Stress (Amsterdam, Netherlands). vol 23. issue 6. 2021-03-24. PMID:32835581. |
while this review finds ample evidence supporting aberrant hpa axis activity in both ptsd and cud, it suggests that more research is needed to understand the unique changes hpa axis activity in ptsd + cud, as well as the bidirectional relationship between stress-susceptibility and motivation to seek cocaine. |
2021-03-24 |
2023-08-13 |
rat |
| Chengxi Li, Jayme M Palka, E Sherwood Brow. Cognitive impairment in individuals with bipolar disorder with and without comorbid alcohol and/or cocaine use disorders. Journal of affective disorders. vol 272. 2021-02-15. PMID:32553378. |
this study compares cognition between individuals with bd with and without current alcohol use disorder (aud), cocaine use disorder (cud), or both, as these disorders may be linked with additive cognitive impairment. |
2021-02-15 |
2023-08-13 |
Not clear |
| Scott J Moeller, Prantik Kundu, Keren Bachi, Thomas Maloney, Pias Malaker, Muhammad A Parvaz, Nelly Alia-Klein, Edythe D London, Rita Z Goldstei. Self-awareness of problematic drug use: Preliminary validation of a new fMRI task to assess underlying neurocircuitry. Drug and alcohol dependence. vol 209. 2021-01-18. PMID:32145661. |
we developed a new fmri task to probe whether racc/vmpfc abnormalities in cocaine use disorder (cud) constitute neural correlates of readiness to change, one facet of insight. |
2021-01-18 |
2023-08-13 |
Not clear |
| Andrew R Mayer, Andrew B Dodd, Claire E Wilcox, Stefan D Klimaj, Eric D Claus, Angela D Brya. Effects of attentional bias modification therapy on the cue reactivity and cognitive control networks in participants with cocaine use disorders. The American journal of drug and alcohol abuse. vol 46. issue 3. 2021-01-11. PMID:31730369. |
while attentional bias modification therapy (abmt) alters drug-related behaviors in some substance users, results have been mixed in individuals with cocaine use disorders (cud). |
2021-01-11 |
2023-08-13 |
human |
| Francina Fonseca, Joan-Ignasi Mestre-Pintó, Àlex Gómez-Gómez, Diana Martinez-Sanvisens, Rocío Rodríguez-Minguela, Esther Papaseit, Clara Pérez-Mañá, Klaus Langohr, Olga Valverde, Óscar J Pozo, Magí Farré, Marta Torrens, On Behalf Of Neurodep Grou. The Tryptophan System in Cocaine-Induced Depression. Journal of clinical medicine. vol 9. issue 12. 2020-12-31. PMID:33352710. |
major depression disorder (mdd) is the most prevalent psychiatric comorbid condition in cocaine use disorder (cud). |
2020-12-31 |
2023-08-13 |
human |