| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Noèlia Fernàndez-Castillo, Judit Cabana-Domínguez, Roser Corominas, Bru Corman. Molecular genetics of cocaine use disorders in humans. Molecular psychiatry. 2021-08-28. PMID:34453125. |
heritability estimates for cud are high and genetic risk factors for cocaine addiction have been investigated by candidate gene association studies (cgas) and genome-wide association studies (gwas), reviewed here. |
2021-08-28 |
2023-08-13 |
Not clear |
| Peter U Hámor, Christina M Gobin, Marek Schwend. The role of glutamate mGlu5 and adenosine A2a receptor interactions in regulating working memory performance and persistent cocaine seeking in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 103. 2021-08-27. PMID:32470496. |
cocaine use disorder (cud) is associated with neurobehavioral deficits that are resistant to current treatments. |
2021-08-27 |
2023-08-13 |
rat |
| Peter U Hámor, Christina M Gobin, Marek Schwend. The role of glutamate mGlu5 and adenosine A2a receptor interactions in regulating working memory performance and persistent cocaine seeking in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 103. 2021-08-27. PMID:32470496. |
thus, despite mglu5 and a2a being exclusively co-localized in the striatum and showing behavioral synergism towards reducing cocaine effects in some studies, our findings advocate against the use of mglu5 + a2a antagonist cocktail as it may further compromise cognitive deficits and augment drug craving in cud. |
2021-08-27 |
2023-08-13 |
rat |
| J R Breedon, H Ziauddeen, J Stochl, K D Ersch. Feeding the addiction: Narrowing of goals to habits. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 42. 2021-08-20. PMID:33246848. |
experimental studies suggest that patients with cocaine use disorder (cud) are particularly prone to develop habits, even in non-drug related contexts. |
2021-08-20 |
2023-08-13 |
human |
| J R Breedon, H Ziauddeen, J Stochl, K D Ersch. Feeding the addiction: Narrowing of goals to habits. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 42. 2021-08-20. PMID:33246848. |
our data suggests cud patients display goal-narrowing towards cocaine, as well as habitual tendencies towards both cocaine and food. |
2021-08-20 |
2023-08-13 |
human |
| Derek Blevins, C Jean Choi, Martina Pavlicova, Diana Martinez, John J Mariani, John Grabowski, Frances R Levi. Impulsiveness as a moderator of amphetamine treatment response for cocaine use disorder among ADHD patients. Drug and alcohol dependence. vol 213. 2021-08-02. PMID:32485656. |
amphetamines are a first-line treatment for adhd and have shown promise for the treatment of cocaine use disorder (cud), both alone and with comorbid adhd. |
2021-08-02 |
2023-08-13 |
Not clear |
| Sarah E Forster, Steven D Forman, Naomi N Gancz, Greg J Siegle, Michael Walsh Dickey, Stuart R Steinhaue. Electrophysiological predictors and indicators of contingency management treatment response: Rationale and design for the ways of rewarding abstinence project (WRAP). Contemporary clinical trials communications. vol 23. 2021-07-30. PMID:34278041. |
veterans are disproportionately affected by disorders of addiction; cocaine use disorder (cud) being particularly problematic due to high relapse rates and the absence of approved pharmacotherapies. |
2021-07-30 |
2023-08-13 |
Not clear |
| Sarah E Forster, Steven D Forman, Naomi N Gancz, Greg J Siegle, Michael Walsh Dickey, Stuart R Steinhaue. Electrophysiological predictors and indicators of contingency management treatment response: Rationale and design for the ways of rewarding abstinence project (WRAP). Contemporary clinical trials communications. vol 23. 2021-07-30. PMID:34278041. |
prize-based contingency management (pbcm) is an evidence-based behavioral intervention for cud, involving incentives for cocaine abstinence but treatment response is variable. |
2021-07-30 |
2023-08-13 |
Not clear |
| Eduardo A Garza-Villarreal, Ruth Alcala-Lozano, Sofia Fernandez-Lozano, Erik Morelos-Santana, Alan Dávalos, Viviana Villicaña, Sarael Alcauter, F Xavier Castellanos, Jorge J Gonzalez-Olver. Clinical and Functional Connectivity Outcomes of 5-Hz Repetitive Transcranial Magnetic Stimulation as an Add-on Treatment in Cocaine Use Disorder: A Double-Blind Randomized Controlled Trial. Biological psychiatry. Cognitive neuroscience and neuroimaging. vol 6. issue 7. 2021-07-16. PMID:33508499. |
cocaine use disorder (cud) is a global condition lacking effective treatment. |
2021-07-16 |
2023-08-13 |
Not clear |
| Kyle A Windisch, Michelle Morochnik, Brian Reed, Mary Jeanne Kree. Nalmefene, a mu opioid receptor antagonist/kappa opioid receptor partial agonist, potentiates cocaine motivation but not intake with extended access self-administration in adult male mice. Neuropharmacology. vol 192. 2021-07-12. PMID:33974940. |
given the greater kor potency and improved bioavailability compared to ntx, nmf may be a promising pharmacotherapeutic for cocaine use disorder (cud). |
2021-07-12 |
2023-08-13 |
mouse |
| Gustavo A Angarita, David Matuskey, Brian Pittman, Jessica L Costeines, Marc N Potenza, Ania M Jastreboff, Heath D Schmidt, Robert T Maliso. Testing the effects of the GLP-1 receptor agonist exenatide on cocaine self-administration and subjective responses in humans with cocaine use disorder. Drug and alcohol dependence. vol 221. 2021-07-01. PMID:33621809. |
we investigated effects of a glp-1 analogue (exenatide) on behavioral and subjective effects of cocaine in individuals with cocaine use disorder (cud). |
2021-07-01 |
2023-08-13 |
Not clear |
| Pierre-Olivier Gaudreault, Akarsh Sharma, Abhishek Datta, Ester M Nakamura-Palacios, Sarah King, Pias Malaker, Ariella Wagner, Devarshi Vasa, Muhammad A Parvaz, Lucas C Parra, Nelly Alia-Klein, Rita Z Goldstei. A double-blind sham-controlled phase 1 clinical trial of tDCS of the dorsolateral prefrontal cortex in cocaine inpatients: Craving, sleepiness, and contemplation to change. The European journal of neuroscience. vol 53. issue 9. 2021-06-30. PMID:33662163. |
dlpfc modulation with transcranial direct current stimulation (tdcs) previously showed craving reduction in inpatients with cocaine use disorder (cud). |
2021-06-30 |
2023-08-13 |
human |
| Lucca Pizzato Tondo, Thiago Wendt Viola, Gabriel R Fries, Bruno Kluwe-Schiavon, Leonardo Mello Rothmann, Renata Cupertino, Pedro Ferreira, Alexandre Rosa Franco, Scott D Lane, Laura Stertz, Zhongming Zhao, Ruifeng Hu, Thomas Meyer, Joy M Schmitz, Consuelo Walss-Bass, Rodrigo Grassi-Oliveir. White matter deficits in cocaine use disorder: convergent evidence from in vivo diffusion tensor imaging and ex vivo proteomic analysis. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33911068. |
white matter (wm) abnormalities in patients with cocaine use disorder (cud) have been studied; however, the reported effects on the human brain are heterogenous and most results have been obtained from male participants. |
2021-06-28 |
2023-08-13 |
human |
| Ewa Galaj, Guo-Hua Bi, Allamar Moore, Kai Chen, Yi He, Eliot Gardner, Zheng-Xiong X. Beta-caryophyllene inhibits cocaine addiction-related behavior by activation of PPARα and PPARγ: repurposing a FDA-approved food additive for cocaine use disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 4. 2021-06-23. PMID:33069159. |
despite intense research, there is still no fda-approved medication to treat cocaine use disorder (cud). |
2021-06-23 |
2023-08-13 |
mouse |
| Raimondo Maria Pavarin, Samantha Sanchini, Leonardo Tadonio, Marco Domenicali, Fabio Caputo, Monica Pacett. Suicide mortality risk in a cohort of individuals treated for alcohol, heroin or cocaine abuse: Results of a follow-up study. Psychiatry research. vol 296. 2021-06-21. PMID:33352416. |
this follow-up study (from 1975 to 2016) was aimed to estimate the mortality risk for suicide in a cohort of patients presenting to a public treatment centre for addiction (serd) with alcohol use disorder (aud), heroin use disorder - hud or cocaine use disorder (cud), also relating to their access to a mental heath service. |
2021-06-21 |
2023-08-13 |
human |
| Ju-Chi Yu, Vincenzo G Fiore, Richard W Briggs, Jacquelyn Braud, Katya Rubia, Bryon Adinoff, Xiaosi G. An insula-driven network computes decision uncertainty and promotes abstinence in chronic cocaine users. The European journal of neuroscience. vol 52. issue 12. 2021-06-21. PMID:33439518. |
here, we used model-based fmri to measure choice uncertainty in a motor decision task in 61 individuals with cocaine use disorder (cud) and 25 healthy controls. |
2021-06-21 |
2023-08-13 |
human |
| Benoît Forget, Romain Icick, Jonathan Robert, Caroline Correia, Marie S Prevost, Marc Gielen, Pierre-Jean Corringer, Frank Bellivier, Florence Vorspan, Morgane Besson, Uwe Masko. Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients. Progress in neurobiology. vol 197. 2021-06-11. PMID:32841724. |
human candidate gene association studies showed that the single nucleotide polymorphism (snp) rs16969968 in the α5 subunit (α5snp) of nicotinic acetylcholine receptors (nachrs), previously associated with increased tobacco dependence, was linked to a lower prevalence of cocaine use disorder (cud). |
2021-06-11 |
2023-08-13 |
human |
| Benoît Forget, Romain Icick, Jonathan Robert, Caroline Correia, Marie S Prevost, Marc Gielen, Pierre-Jean Corringer, Frank Bellivier, Florence Vorspan, Morgane Besson, Uwe Masko. Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients. Progress in neurobiology. vol 197. 2021-06-11. PMID:32841724. |
to investigate the link between this subunit and cud, we submitted rats knockout for the α5 subunit gene (α5ko), or carrying the α5snp, to cocaine self-administration (sa) and showed that the acquisition of cocaine-sa was impaired in α5snp rats while α5ko rats exhibited enhanced cocaine-induced relapse associated with altered neuronal activity in the nucleus accumbens. |
2021-06-11 |
2023-08-13 |
human |
| Benoît Forget, Romain Icick, Jonathan Robert, Caroline Correia, Marie S Prevost, Marc Gielen, Pierre-Jean Corringer, Frank Bellivier, Florence Vorspan, Morgane Besson, Uwe Masko. Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients. Progress in neurobiology. vol 197. 2021-06-11. PMID:32841724. |
in addition, we observed in a human cohort of patients with cud that the α5snp was associated with a slower transition from first cocaine use to cud. |
2021-06-11 |
2023-08-13 |
human |
| Benoît Forget, Romain Icick, Jonathan Robert, Caroline Correia, Marie S Prevost, Marc Gielen, Pierre-Jean Corringer, Frank Bellivier, Florence Vorspan, Morgane Besson, Uwe Masko. Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients. Progress in neurobiology. vol 197. 2021-06-11. PMID:32841724. |
in conclusion, the α5snp is protective against cud by influencing early stages of cocaine exposure while chrna5 expression levels may represent a biomarker for the risk to relapse to cocaine use. |
2021-06-11 |
2023-08-13 |
human |