| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miriami Kleiter, David E Malarkey, David E Ruslander, Donald E Thral. Expression of cyclooxygenase-2 in canine epithelial nasal tumors. Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association. vol 45. issue 3. 2004-07-15. PMID:15200266. |
whether the intensity and distribution of cox-2 expression in nasal tumors can be used as a prognostic marker requires further investigation. |
2004-07-15 |
2023-08-12 |
human |
| Miriami Kleiter, David E Malarkey, David E Ruslander, Donald E Thral. Expression of cyclooxygenase-2 in canine epithelial nasal tumors. Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association. vol 45. issue 3. 2004-07-15. PMID:15200266. |
a combination therapy of irradiation and a selective cox-2 inhibitor appears worthy of clinical investigation in the treatment of canine epithelial nasal tumors. |
2004-07-15 |
2023-08-12 |
human |
| S L Beam, K M Rassnick, A S Moore, S P McDonoug. An immunohistochemical study of cyclooxygenase-2 expression in various feline neoplasms. Veterinary pathology. vol 40. issue 5. 2003-12-12. PMID:12949405. |
no cox-2 immunoreactivity was detected in cutaneous squamous cell carcinomas (6), adenocarcinomas (nine mammary, eight pulmonary, seven intestinal), lymphomas (six nasal, six intestinal), or 10 vaccine-associated sarcomas. |
2003-12-12 |
2023-08-12 |
human |
| A M Vignola, V Belli. Transcriptional regulation of COX-2: a key mechanism in the pathogenesis of nasal polyposis in aspirin-sensitive asthmatics? Allergy. vol 58. issue 2. 2003-07-25. PMID:12622739. |
transcriptional regulation of cox-2: a key mechanism in the pathogenesis of nasal polyposis in aspirin-sensitive asthmatics? |
2003-07-25 |
2023-08-12 |
Not clear |
| C Picado, G Bioque, J Roca-Ferrer, L Pujols, J Mullol, P Benitez, O Bulben. Nuclear factor-kappaB activity is down-regulated in nasal polyps from aspirin-sensitive asthmatics. Allergy. vol 58. issue 2. 2003-07-25. PMID:12622742. |
we examined whether a decreased activity of nuclear factor(nf)-kappab), a transcriptional regulator of cyclooxygenase-2 (cox-2), could account for down-regulation of cox-2 in nasal polyps of aspirin-sensitive asthmatics. |
2003-07-25 |
2023-08-12 |
Not clear |
| Sien-Hung Yang, Chuang-Ye Hong, Chia-Li Y. The stimulatory effects of nasal discharge from patients with perennial allergic rhinitis on normal human neutrophils are normalized after treatment with a new mixed formula of Chinese herbs. International immunopharmacology. vol 2. issue 12. 2003-07-16. PMID:12469937. |
we found the nasal discharge, but not serum, from ar group with high serum ige (h-ige, serum ige >200 kiu/l) before treatment exerted many stimulating effects on normal pmn including delayed apoptosis, enhanced production of soluble intercellular adhesion molecule 1 (sicam-1), interleukin 8 (il-8) and prostaglandin e2 (pge2), increased phagocytosis, and augmented cyclooxygenase 2 (cox-2) mrna expression of pmn. |
2003-07-16 |
2023-08-12 |
human |
| Chang-Bae Yun, Byung-Heon Lee, Tae-Jung Jan. Expression of glucocorticoid receptors and cyclooxygenase-2 in nasal polyps from nonallergic patients. The Annals of otology, rhinology, and laryngology. vol 111. issue 1. 2002-01-31. PMID:11800371. |
in the present study, we examined the presence of glucocorticoid receptors (grs) and cyclooxygenase-2 (cox-2) in the nasal polyps of nonallergic patients as compared with normal controls. |
2002-01-31 |
2023-08-12 |
Not clear |
| Chang-Bae Yun, Byung-Heon Lee, Tae-Jung Jan. Expression of glucocorticoid receptors and cyclooxygenase-2 in nasal polyps from nonallergic patients. The Annals of otology, rhinology, and laryngology. vol 111. issue 1. 2002-01-31. PMID:11800371. |
reverse transcription-polymerase chain reaction analyses revealed the presence of both gr messenger rna and cox-2 messenger rna expression in nasal polyps from nonallergic patients, as well as in normal nasal mucosa from controls. |
2002-01-31 |
2023-08-12 |
Not clear |
| Chang-Bae Yun, Byung-Heon Lee, Tae-Jung Jan. Expression of glucocorticoid receptors and cyclooxygenase-2 in nasal polyps from nonallergic patients. The Annals of otology, rhinology, and laryngology. vol 111. issue 1. 2002-01-31. PMID:11800371. |
importantly, cox-2 labeling was seen in the cytoplasm of surface mucosa, submucosal glands, and the vascular wall in nasal polyps. |
2002-01-31 |
2023-08-12 |
Not clear |
| Chang-Bae Yun, Byung-Heon Lee, Tae-Jung Jan. Expression of glucocorticoid receptors and cyclooxygenase-2 in nasal polyps from nonallergic patients. The Annals of otology, rhinology, and laryngology. vol 111. issue 1. 2002-01-31. PMID:11800371. |
in contrast, in normal nasal tissues, cox-2 labeling was only found in the vascular wall, and the expression was weaker--a finding demonstrating that cox-2 is upregulated in nasal polyps. |
2002-01-31 |
2023-08-12 |
Not clear |
| Chang-Bae Yun, Byung-Heon Lee, Tae-Jung Jan. Expression of glucocorticoid receptors and cyclooxygenase-2 in nasal polyps from nonallergic patients. The Annals of otology, rhinology, and laryngology. vol 111. issue 1. 2002-01-31. PMID:11800371. |
therefore, 1) the presence of grs and cox-2 in nasal polyps from nonallergic patients, as well as upregulation of cox-2 expression, suggests that inflammation may play an important role in the pathophysiology of nasal polyps; and 2) glucocorticoid could be a potential treatment method for suppressing inflammatory processes. |
2002-01-31 |
2023-08-12 |
Not clear |
| J C Fernández-Morata, J Mullol, M Fuentes, L Pujols, J Roca-Ferrer, M Pérez, A Xaubet, C Picad. Regulation of cyclooxygenase-1 and -2 expression in human nasal mucosa. Effects of cytokines and dexamethasone. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 30. issue 9. 2000-10-31. PMID:10971474. |
the regulation of cox-1 and cox-2 expression in nasal mucosa has not been previously reported. |
2000-10-31 |
2023-08-12 |
human |
| J Grzegorczyk, M L Kowalski, T Kornatowski, R Pawlicza. Expression of cyclooxygenase in nasal polyps from atopic and nonatopic subjects. Journal of investigational allergology & clinical immunology. vol 9. issue 6. 2000-03-14. PMID:10664933. |
monoclonal antibodies against cox-total (detecting both cox-1 and cox-2 epitopes) and anti-cox-2 combined with peroxidase-antiperoxidase (pap) visualizing system were used to assess cox-total and cox-2 expression in cryostat sections of nasal polyps from both groups of patients. |
2000-03-14 |
2023-08-12 |
human |
| J Grzegorczyk, M L Kowalski, T Kornatowski, R Pawlicza. Expression of cyclooxygenase in nasal polyps from atopic and nonatopic subjects. Journal of investigational allergology & clinical immunology. vol 9. issue 6. 2000-03-14. PMID:10664933. |
we demonstrated that cryostat sections of nasal polyps from both groups of patients revealed cox-total and cox-2 expression with similar intensity. |
2000-03-14 |
2023-08-12 |
human |
| J Grzegorczyk, M L Kowalski, T Kornatowski, R Pawlicza. Expression of cyclooxygenase in nasal polyps from atopic and nonatopic subjects. Journal of investigational allergology & clinical immunology. vol 9. issue 6. 2000-03-14. PMID:10664933. |
there were no significant differences in distribution of cox-total or cox-2 immunoreactivity in nasal polyps tissue between atopic and nonatopic group. |
2000-03-14 |
2023-08-12 |
human |
| J Grzegorczyk, M L Kowalski, T Kornatowski, R Pawlicza. Expression of cyclooxygenase in nasal polyps from atopic and nonatopic subjects. Journal of investigational allergology & clinical immunology. vol 9. issue 6. 2000-03-14. PMID:10664933. |
our data indicate that cox-2 is expressed in nasal polyps from both atopic and nonatopic patients. |
2000-03-14 |
2023-08-12 |
human |
| D N Watkins, D J Peroni, J C Lenzo, D A Knight, M J Garlepp, P J Thompso. Expression and localization of COX-2 in human airways and cultured airway epithelial cells. The European respiratory journal. vol 13. issue 5. 1999-09-03. PMID:10414396. |
human airway specimens from patients undergoing lung resection surgery for primary lung tumours (n=10) or nasal mucosal resection for non-inflammatory nasal obstruction (n=5) were examined for cox-2 expression by in situ hybridization and immunohistochemistry. |
1999-09-03 |
2023-08-12 |
human |
| C Picado, J C Fernandez-Morata, M Juan, J Roca-Ferrer, M Fuentes, A Xaubet, J Mullo. Cyclooxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmatics. American journal of respiratory and critical care medicine. vol 160. issue 1. 1999-08-11. PMID:10390414. |
we therefore examined the expression of cox-2 messenger rna (mrna) in healthy nasal mucosa (n = 11) and in nasal polyps from both patients with aiar (n = 8) and those with aspirin-tolerant asthma/rhinitis (atar) (n = 20). |
1999-08-11 |
2023-08-12 |
Not clear |
| C Picado, J C Fernandez-Morata, M Juan, J Roca-Ferrer, M Fuentes, A Xaubet, J Mullo. Cyclooxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmatics. American journal of respiratory and critical care medicine. vol 160. issue 1. 1999-08-11. PMID:10390414. |
however, cox-2 mrna expression in nasal polyps from the aiar group (0.38 +/- 0.10) was markedly and significantly lower than in polyps from the atar group (2.93 +/- 0. |
1999-08-11 |
2023-08-12 |
Not clear |