| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Volkan Ergin, Akın Yılmaz, Fatih Celenk, Sabri Uslu, Fikret Ileri, Adnan Menevş. [The role of COX-2, ALOX12 and iNOS genes in nasal polyposis]. Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat. vol 22. issue 5. 2015-03-26. PMID:22991985. |
[the role of cox-2, alox12 and inos genes in nasal polyposis]. |
2015-03-26 |
2023-08-12 |
Not clear |
| Volkan Ergin, Akın Yılmaz, Fatih Celenk, Sabri Uslu, Fikret Ileri, Adnan Menevş. [The role of COX-2, ALOX12 and iNOS genes in nasal polyposis]. Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat. vol 22. issue 5. 2015-03-26. PMID:22991985. |
the aim of this study was to investigate whether cyclooxygenase-2 (cox-2), arachidonate 12-lipoxygenase (alox12) and inducible nitric oxide synthase (inos) which are well-known mediators in inflammatory process play a role in nasal polyposis (np) and to show their roles in initiation and progression of inflammation. |
2015-03-26 |
2023-08-12 |
Not clear |
| Demet Yazici, Ülkü Tuncer, Aysun Uğu. The effect of corticosteroid therapy on cyclooxygenase 2, vascular endothelial growth factor, and inducible nitric oxide synthase expression levels in nasal polyposis. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 271. issue 6. 2015-01-02. PMID:24077870. |
nasal polyp biopsies were taken before and after medical treatment and immunohistochemical staining for cyclooxygenase 2 (cox-2), vascular endothelial growth factor (vegf) and inducible nitric oxide synthase (inos) were applied to the specimens. |
2015-01-02 |
2023-08-12 |
Not clear |
| Demet Yazici, Ülkü Tuncer, Aysun Uğu. The effect of corticosteroid therapy on cyclooxygenase 2, vascular endothelial growth factor, and inducible nitric oxide synthase expression levels in nasal polyposis. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 271. issue 6. 2015-01-02. PMID:24077870. |
short-term steroid therapy does not affect cox-2 level of the nasal polyposis tissue, but has an influence on inos and vegf levels. |
2015-01-02 |
2023-08-12 |
Not clear |
| Francesc Josep Garcia-Garcia, Joaquim Mullol, Maria Perez-Gonzalez, Laura Pujols, Isam Alobid, Jordi Roca-Ferrer, Cesar Picad. Signal transduction pathways (MAPKs, NF-κB, and C/EBP) regulating COX-2 expression in nasal fibroblasts from asthma patients with aspirin intolerance. PloS one. vol 7. issue 12. 2013-05-30. PMID:23240010. |
signal transduction pathways (mapks, nf-κb, and c/ebp) regulating cox-2 expression in nasal fibroblasts from asthma patients with aspirin intolerance. |
2013-05-30 |
2023-08-12 |
Not clear |
| Przemyslaw Sitarek, Hanna Zielinska-Blizniewska, Lukasz Dziki, Jaroslaw Milonski, Karolina Przybylowska, Bartosz Mucha, Jurek Olszewski, Ireneusz Majstere. Association of the -14C/G MET and the -765G/C COX-2 gene polymorphisms with the risk of chronic rhinosinusitis with nasal polyps in a Polish population. DNA and cell biology. vol 31. issue 7. 2012-09-20. PMID:22416915. |
association of the -14c/g met and the -765g/c cox-2 gene polymorphisms with the risk of chronic rhinosinusitis with nasal polyps in a polish population. |
2012-09-20 |
2023-08-12 |
human |
| Przemyslaw Sitarek, Hanna Zielinska-Blizniewska, Lukasz Dziki, Jaroslaw Milonski, Karolina Przybylowska, Bartosz Mucha, Jurek Olszewski, Ireneusz Majstere. Association of the -14C/G MET and the -765G/C COX-2 gene polymorphisms with the risk of chronic rhinosinusitis with nasal polyps in a Polish population. DNA and cell biology. vol 31. issue 7. 2012-09-20. PMID:22416915. |
the following study tested the association of the -765 g/c polymorphism of cyclooxygenase-2 (cox-2) encoding gene and the -14c/g polymorphism of protooncogen met (met) encoding gene with a risk of chronic rhinosinusitis with nasal polyps in a polish population. |
2012-09-20 |
2023-08-12 |
human |
| Przemyslaw Sitarek, Hanna Zielinska-Blizniewska, Lukasz Dziki, Jaroslaw Milonski, Karolina Przybylowska, Bartosz Mucha, Jurek Olszewski, Ireneusz Majstere. Association of the -14C/G MET and the -765G/C COX-2 gene polymorphisms with the risk of chronic rhinosinusitis with nasal polyps in a Polish population. DNA and cell biology. vol 31. issue 7. 2012-09-20. PMID:22416915. |
we reported that the -765 g/c cox-2 (odds ratio [or] 7.79; 95% confidence interval [ci] 4.88-12.4, p<0.001) and the -14c/g met (or 2.83; 95% ci 1.74-4.61, p<0.001) were associated with an increased risk of chronic rhinosinusitis with nasal polyps among analyzed group of patients. |
2012-09-20 |
2023-08-12 |
human |
| Przemyslaw Sitarek, Hanna Zielinska-Blizniewska, Lukasz Dziki, Jaroslaw Milonski, Karolina Przybylowska, Bartosz Mucha, Jurek Olszewski, Ireneusz Majstere. Association of the -14C/G MET and the -765G/C COX-2 gene polymorphisms with the risk of chronic rhinosinusitis with nasal polyps in a Polish population. DNA and cell biology. vol 31. issue 7. 2012-09-20. PMID:22416915. |
moreover, the group of patients without allergy or asthma indicated the association of the -765 c/g (or 7.25; 95% ci 4.38-12.1, p<0.001 and or 7.61; 95% ci 4.47-12.6, p<0.001) genotype of the cox-2 as wells as the -14c/g (or 2.47; 95% ci 1.46-4.17, p<0.001 and or 2.59; 95% ci 1.54-4.37, p<0.001) genotype of met with an increased risk of chronic rhinosinusitis with nasal polyps. |
2012-09-20 |
2023-08-12 |
human |
| Przemyslaw Sitarek, Hanna Zielinska-Blizniewska, Lukasz Dziki, Jaroslaw Milonski, Karolina Przybylowska, Bartosz Mucha, Jurek Olszewski, Ireneusz Majstere. Association of the -14C/G MET and the -765G/C COX-2 gene polymorphisms with the risk of chronic rhinosinusitis with nasal polyps in a Polish population. DNA and cell biology. vol 31. issue 7. 2012-09-20. PMID:22416915. |
finally, it was also found that the selected group of patients with allergy or asthma indicated a very strong association of the -765 g/c (or 5.64; 95% ci 2.91-10.9 and or 4.74; 95% ci 2.49-9.03, p<0.001, respectively) genotype of the cox-2 with an increased risk of chronic rhinosinusitis with nasal polyps. |
2012-09-20 |
2023-08-12 |
human |
| Przemyslaw Sitarek, Hanna Zielinska-Blizniewska, Lukasz Dziki, Jaroslaw Milonski, Karolina Przybylowska, Bartosz Mucha, Jurek Olszewski, Ireneusz Majstere. Association of the -14C/G MET and the -765G/C COX-2 gene polymorphisms with the risk of chronic rhinosinusitis with nasal polyps in a Polish population. DNA and cell biology. vol 31. issue 7. 2012-09-20. PMID:22416915. |
thus, our results suggest that cox-2 and met gene polymorphisms may have deep impact on the risk of rhinosinusitis nasal polyp formation, which may also depend on asthma or allergy. |
2012-09-20 |
2023-08-12 |
human |
| Przemyslaw Sitarek, Hanna Zielinska-Blizniewska, Lukasz Dziki, Jaroslaw Milonski, Karolina Przybylowska, Bartosz Mucha, Jurek Olszewski, Ireneusz Majstere. Association of the -14C/G MET and the -765G/C COX-2 gene polymorphisms with the risk of chronic rhinosinusitis with nasal polyps in a Polish population. DNA and cell biology. vol 31. issue 7. 2012-09-20. PMID:22416915. |
our results showed that the -765 g/c polymorphism of cox-2 gene and the -14c/g polymorphism of the met gene may be associated with the risk of chronic rhinosinusitis with nasal polyps in a polish population. |
2012-09-20 |
2023-08-12 |
human |
| Zhenlin Wang, Peng Li, Yuan Li, Qiuhang Zhang, Qiuyi Qu, Yan Q. [A preliminary study on the regulation mechanism of p38MAPK on MUC5AC in allergic rhinitis]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 25. issue 20. 2012-06-08. PMID:22239058. |
to detect the effect of p38 mitogen activated protein kinase (p38mapk) and cyclooxygenase-2 (cox-2) on the expression of mucin5ac (muc5ac) in human nasal mucosa induced by histamine in vitro, and to investigate the pathogenesis of mucus hypersecretion in allergic rhinitis (ar). |
2012-06-08 |
2023-08-12 |
human |
| Z Belshaw, F Constantio-Casas, M J Brearley, M D Dunning, M A Holmes, J M Dobso. COX-2 expression and outcome in canine nasal carcinomas treated with hypofractionated radiotherapy. Veterinary and comparative oncology. vol 9. issue 2. 2011-10-12. PMID:21569199. |
cox-2 expression and outcome in canine nasal carcinomas treated with hypofractionated radiotherapy. |
2011-10-12 |
2023-08-12 |
human |
| Z Belshaw, F Constantio-Casas, M J Brearley, M D Dunning, M A Holmes, J M Dobso. COX-2 expression and outcome in canine nasal carcinomas treated with hypofractionated radiotherapy. Veterinary and comparative oncology. vol 9. issue 2. 2011-10-12. PMID:21569199. |
the expression of cyclooxygenase isoform 2 (cox-2) in canine nasal carcinomas has been well documented. |
2011-10-12 |
2023-08-12 |
human |
| Z Belshaw, F Constantio-Casas, M J Brearley, M D Dunning, M A Holmes, J M Dobso. COX-2 expression and outcome in canine nasal carcinomas treated with hypofractionated radiotherapy. Veterinary and comparative oncology. vol 9. issue 2. 2011-10-12. PMID:21569199. |
the aims of this study were to assess the correlation between immunohistochemical cox-2 expression and prognosis using rhinoscopic biopsies from 42 dogs with nasal carcinomas treated with hypofractionated radiotherapy, and to establish a replicable cox-2 scoring system. |
2011-10-12 |
2023-08-12 |
human |
| Z Belshaw, F Constantio-Casas, M J Brearley, M D Dunning, M A Holmes, J M Dobso. COX-2 expression and outcome in canine nasal carcinomas treated with hypofractionated radiotherapy. Veterinary and comparative oncology. vol 9. issue 2. 2011-10-12. PMID:21569199. |
immunohistochemical cox-2 expression appears unlikely to be of prognostic significance for canine nasal carcinoma. |
2011-10-12 |
2023-08-12 |
human |
| Jordi Roca-Ferrer, Francesc J Garcia-Garcia, Javier Pereda, Maria Perez-Gonzalez, Laura Pujols, Isam Alobid, Joaquim Mullol, Cesar Picad. Reduced expression of COXs and production of prostaglandin E(2) in patients with nasal polyps with or without aspirin-intolerant asthma. The Journal of allergy and clinical immunology. vol 128. issue 1. 2011-09-12. PMID:21397936. |
researchers have debated whether regulation of the cox enzymes (cox-1 and cox-2), which mediate production of prostaglandins (pgs), affects the pathogenesis of nasal polyps (nps) and aspirin-intolerant asthma (aia). |
2011-09-12 |
2023-08-12 |
Not clear |
| Koen Van Crombruggen, L Van Nassauw, L Derycke, J-P Timmermans, G Holtappels, D Hall, C Bacher. Capsaicin-induced vasodilatation in human nasal vasculature is mediated by modulation of cyclooxygenase-2 activity and abrogated by sulprostone. Naunyn-Schmiedeberg's archives of pharmacology. vol 383. issue 6. 2011-09-01. PMID:21523557. |
in conclusion, capsaicin-at concentrations clinically applied or under investigation for diverse disease backgrounds-induces a vasodilatory response in human nasal mucosa via a mechanism involving trpv1-independent reduction of pge(2) production by modulation of cox-2 enzymatic activity. |
2011-09-01 |
2023-08-12 |
human |
| Mingxia Zhang, Yuan Li, Zhenlin Wang, Peng Li, Gehua Zhang, Qiuhang Zhan. [Effect of clarithromycin on the expressions of cyclooxygenase-2 and nuclear factor-kappa B in nasal polyps in vitro]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 23. issue 17. 2011-07-08. PMID:20030038. |
to detect the expression and correlation of cyclooxygenase-2 (cox-2) and nuclear factor-kappa b (nf-kappab) in nasal polyps co-cultured with clarithromycin, and to investigate their roles in crs pathogenesis. |
2011-07-08 |
2023-08-12 |
Not clear |