| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zetang Wu, Shiyong Wang, Sandy Gruber, Marina Mata, David J Fin. Full-length membrane-bound tumor necrosis factor-α acts through tumor necrosis factor receptor 2 to modify phenotype of sensory neurons. Pain. vol 154. issue 9. 2014-03-21. PMID:23711481. |
co-culture of drg neurons with crtnfα-expressing cos-7 cells resulted in a significant increase in the expression of voltage-gated sodium channel isoforms nav1.7 and nav1.8, and voltage-gated calcium channel subunit cav3.2 at both mrna and protein levels, and enhanced ccl2 expression and release from the drg neurons. |
2014-03-21 |
2023-08-12 |
Not clear |
| Zetang Wu, Shiyong Wang, Sandy Gruber, Marina Mata, David J Fin. Full-length membrane-bound tumor necrosis factor-α acts through tumor necrosis factor receptor 2 to modify phenotype of sensory neurons. Pain. vol 154. issue 9. 2014-03-21. PMID:23711481. |
treatment of the cells with an sirna against tumor necrosis factor receptor 2 (tnfr2) significantly reduced crtnfα-induced gene expression changes in drg neurons, whereas administration of ccr2 inhibitor had no significant effect on crtnfα-induced increase in gene expression and ccl2 release in drg neurons. |
2014-03-21 |
2023-08-12 |
Not clear |
| Zetang Wu, Shiyong Wang, Sandy Gruber, Marina Mata, David J Fin. Full-length membrane-bound tumor necrosis factor-α acts through tumor necrosis factor receptor 2 to modify phenotype of sensory neurons. Pain. vol 154. issue 9. 2014-03-21. PMID:23711481. |
taken together, the results of this study suggest that mtnfα expressed in spinal microglia can facilitate pain signaling by up-regulating the expression of cation channels and ccl2 in drg neurons in a tnfr2-dependent manner. |
2014-03-21 |
2023-08-12 |
Not clear |
| Der-Jang Kao, Allen H Li, Jin-Chung Chen, Ro-Sun Luo, Ying-Ling Chen, Juu-Chin Lu, Hung-Li Wan. CC chemokine ligand 2 upregulates the current density and expression of TRPV1 channels and Nav1.8 sodium channels in dorsal root ganglion neurons. Journal of neuroinflammation. vol 9. 2013-06-17. PMID:22870919. |
inflammation or nerve injury-induced upregulation and release of chemokine cc chemokine ligand 2 (ccl2) within the dorsal root ganglion (drg) is believed to enhance the activity of drg nociceptive neurons and cause hyperalgesia. |
2013-06-17 |
2023-08-12 |
Not clear |
| Der-Jang Kao, Allen H Li, Jin-Chung Chen, Ro-Sun Luo, Ying-Ling Chen, Juu-Chin Lu, Hung-Li Wan. CC chemokine ligand 2 upregulates the current density and expression of TRPV1 channels and Nav1.8 sodium channels in dorsal root ganglion neurons. Journal of neuroinflammation. vol 9. 2013-06-17. PMID:22870919. |
we therefore tested the hypothesis that ccl2 causes peripheral sensitization of nociceptive drg neurons by upregulating the function and expression of trpv1 and nav1.8 channels. |
2013-06-17 |
2023-08-12 |
Not clear |
| Mounir Belkouch, Marc-André Dansereau, Annabelle Réaux-Le Goazigo, Juliette Van Steenwinckel, Nicolas Beaudet, Ahmed Chraibi, Stéphane Melik-Parsadaniantz, Philippe Sarre. The chemokine CCL2 increases Nav1.8 sodium channel activity in primary sensory neurons through a Gβγ-dependent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 50. 2012-02-09. PMID:22171040. |
in this study, we therefore investigated the effects of ccl2 on the density and kinetic properties of ttx-r na(v)1.8 currents in acutely small/medium dissociated lumbar drg neurons from naive adult rats. |
2012-02-09 |
2023-08-12 |
rat |
| Chang-Hui Wang, Li-Jing Zou, Yi-Li Zhang, Ying-Fu Jiao, Ji-Hu Su. The excitatory effects of the chemokine CCL2 on DRG somata are greater after an injury of the ganglion than after an injury of the spinal or peripheral nerve. Neuroscience letters. vol 475. issue 1. 2010-06-30. PMID:20346391. |
the excitatory effects of the chemokine ccl2 on drg somata are greater after an injury of the ganglion than after an injury of the spinal or peripheral nerve. |
2010-06-30 |
2023-08-12 |
rat |
| Chang-Hui Wang, Li-Jing Zou, Yi-Li Zhang, Ying-Fu Jiao, Ji-Hu Su. The excitatory effects of the chemokine CCL2 on DRG somata are greater after an injury of the ganglion than after an injury of the spinal or peripheral nerve. Neuroscience letters. vol 475. issue 1. 2010-06-30. PMID:20346391. |
whole-cell patch-clamp recordings revealed that ccl2, a ligand for ccr2 receptor, depolarized nociceptive drg neurons from rats of the all three models. |
2010-06-30 |
2023-08-12 |
rat |
| Chang-Hui Wang, Li-Jing Zou, Yi-Li Zhang, Ying-Fu Jiao, Ji-Hu Su. The excitatory effects of the chemokine CCL2 on DRG somata are greater after an injury of the ganglion than after an injury of the spinal or peripheral nerve. Neuroscience letters. vol 475. issue 1. 2010-06-30. PMID:20346391. |
thus, the injury-induced effects of ccl2 in increasing the excitability of the cell bodies of drg neurons depend on the site of the injury--with greater effects occurring after an injury of the ganglion than after an injury of the spinal or peripheral nerve. |
2010-06-30 |
2023-08-12 |
rat |
| Marc-André Dansereau, Romain-Daniel Gosselin, Michel Pohl, Blandine Pommier, Patricia Mechighel, Annie Mauborgne, William Rostene, Patrick Kitabgi, Nicolas Beaudet, Philippe Sarret, Stéphane Melik-Parsadaniant. Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats. Journal of neurochemistry. vol 106. issue 2. 2008-09-16. PMID:18419759. |
accordingly, using in vitro superfusion system of lumbar dorsal root ganglion and spinal cord explants of healthy rats, we show that potassium or capsaicin evoke calcium-dependent release of ccl2. |
2008-09-16 |
2023-08-12 |
rat |
| Hosung Jung, Peter T Toth, Fletcher A White, Richard J Mille. Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons. Journal of neurochemistry. vol 104. issue 1. 2008-02-18. PMID:17944871. |
it has previously been observed that expression of chemokine monocyte chemoattractant protein-1 (mcp-1/cc chemokine ligand 2 (ccl2)) and its receptor cc chemokine receptor 2 (ccr2) is up-regulated by dorsal root ganglion (drg) neurons in association with rodent models of neuropathic pain. |
2008-02-18 |
2023-08-12 |
Not clear |
| J Menetski, S Mistry, M Lu, J S Mudgett, R M Ransohoff, J A Demartino, D E Macintyre, C Abbadi. Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses. Neuroscience. vol 149. issue 3. 2008-01-16. PMID:17870246. |
consequently, proinflammatory cytokine mrna expression (il-1beta, il-6, and tnfalpha) levels were greater in skin, dorsal root ganglia (drg), and spinal cord, whereas the anti-inflammatory cytokine (il-10) level was lower in skin and drg in ccl2 overexpressing mice than in control mice. |
2008-01-16 |
2023-08-12 |
mouse |
| Victoria C J Wallace, Julie Blackbeard, Andrew R Segerdahl, Fauzia Hasnie, Timothy Pheby, Stephen B McMahon, Andrew S C Ric. Characterization of rodent models of HIV-gp120 and anti-retroviral-associated neuropathic pain. Brain : a journal of neurology. vol 130. issue Pt 10. 2007-11-13. PMID:17761732. |
however, the chemokine ccl2 is significantly expressed in the drg of rats treated with perineural hiv-gp120 and/or ddc and there is a reduction in intraepidermal nerve fibre density, comparable to that seen in herpes zoster infection. |
2007-11-13 |
2023-08-12 |
human |
| Iryna A Khasabova, Cheryl L Stucky, Catherine Harding-Rose, Laura Eikmeier, Alvin J Beitz, Lia G Coicou, Amy E Hanson, Donald A Simone, Virginia S Seybol. Chemical interactions between fibrosarcoma cancer cells and sensory neurons contribute to cancer pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 38. 2007-10-11. PMID:17881535. |
similar increases in neuronal responsiveness occurred when drg neurons from naive mice and fibrosarcoma cells were cocultured for 48 h. the cc chemokine ligand 2 (ccl2) may contribute to the tumor cell-induced sensitization because ccl2 immunoreactivity was present in tumors, high levels of ccl2 peptide were present in microperfusates from tumors, and treatment of drg neurons in vitro with ccl2 increased the amount of mrna for the alpha2delta1 subunit. |
2007-10-11 |
2023-08-12 |
mouse |
| Xiaomei Qin, You Wan, Xian Wan. CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons. Journal of neuroscience research. vol 82. issue 1. 2006-02-07. PMID:16047385. |
in this study, cgrp radioimmunoassay was used to investigate whether the chemokines ccl2 and cxcl1 could trigger cgrp release from cultured drg neurons of neonatal rats and, if so, which cellular signaling pathway was involved. |
2006-02-07 |
2023-08-12 |
rat |
| Xiaomei Qin, You Wan, Xian Wan. CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons. Journal of neuroscience research. vol 82. issue 1. 2006-02-07. PMID:16047385. |
these data suggest that ccl2 and cxcl1 can stimulate cgrp release and intracellular calcium elevation in drg neurons. |
2006-02-07 |
2023-08-12 |
rat |