| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sui-Bin Ma, Hang Xian, Wen-Bin Wu, Shuo-Yao Ma, Yu-Ke Liu, Yu-Tong Liang, Huan Guo, Jun-Jun Kang, Ying-Ying Liu, Hui Zhang, Sheng-Xi Wu, Ceng Luo, Rou-Gang Xi. CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals. Molecular brain. vol 13. issue 1. 2021-08-05. PMID:33228784. |
behavioral experiments show that intervertebral foramen injection ccr2 antagonists into dorsal root ganglion (drg) can inhibit the inflammatory pain caused by ccl2 in spinal cord. |
2021-08-05 |
2023-08-13 |
Not clear |
| Yan Li, Tejaswi Marri, Robert Y North, Haley R Rhodes, Megan L Uhelski, Claudio E Tatsui, Laurence D Rhines, Ganesh Rao, German Corrales, Taylor J Abercrombie, Caj A Johansson, Patrick M Doughert. Chemotherapy-induced peripheral neuropathy in a dish: dorsal root ganglion cells treated in vitro with paclitaxel show biochemical and physiological responses parallel to that seen in vivo. Pain. vol 162. issue 1. 2021-05-14. PMID:32694383. |
in primary rat dorsal root ganglion (drg) culture with paclitaxel, an increase of perk and pp38 was observed at 2 hours, and this was accompanied by an increase in expression and release of c-c chemokine ligand 2 (ccl2). |
2021-05-14 |
2023-08-13 |
rat |
| Shahani Noor, Joshua J Sanchez, Melody S Sun, Zinia Pervin, Jacob E Sanchez, Mara A Havard, Lauren T Epler, Monique V Nysus, Jeffrey P Norenberg, Carston R Wagner, Suzy Davies, Jennifer L Wagner, Daniel D Savage, Lauren L Jantzie, Nikolaos Mellios, Erin D Milliga. The LFA-1 antagonist BIRT377 reverses neuropathic pain in prenatal alcohol-exposed female rats via actions on peripheral and central neuroimmune function in discrete pain-relevant tissue regions. Brain, behavior, and immunity. vol 87. 2021-04-27. PMID:31918004. |
the data also show substantial increases in t cell-associated proinflammatory cytokine mrna and proteins, along with evidence of augmented myeloid/glial activation (mrna) and induction of myeloid/glial-related proinflammatory cytokines, ccl2, il-1β and tnf in discrete regions along the pain pathway (damaged sciatic nerve, dorsal root ganglia; drg, and spinal cord). |
2021-04-27 |
2023-08-13 |
rat |
| Inmaculada Bravo-Caparrós, M Carmen Ruiz-Cantero, Gloria Perazzoli, Shane J F Cronin, José M Vela, Mohamed F Hamed, Josef M Penninger, José M Baeyens, Enrique J Cobos, Francisco R Niet. Sigma-1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 4. 2021-01-19. PMID:32157739. |
in wt mice, injured drg produced the chemokine ccl2, and this was followed by massive infiltration of macrophages/monocytes, which clustered mainly around sensory neurons with translocated sig-1r, accompanied by robust il-6 increase and mechanical allodynia. |
2021-01-19 |
2023-08-13 |
mouse |
| Inmaculada Bravo-Caparrós, M Carmen Ruiz-Cantero, Gloria Perazzoli, Shane J F Cronin, José M Vela, Mohamed F Hamed, Josef M Penninger, José M Baeyens, Enrique J Cobos, Francisco R Niet. Sigma-1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 4. 2021-01-19. PMID:32157739. |
in contrast, sig-1r knockout (sig-1r-ko) mice showed reduced levels of ccl2, decreased macrophage/monocyte infiltration into drg, and less il-6 and neuropathic mechanical allodynia after sni. |
2021-01-19 |
2023-08-13 |
mouse |
| Nan Cheng, Zheng Zhang, Yue Guo, Zhuo-Lin Qiu, Jing-Yi Du, Zi-Qing Hei, Xiang L. Weighted gene co-expression network analysis reveals specific modules and hub genes related to neuropathic pain in dorsal root ganglions. Bioscience reports. vol 39. issue 11. 2020-09-25. PMID:31696225. |
the in vivo studies validated that mrna and protein levels of ccl2, fos and timp1 were up-regulated in drg and spinal cord tissues after tnt. |
2020-09-25 |
2023-08-13 |
rat |
| Katarzyna Pawlik, Anna Piotrowska, Klaudia Kwiatkowski, Katarzyna Ciapała, Katarzyna Popiolek-Barczyk, Wioletta Makuch, Joanna Mik. The blockade of CC chemokine receptor type 1 influences the level of nociceptive factors and enhances opioid analgesic potency in a rat model of neuropathic pain. Immunology. vol 159. issue 4. 2020-07-27. PMID:31919846. |
our study provides evidence that the development of hypersensitivity in rats following chronic constriction injury (cci) of the sciatic nerve is associated with significant up-regulation of endogenous ccr1 ligands, namely, ccl2, ccl3, ccl4, ccl6, ccl7 and ccl9 in the spinal cord and ccl2, ccl6, ccl7 and ccl9 in dorsal root ganglia (drg). |
2020-07-27 |
2023-08-13 |
rat |
| Haowu Jiang, Huan Cui, Tao Wang, Steven G Shimada, Rui Sun, Zhiyong Tan, Chao Ma, Robert H LaMott. CCL2/CCR2 signaling elicits itch- and pain-like behavior in a murine model of allergic contact dermatitis. Brain, behavior, and immunity. vol 80. 2020-05-29. PMID:30981714. |
by 24 h after the 2nd challenge to the hind paw ccl2 and ccr2 mrna, protein, and signaling activity were upregulated in the dorsal root ganglion (drg). |
2020-05-29 |
2023-08-13 |
mouse |
| Haowu Jiang, Huan Cui, Tao Wang, Steven G Shimada, Rui Sun, Zhiyong Tan, Chao Ma, Robert H LaMott. CCL2/CCR2 signaling elicits itch- and pain-like behavior in a murine model of allergic contact dermatitis. Brain, behavior, and immunity. vol 80. 2020-05-29. PMID:30981714. |
calcium imaging and whole-cell current-clamp recordings revealed that ccl2 directly acted on its neuronal receptor, ccr2 to activate a subset of small-diameter, nociceptive-like drg neurons retrogradely labeled from the chs site. |
2020-05-29 |
2023-08-13 |
mouse |
| Haowu Jiang, Huan Cui, Tao Wang, Steven G Shimada, Rui Sun, Zhiyong Tan, Chao Ma, Robert H LaMott. CCL2/CCR2 signaling elicits itch- and pain-like behavior in a murine model of allergic contact dermatitis. Brain, behavior, and immunity. vol 80. 2020-05-29. PMID:30981714. |
results are consistent with the hypothesis that chs upregulates ccl2/ccr2 signaling in a subpopulation of cutaneous small diameter drg neurons and that ccl2 can activate these neurons through neuronal ccr2 to elicit itch- and pain-behavior. |
2020-05-29 |
2023-08-13 |
mouse |
| Joshua J Sanchez, Jacob E Sanchez, Shahani Noor, Chaselyn D Ruffaner-Hanson, Suzy Davies, Carston R Wagner, Lauren L Jantzie, Nikolaos Mellios, Daniel D Savage, Erin D Milliga. Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure. Acta neuropathologica communications. vol 7. issue 1. 2020-04-21. PMID:30961664. |
chemokine mrna analyses from scn, drg and spinal cord reveal that increased ccl2 occurs following cci injury regardless of pae and birt-377 treatment. |
2020-04-21 |
2023-08-13 |
rat |
| Rui Wu, Ping-An Zhang, Xuelian Liu, Yuan Zhou, Meijie Xu, Xinghong Jiang, Jun Yan, Guang-Yin X. Decreased miR-325-5p Contributes to Visceral Hypersensitivity Through Post-transcriptional Upregulation of CCL2 in Rat Dorsal Root Ganglia. Neuroscience bulletin. vol 35. issue 5. 2020-03-03. PMID:30980241. |
ccl2 was co-expressed in neun-positive drg neurons but not in glutamine synthetase-positive glial cells. |
2020-03-03 |
2023-08-13 |
rat |
| Rui Wu, Ping-An Zhang, Xuelian Liu, Yuan Zhou, Meijie Xu, Xinghong Jiang, Jun Yan, Guang-Yin X. Decreased miR-325-5p Contributes to Visceral Hypersensitivity Through Post-transcriptional Upregulation of CCL2 in Rat Dorsal Root Ganglia. Neuroscience bulletin. vol 35. issue 5. 2020-03-03. PMID:30980241. |
furthermore, ccl2 was mainly expressed in isolectin b4-binding- and calcitonin gene-related peptide-positive drg neurons but in few nf-200-positive cells. |
2020-03-03 |
2023-08-13 |
rat |
| Rui Wu, Ping-An Zhang, Xuelian Liu, Yuan Zhou, Meijie Xu, Xinghong Jiang, Jun Yan, Guang-Yin X. Decreased miR-325-5p Contributes to Visceral Hypersensitivity Through Post-transcriptional Upregulation of CCL2 in Rat Dorsal Root Ganglia. Neuroscience bulletin. vol 35. issue 5. 2020-03-03. PMID:30980241. |
more importantly, ccl2 was expressed in mir-325-5p-positive drg neurons. |
2020-03-03 |
2023-08-13 |
rat |
| Richard E Zigmond, Franklin D Echevarri. Macrophage biology in the peripheral nervous system after injury. Progress in neurobiology. vol 173. 2020-02-17. PMID:30579784. |
in mice in which the genes for ccl2 or ccr2 are deleted, neither macrophage infiltration nor the conditioning lesion response occurs in dorsal root ganglia (drg). |
2020-02-17 |
2023-08-13 |
mouse |
| Richard E Zigmond, Franklin D Echevarri. Macrophage biology in the peripheral nervous system after injury. Progress in neurobiology. vol 173. 2020-02-17. PMID:30579784. |
overexpression of ccl2 in drg in uninjured animals leads to macrophage accumulation in the ganglia and to an increase in the growth potential of drg neurons. |
2020-02-17 |
2023-08-13 |
mouse |
| Yul Huh, Ru-Rong Ji, Gang Che. Neuroinflammation, Bone Marrow Stem Cells, and Chronic Pain. Frontiers in immunology. vol 8. 2019-11-20. PMID:28871264. |
characteristic features of neuroinflammation in chronic pain conditions include infiltration of immune cells into the pns [e.g., the sciatic nerve and dorsal root ganglion (drg)], activation of glial cells such as microglia and astrocytes in the cns (spinal cord and brain), and production and secretion of pro-inflammatory cytokines and chemokines [tnf, interleukin (il)-1β, il-6, ccl2, and cxcl1]. |
2019-11-20 |
2023-08-13 |
Not clear |
| Ping Luo, Jiayun Shao, Yingfu Jiao, Weifeng Yu, Weifang Ron. CC chemokine ligand 2 (CCL2) enhances TTX-sensitive sodium channel activity of primary afferent neurons in the complete Freud adjuvant-induced inflammatory pain model. Acta biochimica et biophysica Sinica. vol 50. issue 12. 2019-03-25. PMID:30339176. |
a significant increase of ccl2 mrna and ccl2 receptor (ccr2) protein expression was detected in the ipsilateral dorsal root ganglion (drg) in cfa-treated rats. |
2019-03-25 |
2023-08-13 |
rat |
| Ping Luo, Jiayun Shao, Yingfu Jiao, Weifeng Yu, Weifang Ron. CC chemokine ligand 2 (CCL2) enhances TTX-sensitive sodium channel activity of primary afferent neurons in the complete Freud adjuvant-induced inflammatory pain model. Acta biochimica et biophysica Sinica. vol 50. issue 12. 2019-03-25. PMID:30339176. |
patch-clamp recording of acutely dissociated drg neurons revealed that ccl2 had minimum effect on the excitability of sensory neurons from control rats. |
2019-03-25 |
2023-08-13 |
rat |
| Amina M Illias, Andrea C Gist, Haijun Zhang, Alyssa K Kosturakis, Patrick M Doughert. Chemokine CCL2 and its receptor CCR2 in the dorsal root ganglion contribute to oxaliplatin-induced mechanical hypersensitivity. Pain. vol 159. issue 7. 2019-02-25. PMID:29554018. |
chemokine ccl2 and its receptor ccr2 in the dorsal root ganglion contribute to oxaliplatin-induced mechanical hypersensitivity. |
2019-02-25 |
2023-08-13 |
Not clear |